Details for: IFI44

Gene ID: 10561

Symbol: IFI44

Ensembl ID: ENSG00000137965

Description: interferon induced protein 44

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,432
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.4
    Marker Score: 78,419
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.33
    Marker Score: 795
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.27
    Marker Score: 1,267
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.25
    Marker Score: 10,946
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.23
    Marker Score: 820
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.09
    Marker Score: 10,773
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.08
    Marker Score: 2,787
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.04
    Marker Score: 2,879
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,738
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,962
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.98
    Marker Score: 11,414
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,402
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.94
    Marker Score: 429
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,713
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.87
    Marker Score: 198
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,252
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.86
    Marker Score: 626
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.86
    Marker Score: 742
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,909
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.85
    Marker Score: 370
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.84
    Marker Score: 196
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.83
    Marker Score: 1,688
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.83
    Marker Score: 2,104
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.82
    Marker Score: 839
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.82
    Marker Score: 735
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.82
    Marker Score: 341
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.82
    Marker Score: 20,917
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.81
    Marker Score: 1,173
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.81
    Marker Score: 863
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.81
    Marker Score: 1,609
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.8
    Marker Score: 258
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.8
    Marker Score: 3,272
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.8
    Marker Score: 918
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 315
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.79
    Marker Score: 1,138
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.78
    Marker Score: 206
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.77
    Marker Score: 2,846
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 587
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.75
    Marker Score: 1,220
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.75
    Marker Score: 1,223
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.74
    Marker Score: 978
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 379
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.73
    Marker Score: 201
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.72
    Marker Score: 419
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.72
    Marker Score: 334
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,988
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 646
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.71
    Marker Score: 293
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.69
    Marker Score: 440
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.69
    Marker Score: 165
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.67
    Marker Score: 2,312
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.67
    Marker Score: 454
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.66
    Marker Score: 817
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.64
    Marker Score: 186
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.63
    Marker Score: 245
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 407
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.61
    Marker Score: 845
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.61
    Marker Score: 1,525
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.61
    Marker Score: 1,036
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.61
    Marker Score: 308
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.6
    Marker Score: 596
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.59
    Marker Score: 156
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.57
    Marker Score: 389
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.57
    Marker Score: 200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.57
    Marker Score: 515
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.57
    Marker Score: 837
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.57
    Marker Score: 1,037
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.56
    Marker Score: 336
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.56
    Marker Score: 406
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.56
    Marker Score: 29,406
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.55
    Marker Score: 3,360
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.55
    Marker Score: 1,063
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.55
    Marker Score: 191
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.54
    Marker Score: 618
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.53
    Marker Score: 581
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.53
    Marker Score: 265
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.53
    Marker Score: 596
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.53
    Marker Score: 534
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.53
    Marker Score: 140
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.53
    Marker Score: 379
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.52
    Marker Score: 828
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.51
    Marker Score: 1,599
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.5
    Marker Score: 128
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5
    Marker Score: 4,992
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.5
    Marker Score: 171
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.49
    Marker Score: 963
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.49
    Marker Score: 428
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.49
    Marker Score: 894
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.49
    Marker Score: 324
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.49
    Marker Score: 124
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.48
    Marker Score: 539
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.48
    Marker Score: 297
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.48
    Marker Score: 117

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IFI44 exhibits several distinct characteristics that set it apart from other interferon-induced proteins. Firstly, its expression is induced by interferons, which are key cytokines involved in the regulation of immune responses. IFI44 is also characterized by its ability to bind to various proteins, including interferons and other immune-related molecules. This protein-protein interaction is crucial for the modulation of immune cell function and the regulation of immune responses. Furthermore, IFI44 has been shown to be expressed in a wide range of cell types, including mural cells, endothelial cells, and epithelial cells. This broad expression pattern suggests that IFI44 may play a role in maintaining tissue homeostasis and regulating immune responses in various tissues. **Pathways and Functions:** IFI44 is involved in several key pathways that regulate immune responses. The most notable pathway is the interferon-induced protein complex formation, which involves IFI44 and other interferon-induced proteins. This complex formation is thought to regulate immune cell function, including the activation and proliferation of immune cells. IFI44 also plays a role in the regulation of immune responses at the cellular level. It has been shown to modulate the function of immune cells, including classical monocytes and dendritic cells, by regulating their cytokine production and antigen presentation. In addition to its role in immune responses, IFI44 has been implicated in the regulation of cellular processes, including cell cycle regulation and apoptosis. Its ability to bind to other proteins suggests that it may also play a role in regulating protein-protein interactions and cellular signaling pathways. **Clinical Significance:** IFI44 has significant clinical implications, particularly in the context of infectious diseases. Its expression in various immune cells suggests that it may play a role in regulating immune responses to viral and bacterial infections. Furthermore, IFI44 has been implicated in the pathogenesis of several diseases, including cancer and autoimmune disorders. Its ability to modulate immune cell function and regulate protein-protein interactions suggests that it may also play a role in the development of these diseases. In conclusion, IFI44 is a complex gene that plays a critical role in regulating immune responses. Its broad expression pattern and ability to bind to various proteins suggest that it may contribute to the regulation of immune responses in various tissues. Further research is needed to fully elucidate the biological significance of IFI44 and its role in disease pathogenesis.

Genular Protein ID: 2193353295

Symbol: IFI44_HUMAN

Name: Interferon-induced protein 44

UniProtKB Accession Codes:

Q8TCB0 B7ZAG3 D3DQ80 Q14496

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7925411

Title: Induction of the human gene for p44, a hepatitis-C-associated microtubular aggregate protein, by interferon-alpha/beta.

PubMed ID: 7925411

DOI: 10.1111/j.1432-1033.1994.00877.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 444
  • Mass: 50491
  • Checksum: C9B699ECD4523D0F
  • Sequence:
    • MAVTTRLTWL HEKILQNHFG GKRLSLLYKG SVHGFRNGVL LDRCCNQGPT LTVIYSEDHI 
IGAYAEESYQ EGKYASIILF ALQDTKISEW KLGLCTPETL FCCDVTKYNS PTNFQIDGRN 
RKVIMDLKTM ENLGLAQNCT ISIQDYEVFR CEDSLDERKI KGVIELRKSL LSALRTYEPY 
GSLVQQIRIL LLGPIGAGKS SFFNSVRSVF QGHVTHQALV GTNTTGISEK YRTYSIRDGK 
DGKYLPFILC DSLGLSEKEG GLCRDDIFYI LNGNIRDRYQ FNPMESIKLN HHDYIDSPSL 
KDRIHCVAFV FDASSIQYFS SQMIVKIKRI RRELVNAGVV HVALLTHVDS MDLITKGDLI 
EIERCEPVRS KLEEVQRKLG FALSDISVVS NYSSEWELDP VKDVLILSAL RRMLWAADDF 
LEDLPFEQIG NLREEIINCA QGKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.