Details for: CENPA

Gene ID: 1058

Symbol: CENPA

Ensembl ID: ENSG00000115163

Description: centromere protein A

Associated with

Other Information

Genular Protein ID: 2197980588

Symbol: CENPA_HUMAN

Name: Histone H3-like centromeric protein A

UniProtKB Accession Codes:

P49450 D6W544 Q53T74 Q9BVW2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 21 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 35 PDBsum 31 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7962047

Title: Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere.

PubMed ID: 7962047

DOI: 10.1083/jcb.127.3.581

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9024683

Title: Assembly of CENP-A into centromeric chromatin requires a cooperative array of nucleosomal DNA contact sites.

PubMed ID: 9024683

DOI: 10.1083/jcb.136.3.501

PubMed ID: 10759786

Title: Autoepitopes on autoantigen centromere protein-A (CENP-A) are restricted to the N-terminal region, which has no homology with histone H3.

PubMed ID: 10759786

DOI: 10.1046/j.1365-2249.2000.01189.x

PubMed ID: 11053442

Title: Degradation of nucleosome-associated centromeric histone H3-like protein CENP-A induced by herpes simplex virus type 1 protein ICP0.

PubMed ID: 11053442

DOI: 10.1074/jbc.m008547200

PubMed ID: 11756469

Title: CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis.

PubMed ID: 11756469

DOI: 10.1083/jcb.200108125

PubMed ID: 14667408

Title: CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function.

PubMed ID: 14667408

DOI: 10.1016/s1534-5807(03)00364-2

PubMed ID: 15702419

Title: Chromosome size and origin as determinants of the level of CENP-A incorporation into human centromeres.

PubMed ID: 15702419

DOI: 10.1007/s10577-005-5377-4

PubMed ID: 15475964

Title: Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin.

PubMed ID: 15475964

DOI: 10.1038/nsmb845

PubMed ID: 15282608

Title: Structural determinants for generating centromeric chromatin.

PubMed ID: 15282608

DOI: 10.1038/nature02766

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16622419

Title: The human CENP-A centromeric nucleosome-associated complex.

PubMed ID: 16622419

DOI: 10.1038/ncb1397

PubMed ID: 17651496

Title: Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres.

PubMed ID: 17651496

DOI: 10.1186/gb-2007-8-7-r148

PubMed ID: 18239465

Title: Aurora-C and Aurora-B share phosphorylation and regulation of CENP-A and Borealin during mitosis.

PubMed ID: 18239465

DOI: 10.4161/cc.7.6.5563

PubMed ID: 18072184

Title: Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells.

PubMed ID: 18072184

DOI: 10.1002/cbic.200700358

PubMed ID: 19412974

Title: Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-B.

PubMed ID: 19412974

DOI: 10.1002/jbio.200810014

PubMed ID: 19114591

Title: Three-dimensional localization of CENP-A suggests a complex higher order structure of centromeric chromatin.

PubMed ID: 19114591

DOI: 10.1083/jcb.200804078

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19410544

Title: Centromere-specific assembly of CENP-A nucleosomes is mediated by HJURP.

PubMed ID: 19410544

DOI: 10.1016/j.cell.2009.02.039

PubMed ID: 19410545

Title: HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres.

PubMed ID: 19410545

DOI: 10.1016/j.cell.2009.02.040

PubMed ID: 19533040

Title: Cancer-upregulated gene 2 (CUG2), a new component of centromere complex, is required for kinetochore function.

PubMed ID: 19533040

DOI: 10.1007/s10059-009-0083-2

PubMed ID: 19543270

Title: Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N.

PubMed ID: 19543270

DOI: 10.1038/ncb1899

PubMed ID: 19503796

Title: The C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation.

PubMed ID: 19503796

DOI: 10.1371/journal.pone.0005832

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23818633

Title: Posttranslational modification of CENP-A influences the conformation of centromeric chromatin.

PubMed ID: 23818633

DOI: 10.1073/pnas.1300325110

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24522885

Title: A CENP-S/X complex assembles at the centromere in S and G2 phases of the human cell cycle.

PubMed ID: 24522885

DOI: 10.1098/rsob.130229

PubMed ID: 25556658

Title: Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell-cycle-dependent deposition at centromeres.

PubMed ID: 25556658

DOI: 10.1016/j.devcel.2014.11.030

PubMed ID: 27499292

Title: The flexible ends of CENP-A nucleosome are required for mitotic fidelity.

PubMed ID: 27499292

DOI: 10.1016/j.molcel.2016.06.023

PubMed ID: 26878239

Title: CENP-C directs a structural transition of CENP-A nucleosomes mainly through sliding of DNA gyres.

PubMed ID: 26878239

DOI: 10.1038/nsmb.3175

PubMed ID: 20739937

Title: The structure of (CENP-A-H4)(2) reveals physical features that mark centromeres.

PubMed ID: 20739937

DOI: 10.1038/nature09323

PubMed ID: 21478274

Title: Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP.

PubMed ID: 21478274

DOI: 10.1101/gad.2045111

PubMed ID: 21743476

Title: Crystal structure of the human centromeric nucleosome containing CENP-A.

PubMed ID: 21743476

DOI: 10.1038/nature10258

PubMed ID: 25408271

Title: Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3.

PubMed ID: 25408271

DOI: 10.1038/srep07115

PubMed ID: 26543159

Title: Molecular basis for histone N-terminal methylation by NRMT1.

PubMed ID: 26543159

DOI: 10.1101/gad.270926.115

Sequence Information:

  • Length: 140
  • Mass: 15991
  • Checksum: 11A28FEB54486489
  • Sequence:
    • MGPRRRSRKP EAPRRRSPSP TPTPGPSRRG PSLGASSHQH SRRRQGWLKE IRKLQKSTHL 
LIRKLPFSRL AREICVKFTR GVDFNWQAQA LLALQEAAEA FLVHLFEDAY LLTLHAGRVT 
LFPKDVQLAR RIRGLEEGLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.