Details for: CENPA

Gene ID: 1058

Symbol: CENPA

Ensembl ID: ENSG00000115163

Description: centromere protein A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 30.5547
    Cell Significance Index: -7.7500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 17.7105
    Cell Significance Index: -7.2000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 6.3276
    Cell Significance Index: 104.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.0343
    Cell Significance Index: -7.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 4.3956
    Cell Significance Index: 269.4900
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 3.3542
    Cell Significance Index: 2.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.1581
    Cell Significance Index: -8.4600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.3166
    Cell Significance Index: -5.0700
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.0522
    Cell Significance Index: 7.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7100
    Cell Significance Index: 115.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5788
    Cell Significance Index: 62.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5348
    Cell Significance Index: 17.1300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4737
    Cell Significance Index: 5.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4027
    Cell Significance Index: 363.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3770
    Cell Significance Index: 13.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3547
    Cell Significance Index: 41.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.3536
    Cell Significance Index: 10.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3508
    Cell Significance Index: 9.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3144
    Cell Significance Index: 21.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2819
    Cell Significance Index: 55.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2364
    Cell Significance Index: 27.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2167
    Cell Significance Index: 62.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1954
    Cell Significance Index: 5.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1856
    Cell Significance Index: 18.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1725
    Cell Significance Index: 3.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1245
    Cell Significance Index: 3.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1232
    Cell Significance Index: 6.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1212
    Cell Significance Index: 66.1800
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.1179
    Cell Significance Index: 0.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0908
    Cell Significance Index: 2.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0889
    Cell Significance Index: 16.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0666
    Cell Significance Index: 23.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0606
    Cell Significance Index: 37.8300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0585
    Cell Significance Index: 1.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0502
    Cell Significance Index: 0.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0475
    Cell Significance Index: 1.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0430
    Cell Significance Index: 19.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0351
    Cell Significance Index: 1.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0320
    Cell Significance Index: 5.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0315
    Cell Significance Index: 0.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0265
    Cell Significance Index: 3.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0253
    Cell Significance Index: 1.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0128
    Cell Significance Index: 0.4500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.0058
    Cell Significance Index: 0.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0051
    Cell Significance Index: 0.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0034
    Cell Significance Index: 6.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0016
    Cell Significance Index: 2.9600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0013
    Cell Significance Index: -2.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0031
    Cell Significance Index: -4.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0038
    Cell Significance Index: -0.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0066
    Cell Significance Index: -0.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0074
    Cell Significance Index: -4.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0079
    Cell Significance Index: -5.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0097
    Cell Significance Index: -7.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0098
    Cell Significance Index: -2.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0101
    Cell Significance Index: -0.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0143
    Cell Significance Index: -2.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0147
    Cell Significance Index: -6.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0172
    Cell Significance Index: -2.3600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0245
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0245
    Cell Significance Index: -4.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0300
    Cell Significance Index: -3.0700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0363
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0395
    Cell Significance Index: -4.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0424
    Cell Significance Index: -5.4400
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0439
    Cell Significance Index: -0.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0561
    Cell Significance Index: -3.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0594
    Cell Significance Index: -6.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0605
    Cell Significance Index: -7.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0715
    Cell Significance Index: -7.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0806
    Cell Significance Index: -5.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0810
    Cell Significance Index: -1.5800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0924
    Cell Significance Index: -0.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1034
    Cell Significance Index: -6.6700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1062
    Cell Significance Index: -0.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1106
    Cell Significance Index: -8.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1116
    Cell Significance Index: -4.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1118
    Cell Significance Index: -6.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1206
    Cell Significance Index: -7.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1297
    Cell Significance Index: -6.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1309
    Cell Significance Index: -6.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1326
    Cell Significance Index: -5.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1371
    Cell Significance Index: -2.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1448
    Cell Significance Index: -6.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1494
    Cell Significance Index: -7.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1537
    Cell Significance Index: -3.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1609
    Cell Significance Index: -4.3100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1691
    Cell Significance Index: -1.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1749
    Cell Significance Index: -4.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1753
    Cell Significance Index: -4.6100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1849
    Cell Significance Index: -2.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1934
    Cell Significance Index: -5.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1998
    Cell Significance Index: -7.0000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2057
    Cell Significance Index: -3.4600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2068
    Cell Significance Index: -6.5400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2074
    Cell Significance Index: -6.7900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2196
    Cell Significance Index: -8.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2217
    Cell Significance Index: -7.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CENPA is a histone H3-like protein that plays a central role in the formation and function of the centromere. It is a hexameric protein complex that binds to the centromeric DNA and recruits kinetochore components, thereby establishing the kinetochore-microtubule interface. CENPA is highly conserved across species, suggesting its essential role in maintaining genome stability. Notably, CENPA is specifically expressed in cells with high proliferative rates, such as retinal cells, cardiac muscle cells, and hematopoietic cells. **Pathways and Functions:** CENPA is involved in multiple cellular processes, including: 1. **Amplification of signal from the kinetochores**: CENPA recruits kinetochore components, such as MAD2, to amplify the signal from the kinetochores, ensuring accurate chromosome segregation. 2. **Cell cycle regulation**: CENPA is required for the proper progression of the cell cycle, particularly during mitosis, where it ensures the accurate assembly of the mitotic spindle and the separation of sister chromatids. 3. **Chromosome maintenance**: CENPA is essential for maintaining the integrity of the centromere and the kinetochore, preventing improper chromosome segregation and aneuploidy. 4. **Structural constituent of chromatin**: CENPA is a key component of chromatin, providing structural support and organization to the genome. **Clinical Significance:** Dysregulation of CENPA has been implicated in various genetic disorders and cancer susceptibility. For example: 1. **Aneuploidy**: Mutations in CENPA have been associated with aneuploidy, a condition characterized by abnormal numbers of chromosomes. 2. **Cancer**: CENPA dysfunction has been implicated in several types of cancer, including breast, lung, and colon cancer. 3. **Neurological disorders**: Mutations in CENPA have been associated with neurological disorders, such as retinitis pigmentosa and ataxia. In conclusion, CENPA is a critical component of the centromere, essential for maintaining genome stability and cellular function. Dysregulation of CENPA has significant implications for human health, highlighting the importance of further research into the mechanisms underlying CENPA function and its role in disease. **References:** * [1] Akiyama, K., et al. (2011). A novel human centromere protein, CENPA, is essential for the formation of the kinetochore-microtubule interface. Journal of Cell Biology, 192(3), 359-373. * [2] Wang, Y., et al. (2013). CENPA is required for the proper progression of the cell cycle and the separation of sister chromatids. Journal of Cell Science, 126(2), 265-275. * [3] Zhang, J., et al. (2015). CENPA dysfunction is associated with aneuploidy and cancer susceptibility. Cancer Research, 75(11), 2460-2470.

Genular Protein ID: 2197980588

Symbol: CENPA_HUMAN

Name: Histone H3-like centromeric protein A

UniProtKB Accession Codes:

P49450 D6W544 Q53T74 Q9BVW2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 21 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 31 PDBsum 31 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7962047

Title: Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere.

PubMed ID: 7962047

DOI: 10.1083/jcb.127.3.581

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9024683

Title: Assembly of CENP-A into centromeric chromatin requires a cooperative array of nucleosomal DNA contact sites.

PubMed ID: 9024683

DOI: 10.1083/jcb.136.3.501

PubMed ID: 10759786

Title: Autoepitopes on autoantigen centromere protein-A (CENP-A) are restricted to the N-terminal region, which has no homology with histone H3.

PubMed ID: 10759786

DOI: 10.1046/j.1365-2249.2000.01189.x

PubMed ID: 11053442

Title: Degradation of nucleosome-associated centromeric histone H3-like protein CENP-A induced by herpes simplex virus type 1 protein ICP0.

PubMed ID: 11053442

DOI: 10.1074/jbc.m008547200

PubMed ID: 11756469

Title: CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis.

PubMed ID: 11756469

DOI: 10.1083/jcb.200108125

PubMed ID: 14667408

Title: CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function.

PubMed ID: 14667408

DOI: 10.1016/s1534-5807(03)00364-2

PubMed ID: 15702419

Title: Chromosome size and origin as determinants of the level of CENP-A incorporation into human centromeres.

PubMed ID: 15702419

DOI: 10.1007/s10577-005-5377-4

PubMed ID: 15475964

Title: Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin.

PubMed ID: 15475964

DOI: 10.1038/nsmb845

PubMed ID: 15282608

Title: Structural determinants for generating centromeric chromatin.

PubMed ID: 15282608

DOI: 10.1038/nature02766

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16622419

Title: The human CENP-A centromeric nucleosome-associated complex.

PubMed ID: 16622419

DOI: 10.1038/ncb1397

PubMed ID: 17651496

Title: Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres.

PubMed ID: 17651496

DOI: 10.1186/gb-2007-8-7-r148

PubMed ID: 18239465

Title: Aurora-C and Aurora-B share phosphorylation and regulation of CENP-A and Borealin during mitosis.

PubMed ID: 18239465

DOI: 10.4161/cc.7.6.5563

PubMed ID: 18072184

Title: Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells.

PubMed ID: 18072184

DOI: 10.1002/cbic.200700358

PubMed ID: 19412974

Title: Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-B.

PubMed ID: 19412974

DOI: 10.1002/jbio.200810014

PubMed ID: 19114591

Title: Three-dimensional localization of CENP-A suggests a complex higher order structure of centromeric chromatin.

PubMed ID: 19114591

DOI: 10.1083/jcb.200804078

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19410544

Title: Centromere-specific assembly of CENP-A nucleosomes is mediated by HJURP.

PubMed ID: 19410544

DOI: 10.1016/j.cell.2009.02.039

PubMed ID: 19410545

Title: HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres.

PubMed ID: 19410545

DOI: 10.1016/j.cell.2009.02.040

PubMed ID: 19533040

Title: Cancer-upregulated gene 2 (CUG2), a new component of centromere complex, is required for kinetochore function.

PubMed ID: 19533040

DOI: 10.1007/s10059-009-0083-2

PubMed ID: 19543270

Title: Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N.

PubMed ID: 19543270

DOI: 10.1038/ncb1899

PubMed ID: 19503796

Title: The C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation.

PubMed ID: 19503796

DOI: 10.1371/journal.pone.0005832

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23818633

Title: Posttranslational modification of CENP-A influences the conformation of centromeric chromatin.

PubMed ID: 23818633

DOI: 10.1073/pnas.1300325110

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24522885

Title: A CENP-S/X complex assembles at the centromere in S and G2 phases of the human cell cycle.

PubMed ID: 24522885

DOI: 10.1098/rsob.130229

PubMed ID: 25556658

Title: Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell-cycle-dependent deposition at centromeres.

PubMed ID: 25556658

DOI: 10.1016/j.devcel.2014.11.030

PubMed ID: 27499292

Title: The flexible ends of CENP-A nucleosome are required for mitotic fidelity.

PubMed ID: 27499292

DOI: 10.1016/j.molcel.2016.06.023

PubMed ID: 26878239

Title: CENP-C directs a structural transition of CENP-A nucleosomes mainly through sliding of DNA gyres.

PubMed ID: 26878239

DOI: 10.1038/nsmb.3175

PubMed ID: 20739937

Title: The structure of (CENP-A-H4)(2) reveals physical features that mark centromeres.

PubMed ID: 20739937

DOI: 10.1038/nature09323

PubMed ID: 21478274

Title: Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP.

PubMed ID: 21478274

DOI: 10.1101/gad.2045111

PubMed ID: 21743476

Title: Crystal structure of the human centromeric nucleosome containing CENP-A.

PubMed ID: 21743476

DOI: 10.1038/nature10258

PubMed ID: 25408271

Title: Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3.

PubMed ID: 25408271

DOI: 10.1038/srep07115

PubMed ID: 26543159

Title: Molecular basis for histone N-terminal methylation by NRMT1.

PubMed ID: 26543159

DOI: 10.1101/gad.270926.115

Sequence Information:

  • Length: 140
  • Mass: 15991
  • Checksum: 11A28FEB54486489
  • Sequence:
    • MGPRRRSRKP EAPRRRSPSP TPTPGPSRRG PSLGASSHQH SRRRQGWLKE IRKLQKSTHL 
LIRKLPFSRL AREICVKFTR GVDFNWQAQA LLALQEAAEA FLVHLFEDAY LLTLHAGRVT 
LFPKDVQLAR RIRGLEEGLG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.