Details for: AGPAT2

Gene ID: 10555

Symbol: AGPAT2

Ensembl ID: ENSG00000169692

Description: 1-acylglycerol-3-phosphate O-acyltransferase 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 3.71
    Marker Score: 1,355
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.06
    Marker Score: 14,671
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.93
    Marker Score: 9,210
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.74
    Marker Score: 5,789
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.58
    Marker Score: 3,974
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.37
    Marker Score: 15,480
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.31
    Marker Score: 3,717
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.08
    Marker Score: 1,163
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.92
    Marker Score: 555
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.84
    Marker Score: 2,929
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.82
    Marker Score: 14,212
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.8
    Marker Score: 11,497
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.79
    Marker Score: 45,791
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.75
    Marker Score: 2,580
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.74
    Marker Score: 4,128
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.71
    Marker Score: 4,594
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.67
    Marker Score: 2,762
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.66
    Marker Score: 14,339
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.6
    Marker Score: 1,529
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.59
    Marker Score: 873
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.56
    Marker Score: 1,233
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.55
    Marker Score: 8,155
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.55
    Marker Score: 1,295
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.54
    Marker Score: 382
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.51
    Marker Score: 3,421
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.49
    Marker Score: 1,544
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.49
    Marker Score: 51,452
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.48
    Marker Score: 720
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.48
    Marker Score: 347
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.48
    Marker Score: 1,566
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.44
    Marker Score: 962
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.42
    Marker Score: 3,571
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.41
    Marker Score: 1,434
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4
    Marker Score: 1,472
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.4
    Marker Score: 525
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.35
    Marker Score: 607
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.33
    Marker Score: 1,608
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.3
    Marker Score: 72,812
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.3
    Marker Score: 7,874
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.27
    Marker Score: 9,478
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.27
    Marker Score: 1,799
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.26
    Marker Score: 10,960
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.26
    Marker Score: 20,210
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.26
    Marker Score: 2,864
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.25
    Marker Score: 360
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.22
    Marker Score: 1,212
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.21
    Marker Score: 1,381
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2
    Marker Score: 12,203
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.2
    Marker Score: 594
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.2
    Marker Score: 2,192
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.17
    Marker Score: 2,441
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.14
    Marker Score: 2,849
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.14
    Marker Score: 4,917
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.14
    Marker Score: 361
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.12
    Marker Score: 2,132
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.12
    Marker Score: 219
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.11
    Marker Score: 706
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.11
    Marker Score: 17,336
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.1
    Marker Score: 514
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.1
    Marker Score: 3,605
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.09
    Marker Score: 2,209
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.08
    Marker Score: 263
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.07
    Marker Score: 752
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.05
    Marker Score: 301
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.03
    Marker Score: 491
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.02
    Marker Score: 1,277
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.02
    Marker Score: 245
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.01
    Marker Score: 315
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1
    Marker Score: 615
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1
    Marker Score: 1,944
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,654
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,879
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.99
    Marker Score: 999
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.98
    Marker Score: 366
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,385
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.98
    Marker Score: 707
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.96
    Marker Score: 5,136
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.95
    Marker Score: 251
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.94
    Marker Score: 631
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,391
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.94
    Marker Score: 380
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.93
    Marker Score: 589
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.93
    Marker Score: 331
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.93
    Marker Score: 5,975
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,216
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1,477
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,721
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.91
    Marker Score: 249
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.9
    Marker Score: 1,056
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.9
    Marker Score: 230
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.9
    Marker Score: 1,533
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.9
    Marker Score: 803
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.89
    Marker Score: 308
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.89
    Marker Score: 938
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.88
    Marker Score: 3,611
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.88
    Marker Score: 2,280
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.88
    Marker Score: 228
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.87
    Marker Score: 364

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AGPAT2 is a member of the 1-acylglycerol-3-phosphate O-acyltransferase family, which is responsible for the conversion of 1-acylglycerol-3-phosphate to phosphatidic acid. This reaction is a critical step in the synthesis of phospholipids, which are essential for maintaining cellular membrane structure and function. AGPAT2 has been shown to be highly specific for the conversion of 1-acylglycerol-3-phosphate to phosphatidic acid, and its activity is regulated by various factors, including calcium ions and phospholipids. **Pathways and Functions:** AGPAT2 is involved in several key pathways, including: 1. **Glycerophospholipid biosynthesis**: AGPAT2 plays a crucial role in the synthesis of phospholipids, which are essential components of cellular membranes. 2. **Immune system**: AGPAT2 has been shown to regulate inflammatory responses and modulate the immune system, particularly in the context of innate immunity. 3. **Metabolism of lipids**: AGPAT2 is involved in the regulation of lipid metabolism, including the synthesis of phospholipids and triglycerides. 4. **Endoplasmic reticulum**: AGPAT2 is localized to the endoplasmic reticulum, where it plays a role in the regulation of phospholipid synthesis. **Clinical Significance:** Dysregulation of AGPAT2 has been implicated in various diseases, including: 1. **Inflammatory disorders**: AGPAT2 has been shown to play a role in the regulation of inflammatory responses, and its dysregulation has been implicated in diseases such as rheumatoid arthritis and atherosclerosis. 2. **Metabolic disorders**: AGPAT2 has been implicated in the regulation of lipid metabolism, and its dysregulation has been linked to metabolic disorders such as obesity and type 2 diabetes. 3. **Cancer**: AGPAT2 has been shown to play a role in the regulation of cellular metabolism and has been implicated in the development of certain types of cancer. In conclusion, AGPAT2 is a critical enzyme involved in the regulation of lipid metabolism and immune response. Its dysregulation has been implicated in various diseases, and further research is needed to fully understand its role in human health and disease.

Genular Protein ID: 2408094561

Symbol: PLCB_HUMAN

Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase beta

UniProtKB Accession Codes:

O15120 O00516 O15106 Q5VUD3 Q5VUD4 Q9BSV7 Q9BWR7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 68 ChEMBL 1 DNASU 1 DisGeNET 1 EC 1 EMBL 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 13 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 34 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9242711

Title: Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3.

PubMed ID: 9242711

DOI: 10.1074/jbc.272.32.20299

PubMed ID: 9291118

Title: A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases.

PubMed ID: 9291118

DOI: 10.1042/bj3260455

PubMed ID: 9212163

Title: Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells.

PubMed ID: 9212163

DOI: 10.1089/dna.1997.16.691

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15028826

Title: Acquired and inherited lipodystrophies.

PubMed ID: 15028826

DOI: 10.1056/nejmra025261

PubMed ID: 15629135

Title: Enzymatic activity of naturally occurring 1-acylglycerol-3-phosphate-O-acyltransferase 2 mutants associated with congenital generalized lipodystrophy.

PubMed ID: 15629135

DOI: 10.1016/j.bbrc.2004.12.024

PubMed ID: 19075029

Title: The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipids.

PubMed ID: 19075029

DOI: 10.1194/jlr.m800567-jlr200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21873652

Title: Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice.

PubMed ID: 21873652

DOI: 10.1074/jbc.m111.250449

PubMed ID: 11967537

Title: AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34.

PubMed ID: 11967537

DOI: 10.1038/ng880

Sequence Information:

  • Length: 278
  • Mass: 30914
  • Checksum: 1E58F537F703BE9F
  • Sequence:
    • MELWPCLAAA LLLLLLLVQL SRAAEFYAKV ALYCALCFTV SAVASLVCLL RHGGRTVENM 
SIIGWFVRSF KYFYGLRFEV RDPRRLQEAR PCVIVSNHQS ILDMMGLMEV LPERCVQIAK 
RELLFLGPVG LIMYLGGVFF INRQRSSTAM TVMADLGERM VRENLKVWIY PEGTRNDNGD 
LLPFKKGAFY LAVQAQVPIV PVVYSSFSSF YNTKKKFFTS GTVTVQVLEA IPTSGLTAAD 
VPALVDTCHR AMRTTFLHIS KTPQENGATA GSGVQPAQ

Genular Protein ID: 3692575829

Symbol: A0A024R8F9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A024R8F9

Database IDs:

Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 1 GenomeRNAi 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 246
  • Mass: 27279
  • Checksum: 2A6E877F48DC3FE9
  • Sequence:
    • MELWPCLAAA LLLLLLLVQL SRAAEFYAKV ALYCALCFTV SAVASLVCLL RHGGRTVENM 
SIIGWFVRSF KYFYGLRFEV RDPRRLQEAR PCVIVSNHQS ILDMMGLMEV LPERCVQIAK 
RELLFLGPVG LIMYLGGVFF INRQRSSTAM TVMADLGERM VRENVPIVPV VYSSFSSFYN 
TKKKFFTSGT VTVQVLEAIP TSGLTAADVP ALVDTCHRAM RTTFLHISKT PQENGATAGS 
GVQPAQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.