Details for: AKAP3

Gene ID: 10566

Symbol: AKAP3

Ensembl ID: ENSG00000111254

Description: A-kinase anchoring protein 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 2.26
    Marker Score: 19,074
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 872
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.11
    Marker Score: 804
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.04
    Marker Score: 2,977
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,059
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,326
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.89
    Marker Score: 371
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,289
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.87
    Marker Score: 589
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,986
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 543
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.69
    Marker Score: 1,207
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.56
    Marker Score: 1,057
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 348
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.52
    Marker Score: 301
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.47
    Marker Score: 7,277
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.45
    Marker Score: 921
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.41
    Marker Score: 173
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.39
    Marker Score: 112
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.34
    Marker Score: 137
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.33
    Marker Score: 474
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.32
    Marker Score: 397
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.3
    Marker Score: 713
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.3
    Marker Score: 134
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.3
    Marker Score: 96
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.28
    Marker Score: 256
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.26
    Marker Score: 378
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.26
    Marker Score: 157
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.22
    Marker Score: 611
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.22
    Marker Score: 143
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.18
    Marker Score: 179
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.17
    Marker Score: 54
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.16
    Marker Score: 76
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.15
    Marker Score: 274
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.14
    Marker Score: 493
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.13
    Marker Score: 78
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.13
    Marker Score: 32
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.13
    Marker Score: 2,707
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.12
    Marker Score: 154
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.12
    Marker Score: 124
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.11
    Marker Score: 48
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.11
    Marker Score: 43
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.11
    Marker Score: 918
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.11
    Marker Score: 26
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.1
    Marker Score: 113
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1
    Marker Score: 629
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.1
    Marker Score: 90
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.1
    Marker Score: 40
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.1
    Marker Score: 66
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.1
    Marker Score: 89
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.1
    Marker Score: 350
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.09
    Marker Score: 967
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.09
    Marker Score: 150
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.09
    Marker Score: 115
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.09
    Marker Score: 67
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.09
    Marker Score: 133
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.08
    Marker Score: 39
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.08
    Marker Score: 16
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.08
    Marker Score: 90
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.08
    Marker Score: 189
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.08
    Marker Score: 43
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.08
    Marker Score: 78
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.08
    Marker Score: 50
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.08
    Marker Score: 79
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 80
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.07
    Marker Score: 131
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.07
    Marker Score: 213
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.07
    Marker Score: 40
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.07
    Marker Score: 15
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.07
    Marker Score: 101
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.06
    Marker Score: 30

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AKAP3 is a member of the A-kinase anchoring protein family, which is characterized by its ability to bind and regulate the activity of protein kinase A (PKA). This interaction enables AKAP3 to modulate the localization and activity of PKA, thereby influencing downstream signaling pathways. AKAP3 is also known for its involvement in the regulation of cellular processes, including cell migration, differentiation, and survival. **Pathways and Functions:** AKAP3 has been implicated in a wide range of cellular processes, including: 1. **Acrosome reaction and fertilization**: AKAP3 is essential for the regulation of the acrosome reaction, a critical event in fertilization. By modulating PKA activity, AKAP3 ensures the proper functioning of the acrosome, enabling sperm to penetrate the egg. 2. **Cell migration and differentiation**: AKAP3 has been shown to regulate cell migration and differentiation in various cell types, including neurons, epithelial cells, and immune cells. 3. **Protein localization**: AKAP3's ability to regulate PKA activity enables it to influence the localization of various proteins within the cell, thereby modulating cellular processes. 4. **Transmembrane receptor signaling**: AKAP3 has been implicated in the regulation of transmembrane receptor signaling pathways, including the PKA signaling pathway. **Clinical Significance:** AKAP3's involvement in various cellular processes has significant implications for human disease. Dysregulation of AKAP3 has been implicated in several disorders, including: 1. **Neurological disorders**: AKAP3's role in regulating neuronal function and differentiation makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: AKAP3's involvement in cell migration and differentiation has led to its identification as a potential target for cancer therapy. 3. **Immunological disorders**: AKAP3's role in regulating immune cell function makes it a potential target for the treatment of immunological disorders, such as autoimmune diseases. In conclusion, AKAP3 is a complex protein that plays a critical role in various cellular processes, including signal transduction, protein localization, and cell development. Its dysregulation has significant implications for human disease, making it a potential target for therapeutic intervention. Further research is necessary to fully elucidate the mechanisms by which AKAP3 influences cellular behavior and to explore its potential as a therapeutic target.

Genular Protein ID: 3755103955

Symbol: AKAP3_HUMAN

Name: A-kinase anchor protein 3

UniProtKB Accession Codes:

O75969 O75945 Q86X01 Q9UM61

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 6 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10334916

Title: Cloning and characterization of SOB1, a new testis-specific cDNA encoding a human sperm protein probably involved in oocyte recognition.

PubMed ID: 10334916

DOI: 10.1006/bbrc.1999.0728

PubMed ID: 10529264

Title: FSP95, a testis-specific 95-kilodalton fibrous sheath antigen that undergoes tyrosine phosphorylation in capacitated human spermatozoa.

PubMed ID: 10529264

DOI: 10.1095/biolreprod61.5.1184

PubMed ID: 10319321

Title: Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein.

PubMed ID: 10319321

DOI: 10.1210/mend.13.5.0278

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11278869

Title: Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA.

PubMed ID: 11278869

DOI: 10.1074/jbc.m011252200

PubMed ID: 12509440

Title: Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation.

PubMed ID: 12509440

DOI: 10.1074/jbc.m202325200

PubMed ID: 30683861

Title: Loss-of-function mutations in QRICH2 cause male infertility with multiple morphological abnormalities of the sperm flagella.

PubMed ID: 30683861

DOI: 10.1038/s41467-018-08182-x

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 35228300

Title: Homozygous variants in AKAP3 induce asthenoteratozoospermia and male infertility.

PubMed ID: 35228300

DOI: 10.1136/jmedgenet-2021-108271

Sequence Information:

  • Length: 853
  • Mass: 94751
  • Checksum: CFDEA26922B5A86E
  • Sequence:
    • MSEKVDWLQS QNGVCKVDVY SPGDNQAQDW KMDTSTDPVR VLSWLRRDLE KSTAEFQDVR 
FKPGESFGGE TSNSGDPHKG FSVDYYNTTT KGTPERLHFE MTHKEIPCQG PRAQLGNGSS 
VDEVSFYANR LTNLVIAMAR KEINEKIDGS ENKCVYQSLY MGNEPTPTKS LSKIASELVN 
ETVSACSRNA APDKAPGSGD RVSGSSQSPP NLKYKSTLKI KESTKERQGP DDKPPSKKSF 
FYKEVFESRN GDYAREGGRF FPRERKRFRG QERPDDFTAS VSEGIMTYAN SVVSDMMVSI 
MKTLKIQVKD TTIATILLKK VLLKHAKEVV SDLIDSFLRN LHSVTGTLMT DTQFVSAVKR 
TVFSHGSQKA TDIMDAMLRK LYNVMFAKKV PEHVRKAQDK AESYSLISMK GMGDPKNRNV 
NFAMKSETKL REKMYSEPKS EEETCAKTLG EHIIKEGLTL WHKTQQKECK SLGFQHAAFE 
APNTQRKPAS DISFEYPEDI GNLSLPPYPP EKPENFMYDS DSWAEDLIVS ALLLIQYHLA 
QGGRRDARSF VEAAGTTNFP ANEPPVAPDE SCLKSAPIVG DQEQAEKKDL RSVFFNFIRN 
LLSETIFKRD QSPEPKVPEQ PVKEDRKLCE RPLASSPPRL YEDDETPGAL SGLTKMAVSQ 
IDGHMSGQMV EHLMNSVMKL CVIIAKSCDA SLAELGDDKS GDASRLTSAF PDSLYECLPA 
KGTGSAEAVL QNAYQAIHNE MRGTSGQPPE GCAAPTVIVS NHNLTDTVQN KQLQAVLQWV 
AASELNVPIL YFAGDDEGIQ EKLLQLSAAA VDKGCSVGEV LQSVLRYEKE RQLNEAVGNV 
TPLQLLDWLM VNL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.