Details for: CCT7

Gene ID: 10574

Symbol: CCT7

Ensembl ID: ENSG00000135624

Description: chaperonin containing TCP1 subunit 7

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.15
    Marker Score: 3,284
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.35
    Marker Score: 9,617
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.31
    Marker Score: 4,818
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.24
    Marker Score: 3,224
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.21
    Marker Score: 14,388
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.2
    Marker Score: 3,116
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.16
    Marker Score: 9,317
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.14
    Marker Score: 2,159
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.14
    Marker Score: 5,814
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.13
    Marker Score: 21,582
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.11
    Marker Score: 2,238
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.11
    Marker Score: 3,578
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.09
    Marker Score: 1,313
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.09
    Marker Score: 1,192
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.07
    Marker Score: 2,207
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.05
    Marker Score: 27,004
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.03
    Marker Score: 23,607
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.01
    Marker Score: 69,720
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2
    Marker Score: 2,243
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.98
    Marker Score: 19,880
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.97
    Marker Score: 1,318
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.97
    Marker Score: 1,857
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.97
    Marker Score: 2,084
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.97
    Marker Score: 726
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.97
    Marker Score: 1,425
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.96
    Marker Score: 2,365
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.96
    Marker Score: 7,684
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.95
    Marker Score: 2,084
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.95
    Marker Score: 4,759
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.94
    Marker Score: 3,445
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.94
    Marker Score: 1,621
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.94
    Marker Score: 2,088
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.91
    Marker Score: 3,127
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.9
    Marker Score: 16,376
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.87
    Marker Score: 4,271
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.87
    Marker Score: 6,940
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.87
    Marker Score: 21,057
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.87
    Marker Score: 3,510
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.85
    Marker Score: 10,987
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.85
    Marker Score: 9,092
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.84
    Marker Score: 2,211
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.84
    Marker Score: 867
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.81
    Marker Score: 2,409
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.8
    Marker Score: 4,892
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.8
    Marker Score: 444
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.8
    Marker Score: 3,130
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.79
    Marker Score: 3,513
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.79
    Marker Score: 1,732
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.79
    Marker Score: 515
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.79
    Marker Score: 635
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.78
    Marker Score: 2,627
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.78
    Marker Score: 1,296
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.78
    Marker Score: 843
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.77
    Marker Score: 15,400
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.77
    Marker Score: 974
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.76
    Marker Score: 3,586
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.76
    Marker Score: 59,971
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.76
    Marker Score: 565
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.76
    Marker Score: 3,145
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.75
    Marker Score: 4,159
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.75
    Marker Score: 1,039
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.75
    Marker Score: 1,187
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.75
    Marker Score: 587
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.74
    Marker Score: 4,093
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.74
    Marker Score: 2,035
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.72
    Marker Score: 17,043
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.7
    Marker Score: 10,868
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.7
    Marker Score: 820
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.7
    Marker Score: 2,616
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.69
    Marker Score: 5,021
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.68
    Marker Score: 823
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.68
    Marker Score: 1,124
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.68
    Marker Score: 7,184
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.67
    Marker Score: 1,572
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.66
    Marker Score: 22,368
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.66
    Marker Score: 1,963
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.66
    Marker Score: 581
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.65
    Marker Score: 2,072
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.65
    Marker Score: 615
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.65
    Marker Score: 2,623
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.64
    Marker Score: 392
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.62
    Marker Score: 85,755
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.62
    Marker Score: 1,560
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.62
    Marker Score: 399
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.61
    Marker Score: 859
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.61
    Marker Score: 1,263
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.61
    Marker Score: 802
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.59
    Marker Score: 1,049
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.58
    Marker Score: 4,971
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.57
    Marker Score: 1,177
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.57
    Marker Score: 6,042
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.56
    Marker Score: 2,591
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.56
    Marker Score: 539
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.56
    Marker Score: 1,467
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.56
    Marker Score: 1,180
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.56
    Marker Score: 365
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.55
    Marker Score: 11,572
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.54
    Marker Score: 1,990
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.54
    Marker Score: 6,425
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.54
    Marker Score: 970

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CCT7 is a subunit of the CCT complex, which is a hexameric ring-shaped structure composed of six identical subunits. Each subunit is composed of 14 α-helices, forming a central cavity that facilitates the binding and folding of guest proteins. CCT7 is one of the seven subunits of the CCT complex, and its unique structure and function are essential for the complex's overall activity. **Pathways and Functions:** CCT7 is involved in various cellular processes, including: 1. **Chaperone-mediated protein folding:** CCT7 works in conjunction with other chaperones to facilitate the correct folding of proteins, preventing protein aggregation and promoting protein stability. 2. **Protein binding:** CCT7 interacts with various proteins, including actin and tubulin, to facilitate their folding and assembly. 3. **Metabolism of proteins:** CCT7 is involved in the regulation of protein metabolism, including protein degradation and synthesis. 4. **Cell signaling:** CCT7 plays a role in cell signaling pathways, including the regulation of telomerase activity and telomere maintenance. **Clinical Significance:** CCT7's involvement in protein folding and quality control makes it an attractive target for therapeutic interventions in diseases characterized by protein misfolding, such as neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease) and cancer (e.g., multiple myeloma). Additionally, CCT7's role in telomere maintenance and telomerase regulation may have implications for the treatment of diseases characterized by telomere shortening, such as certain types of cancer and premature aging disorders. **Significantly Expressed Cells:** CCT7 is highly expressed in various cell types, including: 1. Erythroid progenitor cells 2. Pro-T cells 3. Epithelial cells of the nephron 4. Oogonial cells 5. Interstitial cells of the ovary 6. CD8-alpha-alpha-positive, alpha-beta intraepithelial T cells 7. Decidual cells 8. Fraction A pre-pro B cells 9. Ovarian surface epithelial cells 10. Early pro-B cells In conclusion, CCT7 is a critical component of the CCT complex, playing a vital role in protein folding, quality control, and cell signaling. Its involvement in various cellular processes and its potential implications in disease make it an attractive target for therapeutic interventions. Further research is necessary to fully elucidate the functions and significance of CCT7 in human health and disease.

Genular Protein ID: 1593758706

Symbol: TCPH_HUMAN

Name: T-complex protein 1 subunit eta

UniProtKB Accession Codes:

Q99832 A8K7E6 A8MWI8 B7WNW9 B7Z4T9 B7Z4Z7 O14871 Q6FI26

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 23 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 19 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 3 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 30 PDBsum 26 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 7 RefSeq 6 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9819444

Title: Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT.

PubMed ID: 9819444

DOI: 10.1128/mcb.18.12.7584

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14532270

Title: A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.

PubMed ID: 14532270

DOI: 10.1074/jbc.m309655200

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25467444

Title: Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.

PubMed ID: 25467444

DOI: 10.1016/j.cell.2014.10.059

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 33144677

Title: Dlec1 is required for spermatogenesis and male fertility in mice.

PubMed ID: 33144677

DOI: 10.1038/s41598-020-75957-y

Sequence Information:

  • Length: 543
  • Mass: 59367
  • Checksum: 9F1E33FA80E6238E
  • Sequence:
    • MMPTPVILLK EGTDSSQGIP QLVSNISACQ VIAEAVRTTL GPRGMDKLIV DGRGKATISN 
DGATILKLLD VVHPAAKTLV DIAKSQDAEV GDGTTSVTLL AAEFLKQVKP YVEEGLHPQI 
IIRAFRTATQ LAVNKIKEIA VTVKKADKVE QRKLLEKCAM TALSSKLISQ QKAFFAKMVV 
DAVMMLDDLL QLKMIGIKKV QGGALEDSQL VAGVAFKKTF SYAGFEMQPK KYHNPKIALL 
NVELELKAEK DNAEIRVHTV EDYQAIVDAE WNILYDKLEK IHHSGAKVVL SKLPIGDVAT 
QYFADRDMFC AGRVPEEDLK RTMMACGGSI QTSVNALSAD VLGRCQVFEE TQIGGERYNF 
FTGCPKAKTC TFILRGGAEQ FMEETERSLH DAIMIVRRAI KNDSVVAGGG AIEMELSKYL 
RDYSRTIPGK QQLLIGAYAK ALEIIPRQLC DNAGFDATNI LNKLRARHAQ GGTWYGVDIN 
NEDIADNFEA FVWEPAMVRI NALTAASEAA CLIVSVDETI KNPRSTVDAP TAAGRGRGRG 
RPH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.