Details for: SLC35A1

Gene ID: 10559

Symbol: SLC35A1

Ensembl ID: ENSG00000164414

Description: solute carrier family 35 member A1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.81
    Marker Score: 27,084
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.78
    Marker Score: 16,774
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.77
    Marker Score: 65,414
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.76
    Marker Score: 108,490
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.75
    Marker Score: 13,441
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.75
    Marker Score: 34,833
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.73
    Marker Score: 16,398
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.7
    Marker Score: 64,493
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.66
    Marker Score: 6,404
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.65
    Marker Score: 14,200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.56
    Marker Score: 6,464
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.53
    Marker Score: 2,366
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1
    Marker Score: 418
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,745
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,970
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,399
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.96
    Marker Score: 924
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,402
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 437
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,713
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.9
    Marker Score: 3,674
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.87
    Marker Score: 256
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,252
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,913
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.85
    Marker Score: 232
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.85
    Marker Score: 514
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.82
    Marker Score: 1,321
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.81
    Marker Score: 1,837
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.8
    Marker Score: 926
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.79
    Marker Score: 16,783
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.76
    Marker Score: 11,903
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.75
    Marker Score: 239
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 575
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.75
    Marker Score: 438
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 301
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.71
    Marker Score: 3,058
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 453
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2,929
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7
    Marker Score: 1,026
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 617
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.66
    Marker Score: 794
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.66
    Marker Score: 4,294
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.65
    Marker Score: 458
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.65
    Marker Score: 2,546
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.64
    Marker Score: 591
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.63
    Marker Score: 2,453
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.63
    Marker Score: 190
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.63
    Marker Score: 182
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.63
    Marker Score: 283
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.62
    Marker Score: 369
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.62
    Marker Score: 442
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.61
    Marker Score: 1,603
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.6
    Marker Score: 3,857
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.6
    Marker Score: 297
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.6
    Marker Score: 261
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.6
    Marker Score: 190
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.59
    Marker Score: 397
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.58
    Marker Score: 326
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.58
    Marker Score: 1,381
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.57
    Marker Score: 2,358
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.56
    Marker Score: 593
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.54
    Marker Score: 550
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.54
    Marker Score: 1,365
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.54
    Marker Score: 2,577
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 428
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.53
    Marker Score: 1,082
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.53
    Marker Score: 104
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.52
    Marker Score: 137
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.52
    Marker Score: 121
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.51
    Marker Score: 483
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.51
    Marker Score: 339
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.51
    Marker Score: 342
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.51
    Marker Score: 1,204
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.51
    Marker Score: 284
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.51
    Marker Score: 316
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.5
    Marker Score: 450
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.5
    Marker Score: 162
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.49
    Marker Score: 985
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.49
    Marker Score: 751
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.48
    Marker Score: 543
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.48
    Marker Score: 222
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.48
    Marker Score: 500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.48
    Marker Score: 359
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.48
    Marker Score: 3,163
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.47
    Marker Score: 117
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.47
    Marker Score: 311
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.47
    Marker Score: 418
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 195
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.46
    Marker Score: 134
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.46
    Marker Score: 131
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.46
    Marker Score: 278
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.46
    Marker Score: 1,233
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.46
    Marker Score: 3,964
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.46
    Marker Score: 15,923
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.45
    Marker Score: 25,222

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **SLC35A1 is a transmembrane transporter**: This gene encodes a protein with 12 transmembrane domains, which allows it to facilitate the transport of sugars, nucleotides, and other small molecules across the plasma membrane. 2. **Involvement in glycosylation**: SLC35A1 is essential for the biosynthesis of the dolichol lipid-linked oligosaccharide (LLO), a precursor to N-glycans. These glycosylation processes are critical for protein folding, stability, and cell signaling. 3. **Expression in neurons**: SLC35A1 is predominantly expressed in GABAergic cortical interneurons, which are involved in regulating neural activity and synaptic transmission. 4. **Implicated in congenital disorders**: Mutations in SLC35A1 have been linked to CDG2F, a rare genetic disorder characterized by impaired glycosylation and developmental abnormalities. **Pathways and Functions:** 1. **Glycosylation pathways**: SLC35A1 is involved in the biosynthesis of LLO, which is then transferred to nascent proteins, modifying their structure and function. 2. **Antiporter activity**: SLC35A1 can transport sugars, nucleotides, and other small molecules across the plasma membrane, regulating their concentrations and availability. 3. **Golgi apparatus and membrane trafficking**: SLC35A1 is localized to the Golgi apparatus and plasma membrane, where it plays a role in regulating membrane trafficking and protein modification. 4. **Synaptic transmission and neuronal development**: SLC35A1's expression in GABAergic cortical interneurons suggests its involvement in regulating synaptic transmission and neuronal development. **Clinical Significance:** 1. **Congenital disorders of glycosylation (CDG)**: Mutations in SLC35A1 can lead to CDG2F, a rare genetic disorder characterized by impaired glycosylation and developmental abnormalities. 2. **Neurodevelopmental disorders**: SLC35A1's expression in GABAergic cortical interneurons suggests its potential involvement in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 3. **Cancer research**: SLC35A1's role in glycosylation and membrane trafficking may provide new insights into cancer biology, particularly in understanding the mechanisms of metastasis and tumor progression. 4. **Therapeutic applications**: Understanding SLC35A1's functions and pathways may lead to the development of novel therapeutic strategies for treating CDG and other neurodevelopmental disorders. In conclusion, SLC35A1 is a complex gene involved in glycosylation and transmembrane transport, with significant implications for neuronal development and function. Further research is needed to fully elucidate its functions and to explore its potential applications in treating CDG and other neurodevelopmental disorders.

Genular Protein ID: 1622829133

Symbol: S35A1_HUMAN

Name: Solute carrier family 35 member A1

UniProtKB Accession Codes:

P78382 Q5W1L8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 14 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 Rhea 4 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9010752

Title: Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family.

PubMed ID: 9010752

DOI: 10.1093/oxfordjournals.jbchem.a021523

PubMed ID: 15576474

Title: Genetic complementation reveals a novel human congenital disorder of glycosylation of type II, due to inactivation of the Golgi CMP-sialic acid transporter.

PubMed ID: 15576474

DOI: 10.1182/blood-2004-09-3509

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12682060

Title: Substrate recognition by nucleotide sugar transporters: further characterization of substrate recognition regions by analyses of UDP-galactose/CMP-sialic acid transporter chimeras and biochemical analysis of the substrate specificity of parental and chimeric transporters.

PubMed ID: 12682060

DOI: 10.1074/jbc.m302620200

PubMed ID: 30985278

Title: Structural basis for mammalian nucleotide sugar transport.

PubMed ID: 30985278

DOI: 10.7554/elife.45221

PubMed ID: 23873973

Title: Intellectual disability and bleeding diathesis due to deficient CMP--sialic acid transport.

PubMed ID: 23873973

DOI: 10.1212/wnl.0b013e3182a08f53

PubMed ID: 28856833

Title: Encephalopathy caused by novel mutations in the CMP-sialic acid transporter, SLC35A1.

PubMed ID: 28856833

DOI: 10.1002/ajmg.a.38412

Sequence Information:

  • Length: 337
  • Mass: 36779
  • Checksum: 508DD77F5EEBB5A7
  • Sequence:
    • MAAPRDNVTL LFKLYCLAVM TLMAAVYTIA LRYTRTSDKE LYFSTTAVCI TEVIKLLLSV 
GILAKETGSL GRFKASLREN VLGSPKELLK LSVPSLVYAV QNNMAFLALS NLDAAVYQVT 
YQLKIPCTAL CTVLMLNRTL SKLQWVSVFM LCAGVTLVQW KPAQATKVVV EQNPLLGFGA 
IAIAVLCSGF AGVYFEKVLK SSDTSLWVRN IQMYLSGIIV TLAGVYLSDG AEIKEKGFFY 
GYTYYVWFVI FLASVGGLYT SVVVKYTDNI MKGFSAAAAI VLSTIASVML FGLQITLTFA 
LGTLLVCVSI YLYGLPRQDT TSIQQGETAS KERVIGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.