Details for: RPP30

Gene ID: 10556

Symbol: RPP30

Ensembl ID: ENSG00000148688

Description: ribonuclease P/MRP subunit p30

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.5
    Marker Score: 1,564
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.41
    Marker Score: 956
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.38
    Marker Score: 1,981
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.34
    Marker Score: 1,675
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.31
    Marker Score: 378
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.31
    Marker Score: 3,555
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3
    Marker Score: 5,091
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.25
    Marker Score: 1,262
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.23
    Marker Score: 2,560
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.21
    Marker Score: 1,112
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.19
    Marker Score: 1,262
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.14
    Marker Score: 1,939
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.13
    Marker Score: 4,606
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.1
    Marker Score: 823
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.09
    Marker Score: 1,021
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.05
    Marker Score: 9,005
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.04
    Marker Score: 574
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.04
    Marker Score: 9,846
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.02
    Marker Score: 1,091
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,662
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,886
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.99
    Marker Score: 1,055
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.99
    Marker Score: 1,530
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.99
    Marker Score: 245
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.99
    Marker Score: 2,689
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.98
    Marker Score: 2,911
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,386
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.98
    Marker Score: 1,297
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.97
    Marker Score: 467
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.94
    Marker Score: 58,053
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,388
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.94
    Marker Score: 265
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 477
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.92
    Marker Score: 12,197
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.92
    Marker Score: 1,352
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14,297
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.9
    Marker Score: 975
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.89
    Marker Score: 2,680
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5,100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.88
    Marker Score: 587
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.88
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,288
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.86
    Marker Score: 259
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.86
    Marker Score: 628
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.85
    Marker Score: 7,344
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.84
    Marker Score: 1,496
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.84
    Marker Score: 3,633
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.84
    Marker Score: 3,105
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.84
    Marker Score: 526
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.83
    Marker Score: 1,274
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.83
    Marker Score: 777
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.82
    Marker Score: 1,929
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.82
    Marker Score: 7,681
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.81
    Marker Score: 725
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.81
    Marker Score: 283
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 325
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.81
    Marker Score: 331
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.81
    Marker Score: 329
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.81
    Marker Score: 334
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.8
    Marker Score: 398
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.8
    Marker Score: 29,340
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8
    Marker Score: 5,172
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.79
    Marker Score: 436
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.79
    Marker Score: 499
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.79
    Marker Score: 361
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.78
    Marker Score: 1,577
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 591
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.77
    Marker Score: 180
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.77
    Marker Score: 2,966
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.77
    Marker Score: 8,634
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.77
    Marker Score: 897
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.76
    Marker Score: 1,080
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.76
    Marker Score: 476
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.76
    Marker Score: 25,831
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.76
    Marker Score: 1,322
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.76
    Marker Score: 370
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.75
    Marker Score: 508
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.74
    Marker Score: 495
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.74
    Marker Score: 3,099
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.74
    Marker Score: 14,752
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.74
    Marker Score: 7,431
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.73
    Marker Score: 25,363
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.73
    Marker Score: 180
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.73
    Marker Score: 174
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.73
    Marker Score: 730
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.73
    Marker Score: 1,810
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.73
    Marker Score: 7,487
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.72
    Marker Score: 1,199
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.72
    Marker Score: 1,185
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.72
    Marker Score: 457
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.72
    Marker Score: 695
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.72
    Marker Score: 165
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.71
    Marker Score: 3,503
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.71
    Marker Score: 347
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.71
    Marker Score: 8,232
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.71
    Marker Score: 1,680

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RPP30 is a 30-kilodalton protein that is highly conserved across species, suggesting its essential role in the processing of pre-tRNAs. The protein is part of the RNase P complex, which is a multimeric enzyme that consists of a ribonuclease and a RNA-binding protein. The RNase P complex is responsible for the maturation of pre-tRNAs, which involves the removal of the 5'-leader sequence and the processing of the tRNA stem-loop structure. RPP30 is significantly expressed in cells that are involved in the production of tRNAs, including erythroid progenitor cells, oogonial cells, and male germ cells. **Pathways and Functions** The RPP30 gene is involved in the following pathways: * RNA processing: RPP30 is essential for the maturation of pre-tRNAs, which is a critical step in protein synthesis. * Metabolism of RNA: RPP30 is involved in the processing of pre-tRNAs, which is a key step in the regulation of gene expression. * Multimeric ribonuclease P complex: RPP30 is a subunit of the RNase P complex, which is a multimeric enzyme that consists of a ribonuclease and a RNA-binding protein. * Nucleolar ribonuclease P complex: RPP30 is also a subunit of the nucleolar RNase P complex, which is responsible for the processing of pre-tRNAs in the nucleolus. * Protein binding: RPP30 has been shown to bind to proteins, including the ribonuclease P RNA substrate, which is essential for the processing of pre-tRNAs. **Clinical Significance** Mutations in the RPP30 gene have been associated with various diseases, including: * Cancer: Mutations in the RPP30 gene have been found in several types of cancer, including leukemia and lymphoma. * Genetic disorders: Mutations in the RPP30 gene have been associated with genetic disorders, including Diamond-Blackfan anemia and congenital hypoplastic anemia. * Neurological disorders: Mutations in the RPP30 gene have been associated with neurological disorders, including myotonic dystrophy and Charcot-Marie-Tooth disease. * Reproductive disorders: Mutations in the RPP30 gene have been associated with reproductive disorders, including infertility and miscarriage. In conclusion, RPP30 is an essential component of the RNase P complex, which plays a critical role in the processing of pre-tRNAs in both the nucleus and cytosol. Mutations in the RPP30 gene have been associated with various diseases, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 4049426939

Symbol: RPP30_HUMAN

Name: Ribonuclease P protein subunit p30

UniProtKB Accession Codes:

P78346 B2R799 E9PB02

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DNASU 1 EMBL 6 EMDB 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 6 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9037013

Title: Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P.

PubMed ID: 9037013

DOI: 10.1073/pnas.94.4.1101

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9630247

Title: Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P.

PubMed ID: 9630247

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16723659

Title: Differential association of protein subunits with the human RNase MRP and RNase P complexes.

PubMed ID: 16723659

DOI: 10.1261/rna.2293906

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25489052

Title: Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.

PubMed ID: 25489052

DOI: 10.1093/hmg/ddu611

PubMed ID: 28115465

Title: Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing.

PubMed ID: 28115465

DOI: 10.1101/gad.286963.116

PubMed ID: 30454648

Title: Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.

PubMed ID: 30454648

DOI: 10.1016/j.cell.2018.10.003

Sequence Information:

  • Length: 268
  • Mass: 29321
  • Checksum: 2AB492D98ACDCCBB
  • Sequence:
    • MAVFADLDLR AGSDLKALRG LVETAAHLGY SVVAINHIVD FKEKKQEIEK PVAVSELFTT 
LPIVQGKSRP IKILTRLTII VSDPSHCNVL RATSSRARLY DVVAVFPKTE KLFHIACTHL 
DVDLVCITVT EKLPFYFKRP PINVAIDRGL AFELVYSPAI KDSTMRRYTI SSALNLMQIC 
KGKNVIISSA AERPLEIRGP YDVANLGLLF GLSESDAKAA VSTNCRAALL HGETRKTAFG 
IISTVKKPRP SEGDEDCLPA SKKAKCEG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.