Details for: ARFGEF2

Gene ID: 10564

Symbol: ARFGEF2

Ensembl ID: ENSG00000124198

Description: ADP ribosylation factor guanine nucleotide exchange factor 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.98
    Marker Score: 52,942
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.47
    Marker Score: 55,132
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.4
    Marker Score: 1,430
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.12
    Marker Score: 4,655
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.12
    Marker Score: 78,037
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.02
    Marker Score: 8,448
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.93
    Marker Score: 28,891
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.91
    Marker Score: 117,664
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.88
    Marker Score: 37,429
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.85
    Marker Score: 7,674
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.85
    Marker Score: 14,146
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.83
    Marker Score: 69,532
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.81
    Marker Score: 17,017
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.79
    Marker Score: 945
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.79
    Marker Score: 15,369
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.78
    Marker Score: 6,884
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.78
    Marker Score: 16,913
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.77
    Marker Score: 743
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.76
    Marker Score: 37,564
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.75
    Marker Score: 1,019
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.75
    Marker Score: 7,112
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.74
    Marker Score: 17,996
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.7
    Marker Score: 1,180
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.69
    Marker Score: 1,464
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.68
    Marker Score: 1,861
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.64
    Marker Score: 480
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.64
    Marker Score: 1,263
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.59
    Marker Score: 7,350
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.56
    Marker Score: 2,401
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.53
    Marker Score: 1,760
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.52
    Marker Score: 2,042
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.51
    Marker Score: 885
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.5
    Marker Score: 5,329
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.49
    Marker Score: 471
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.45
    Marker Score: 1,645
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.42
    Marker Score: 2,734
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.41
    Marker Score: 1,253
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.41
    Marker Score: 2,466
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.38
    Marker Score: 398
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.36
    Marker Score: 761
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.36
    Marker Score: 372
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.34
    Marker Score: 1,616
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.33
    Marker Score: 2,225
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.31
    Marker Score: 1,413
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.3
    Marker Score: 3,717
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.26
    Marker Score: 1,031
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.24
    Marker Score: 500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.23
    Marker Score: 19,294
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.23
    Marker Score: 3,298
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.22
    Marker Score: 1,777
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.22
    Marker Score: 7,855
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.17
    Marker Score: 1,452
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.16
    Marker Score: 5,013
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.14
    Marker Score: 764
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.14
    Marker Score: 2,309
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.12
    Marker Score: 1,141
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.12
    Marker Score: 356
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.11
    Marker Score: 1,103
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.11
    Marker Score: 1,055
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.11
    Marker Score: 1,184
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.1
    Marker Score: 37,229
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.09
    Marker Score: 408
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.09
    Marker Score: 345
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.07
    Marker Score: 1,521
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.07
    Marker Score: 5,763
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.07
    Marker Score: 17,111
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.05
    Marker Score: 524
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.05
    Marker Score: 510
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.04
    Marker Score: 904
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.04
    Marker Score: 210
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.03
    Marker Score: 262
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.03
    Marker Score: 2,345
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.02
    Marker Score: 320
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.02
    Marker Score: 1,496
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.01
    Marker Score: 3,318
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.01
    Marker Score: 521
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1
    Marker Score: 495
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,692
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,916
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.98
    Marker Score: 1,188
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,390
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.98
    Marker Score: 568
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.97
    Marker Score: 2,438
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.97
    Marker Score: 527
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.97
    Marker Score: 964
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.96
    Marker Score: 536
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.96
    Marker Score: 325
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.95
    Marker Score: 349
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.95
    Marker Score: 2,241
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.95
    Marker Score: 568
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,399
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.93
    Marker Score: 257
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 439
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.92
    Marker Score: 3,161
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.92
    Marker Score: 966
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.92
    Marker Score: 1,487
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.92
    Marker Score: 241
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.91
    Marker Score: 343
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,706

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Guanyl-nucleotide exchange factor activity**: ARFGEF2 is a guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP in ADP-ribosylation factor (ARF) proteins, regulating their activation and subsequent downstream effects. 2. **Intracellular trafficking**: ARFGEF2 is involved in regulating the trafficking of proteins and organelles within the cell, including endoplasmic reticulum, Golgi apparatus, and lysosomes. 3. **Protein folding**: ARFGEF2 contributes to the proper folding of proteins, particularly those involved in signal transduction and trafficking. 4. **Signal transduction**: ARFGEF2 modulates various signaling pathways, including those involved in cell proliferation, differentiation, and survival. **Pathways and Functions:** ARFGEF2 is associated with numerous cellular processes, including: 1. **Association of tric/cct with target proteins during biosynthesis**: ARFGEF2 regulates the interaction between tric (a component of the AAA+ ATPase ATPase) and its target proteins, ensuring proper protein biosynthesis and folding. 2. **Asymmetric synapse**: ARFGEF2 is involved in the regulation of asymmetric synapse formation and function, which is critical for neural circuit development and plasticity. 3. **Axonemal microtubule**: ARFGEF2 modulates the dynamics of axonemal microtubules, which are essential for ciliary function and motility. 4. **Centrosome**: ARFGEF2 regulates the organization and dynamics of centrosomes, a critical component of the microtubule organizing center. 5. **Chaperonin-mediated protein folding**: ARFGEF2 contributes to the proper folding of proteins assisted by chaperonins, which are molecular chaperones that assist in protein folding and assembly. 6. **Cytoplasmic vesicle**: ARFGEF2 regulates the trafficking of cytoplasmic vesicles, which are essential for the transport of proteins and organelles within the cell. 7. **Exocytosis**: ARFGEF2 modulates the regulation of exocytosis, a critical process for the release of neurotransmitters and other molecules. **Clinical Significance:** Dysregulation of ARFGEF2 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: Mutations in ARFGEF2 have been associated with neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: ARFGEF2 is overexpressed in several types of cancer, including breast cancer and lung cancer, suggesting its potential as a therapeutic target. 3. **Cardiovascular disease**: ARFGEF2 is involved in the regulation of cardiac function and has been implicated in the pathogenesis of cardiovascular disease. In conclusion, ARFGEF2 is a multifaceted gene that plays a critical role in regulating various cellular processes, including intracellular trafficking, protein folding, and signal transduction. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying its function and potential therapeutic applications.

Genular Protein ID: 4190697264

Symbol: BIG2_HUMAN

Name: Brefeldin A-inhibited guanine nucleotide-exchange protein 2

UniProtKB Accession Codes:

Q9Y6D5 Q5TFT9 Q9NTS1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 1 GO 31 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10212200

Title: Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.

PubMed ID: 10212200

DOI: 10.1074/jbc.274.18.12308

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 10716990

Title: Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.

PubMed ID: 10716990

DOI: 10.1073/pnas.97.6.2567

PubMed ID: 12051703

Title: Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins.

PubMed ID: 12051703

DOI: 10.1016/s0006-291x(02)00456-4

PubMed ID: 12571360

Title: Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2).

PubMed ID: 12571360

DOI: 10.1073/pnas.0337678100

PubMed ID: 15385626

Title: BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and implication in the endosome integrity.

PubMed ID: 15385626

DOI: 10.1091/mbc.e04-05-0388

PubMed ID: 15705715

Title: Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70.

PubMed ID: 15705715

DOI: 10.1073/pnas.0409871102

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16866877

Title: AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors.

PubMed ID: 16866877

DOI: 10.1111/j.1365-2443.2006.00991.x

PubMed ID: 16477018

Title: Association of brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2) with recycling endosomes during transferrin uptake.

PubMed ID: 16477018

DOI: 10.1073/pnas.0510599103

PubMed ID: 17276987

Title: The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles.

PubMed ID: 17276987

DOI: 10.1074/jbc.m607122200

PubMed ID: 17640864

Title: Interactions between conserved domains within homodimers in the BIG1, BIG2, and GBF1 Arf guanine nucleotide exchange factors.

PubMed ID: 17640864

DOI: 10.1074/jbc.m705525200

PubMed ID: 17360629

Title: Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma.

PubMed ID: 17360629

DOI: 10.1073/pnas.0611696104

PubMed ID: 18625701

Title: cAMP-dependent protein kinase A (PKA) signaling induces TNFR1 exosome-like vesicle release via anchoring of PKA regulatory subunit RIIbeta to BIG2.

PubMed ID: 18625701

DOI: 10.1074/jbc.m804966200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19332778

Title: Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity.

PubMed ID: 19332778

DOI: 10.1073/pnas.0901558106

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20360857

Title: Specific functions of BIG1 and BIG2 in endomembrane organization.

PubMed ID: 20360857

DOI: 10.1371/journal.pone.0009898

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23812912

Title: West syndrome, microcephaly, grey matter heterotopia and hypoplasia of corpus callosum due to a novel ARFGEF2 mutation.

PubMed ID: 23812912

DOI: 10.1136/jmedgenet-2013-101752

PubMed ID: 14647276

Title: Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex.

PubMed ID: 14647276

DOI: 10.1038/ng1276

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25160555

Title: Periventricular nodular heterotopia and dystonia due to an ARFGEF2 mutation.

PubMed ID: 25160555

DOI: 10.1016/j.pediatrneurol.2014.05.008

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

Sequence Information:

  • Length: 1785
  • Mass: 202038
  • Checksum: D419106E5BAF19C2
  • Sequence:
    • MQESQTKSMF VSRALEKILA DKEVKRPQHS QLRRACQVAL DEIKAEIEKQ RLGTAAPPKA 
NFIEADKYFL PFELACQSKS PRVVSTSLDC LQKLIAYGHI TGNAPDSGAP GKRLIDRIVE 
TICSCFQGPQ TDEGVQLQII KALLTAVTSP HIEIHEGTIL QTVRTCYNIY LASKNLINQT 
TAKATLTQML NVIFTRMENQ VLQEARELEK PIQSKPQSPV IQAAAVSPKF VRLKHSQAQS 
KPTTPEKTDL TNGEHARSDS GKVSTENGDA PRERGSSLSG TDDGAQEVVK DILEDVVTSA 
IKEAAEKHGL TEPERVLGEL ECQECAIPPG VDENSQTNGI ADDRQSLSSA DNLESDAQGH 
QVAARFSHVL QKDAFLVFRS LCKLSMKPLG EGPPDPKSHE LRSKVVSLQL LLSVLQNAGP 
VFRTHEMFIN AIKQYLCVAL SKNGVSSVPD VFELSLAIFL TLLSNFKMHL KMQIEVFFKE 
IFLNILETST SSFEHRWMVI QTLTRICADA QCVVDIYVNY DCDLNAANIF ERLVNDLSKI 
AQGRSGHELG MTPLQELSLR KKGLECLVSI LKCMVEWSKD LYVNPNHQTS LGQERLTDQE 
IGDGKGLDMA RRCSVTSMES TVSSGTQTTV QDDPEQFEVI KQQKEIIEHG IELFNKKPKR 
GIQFLQEQGM LGTSVEDIAQ FLHQEERLDS TQVGDFLGDS ARFNKEVMYA YVDQLDFCEK 
EFVSALRTFL EGFRLPGEAQ KIDRLMEKFA ARYIECNQGQ TLFASADTAY VLAYSIIMLT 
TDLHSPQVKN KMTKEQYIKM NRGINDSKDL PEEYLSSIYE EIEGKKIAMK ETKELTIATK 
STKQNVASEK QRRLLYNLEM EQMAKTAKAL MEAVSHAKAP FTSATHLDHV RPMFKLVWTP 
LLAAYSIGLQ NCDDTEVASL CLEGIRCAIR IACIFGMQLE RDAYVQALAR FSLLTASSSI 
TEMKQKNIDT IKTLITVAHT DGNYLGNSWH EILKCISQLE LAQLIGTGVK TRYLSGSGRE 
REGSLKGHTL AGEEFMGLGL GNLVSGGVDK RQMASFQESV GETSSQSVVV AVDRIFTGST 
RLDGNAIVDF VRWLCAVSMD ELASPHHPRM FSLQKIVEIS YYNMNRIRLQ WSRIWHVIGD 
HFNKVGCNPN EDVAIFAVDS LRQLSMKFLE KGELANFRFQ KDFLRPFEHI MKKNRSPTIR 
DMAIRCIAQM VNSQAANIRS GWKNIFAVFH QAASDHDGNI VELAFQTTCH IVTTIFQHHF 
PAAIDSFQDA VKCLSEFACN AAFPDTSMEA IRLIRFCGKY VSERPRVLQE YTSDDMNVAP 
GDRVWVRGWF PILFELSCII NRCKLDVRTR GLTVMFEIMK SYGHTFEKHW WQDLFRIVFR 
IFDNMKLPEQ LSEKSEWMTT TCNHALYAIC DVFTQFYEAL NEVLLSDVFA QLQWCVKQDN 
EQLARSGTNC LENLVISNGE KFSPEVWDET CNCMLDIFKT TIPHVLLTWR PVGMEEDSSE 
KHLDVDLDRQ SLSSIDKNPS ERGQSQLSNP TDDSWKGRPY ANQKLFASLL IKCVVQLELI 
QTIDNIVFYP ATSKKEDAEH MVAAQQDTLD ADIHIETEDQ GMYKYMSSQH LFKLLDCLQE 
SHSFSKAFNS NYEQRTVLWR AGFKGKSKPN LLKQETSSLA CCLRILFRMY VDENRRDSWE 
EIQQRLLTVC SEALAYFITV NSESHREAWT SLLLLLLTKT LKINDEKFKA HASMYYPYLC 
EIMQFDLIPE LRAVLRKFFL RIGVVYKIWI PEEPSQVPAA LSPVW

Genular Protein ID: 1711206203

Symbol: Q59FR3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FR3

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 821
  • Mass: 94405
  • Checksum: EFFBBA502CA3ECEA
  • Sequence:
    • QKNIDTIKTL ITVAHTDGNY LGNSWHEILK CISQLELAQL IGTGVKTRYL SGSGREREGS 
LKGHTLAGEE FMGLGLGNLV SGGVDKRQMA SFQESVGETS SQSVVVAVDR IFTGSTRLDG 
NAIVDFVRWL CAVSMDELAS PHHPRMFSLQ KIVEISYYNM NRIRLQWSRI WHVIGDHFNK 
VGCNPNEDVA IFAVDSLRQL SMKFLEKGEL ANFRFQKDFL RPFEHIMKKN RSPTIRDMAI 
RCIAQMVNSQ AANIRSGWKN IFAVFHQAAS DHDGNIVELA FQTTCHIVTT IFQHHFPAAI 
DSFQDAVKCL SEFACNAAFP DTSMEAIRLI RFCGKYVSER PRVLQEYTSD DMNVAPGDRV 
WVRGWFPILF ELSCIINRCK LDVRTRGLTV MFEIMKSYGH TFEKHWWQDL FRIVFRIFDN 
MKLPEQLSEK SEWMTTTCNH ALYAICDVFT QFYEALNEVL LSDVFAQLQW CVKQDNEQLA 
RSGTNCLENL VISNGEKFSP EVWDETCNCM LDIFKTTIPH VLLTWRPVGM EEDSSEKHLD 
VDLDRQSLSS IDKNPSERGQ SQLSNPTDDS WKGRPYANQK LFASLLIKCV VQLELIQTID 
NIVFYPATSK KEDAEHMVAA QQDTLDADIH IETEDQGMYK YMSSQHLFKL LDCLQESHSF 
SKAFNSNYEQ RTVLWRAGFK GKSKPNLLKQ ETSSLACCLR ILFRMYVDEN RRDSWEEIQQ 
RLLTVCSEAL AYFITVNSES HREAWTSLLL LLLTKTLKIN DEKFKAHASM YYPYLCEIMQ 
FDLIPELRAV LRKFFLRIGV VYKIWIPEEP SQVPAALSPV W

Genular Protein ID: 1165971754

Symbol: Q86TH5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86TH5

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 4 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 832
  • Mass: 92997
  • Checksum: 9C9CACD99F234028
  • Sequence:
    • MQESQTKSMF VSRALEKILA DKEVKRPQHS QLRRACQVAL DEIKAEIEKQ RLGTAAPPKA 
NFIEADKYFL PFELACQSKS PRVVSTSLDC LQKLIAYGHI TGNAPDSGAP GKRLIDRIVE 
TICSCFQGPQ TDEGVQLQII KALLTAVTSP HIEIHEGTIL QTVRTCYNIY LASKNLINQT 
TAKATLTQML NVIFTRMENQ VLQEARELEK PIQSKPQSPV IQAAAVSPKF VRLKHSQAQS 
KPTTPEKTDL TNGEHARSDS GKVSTENGDA PRERGSSLSG TDDGAQEVVK DILEDVVTSA 
IKEAAEKHGL TEPERVLGEL ECQECAIPPG VDENSQTNGI ADDRQSLSSA DNLESDAQGH 
QVAARFSHVL QKDAFLVFRS LCKLSMKPLG EGPPDPKSHE LRSKVVSLQL LLSVLQNAGP 
VFRTHEMFIN AIKQYLCVAL SKNGVSSVPD VFELSLAIFL TLLSNFKMHL KMQIEVFFKE 
IFLNILETST SSFEHRWMVI QTLTRICADA QCVVDIYVNY DCDLNAANIF ERLVNDLSKI 
AQGRSGHELG MTPLQELSLR KKGLECLVSI LKCMVEWSKD LYVNPNHQTS LGQERLTDQE 
IGDGKGLDMA RRCSVTSMES TVSSGTQTTV QDDPEQFEVI KQQKEIIEHG IELFNKKPKR 
GIQFLQEQGM LGTSVEDIAQ FLHQEERLDS TQVGDFLGDS ARFNKEVMYA YVDQLDFCEK 
EFVSALRTFL EGFRLPGEAQ KIDRLMEKFA ARYIECNQGQ TLFASADTAY VLAYSIIMLT 
TDLHSPQVKN KMTKEQYIKM NRGINDSKDL PEEYLSSIYE EIEGKKIAKK KK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.