Details for: SLC34A2

Gene ID: 10568

Symbol: SLC34A2

Ensembl ID: ENSG00000157765

Description: solute carrier family 34 member 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 4.05
    Marker Score: 16,894
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.69
    Marker Score: 19,373
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 3.54
    Marker Score: 6,734
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.49
    Marker Score: 22,777
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 3.15
    Marker Score: 5,056
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.94
    Marker Score: 1,626
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.88
    Marker Score: 3,470
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.83
    Marker Score: 45,373
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.1
    Marker Score: 942
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.99
    Marker Score: 26,750
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.95
    Marker Score: 16,953
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.66
    Marker Score: 2,152
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.64
    Marker Score: 864
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.63
    Marker Score: 806
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6
    Marker Score: 1,689
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.59
    Marker Score: 459
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.54
    Marker Score: 53,268
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.51
    Marker Score: 1,510
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.47
    Marker Score: 375
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.41
    Marker Score: 634
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.35
    Marker Score: 857
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.34
    Marker Score: 2,135
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.34
    Marker Score: 2,533
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.24
    Marker Score: 842
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.18
    Marker Score: 3,219
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.17
    Marker Score: 1,367
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.16
    Marker Score: 368
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.14
    Marker Score: 478
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.03
    Marker Score: 3,529
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.02
    Marker Score: 527
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1.02
    Marker Score: 309
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1
    Marker Score: 355
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,772
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,998
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1
    Marker Score: 1,011
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.99
    Marker Score: 1,799
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.93
    Marker Score: 1,655
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,279
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.92
    Marker Score: 223
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.89
    Marker Score: 424
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,270
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.85
    Marker Score: 3,280
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 636
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.83
    Marker Score: 219
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.82
    Marker Score: 12,796
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.81
    Marker Score: 380
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.79
    Marker Score: 3,314
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.78
    Marker Score: 1,592
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.78
    Marker Score: 692
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,256
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 700
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.75
    Marker Score: 676
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.73
    Marker Score: 1,660
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.72
    Marker Score: 300
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.71
    Marker Score: 356
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 456
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.71
    Marker Score: 204
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.67
    Marker Score: 310
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.65
    Marker Score: 153
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.65
    Marker Score: 408
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.64
    Marker Score: 294
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 377
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6
    Marker Score: 437
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.59
    Marker Score: 958
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.58
    Marker Score: 398
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.58
    Marker Score: 158
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.57
    Marker Score: 545
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.57
    Marker Score: 348
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.56
    Marker Score: 324
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.54
    Marker Score: 224
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.52
    Marker Score: 557
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.49
    Marker Score: 1,210
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.49
    Marker Score: 1,742
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.48
    Marker Score: 468
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.48
    Marker Score: 836
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.48
    Marker Score: 1,286
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.47
    Marker Score: 113,975
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.45
    Marker Score: 300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.45
    Marker Score: 499
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.43
    Marker Score: 442
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 183
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.42
    Marker Score: 405
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.42
    Marker Score: 3,652
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.4
    Marker Score: 445
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.4
    Marker Score: 442
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.4
    Marker Score: 479
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.39
    Marker Score: 164

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SLC34A2 is a member of the solute carrier family 34, which is characterized by its ability to transport inorganic cations, anions, and amino acids/oligopeptides across cell membranes. The NPT2B protein, encoded by SLC34A2, is a type II sodium-potassium-pi cotransporter that is highly expressed in epithelial cells of the lower respiratory tract, lung, and other tissues. The protein has a high affinity for phosphate ions and is capable of transporting phosphate into cells in exchange for sodium ions. **Pathways and Functions:** The SLC34A2 gene is involved in several key pathways, including: 1. **Intracellular Phosphate Ion Homeostasis:** The NPT2B protein plays a critical role in maintaining intracellular phosphate ion homeostasis by transporting phosphate ions into cells in exchange for sodium ions. 2. **Surfactant Metabolism:** SLC34A2 is involved in the regulation of surfactant metabolism, which is essential for maintaining lung function and preventing respiratory distress syndrome. 3. **Phosphate Ion Transport:** The NPT2B protein is capable of transporting phosphate ions across cell membranes, which is essential for various cellular processes, including DNA synthesis and cell growth. 4. **Sodium-Coupled Phosphate Cotransport:** SLC34A2 is a type II sodium-potassium-pi cotransporter, which means that it uses sodium ions to transport phosphate ions into cells. **Clinical Significance:** Mutations in SLC34A2 have been associated with various diseases, including: 1. **Palm:** A rare disorder characterized by the formation of calcium phosphate stones in the hands and feet. 2. **Pulmonary Alveolar Microlithiasis (PAM):** A rare disorder characterized by the formation of calcium phosphate stones in the lungs. 3. **Surfactant Metabolic Disorders:** SLC34A2 mutations have been associated with surfactant metabolic disorders, which can lead to respiratory distress syndrome and other lung-related complications. In conclusion, the SLC34A2 gene plays a critical role in regulating phosphate homeostasis and surfactant metabolism. Mutations in this gene can lead to various diseases, highlighting the importance of this gene in maintaining human health. Further research is needed to fully understand the mechanisms underlying SLC34A2-mediated diseases and to develop effective therapeutic strategies for these disorders.

Genular Protein ID: 3717124603

Symbol: NPT2B_HUMAN

Name: Sodium-dependent phosphate transport protein 2B

UniProtKB Accession Codes:

O95436 A5PL17 Q8N2K2 Q8WYA9 Q9P0V7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 7 Ensembl 4 ExpressionAtlas 1 GO 15 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 2 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 4 RefSeq 3 Rhea 4 SAM 1 SIGNOR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10329428

Title: Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine.

PubMed ID: 10329428

DOI: 10.1006/bbrc.1999.0666

PubMed ID: 10610722

Title: Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2).

PubMed ID: 10610722

DOI: 10.1006/geno.1999.6009

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11171583

Title: Regulation of the human sodium-phosphate cotransporter NaPi-IIb gene promoter by epidermal growth factor.

PubMed ID: 11171583

DOI: 10.1152/ajpcell.2001.280.3.c628

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12661006

Title: Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21).

PubMed ID: 12661006

DOI: 10.1002/gcc.10207

PubMed ID: 16960801

Title: Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis.

PubMed ID: 16960801

DOI: 10.1086/508263

Sequence Information:

  • Length: 690
  • Mass: 75759
  • Checksum: 3BDB1920CA92C035
  • Sequence:
    • MAPWPELGDA QPNPDKYLEG AAGQQPTAPD KSKETNKTDN TEAPVTKIEL LPSYSTATLI 
DEPTEVDDPW NLPTLQDSGI KWSERDTKGK ILCFFQGIGR LILLLGFLYF FVCSLDILSS 
AFQLVGGKMA GQFFSNSSIM SNPLLGLVIG VLVTVLVQSS STSTSIVVSM VSSSLLTVRA 
AIPIIMGANI GTSITNTIVA LMQVGDRSEF RRAFAGATVH DFFNWLSVLV LLPVEVATHY 
LEIITQLIVE SFHFKNGEDA PDLLKVITKP FTKLIVQLDK KVISQIAMND EKAKNKSLVK 
IWCKTFTNKT QINVTVPSTA NCTSPSLCWT DGIQNWTMKN VTYKENIAKC QHIFVNFHLP 
DLAVGTILLI LSLLVLCGCL IMIVKILGSV LKGQVATVIK KTINTDFPFP FAWLTGYLAI 
LVGAGMTFIV QSSSVFTSAL TPLIGIGVIT IERAYPLTLG SNIGTTTTAI LAALASPGNA 
LRSSLQIALC HFFFNISGIL LWYPIPFTRL PIRMAKGLGN ISAKYRWFAV FYLIIFFFLI 
PLTVFGLSLA GWRVLVGVGV PVVFIIILVL CLRLLQSRCP RVLPKKLQNW NFLPLWMRSL 
KPWDAVVSKF TGCFQMRCCC CCRVCCRACC LLCDCPKCCR CSKCCEDLEE AQEGQDVPVK 
APETFDNITI SREAQGEVPA SDSKTECTAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.