Details for: HTATIP2

Gene ID: 10553

Symbol: HTATIP2

Ensembl ID: ENSG00000109854

Description: HIV-1 Tat interactive protein 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.21
    Marker Score: 10,630
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 1.78
    Marker Score: 1,706
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.63
    Marker Score: 9,906
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.6
    Marker Score: 40,864
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.58
    Marker Score: 2,432
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.54
    Marker Score: 1,523
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.46
    Marker Score: 4,581
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.41
    Marker Score: 2,077
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.41
    Marker Score: 1,348
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.39
    Marker Score: 2,471
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.37
    Marker Score: 11,813
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.34
    Marker Score: 10,473
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.34
    Marker Score: 1,410
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.31
    Marker Score: 8,344
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.29
    Marker Score: 3,173
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.23
    Marker Score: 2,790
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.19
    Marker Score: 2,717
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.18
    Marker Score: 7,515
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.17
    Marker Score: 978
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.16
    Marker Score: 1,239
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.15
    Marker Score: 633
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.13
    Marker Score: 391
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.12
    Marker Score: 4,382
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.11
    Marker Score: 396
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.05
    Marker Score: 703
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.04
    Marker Score: 2,034
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.03
    Marker Score: 2,454
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.03
    Marker Score: 1,028
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.02
    Marker Score: 383
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.01
    Marker Score: 7,528
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1
    Marker Score: 55,943
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,665
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,885
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,386
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.98
    Marker Score: 559
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.97
    Marker Score: 967
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.96
    Marker Score: 402
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.95
    Marker Score: 274
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,396
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.94
    Marker Score: 1,133
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.94
    Marker Score: 228
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.93
    Marker Score: 8,078
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.92
    Marker Score: 267
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.92
    Marker Score: 431
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.92
    Marker Score: 10,716
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,725
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,187
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.9
    Marker Score: 1,026
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.89
    Marker Score: 9,055
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.89
    Marker Score: 372
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.89
    Marker Score: 331
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.88
    Marker Score: 219
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.88
    Marker Score: 916
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.87
    Marker Score: 1,265
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.87
    Marker Score: 958
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.86
    Marker Score: 215
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,217
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.86
    Marker Score: 1,323
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.86
    Marker Score: 359
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.86
    Marker Score: 444
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.86
    Marker Score: 624
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.86
    Marker Score: 215
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.85
    Marker Score: 671
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.85
    Marker Score: 355
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.84
    Marker Score: 2,058
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.84
    Marker Score: 188
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.84
    Marker Score: 1,597
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.83
    Marker Score: 740
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.83
    Marker Score: 2,849
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.83
    Marker Score: 8,198
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.83
    Marker Score: 1,370
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.82
    Marker Score: 2,921
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.82
    Marker Score: 405
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.82
    Marker Score: 356
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.82
    Marker Score: 955
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.82
    Marker Score: 223
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.81
    Marker Score: 1,083
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.81
    Marker Score: 1,485
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.8
    Marker Score: 1,400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 611
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 318
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.79
    Marker Score: 274
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.79
    Marker Score: 250
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.79
    Marker Score: 772
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.79
    Marker Score: 173
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.79
    Marker Score: 1,249
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,266
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.78
    Marker Score: 26,471
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.78
    Marker Score: 1,199
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.78
    Marker Score: 692
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.77
    Marker Score: 1,947
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.77
    Marker Score: 471
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.76
    Marker Score: 1,827
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.76
    Marker Score: 531
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.76
    Marker Score: 189
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.76
    Marker Score: 344
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.76
    Marker Score: 178

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HTATIP2 shares structural homology with the HIV-1 Tat protein, a potent transcriptional activator. However, unlike Tat, HTATIP2 lacks the N-terminal transactivation domain, rendering it a distinct entity with its own set of functional properties. Notably, HTATIP2 exhibits: 1. **Oxidoreductase activity**: HTATIP2 possesses oxidoreductase activity, which suggests its potential role in redox regulation and cellular stress response. 2. **Serine/threonine kinase activity**: This enzyme activity implies that HTATIP2 can phosphorylate and modulate the activity of various substrates, including transcription factors and signaling proteins. 3. **Transcription coactivator activity**: HTATIP2 can interact with RNA polymerase II and other transcriptional coactivators, suggesting its involvement in regulating gene expression. **Pathways and Functions:** HTATIP2's multifunctional nature has led to the identification of several key pathways and functions: 1. **Angiogenesis regulation**: HTATIP2 has been implicated in the regulation of angiogenesis, a critical process in tumor growth and metastasis. 2. **Apoptotic process regulation**: HTATIP2 can modulate the apoptotic process, influencing cell survival and death. 3. **Cell differentiation**: HTATIP2 may play a role in regulating cell differentiation, particularly in the context of immune cell development. 4. **Transcriptional regulation**: HTATIP2's ability to interact with RNA polymerase II and other transcriptional coactivators positions it as a key player in regulating gene expression. **Clinical Significance:** The discovery of HTATIP2's involvement in immune regulation and disease pathogenesis has significant implications for the development of novel therapeutic strategies: 1. **Cancer therapy**: HTATIP2's role in angiogenesis and transcriptional regulation make it a potential target for cancer therapy. 2. **Autoimmune diseases**: HTATIP2's involvement in immune cell differentiation and regulation may provide insights into the pathogenesis of autoimmune diseases. 3. **Infectious diseases**: HTATIP2's interaction with HIV-1 Tat protein has implications for understanding the mechanisms of HIV-1 infection and potential therapeutic interventions. In conclusion, HTATIP2 is a complex protein with multifunctional properties that have far-reaching implications for our understanding of immune regulation and disease pathogenesis. Further research is needed to fully elucidate the role of HTATIP2 in human health and disease, and to explore its potential as a therapeutic target.

Genular Protein ID: 4291269237

Symbol: HTAI2_HUMAN

Name: Oxidoreductase HTATIP2

UniProtKB Accession Codes:

Q9BUP3 A8K7S7 D3DQY8 O15383 O60520 O95345 Q53GC1 Q53GG2 Q6IBI3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 18 EPD 1 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9174052

Title: A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma.

PubMed ID: 9174052

DOI: 10.1038/sj.onc.1201059

PubMed ID: 9482853

Title: A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription.

PubMed ID: 9482853

DOI: 10.1073/pnas.95.5.2146

PubMed ID: 10611237

Title: Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis.

PubMed ID: 10611237

DOI: 10.1128/mcb.20.2.583-593.2000

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10698937

Title: TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes.

PubMed ID: 10698937

DOI: 10.1093/emboj/19.5.956

PubMed ID: 11313954

Title: Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro.

PubMed ID: 11313954

DOI: 10.1038/sj.onc.1204075

PubMed ID: 14695192

Title: TIP30 deficiency increases susceptibility to tumorigenesis.

PubMed ID: 14695192

PubMed ID: 15073177

Title: TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription.

PubMed ID: 15073177

DOI: 10.1074/jbc.m401809200

PubMed ID: 15282309

Title: Inhibition of nuclear import by the proapoptotic protein CC3.

PubMed ID: 15282309

DOI: 10.1128/mcb.24.16.7091-7101.2004

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15728189

Title: Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor.

PubMed ID: 15728189

DOI: 10.1074/jbc.m501113200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24237036

Title: Large-scale quantification of single amino-acid variations by a variation-associated database search strategy.

PubMed ID: 24237036

DOI: 10.1021/pr400544j

Sequence Information:

  • Length: 242
  • Mass: 27049
  • Checksum: 6A26E4A095243678
  • Sequence:
    • MAETEALSKL REDFRMQNKS VFILGASGET GRVLLKEILE QGLFSKVTLI GRRKLTFDEE 
AYKNVNQEVV DFEKLDDYAS AFQGHDVGFC CLGTTRGKAG AEGFVRVDRD YVLKSAELAK 
AGGCKHFNLL SSKGADKSSN FLYLQVKGEV EAKVEELKFD RYSVFRPGVL LCDRQESRPG 
EWLVRKFFGS LPDSWASGHS VPVVTVVRAM LNNVVRPRDK QMELLENKAI HDLGKAHGSL 
KP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.