AGPAT2 | ENSG00000169692 | NCBI 10555

Details for: AGPAT2

Gene ID: 10555

Symbol: AGPAT2

Ensembl ID: ENSG00000169692

Description: 1-acylglycerol-3-phosphate O-acyltransferase 2

Associated with

Glycerophospholipid biosynthesis
(R-HSA-1483206)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Neutrophil degranulation
(R-HSA-6798695)
Phospholipid metabolism
(R-HSA-1483257)
Synthesis of pa
(R-HSA-1483166)
1-acylglycerol-3-phosphate o-acyltransferase activity
(GO:0003841)
Cdp-diacylglycerol biosynthetic process
(GO:0016024)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Epidermis development
(GO:0008544)
Phosphatidic acid biosynthetic process
(GO:0006654)
Phospholipid metabolic process
(GO:0006644)
Plasma membrane
(GO:0005886)
Positive regulation of cytokine-mediated signaling pathway
(GO:0001961)
Positive regulation of cytokine production
(GO:0001819)
Response to xenobiotic stimulus
(GO:0009410)
Specific granule membrane
(GO:0035579)
Triglyceride biosynthetic process
(GO:0019432)

Other Information

Proteins

1-acyl-sn-glycerol-3-phosphate acyltransferase beta
A0A024R8F9_HUMAN

Genular Protein ID: 2408094561

Symbol: PLCB_HUMAN

Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase beta

UniProtKB Accession Codes:

O15120 O00516 O15106 Q5VUD3 Q5VUD4 Q9BSV7 Q9BWR7

Database IDs:

Citations:

PubMed ID: 9242711

Title: Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3.

PubMed ID: 9242711

DOI: 10.1074/jbc.272.32.20299

PubMed ID: 9291118

Title: A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases.

PubMed ID: 9291118

DOI: 10.1042/bj3260455

PubMed ID: 9212163

Title: Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells.

PubMed ID: 9212163

DOI: 10.1089/dna.1997.16.691

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15028826

Title: Acquired and inherited lipodystrophies.

PubMed ID: 15028826

DOI: 10.1056/nejmra025261

PubMed ID: 15629135

Title: Enzymatic activity of naturally occurring 1-acylglycerol-3-phosphate-O-acyltransferase 2 mutants associated with congenital generalized lipodystrophy.

PubMed ID: 15629135

DOI: 10.1016/j.bbrc.2004.12.024

PubMed ID: 19075029

Title: The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids.

PubMed ID: 19075029

DOI: 10.1194/jlr.m800567-jlr200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21873652

Title: Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice.

PubMed ID: 21873652

DOI: 10.1074/jbc.m111.250449

PubMed ID: 11967537

Title: AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34.

PubMed ID: 11967537

DOI: 10.1038/ng880

Sequence Information:

Length: 278
Mass: 30914
Checksum: 1E58F537F703BE9F
Sequence:

MELWPCLAAA LLLLLLLVQL SRAAEFYAKV ALYCALCFTV SAVASLVCLL RHGGRTVENM 
SIIGWFVRSF KYFYGLRFEV RDPRRLQEAR PCVIVSNHQS ILDMMGLMEV LPERCVQIAK 
RELLFLGPVG LIMYLGGVFF INRQRSSTAM TVMADLGERM VRENLKVWIY PEGTRNDNGD 
LLPFKKGAFY LAVQAQVPIV PVVYSSFSSF YNTKKKFFTS GTVTVQVLEA IPTSGLTAAD 
VPALVDTCHR AMRTTFLHIS KTPQENGATA GSGVQPAQ

Genular Protein ID: 3692575829

Symbol: A0A024R8F9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A024R8F9

Database IDs:

Sequence Information:

Length: 246
Mass: 27279
Checksum: 2A6E877F48DC3FE9
Sequence:

MELWPCLAAA LLLLLLLVQL SRAAEFYAKV ALYCALCFTV SAVASLVCLL RHGGRTVENM 
SIIGWFVRSF KYFYGLRFEV RDPRRLQEAR PCVIVSNHQS ILDMMGLMEV LPERCVQIAK 
RELLFLGPVG LIMYLGGVFF INRQRSSTAM TVMADLGERM VRENVPIVPV VYSSFSSFYN 
TKKKFFTSGT VTVQVLEAIP TSGLTAADVP ALVDTCHRAM RTTFLHISKT PQENGATAGS 
GVQPAQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AGPAT2

Associated with

Other Information

Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3. PubMed ID: 9242711

A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases. PubMed ID: 9291118

Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells. PubMed ID: 9212163

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Acquired and inherited lipodystrophies. PubMed ID: 15028826

Enzymatic activity of naturally occurring 1-acylglycerol-3-phosphate-O-acyltransferase 2 mutants associated with congenital generalized lipodystrophy. PubMed ID: 15629135

The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids. PubMed ID: 19075029

Initial characterization of the human central proteome. PubMed ID: 21269460

Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice. PubMed ID: 21873652

AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34. PubMed ID: 11967537