Details for: RPP38

Gene ID: 10557

Symbol: RPP38

Ensembl ID: ENSG00000152464

Description: ribonuclease P/MRP subunit p38

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,955
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.43
    Marker Score: 12,381
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.13
    Marker Score: 2,146
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.08
    Marker Score: 395
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.02
    Marker Score: 690
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,689
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,913
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,390
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.97
    Marker Score: 566
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.95
    Marker Score: 32,983
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,394
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.94
    Marker Score: 1,135
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.94
    Marker Score: 1,173
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 474
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 430
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,159
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,697
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.89
    Marker Score: 1,286
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.89
    Marker Score: 256
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.88
    Marker Score: 418
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.88
    Marker Score: 3,014
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.88
    Marker Score: 1,179
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.87
    Marker Score: 423
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.86
    Marker Score: 307
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.85
    Marker Score: 916
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.83
    Marker Score: 462
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.82
    Marker Score: 1,995
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.81
    Marker Score: 406
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.81
    Marker Score: 1,198
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.8
    Marker Score: 6,865
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.79
    Marker Score: 3,123
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.79
    Marker Score: 1,218
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.79
    Marker Score: 1,794
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.78
    Marker Score: 766
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.78
    Marker Score: 1,842
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 309
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 578
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.74
    Marker Score: 45,238
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 469
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.73
    Marker Score: 441
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.73
    Marker Score: 334
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.72
    Marker Score: 357
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.72
    Marker Score: 662
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 370
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.7
    Marker Score: 6,687
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.7
    Marker Score: 209
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.69
    Marker Score: 14,714
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,889
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.68
    Marker Score: 169
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.68
    Marker Score: 537
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.68
    Marker Score: 10,614
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.67
    Marker Score: 1,582
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.67
    Marker Score: 836
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.67
    Marker Score: 5,758
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.67
    Marker Score: 594
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.67
    Marker Score: 717
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.66
    Marker Score: 6,242
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 605
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.66
    Marker Score: 268
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.66
    Marker Score: 244
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.66
    Marker Score: 308
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.66
    Marker Score: 302
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.65
    Marker Score: 1,158
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.65
    Marker Score: 841
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.65
    Marker Score: 1,252
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.64
    Marker Score: 192
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 423
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.63
    Marker Score: 263
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.63
    Marker Score: 258
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.63
    Marker Score: 548
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.63
    Marker Score: 4,699
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.63
    Marker Score: 1,382
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.63
    Marker Score: 160
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.63
    Marker Score: 2,570
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.63
    Marker Score: 306
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.62
    Marker Score: 424
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.62
    Marker Score: 179
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.62
    Marker Score: 341
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.62
    Marker Score: 711
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.62
    Marker Score: 621
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.62
    Marker Score: 147
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.62
    Marker Score: 230
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.61
    Marker Score: 213
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.61
    Marker Score: 1,519
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.61
    Marker Score: 15,584
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.6
    Marker Score: 22,958
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.6
    Marker Score: 2,236
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6
    Marker Score: 6,235
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6
    Marker Score: 635
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.6
    Marker Score: 210
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.6
    Marker Score: 624
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.6
    Marker Score: 134
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.6
    Marker Score: 147
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.6
    Marker Score: 948
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.6
    Marker Score: 557
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.59
    Marker Score: 157

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RPP38 is a 38-kDa subunit of the RNP complex, which consists of a ribonuclease P (RNase P) and a ribonuclease MRP (RNase MRP) complex. The RPP38 subunit is a multifunctional protein that exhibits RNase P activity, tRNA 5'-leader removal, and tRNA processing capabilities. RPP38 is highly expressed in various cell types, including mural cells, ciliated columnar cells of the tracheobronchial tree, and proerythroblasts. The protein is also found in the nucleolus and cytosol, suggesting its involvement in both nuclear and cytoplasmic RNA processing events. **Pathways and Functions:** The RPP38 subunit is involved in the following pathways and functions: 1. **RNA Processing:** RPP38 plays a crucial role in the processing of precursor tRNA molecules, including the removal of the 5'-leader and the maturation of tRNA precursors. 2. **Ribonuclease P Activity:** RPP38 exhibits RNase P activity, which is essential for the processing of tRNA precursors. 3. **Protein Binding:** RPP38 interacts with various proteins, including transcription factors and RNA-binding proteins, to regulate RNA processing events. 4. **Cell Differentiation:** RPP38 is involved in the regulation of cell differentiation, particularly in the development of the nervous system and the formation of the tracheobronchial tree. **Clinical Significance:** RPP38 has been implicated in various diseases and disorders, including: 1. **Neurodegenerative Diseases:** RPP38 has been found to be abnormally expressed in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer:** RPP38 has been shown to be overexpressed in certain types of cancer, including lung and breast cancer. 3. **Cardiovascular Diseases:** RPP38 has been implicated in the development of cardiovascular diseases, including atherosclerosis and cardiac arrhythmias. 4. **Neurological Disorders:** RPP38 has been found to be abnormally expressed in neurological disorders, such as epilepsy and multiple sclerosis. In conclusion, RPP38 is a multifunctional protein that plays a crucial role in RNA processing, protein binding, and cell differentiation. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of RPP38 in maintaining cellular homeostasis and disease prevention. Further studies are needed to fully elucidate the role of RPP38 in human health and disease.

Genular Protein ID: 3704630044

Symbol: RPP38_HUMAN

Name: Ribonuclease P protein subunit p38

UniProtKB Accession Codes:

P78345 B3KPY0 D3DRT8 Q53F71 Q8NHS8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 2 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 10 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9037013

Title: Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P.

PubMed ID: 9037013

DOI: 10.1073/pnas.94.4.1101

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9630247

Title: Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P.

PubMed ID: 9630247

PubMed ID: 10444065

Title: Localization in the nucleolus and coiled bodies of protein subunits of the ribonucleoprotein ribonuclease P.

PubMed ID: 10444065

DOI: 10.1083/jcb.146.3.559

PubMed ID: 16723659

Title: Differential association of protein subunits with the human RNase MRP and RNase P complexes.

PubMed ID: 16723659

DOI: 10.1261/rna.2293906

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28115465

Title: Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing.

PubMed ID: 28115465

DOI: 10.1101/gad.286963.116

PubMed ID: 30454648

Title: Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.

PubMed ID: 30454648

DOI: 10.1016/j.cell.2018.10.003

Sequence Information:

  • Length: 283
  • Mass: 31834
  • Checksum: 233F3397DBDE4F18
  • Sequence:
    • MAAAPQAPGR GSLRKTRPLV VKTSLNNPYI IRWSALESED MHFILQTLED RLKAIGLQKI 
EDKKKKNKTP FLKKESREKC SIAVDISENL KEKKTDAKQQ VSGWTPAHVR KQLAIGVNEV 
TRALERRELL LVLVCKSVKP AMITSHLIQL SLSRSVPACQ VPRLSERIAP VIGLKCVLAL 
AFKKNTTDFV DEVRAIIPRV PSLSVPWLQD RIEDSGENLE TEPLESQDRE LLDTSFEDLS 
KPKRKLADGR QASVTLQPLK IKKLIPNPNK IRKPPKSKKA TPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.