Details for: SLU7

Gene ID: 10569

Symbol: SLU7

Ensembl ID: ENSG00000164609

Description: SLU7 homolog, splicing factor

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.58
    Marker Score: 3,218
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.56
    Marker Score: 1,541
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.56
    Marker Score: 1,062
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.53
    Marker Score: 2,706
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166,826
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.45
    Marker Score: 14,717
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.44
    Marker Score: 867
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.43
    Marker Score: 3,269
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.36
    Marker Score: 1,429
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.35
    Marker Score: 389
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.31
    Marker Score: 464
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3
    Marker Score: 1,918
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.28
    Marker Score: 1,286
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.27
    Marker Score: 847
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.22
    Marker Score: 1,142
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.2
    Marker Score: 1,274
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.2
    Marker Score: 1,728
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.18
    Marker Score: 3,206
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.17
    Marker Score: 2,449
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.17
    Marker Score: 504
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.15
    Marker Score: 765
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.14
    Marker Score: 29,135
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.13
    Marker Score: 3,884
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.13
    Marker Score: 1,364
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.12
    Marker Score: 278
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.12
    Marker Score: 4,577
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.12
    Marker Score: 1,340
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.11
    Marker Score: 1,050
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.11
    Marker Score: 383
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.11
    Marker Score: 264
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.1
    Marker Score: 12,795
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.1
    Marker Score: 1,185
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.09
    Marker Score: 622
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.07
    Marker Score: 1,033
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.07
    Marker Score: 2,011
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.06
    Marker Score: 330
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.06
    Marker Score: 214
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.06
    Marker Score: 1,799
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.06
    Marker Score: 1,128
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.05
    Marker Score: 10,426
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.05
    Marker Score: 522
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.04
    Marker Score: 257
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.03
    Marker Score: 748
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.03
    Marker Score: 2,568
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.03
    Marker Score: 3,975
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.03
    Marker Score: 241
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.02
    Marker Score: 1,285
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.02
    Marker Score: 647
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.02
    Marker Score: 697
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1
    Marker Score: 290
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1
    Marker Score: 4,323
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1
    Marker Score: 246
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1
    Marker Score: 61,314
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1
    Marker Score: 262
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,575
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.99
    Marker Score: 52,565
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.99
    Marker Score: 263
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,800
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,366
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.98
    Marker Score: 5,933
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.97
    Marker Score: 1,946
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.97
    Marker Score: 3,074
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.97
    Marker Score: 1,089
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.97
    Marker Score: 289
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.97
    Marker Score: 10,881
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.97
    Marker Score: 1,367
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.96
    Marker Score: 8,353
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.96
    Marker Score: 1,574
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.96
    Marker Score: 288
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.96
    Marker Score: 1,128
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.95
    Marker Score: 526
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.95
    Marker Score: 53,286
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.95
    Marker Score: 1,660
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.95
    Marker Score: 270
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.95
    Marker Score: 987
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.95
    Marker Score: 242
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.95
    Marker Score: 463
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.95
    Marker Score: 8,147
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.94
    Marker Score: 1,026
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.94
    Marker Score: 265
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.94
    Marker Score: 793
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.94
    Marker Score: 206
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.93
    Marker Score: 263
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.93
    Marker Score: 2,372
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.93
    Marker Score: 937
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 0.93
    Marker Score: 275
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.93
    Marker Score: 298
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.92
    Marker Score: 428
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.92
    Marker Score: 253
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.92
    Marker Score: 322
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.92
    Marker Score: 212
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.92
    Marker Score: 317
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 473
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.92
    Marker Score: 302
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.92
    Marker Score: 1,261
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.92
    Marker Score: 3,601
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.92
    Marker Score: 1,457
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.92
    Marker Score: 7,887
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.91
    Marker Score: 383
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.91
    Marker Score: 3,387

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SLU7 is a highly conserved gene, with its human homolog (SLU7_HUMAN) exhibiting high sequence similarity to its counterparts in other species. This gene is primarily expressed in various cell types, including GABAergic amacrine cells, IgG-negative class switched memory B cells, squamous epithelial cells, and early pro-B cells. The SLU7 protein is a pre-mRNA splicing factor that interacts with other components of the spliceosome complex to facilitate the recognition and excision of introns. **Pathways and Functions:** SLU7 is involved in multiple cellular processes, including alternative mRNA splicing, mRNA 3'-end processing, and mRNA splicing via the spliceosome. The spliceosome complex, in which SLU7 plays a crucial role, is responsible for recognizing and excising introns from pre-mRNA, thus influencing the final transcript's translation and cellular function. SLU7's involvement in these pathways highlights its importance in regulating gene expression and protein diversity. The SLU7 protein's interactions with other components of the spliceosome complex, such as the small nuclear ribonucleoprotein (snRNP) complex, demonstrate its role in the catalytic step 2 of the spliceosome. Additionally, SLU7's association with zinc ions suggests its involvement in the recognition and binding of specific RNA sequences, thereby facilitating the splicing process. **Clinical Significance:** Dysregulation of SLU7 expression or function has been implicated in various diseases, including cancer and immunological disorders. For instance, alterations in SLU7 expression have been observed in IgG-negative class switched memory B cells, which are often associated with autoimmune diseases. Furthermore, SLU7's role in regulating gene expression and protein diversity makes it a potential target for the development of novel therapeutic strategies. In cancer, SLU7's involvement in alternative mRNA splicing and mRNA 3'-end processing has been linked to the development and progression of various tumor types. For example, alterations in SLU7 expression have been observed in squamous epithelial cells, which are often involved in cancer development. Therefore, SLU7 may serve as a valuable biomarker for cancer diagnosis and a potential therapeutic target. In conclusion, the SLU7 gene plays a critical role in regulating RNA splicing and gene expression, with implications for various cellular processes and diseases. Further research into the mechanisms of SLU7 function and its clinical significance is necessary to fully appreciate its importance in human health and disease.

Genular Protein ID: 67242814

Symbol: SLU7_HUMAN

Name: Pre-mRNA-splicing factor SLU7

UniProtKB Accession Codes:

O95391 D3DQK2 Q3LUJ0 Q3LUJ1 Q6RXQ5 Q96FM9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 20 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 6 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SAM 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10197984

Title: Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing.

PubMed ID: 10197984

DOI: 10.1101/gad.13.7.841

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10647016

Title: The RNA splicing factor hSlu7 is required for correct 3' splice-site choice.

PubMed ID: 10647016

DOI: 10.1038/46086

PubMed ID: 12764196

Title: The birth of an alternatively spliced exon: 3' splice-site selection in Alu exons.

PubMed ID: 12764196

DOI: 10.1126/science.1082588

PubMed ID: 15181151

Title: Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus.

PubMed ID: 15181151

DOI: 10.1091/mbc.e04-02-0152

PubMed ID: 15728250

Title: Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing.

PubMed ID: 15728250

DOI: 10.1242/jcs.01720

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21122810

Title: Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7.

PubMed ID: 21122810

DOI: 10.1016/j.bbamcr.2010.11.010

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 30705154

Title: A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation.

PubMed ID: 30705154

DOI: 10.1126/science.aaw5569

Sequence Information:

  • Length: 586
  • Mass: 68387
  • Checksum: 237B8C8014EEAB6E
  • Sequence:
    • MSATVVDAVN AAPLSGSKEM SLEEPKKMTR EDWRKKKELE EQRKLGNAPA EVDEEGKDIN 
PHIPQYISSV PWYIDPSKRP TLKHQRPQPE KQKQFSSSGE WYKRGVKENS IITKYRKGAC 
ENCGAMTHKK KDCFERPRRV GAKFTGTNIA PDEHVQPQLM FDYDGKRDRW NGYNPEEHMK 
IVEEYAKVDL AKRTLKAQKL QEELASGKLV EQANSPKHQW GEEEPNSQME KDHNSEDEDE 
DKYADDIDMP GQNFDSKRRI TVRNLRIRED IAKYLRNLDP NSAYYDPKTR AMRENPYANA 
GKNPDEVSYA GDNFVRYTGD TISMAQTQLF AWEAYDKGSE VHLQADPTKL ELLYKSFKVK 
KEDFKEQQKE SILEKYGGQE HLDAPPAELL LAQTEDYVEY SRHGTVIKGQ ERAVACSKYE 
EDVKIHNHTH IWGSYWKEGR WGYKCCHSFF KYSYCTGEAG KEIVNSEECI INEITGEESV 
KKPQTLMELH QEKLKEEKKK KKKKKKKHRK SSSDSDDEEK KHEKLKKALN AEEARLLHVK 
ETMQIDERKR PYNSMYETRE PTEEEMEAYR MKRQRPDDPM ASFLGQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.