Details for: OLFM4

Gene ID: 10562

Symbol: OLFM4

Ensembl ID: ENSG00000102837

Description: olfactomedin 4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 3.95
    Marker Score: 2,226
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.64
    Marker Score: 1,833
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.5
    Marker Score: 5,931
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.08
    Marker Score: 2,097
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.95
    Marker Score: 735
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.73
    Marker Score: 1,364
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.58
    Marker Score: 7,570
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.46
    Marker Score: 2,250
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.38
    Marker Score: 2,606
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 1.35
    Marker Score: 386
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.16
    Marker Score: 501
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.07
    Marker Score: 1,026
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.07
    Marker Score: 2,174
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.05
    Marker Score: 667
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 792
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,047
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.99
    Marker Score: 240
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.99
    Marker Score: 983
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,284
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.78
    Marker Score: 492
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,258
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 304
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.74
    Marker Score: 11,519
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 668
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.73
    Marker Score: 437
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.71
    Marker Score: 177
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.7
    Marker Score: 687
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.68
    Marker Score: 242
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2,812
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.66
    Marker Score: 1,022
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.66
    Marker Score: 2,082
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.66
    Marker Score: 938
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.63
    Marker Score: 397
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.59
    Marker Score: 150
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.54
    Marker Score: 557
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.53
    Marker Score: 371
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.52
    Marker Score: 240
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.51
    Marker Score: 757
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.47
    Marker Score: 196
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.47
    Marker Score: 135
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 195
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 274
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.45
    Marker Score: 124
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.4
    Marker Score: 193
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4
    Marker Score: 292
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.39
    Marker Score: 379
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.38
    Marker Score: 205
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.36
    Marker Score: 93
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.33
    Marker Score: 88
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.33
    Marker Score: 251
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.33
    Marker Score: 94
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.32
    Marker Score: 150
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.32
    Marker Score: 64
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.31
    Marker Score: 758
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.31
    Marker Score: 137
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 308
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.29
    Marker Score: 669
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.29
    Marker Score: 142
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.28
    Marker Score: 279
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.28
    Marker Score: 97
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.28
    Marker Score: 147
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.26
    Marker Score: 133
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.25
    Marker Score: 87
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.24
    Marker Score: 543
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.23
    Marker Score: 84
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.23
    Marker Score: 369
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.23
    Marker Score: 203
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.23
    Marker Score: 138
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.22
    Marker Score: 49
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.22
    Marker Score: 142
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.22
    Marker Score: 57
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.21
    Marker Score: 380
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.21
    Marker Score: 121
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.21
    Marker Score: 135
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2
    Marker Score: 57
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.2
    Marker Score: 86
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.19
    Marker Score: 58
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.18
    Marker Score: 1,218
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.18
    Marker Score: 107
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.18
    Marker Score: 79
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.18
    Marker Score: 378
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 0.18
    Marker Score: 57
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.17
    Marker Score: 55
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.17
    Marker Score: 99
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.17
    Marker Score: 143
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.17
    Marker Score: 77
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.16
    Marker Score: 158
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.15
    Marker Score: 173
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.15
    Marker Score: 90

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** OLFM4 is widely expressed in epithelial cells, stem cells, and endothelial cells, suggesting its involvement in tissue development, maintenance, and immune responses. 2. **Cell Adhesion:** OLFM4 mediates cell adhesion through its interaction with specific granule proteins, which are involved in the regulation of cell spreading and migration. 3. **Signal Transduction:** The gene is also involved in signal transduction pathways, influencing the activation of various immune cells, including neutrophils and endothelial cells. 4. **Extracellular Secretion:** OLFM4 is secreted into the extracellular space, where it can interact with other molecules, modulate immune responses, and influence cellular behavior. **Pathways and Functions:** 1. **Azurophil Granule Pathway:** OLFM4 interacts with azurophilic granule proteins, regulating the release of granule contents and modulating immune responses. 2. **Cadherin Binding Pathway:** The gene binds to cadherins, which are essential for cell adhesion and tissue integrity. 3. **Immune System Pathway:** OLFM4 influences the activation of immune cells, including neutrophils and endothelial cells, and modulates the innate and adaptive immune responses. 4. **Extracellular Exosome Pathway:** The gene is secreted into exosomes, where it can interact with other cells and influence cellular behavior. **Clinical Significance:** 1. **Inflammatory Diseases:** Abnormalities in OLFM4 expression have been linked to inflammatory diseases, such as atherosclerosis and autoimmune disorders. 2. **Cancer:** The gene's role in cell adhesion and signal transduction suggests its potential involvement in cancer development and progression. 3. **Neurological Disorders:** OLFM4's involvement in immune responses and cell adhesion may also contribute to neurological disorders, such as multiple sclerosis and Alzheimer's disease. 4. **Regenerative Medicine:** The gene's expression in stem cells and endothelial cells highlights its potential as a therapeutic target for regenerative medicine applications. In conclusion, OLFM4 is a complex gene that plays a multifaceted role in the regulation of immune responses, cell adhesion, and signal transduction. Its involvement in various cellular processes and its clinical significance make it an attractive target for further research and therapeutic interventions.

Genular Protein ID: 1280020859

Symbol: OLFM4_HUMAN

Name: Olfactomedin-4

UniProtKB Accession Codes:

Q6UX06 O95362 Q5VWG0 Q86T22

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 18 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRIDE 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11867215

Title: Identification and characterization of a novel member of olfactomedin-related protein family, hGC-1, expressed during myeloid lineage development.

PubMed ID: 11867215

DOI: 10.1016/s0378-1119(01)00763-6

PubMed ID: 15059901

Title: GW112, a novel antiapoptotic protein that promotes tumor growth.

PubMed ID: 15059901

DOI: 10.1158/0008-5472.can-03-3443

PubMed ID: 16566923

Title: The glycoprotein hGC-1 binds to cadherin and lectins.

PubMed ID: 16566923

DOI: 10.1016/j.yexcr.2006.02.011

PubMed ID: 17270022

Title: Olfactomedin 4 promotes S-phase transition in proliferation of pancreatic cancer cells.

PubMed ID: 17270022

DOI: 10.1111/j.1349-7006.2007.00397.x

PubMed ID: 20724538

Title: Olfactomedin 4 is a novel target gene of retinoic acids and 5-aza-2'-deoxycytidine involved in human myeloid leukemia cell growth, differentiation, and apoptosis.

PubMed ID: 20724538

DOI: 10.1182/blood-2009-10-246439

Sequence Information:

  • Length: 510
  • Mass: 57280
  • Checksum: ACF03365D2164900
  • Sequence:
    • MRPGLSFLLA LLFFLGQAAG DLGDVGPPIP SPGFSSFPGV DSSSSFSSSS RSGSSSSRSL 
GSGGSVSQLF SNFTGSVDDR GTCQCSVSLP DTTFPVDRVE RLEFTAHVLS QKFEKELSKV 
REYVQLISVY EKKLLNLTVR IDIMEKDTIS YTELDFELIK VEVKEMEKLV IQLKESFGGS 
SEIVDQLEVE IRNMTLLVEK LETLDKNNVL AIRREIVALK TKLKECEASK DQNTPVVHPP 
PTPGSCGHGG VVNISKPSVV QLNWRGFSYL YGAWGRDYSP QHPNKGLYWV APLNTDGRLL 
EYYRLYNTLD DLLLYINARE LRITYGQGSG TAVYNNNMYV NMYNTGNIAR VNLTTNTIAV 
TQTLPNAAYN NRFSYANVAW QDIDFAVDEN GLWVIYSTEA STGNMVISKL NDTTLQVLNT 
WYTKQYKPSA SNAFMVCGVL YATRTMNTRT EEIFYYYDTN TGKEGKLDIV MHKMQEKVQS 
INYNPFDQKL YVYNDGYLLN YDLSVLQKPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.