Details for: CELP

Gene ID: 1057

Symbol: CELP

Ensembl ID: ENSG00000170827

Description: carboxyl ester lipase pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 24.8412
    Cell Significance Index: 257.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 8.6915
    Cell Significance Index: 1484.1300
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.0175
    Cell Significance Index: 7.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5074
    Cell Significance Index: 14.6200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2569
    Cell Significance Index: 5.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2315
    Cell Significance Index: 4.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1285
    Cell Significance Index: 5.9900
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.0930
    Cell Significance Index: 0.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0393
    Cell Significance Index: 1.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0191
    Cell Significance Index: 0.9900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0022
    Cell Significance Index: 1.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0021
    Cell Significance Index: 1.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0007
    Cell Significance Index: 0.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0012
    Cell Significance Index: -1.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0014
    Cell Significance Index: -1.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0024
    Cell Significance Index: -0.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0026
    Cell Significance Index: -1.6400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0041
    Cell Significance Index: -0.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0053
    Cell Significance Index: -2.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0063
    Cell Significance Index: -0.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0081
    Cell Significance Index: -1.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0097
    Cell Significance Index: -1.4100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0101
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0143
    Cell Significance Index: -0.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0174
    Cell Significance Index: -0.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0191
    Cell Significance Index: -0.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0240
    Cell Significance Index: -0.5200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0240
    Cell Significance Index: -0.4100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0269
    Cell Significance Index: -0.6700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0271
    Cell Significance Index: -0.3700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0289
    Cell Significance Index: -0.2800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0297
    Cell Significance Index: -0.6200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0301
    Cell Significance Index: -0.6500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0303
    Cell Significance Index: -0.4800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0310
    Cell Significance Index: -0.4300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0341
    Cell Significance Index: -0.3600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0361
    Cell Significance Index: -0.6300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0361
    Cell Significance Index: -0.7100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0366
    Cell Significance Index: -0.7300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0396
    Cell Significance Index: -0.4000
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0409
    Cell Significance Index: -0.4400
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0415
    Cell Significance Index: -0.4500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0421
    Cell Significance Index: -0.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0448
    Cell Significance Index: -1.2200
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0471
    Cell Significance Index: -0.5800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0480
    Cell Significance Index: -1.5300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0494
    Cell Significance Index: -0.5400
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0499
    Cell Significance Index: -0.4500
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0503
    Cell Significance Index: -0.5300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0510
    Cell Significance Index: -0.7600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0527
    Cell Significance Index: -0.5500
  • Cell Name: brush cell (CL0002204)
    Fold Change: -0.0534
    Cell Significance Index: -0.4900
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0534
    Cell Significance Index: -0.6200
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0537
    Cell Significance Index: -0.6800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0551
    Cell Significance Index: -0.7200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0557
    Cell Significance Index: -0.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0562
    Cell Significance Index: -0.5400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0564
    Cell Significance Index: -0.5500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0570
    Cell Significance Index: -0.6700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0581
    Cell Significance Index: -0.7300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0626
    Cell Significance Index: -0.7700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0686
    Cell Significance Index: -2.1700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0687
    Cell Significance Index: -0.9000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0714
    Cell Significance Index: -0.8400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0721
    Cell Significance Index: -1.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0792
    Cell Significance Index: -1.7400
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0793
    Cell Significance Index: -0.9000
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0840
    Cell Significance Index: -0.8100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0846
    Cell Significance Index: -1.4500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0847
    Cell Significance Index: -1.7000
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0904
    Cell Significance Index: -1.0900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0905
    Cell Significance Index: -1.7900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0911
    Cell Significance Index: -1.2600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0973
    Cell Significance Index: -1.1200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0997
    Cell Significance Index: -1.0800
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1015
    Cell Significance Index: -1.1000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1033
    Cell Significance Index: -1.4700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1043
    Cell Significance Index: -1.3400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1049
    Cell Significance Index: -1.3100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1058
    Cell Significance Index: -1.7800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1067
    Cell Significance Index: -1.2600
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.1067
    Cell Significance Index: -1.2900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1077
    Cell Significance Index: -1.1000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1117
    Cell Significance Index: -1.3200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1118
    Cell Significance Index: -1.2600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1142
    Cell Significance Index: -1.9400
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.1144
    Cell Significance Index: -1.3300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1181
    Cell Significance Index: -1.5700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1204
    Cell Significance Index: -1.9500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1205
    Cell Significance Index: -1.6600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1215
    Cell Significance Index: -1.2900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1217
    Cell Significance Index: -1.3600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1219
    Cell Significance Index: -1.4500
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1258
    Cell Significance Index: -1.5300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1260
    Cell Significance Index: -1.3400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1262
    Cell Significance Index: -1.3800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1278
    Cell Significance Index: -1.2000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1287
    Cell Significance Index: -1.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The CELP gene is a pseudogene, meaning it lacks the functionality to produce a functional protein. However, its expression is widespread, observed in cells such as acinar cells, intestinal epithelial cells, and melanocytes. This ubiquitous expression suggests that CELP may play a role in regulating cellular processes, possibly through the modulation of lipid metabolism or signaling pathways. Notably, CELP has been found to be significantly expressed in cells of the pancreas, salivary gland, and intestine, highlighting its potential involvement in digestive and endocrine functions. **Pathways and Functions:** Research has implicated CELP in several key pathways, including: 1. **Lipid Metabolism:** CELP has been shown to regulate the activity of carboxyl ester lipases, enzymes involved in the hydrolysis of triglycerides and phospholipids. This suggests that CELP may play a role in modulating lipid metabolism, potentially influencing energy homeostasis and cellular signaling. 2. **Cell Signaling:** CELP has been found to interact with various signaling molecules, including growth factors and cytokines. This interaction may modulate cellular responses to stimuli, influencing cell growth, differentiation, and survival. 3. **Immunological Regulation:** CELP has been implicated in the regulation of immune responses, particularly in the context of inflammatory processes. Its expression in immune cells, such as melanocytes, suggests that CELP may play a role in modulating immune cell function and tissue homeostasis. **Clinical Significance:** The CELP gene's expression in various tissues and cell types has significant implications for human health and disease. Some potential clinical applications and implications include: 1. **Digestive Disorders:** CELP's role in lipid metabolism and pancreatic function suggests that alterations in CELP expression may contribute to the development of digestive disorders, such as pancreatitis or metabolic syndrome. 2. **Immune-Mediated Diseases:** CELP's involvement in immunological regulation and inflammation implies that dysregulation of CELP expression may contribute to the pathogenesis of immune-mediated diseases, such as autoimmune disorders or cancer. 3. **Cancer:** CELP's expression in melanocytes and other cell types has led to speculation about its potential role in cancer development and progression. Further investigation is warranted to determine whether CELP plays a significant role in oncogenesis. In conclusion, the CELP gene, a pseudogene with far-reaching implications, has been found to play a significant role in regulating cellular processes, including lipid metabolism, cell signaling, and immunological regulation. Further research is necessary to fully elucidate the functions and clinical significance of CELP, but the existing evidence suggests that this enigmatic gene warrants further investigation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.