CCT2 | ENSG00000166226 | NCBI 10576

Details for: CCT2

Gene ID: 10576

Symbol: CCT2

Ensembl ID: ENSG00000166226

Description: chaperonin containing TCP1 subunit 2

Associated with

Association of tric/cct with target proteins during biosynthesis
(R-HSA-390471)
Bbsome-mediated cargo-targeting to cilium
(R-HSA-5620922)
Cargo trafficking to the periciliary membrane
(R-HSA-5620920)
Chaperonin-mediated protein folding
(R-HSA-390466)
Cilium assembly
(R-HSA-5617833)
Cooperation of pdcl (phlp1) and tric/cct in g-protein beta folding
(R-HSA-6814122)
Cooperation of prefoldin and tric/cct in actin and tubulin folding
(R-HSA-389958)
Folding of actin by cct/tric
(R-HSA-390450)
Formation of tubulin folding intermediates by cct/tric
(R-HSA-389960)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Metabolism of proteins
(R-HSA-392499)
Neutrophil degranulation
(R-HSA-6798695)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Prefoldin mediated transfer of substrate to cct/tric
(R-HSA-389957)
Rhobtb1 gtpase cycle
(R-HSA-9013422)
Rhobtb2 gtpase cycle
(R-HSA-9013418)
Rhobtb gtpase cycle
(R-HSA-9706574)
Rho gtpase cycle
(R-HSA-9012999)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Atp-dependent protein folding chaperone
(GO:0140662)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Azurophil granule lumen
(GO:0035578)
Binding of sperm to zona pellucida
(GO:0007339)
Cell body
(GO:0044297)
Chaperone-mediated protein complex assembly
(GO:0051131)
Chaperone-mediated protein folding
(GO:0061077)
Chaperone mediated protein folding independent of cofactor
(GO:0051086)
Chaperonin-containing t-complex
(GO:0005832)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Microtubule
(GO:0005874)
Positive regulation of establishment of protein localization to telomere
(GO:1904851)
Positive regulation of protein localization to cajal body
(GO:1904871)
Positive regulation of telomerase activity
(GO:0051973)
Positive regulation of telomerase rna localization to cajal body
(GO:1904874)
Positive regulation of telomere maintenance via telomerase
(GO:0032212)
Protein binding
(GO:0005515)
Protein folding
(GO:0006457)
Protein folding chaperone
(GO:0044183)
Protein stabilization
(GO:0050821)
Scarna localization to cajal body
(GO:0090666)
Ubiquitin protein ligase binding
(GO:0031625)
Unfolded protein binding
(GO:0051082)
Zona pellucida receptor complex
(GO:0002199)

Other Information

Proteins

T-complex protein 1 subunit beta

Genular Protein ID: 67395157

Symbol: TCPB_HUMAN

Name: T-complex protein 1 subunit beta

UniProtKB Accession Codes:

P78371 A8K402 B5BTY7 B7Z243 B7Z7K4 B7ZAT2 Q14D36 Q6IAT3

Database IDs:

Citations:

PubMed ID: 9819444

Title: Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT.

PubMed ID: 9819444

DOI: 10.1128/mcb.18.12.7584

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 14532270

Title: A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.

PubMed ID: 14532270

DOI: 10.1074/jbc.m309655200

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20080638

Title: BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly.

PubMed ID: 20080638

DOI: 10.1073/pnas.0910268107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 25467444

Title: Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1.

PubMed ID: 25467444

DOI: 10.1016/j.cell.2014.10.059

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27353360

Title: The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.

PubMed ID: 27353360

DOI: 10.1038/ncomms12037

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 33144677

Title: Dlec1 is required for spermatogenesis and male fertility in mice.

PubMed ID: 33144677

DOI: 10.1038/s41598-020-75957-y

Sequence Information:

Length: 535
Mass: 57488
Checksum: 57F9E1720D84A31F
Sequence:

MASLSLAPVN IFKAGADEER AETARLTSFI GAIAIGDLVK STLGPKGMDK ILLSSGRDAS 
LMVTNDGATI LKNIGVDNPA AKVLVDMSRV QDDEVGDGTT SVTVLAAELL REAESLIAKK 
IHPQTIIAGW REATKAAREA LLSSAVDHGS DEVKFRQDLM NIAGTTLSSK LLTHHKDHFT 
KLAVEAVLRL KGSGNLEAIH IIKKLGGSLA DSYLDEGFLL DKKIGVNQPK RIENAKILIA 
NTGMDTDKIK IFGSRVRVDS TAKVAEIEHA EKEKMKEKVE RILKHGINCF INRQLIYNYP 
EQLFGAAGVM AIEHADFAGV ERLALVTGGE IASTFDHPEL VKLGSCKLIE EVMIGEDKLI 
HFSGVALGEA CTIVLRGATQ QILDEAERSL HDALCVLAQT VKDSRTVYGG GCSEMLMAHA 
VTQLANRTPG KEAVAMESYA KALRMLPTII ADNAGYDSAD LVAQLRAAHS EGNTTAGLDM 
REGTIGDMAI LGITESFQVK RQVLLSAAEA AEVILRVDNI IKAAPRKRVP DHHPC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CCT2

Associated with

Other Information

Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. PubMed ID: 9819444

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. PubMed ID: 14532270

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly. PubMed ID: 20080638

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1. PubMed ID: 25467444

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. PubMed ID: 27353360

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Dlec1 is required for spermatogenesis and male fertility in mice. PubMed ID: 33144677