Details for: CXCL13

Gene ID: 10563

Symbol: CXCL13

Ensembl ID: ENSG00000156234

Description: C-X-C motif chemokine ligand 13

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 3.92
    Marker Score: 11,420
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3
    Marker Score: 25,345
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.58
    Marker Score: 7,373
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.47
    Marker Score: 7,092
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.09
    Marker Score: 937
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.92
    Marker Score: 1,635
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.78
    Marker Score: 3,380
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169,436
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 866
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.2
    Marker Score: 269
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.08
    Marker Score: 825
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.06
    Marker Score: 2,147
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 793
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,045
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.99
    Marker Score: 567
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.97
    Marker Score: 2,469
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,319
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.92
    Marker Score: 1,904
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,290
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.86
    Marker Score: 516
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.86
    Marker Score: 13,433
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.78
    Marker Score: 176
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 499
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.71
    Marker Score: 341
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.6
    Marker Score: 402
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.59
    Marker Score: 6,673
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.52
    Marker Score: 2,244
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.51
    Marker Score: 161
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.5
    Marker Score: 440
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 473
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.47
    Marker Score: 195
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.4
    Marker Score: 2,416
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.38
    Marker Score: 14,015
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.36
    Marker Score: 93
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.36
    Marker Score: 203
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.36
    Marker Score: 138
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.35
    Marker Score: 13,422
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.35
    Marker Score: 147
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.35
    Marker Score: 636
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.34
    Marker Score: 268
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.34
    Marker Score: 149
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.31
    Marker Score: 99
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.3
    Marker Score: 1,243
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.27
    Marker Score: 1,051
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.26
    Marker Score: 216
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.25
    Marker Score: 254
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.24
    Marker Score: 564
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.22
    Marker Score: 130
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.21
    Marker Score: 98
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.2
    Marker Score: 232
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.19
    Marker Score: 335
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.19
    Marker Score: 146
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.19
    Marker Score: 299
  • Cell Name: follicular dendritic cell (CL0000442)
    Fold Change: 0.19
    Marker Score: 67
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.18
    Marker Score: 204
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.18
    Marker Score: 105
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.18
    Marker Score: 62
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.18
    Marker Score: 158
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.18
    Marker Score: 71
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.17
    Marker Score: 151
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.17
    Marker Score: 2,797
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.17
    Marker Score: 224
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.16
    Marker Score: 108
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.16
    Marker Score: 287
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.16
    Marker Score: 156
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.16
    Marker Score: 1,062
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.16
    Marker Score: 184
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.16
    Marker Score: 49
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.15
    Marker Score: 104
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.14
    Marker Score: 29
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.14
    Marker Score: 440
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.14
    Marker Score: 4,837
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.14
    Marker Score: 365
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.14
    Marker Score: 81
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.13
    Marker Score: 61
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.13
    Marker Score: 1,148
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.13
    Marker Score: 127
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.13
    Marker Score: 109
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.13
    Marker Score: 314
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.13
    Marker Score: 141
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.13
    Marker Score: 71
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.13
    Marker Score: 46
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.13
    Marker Score: 72
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.13
    Marker Score: 3,207
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.12
    Marker Score: 71
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.12
    Marker Score: 2,378
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.12
    Marker Score: 132
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.12
    Marker Score: 26

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CXCL13 is a small, four-cysteine-containing chemokine that belongs to the CXC chemokine family. It is characterized by its ability to bind to the CCR6 receptor, which is expressed on the surface of various immune cells, including T cells, B cells, and dendritic cells. CXCL13 is produced by a wide range of cell types, including epithelial cells, endothelial cells, and immune cells, and is secreted into the extracellular space, where it plays a key role in chemotaxis and cell-cell signaling. **Pathways and Functions** CXCL13 is involved in various signaling pathways that regulate immune responses, including: 1. **Cell-cell signaling**: CXCL13 binds to the CCR6 receptor, triggering a signaling cascade that regulates cell-cell interactions, adhesion, and migration. 2. **Chemokine-mediated signaling pathway**: CXCL13 activates downstream signaling pathways that regulate chemotaxis, proliferation, and differentiation of immune cells. 3. **G-protein coupled receptor (GPCR) signaling**: CXCL13 binds to the CCR6 receptor, activating G-protein coupled signaling pathways that regulate immune responses. 4. **Antimicrobial humoral immune response**: CXCL13 is involved in the recruitment and activation of immune cells, including B cells and neutrophils, in response to antimicrobial peptides. **Clinical Significance** CXCL13 has been implicated in the pathogenesis of various diseases, including: 1. **Autoimmune disorders**: CXCL13 has been linked to the development of autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, and lupus. 2. **Inflammatory conditions**: CXCL13 is involved in the recruitment and activation of immune cells in inflammatory conditions, such as asthma, chronic obstructive pulmonary disease (COPD), and inflammatory bowel disease (IBD). 3. **Cancer**: CXCL13 has been implicated in the metastasis and progression of various cancers, including breast cancer, lung cancer, and colon cancer. In conclusion, CXCL13 is a key chemokine that regulates immune responses, particularly in the context of lymphoid organ development and function. Its dysregulation has been implicated in the pathogenesis of various diseases, highlighting its potential as a therapeutic target for the treatment of autoimmune disorders, inflammatory conditions, and cancer.

Genular Protein ID: 1101403243

Symbol: CXL13_HUMAN

Name: C-X-C motif chemokine 13

UniProtKB Accession Codes:

O43927

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CPTC 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9486651

Title: A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1.

PubMed ID: 9486651

DOI: 10.1038/35876

PubMed ID: 9463416

Title: B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5.

PubMed ID: 9463416

DOI: 10.1084/jem.187.4.655

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 109
  • Mass: 12664
  • Checksum: 4057FCA8EFF658A8
  • Sequence:
    • MKFISTSLLL MLLVSSLSPV QGVLEVYYTS LRCRCVQESS VFIPRRFIDR IQILPRGNGC 
PRKEIIVWKK NKSIVCVDPQ AEWIQRMMEV LRKRSSSTLP VPVFKRKIP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.