Details for: AGPAT1

Gene ID: 10554

Symbol: AGPAT1

Ensembl ID: ENSG00000204310

Description: 1-acylglycerol-3-phosphate O-acyltransferase 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.95
    Marker Score: 3,400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.78
    Marker Score: 1,588
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.27
    Marker Score: 850
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.27
    Marker Score: 1,421
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.25
    Marker Score: 757
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.2
    Marker Score: 578
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.18
    Marker Score: 627
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.17
    Marker Score: 394
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.14
    Marker Score: 2,315
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.04
    Marker Score: 434
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.04
    Marker Score: 975
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,393
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.96
    Marker Score: 1,203
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.95
    Marker Score: 644
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,394
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.94
    Marker Score: 2,206
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.94
    Marker Score: 293
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.92
    Marker Score: 4,415
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.91
    Marker Score: 682
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.91
    Marker Score: 3,567
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,699
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.9
    Marker Score: 255
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.89
    Marker Score: 287
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.89
    Marker Score: 1,275
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.87
    Marker Score: 1,286
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,289
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.87
    Marker Score: 1,820
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.87
    Marker Score: 936
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.86
    Marker Score: 573
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.84
    Marker Score: 891
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.84
    Marker Score: 1,911
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4,793
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.83
    Marker Score: 882
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.82
    Marker Score: 372
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.82
    Marker Score: 388
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1,328
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.79
    Marker Score: 6,823
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.79
    Marker Score: 1,868
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.78
    Marker Score: 184
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.78
    Marker Score: 443
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.78
    Marker Score: 3,607
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.78
    Marker Score: 5,065
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.78
    Marker Score: 2,084
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.78
    Marker Score: 3,353
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.78
    Marker Score: 387
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 310
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.77
    Marker Score: 968
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.76
    Marker Score: 7,683
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 579
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.75
    Marker Score: 314
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.75
    Marker Score: 2,032
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.75
    Marker Score: 8,405
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.74
    Marker Score: 521
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.73
    Marker Score: 887
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.73
    Marker Score: 417
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.73
    Marker Score: 1,123
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.73
    Marker Score: 777
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.72
    Marker Score: 684
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.72
    Marker Score: 678
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.72
    Marker Score: 1,218
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.72
    Marker Score: 394
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.71
    Marker Score: 4,206
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.7
    Marker Score: 732
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.7
    Marker Score: 931
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.7
    Marker Score: 415
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.7
    Marker Score: 1,754
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 629
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.69
    Marker Score: 23,800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.67
    Marker Score: 677
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.67
    Marker Score: 1,034
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.67
    Marker Score: 1,527
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.67
    Marker Score: 277
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.67
    Marker Score: 6,346
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2,798
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.66
    Marker Score: 2,356
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.66
    Marker Score: 193
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.65
    Marker Score: 409
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.65
    Marker Score: 689
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.65
    Marker Score: 656
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.65
    Marker Score: 8,522
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.64
    Marker Score: 148
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.63
    Marker Score: 236
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.63
    Marker Score: 38,644
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.63
    Marker Score: 7,280
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.62
    Marker Score: 1,031
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 411
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.62
    Marker Score: 2,403
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.62
    Marker Score: 270
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.61
    Marker Score: 5,397
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.61
    Marker Score: 246
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.61
    Marker Score: 229
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.61
    Marker Score: 278
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.61
    Marker Score: 842
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.6
    Marker Score: 149
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.6
    Marker Score: 155

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AGPAT1 is a member of the O-acyltransferase family and is responsible for the transfer of an acyl group from acyl-CoA to 1-acylglycerol-3-phosphate, resulting in the formation of phosphatidic acid. This reaction is a critical step in the biosynthesis of phospholipids, which are essential components of cellular membranes. AGPAT1 has been shown to be highly expressed in cells involved in energy metabolism, such as skeletal muscle and adipocytes. **Pathways and Functions:** AGPAT1 plays a crucial role in various cellular pathways, including: 1. **Glycerophospholipid biosynthesis**: AGPAT1 is involved in the synthesis of phospholipids, which are essential components of cellular membranes. 2. **Integration of energy metabolism**: AGPAT1 is expressed in cells involved in energy metabolism, such as skeletal muscle and adipocytes, and is involved in the regulation of energy homeostasis. 3. **Cytokine-mediated signaling pathway**: AGPAT1 has been shown to regulate cytokine production, which is essential for the immune response. 4. **Phospholipid metabolic process**: AGPAT1 is involved in the regulation of phospholipid metabolism, which is critical for maintaining cellular homeostasis. **Clinical Significance:** Dysregulation of AGPAT1 has been implicated in various diseases, including: 1. **Obesity**: AGPAT1 has been shown to play a role in the regulation of energy homeostasis, and its dysregulation has been linked to obesity. 2. **Metabolic disorders**: AGPAT1 has been implicated in the regulation of lipid metabolism, and its dysregulation has been linked to metabolic disorders such as type 2 diabetes. 3. **Neurological disorders**: AGPAT1 has been shown to play a role in the regulation of cytokine production, and its dysregulation has been linked to neurological disorders such as multiple sclerosis. In conclusion, AGPAT1 is a critical enzyme involved in lipid metabolism and energy homeostasis. Its dysregulation has been implicated in various diseases, highlighting the importance of AGPAT1 in maintaining cellular homeostasis. Further research is needed to fully understand the role of AGPAT1 in human disease and to develop therapeutic strategies to target this enzyme.

Genular Protein ID: 76197157

Symbol: PLCA_HUMAN

Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

UniProtKB Accession Codes:

Q99943 A2BFI5 Q5BL03

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 72 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 16 EPD 1 Ensembl 42 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 Rhea 36 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9212163

Title: Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells.

PubMed ID: 9212163

DOI: 10.1089/dna.1997.16.691

PubMed ID: 9291118

Title: A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases.

PubMed ID: 9291118

DOI: 10.1042/bj3260455

PubMed ID: 9461603

Title: Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex.

PubMed ID: 9461603

DOI: 10.1074/jbc.273.7.4096

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21873652

Title: Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice.

PubMed ID: 21873652

DOI: 10.1074/jbc.m111.250449

Sequence Information:

  • Length: 283
  • Mass: 31717
  • Checksum: 71F3207259747C68
  • Sequence:
    • MDLWPGAWML LLLLFLLLLF LLPTLWFCSP SAKYFFKMAF YNGWILFLAV LAIPVCAVRG 
RNVENMKILR LMLLHIKYLY GIRVEVRGAH HFPPSQPYVV VSNHQSSLDL LGMMEVLPGR 
CVPIAKRELL WAGSAGLACW LAGVIFIDRK RTGDAISVMS EVAQTLLTQD VRVWVFPEGT 
RNHNGSMLPF KRGAFHLAVQ AQVPIVPIVM SSYQDFYCKK ERRFTSGQCQ VRVLPPVPTE 
GLTPDDVPAL ADRVRHSMLT VFREISTDGR GGGDYLKKPG GGG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.