Details for: RABAC1

Gene ID: 10567

Symbol: RABAC1

Ensembl ID: ENSG00000105404

Description: Rab acceptor 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.02
    Marker Score: 8,486
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 3.81
    Marker Score: 1,116
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.69
    Marker Score: 3,294
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.48
    Marker Score: 2,963
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.16
    Marker Score: 2,680
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.1
    Marker Score: 2,185
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.88
    Marker Score: 5,412
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.85
    Marker Score: 4,131
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 2.83
    Marker Score: 1,582
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.82
    Marker Score: 6,417
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.79
    Marker Score: 27,590
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.77
    Marker Score: 7,664
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.76
    Marker Score: 1,832
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.75
    Marker Score: 1,958
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.74
    Marker Score: 11,382
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.7
    Marker Score: 11,653
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.68
    Marker Score: 6,752
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.67
    Marker Score: 30,047
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.65
    Marker Score: 3,458
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 2.63
    Marker Score: 1,599
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.62
    Marker Score: 2,512
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.61
    Marker Score: 1,747
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.58
    Marker Score: 6,744
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.53
    Marker Score: 86,227
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.53
    Marker Score: 1,431
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.53
    Marker Score: 812
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.52
    Marker Score: 3,036
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.52
    Marker Score: 6,754
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.51
    Marker Score: 6,384
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.5
    Marker Score: 5,003
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.5
    Marker Score: 86,717
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.49
    Marker Score: 2,525
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.48
    Marker Score: 3,986
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.45
    Marker Score: 5,557
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.44
    Marker Score: 1,603
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.43
    Marker Score: 2,724
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.42
    Marker Score: 4,005
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.42
    Marker Score: 11,592
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.4
    Marker Score: 1,197
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.39
    Marker Score: 3,285
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.37
    Marker Score: 15,110
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.32
    Marker Score: 23,483
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.31
    Marker Score: 31,055
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.31
    Marker Score: 776
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.3
    Marker Score: 4,680
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.3
    Marker Score: 713
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.29
    Marker Score: 30,239
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.28
    Marker Score: 127,729
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.28
    Marker Score: 721
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.27
    Marker Score: 1,991
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.26
    Marker Score: 825
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.26
    Marker Score: 14,428
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.26
    Marker Score: 7,119
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.25
    Marker Score: 3,313
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.25
    Marker Score: 2,715
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.25
    Marker Score: 8,670
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.24
    Marker Score: 834
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.22
    Marker Score: 1,180
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.21
    Marker Score: 1,601
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.2
    Marker Score: 14,367
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.18
    Marker Score: 1,125
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.18
    Marker Score: 617
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.17
    Marker Score: 489
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.17
    Marker Score: 1,200
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.17
    Marker Score: 748
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.16
    Marker Score: 2,322
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.15
    Marker Score: 902
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.15
    Marker Score: 3,045
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.14
    Marker Score: 2,381
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.14
    Marker Score: 1,352
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.14
    Marker Score: 3,826
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.14
    Marker Score: 2,224
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.14
    Marker Score: 810
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.14
    Marker Score: 1,214
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.13
    Marker Score: 1,012
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.13
    Marker Score: 1,052
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.13
    Marker Score: 886
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.12
    Marker Score: 2,266
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.12
    Marker Score: 507
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.12
    Marker Score: 24,621
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.12
    Marker Score: 1,208
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.1
    Marker Score: 8,599
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 2.09
    Marker Score: 914
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.09
    Marker Score: 3,010
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.09
    Marker Score: 1,865
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.09
    Marker Score: 7,420
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.09
    Marker Score: 515
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.09
    Marker Score: 602
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.08
    Marker Score: 2,951
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.08
    Marker Score: 1,213
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.08
    Marker Score: 6,075
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 2.07
    Marker Score: 901
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.06
    Marker Score: 716
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.05
    Marker Score: 6,444
  • Cell Name: PP cell (CL0000696)
    Fold Change: 2.05
    Marker Score: 462
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.05
    Marker Score: 471
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.05
    Marker Score: 1,761
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.04
    Marker Score: 3,612
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.03
    Marker Score: 1,711
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.03
    Marker Score: 1,053

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RABAC1 is a proline-rich protein that binds to Rab GTPases, modifying their activity and facilitating their interactions with downstream effectors. This post-translational modification is essential for regulating vesicle trafficking, membrane dynamics, and cell signaling. The protein's ability to interact with various cellular components, including the Golgi apparatus, plasma membrane, and synaptic vesicles, highlights its broad functional scope. **Pathways and Functions:** RABAC1 is involved in several critical cellular processes, including: 1. **Golgi apparatus organization**: RABAC1 regulates the structure and function of the Golgi apparatus, ensuring proper protein sorting and modification. 2. **Membrane trafficking**: The protein facilitates the movement of vesicles and proteins between the plasma membrane and internal compartments, influencing cell-cell interactions and signaling. 3. **Synaptic vesicle dynamics**: RABAC1 plays a role in regulating the formation and release of synaptic vesicles, which is essential for neurotransmission and synaptic plasticity. 4. **Immune cell function**: RABAC1 is expressed in various immune cells, including T cells, monocytes, and endothelial cells, and is involved in regulating their activation, migration, and cytokine production. **Clinical Significance:** Dysregulation of RABAC1 has been implicated in several diseases, including: 1. **Immunodeficiency disorders**: RABAC1 mutations have been associated with impaired immune cell function and increased susceptibility to infections. 2. **Neurological disorders**: Alterations in RABAC1 expression have been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Cancer**: RABAC1 has been identified as a potential oncogene, with its overexpression contributing to tumor progression and metastasis. In conclusion, RABAC1 is a critical gene that plays a multifaceted role in regulating cellular processes, including immune function, vesicle trafficking, and cell signaling. Further research is necessary to fully elucidate the functions of RABAC1 and its implications in human disease, ultimately paving the way for the development of novel therapeutic strategies. **References:** * [Insert relevant references to support the discussion] **Note:** As an expert immunologist, I would like to emphasize the importance of continued research on RABAC1 and its role in immune function. Future studies should aim to elucidate the specific mechanisms by which RABAC1 regulates immune cell function and identify potential therapeutic targets for immunodeficiency disorders and other diseases.

Genular Protein ID: 3646406620

Symbol: PRAF1_HUMAN

Name: Prenylated Rab acceptor protein 1

UniProtKB Accession Codes:

Q9UI14 Q7Z4Y2 Q9Y3R1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10329441

Title: Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1).

PubMed ID: 10329441

DOI: 10.1006/bbrc.1999.0651

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11520070

Title: Expression analysis and chromosomal assignment of PRA1 and RILP genes.

PubMed ID: 11520070

DOI: 10.1006/bbrc.2001.5466

PubMed ID: 15922294

Title: NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24.

PubMed ID: 15922294

DOI: 10.1016/j.bbrc.2005.05.050

PubMed ID: 16481131

Title: Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2).

PubMed ID: 16481131

DOI: 10.1016/j.gene.2005.12.009

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 185
  • Mass: 20648
  • Checksum: A85BD5BDCF6C23E4
  • Sequence:
    • MAAQKDQQKD AEAEGLSGTT LLPKLIPSGA GREWLERRRA TIRPWSTFVD QQRFSRPRNL 
GELCQRLVRN VEYYQSNYVF VFLGLILYCV VTSPMLLVAL AVFFGACYIL YLRTLESKLV 
LFGREVSPAH QYALAGGISF PFFWLAGAGS AVFWVLGATL VVIGSHAAFH QIEAVDGEEL 
QMEPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.