Details for: CENPB

Gene ID: 1059

Symbol: CENPB

Ensembl ID: ENSG00000125817

Description: centromere protein B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 112.8289
    Cell Significance Index: -17.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 68.7580
    Cell Significance Index: -17.4400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.1636
    Cell Significance Index: -18.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 38.6455
    Cell Significance Index: -15.7000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 34.2350
    Cell Significance Index: -17.6100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.6721
    Cell Significance Index: -18.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.5345
    Cell Significance Index: -17.5100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 5.8810
    Cell Significance Index: 96.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6604
    Cell Significance Index: -18.3900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.3041
    Cell Significance Index: -13.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.0733
    Cell Significance Index: 337.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4905
    Cell Significance Index: 89.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7987
    Cell Significance Index: 41.4900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7157
    Cell Significance Index: 49.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6199
    Cell Significance Index: 16.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5802
    Cell Significance Index: 71.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5331
    Cell Significance Index: 96.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5303
    Cell Significance Index: 72.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5170
    Cell Significance Index: 14.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4956
    Cell Significance Index: 219.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4441
    Cell Significance Index: 20.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4037
    Cell Significance Index: 28.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3631
    Cell Significance Index: 16.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3584
    Cell Significance Index: 195.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3331
    Cell Significance Index: 66.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2477
    Cell Significance Index: 11.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1960
    Cell Significance Index: 1.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1927
    Cell Significance Index: 12.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1880
    Cell Significance Index: 4.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1811
    Cell Significance Index: 4.1900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.1634
    Cell Significance Index: 1.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1587
    Cell Significance Index: 4.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1408
    Cell Significance Index: 26.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1195
    Cell Significance Index: 13.6900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1065
    Cell Significance Index: 1.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0864
    Cell Significance Index: 17.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0836
    Cell Significance Index: 1.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0803
    Cell Significance Index: 2.8200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0803
    Cell Significance Index: 1.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0750
    Cell Significance Index: 9.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0646
    Cell Significance Index: 4.0700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0531
    Cell Significance Index: 5.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0507
    Cell Significance Index: 18.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0266
    Cell Significance Index: 0.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0121
    Cell Significance Index: 2.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0097
    Cell Significance Index: 7.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0005
    Cell Significance Index: -0.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0045
    Cell Significance Index: -8.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0087
    Cell Significance Index: -2.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0107
    Cell Significance Index: -1.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0120
    Cell Significance Index: -0.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0131
    Cell Significance Index: -24.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0157
    Cell Significance Index: -24.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0174
    Cell Significance Index: -23.6900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0196
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0205
    Cell Significance Index: -15.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0207
    Cell Significance Index: -13.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0212
    Cell Significance Index: -2.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0251
    Cell Significance Index: -14.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0309
    Cell Significance Index: -19.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0353
    Cell Significance Index: -16.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0364
    Cell Significance Index: -0.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0483
    Cell Significance Index: -1.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0501
    Cell Significance Index: -5.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0552
    Cell Significance Index: -6.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0843
    Cell Significance Index: -1.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0947
    Cell Significance Index: -19.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1063
    Cell Significance Index: -15.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1095
    Cell Significance Index: -6.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1135
    Cell Significance Index: -2.4600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1299
    Cell Significance Index: -2.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1365
    Cell Significance Index: -7.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1524
    Cell Significance Index: -12.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1673
    Cell Significance Index: -4.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1696
    Cell Significance Index: -4.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1739
    Cell Significance Index: -18.1100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1806
    Cell Significance Index: -1.8700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1997
    Cell Significance Index: -6.4000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2094
    Cell Significance Index: -1.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2139
    Cell Significance Index: -14.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2187
    Cell Significance Index: -16.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2487
    Cell Significance Index: -15.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2502
    Cell Significance Index: -14.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2557
    Cell Significance Index: -4.2800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2830
    Cell Significance Index: -4.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2893
    Cell Significance Index: -6.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3118
    Cell Significance Index: -16.3700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.3226
    Cell Significance Index: -2.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3370
    Cell Significance Index: -11.7100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3470
    Cell Significance Index: -10.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3757
    Cell Significance Index: -16.6200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3921
    Cell Significance Index: -5.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4081
    Cell Significance Index: -14.9800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4094
    Cell Significance Index: -20.6900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4119
    Cell Significance Index: -16.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4528
    Cell Significance Index: -11.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4537
    Cell Significance Index: -17.1800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4572
    Cell Significance Index: -3.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4595
    Cell Significance Index: -11.7400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4607
    Cell Significance Index: -13.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CENPB is a highly conserved protein, with a high degree of sequence similarity across species. It is primarily localized to the centromere region of chromosomes and is involved in the formation of the centromeric chromatin structure. CENPB has been shown to interact with other centromere proteins, such as CENPF and CENPE, to regulate the assembly of the kinetochore complex. Its expression is highly restricted to specific cell types, including pancreatic A cells, acinar cells of the salivary gland, and GABAergic interneurons in the cerebral cortex. **Pathways and Functions:** CENPB is involved in several key pathways that regulate genome stability and centromeric function. These include: 1. **Centromeric DNA binding:** CENPB binds to specific DNA sequences within the centromere region, regulating the assembly of the centromeric chromatin structure. 2. **Chromatin binding:** CENPB interacts with other chromatin-associated proteins to regulate chromatin structure and function. 3. **Chromosome segregation:** CENPB plays a critical role in ensuring proper chromosome segregation during mitosis and meiosis. 4. **Nuclear body formation:** CENPB is involved in the formation of nuclear bodies, which are structures that regulate gene expression and genome stability. **Clinical Significance:** CENPB has been implicated in several autoimmune disorders, including: 1. **Autoimmune myositis:** CENPB has been identified as a major autoantigen in patients with autoimmune myositis. 2. **Autoimmune pancreatitis:** CENPB has been shown to be overexpressed in patients with autoimmune pancreatitis. 3. **Autoimmune thyroid disease:** CENPB has been implicated in the pathogenesis of autoimmune thyroid disease. In conclusion, CENPB is a critical protein involved in maintaining genome stability and centromeric function. Its dysregulation has been implicated in several autoimmune disorders, highlighting the importance of CENPB in the development of autoimmune diseases. Further research is needed to fully elucidate the role of CENPB in immune regulation and to develop novel therapeutic strategies for autoimmune disorders. **References:** [Insert relevant references] **Author's Note:** This review is intended to provide a comprehensive overview of the current understanding of CENPB's characteristics, pathways, and functions, as well as its clinical significance in autoimmune disorders. However, further research is needed to fully elucidate the role of CENPB in immune regulation and to develop novel therapeutic strategies for autoimmune disorders.

Genular Protein ID: 3451939280

Symbol: CENPB_HUMAN

Name: Major centromere autoantigen B

UniProtKB Accession Codes:

P07199 Q96EI4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1893793

Title: CENP-B is a highly conserved mammalian centromere protein with homology to the helix-loop-helix family of proteins.

PubMed ID: 1893793

DOI: 10.1007/bf00337514

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2435739

Title: Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen.

PubMed ID: 2435739

DOI: 10.1083/jcb.104.4.817

PubMed ID: 1469042

Title: A human centromere protein, CENP-B, has a DNA binding domain containing four potential alpha helices at the NH2 terminus, which is separable from dimerizing activity.

PubMed ID: 1469042

DOI: 10.1083/jcb.119.6.1413

PubMed ID: 18072184

Title: Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells.

PubMed ID: 18072184

DOI: 10.1002/cbic.200700358

PubMed ID: 19412974

Title: Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-B.

PubMed ID: 19412974

DOI: 10.1002/jbio.200810014

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23978223

Title: Identification of novel alpha-n-methylation of CENP-B that regulates its binding to the centromeric DNA.

PubMed ID: 23978223

DOI: 10.1021/pr400498y

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24522885

Title: A CENP-S/X complex assembles at the centromere in S and G2 phases of the human cell cycle.

PubMed ID: 24522885

DOI: 10.1098/rsob.130229

PubMed ID: 27499292

Title: The flexible ends of CENP-A nucleosome are required for mitotic fidelity.

PubMed ID: 27499292

DOI: 10.1016/j.molcel.2016.06.023

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 9451007

Title: A helix-turn-helix structure unit in human centromere protein B (CENP-B).

PubMed ID: 9451007

DOI: 10.1093/emboj/17.3.827

PubMed ID: 11726497

Title: Crystal structure of the CENP-B protein-DNA complex: the DNA-binding domains of CENP-B induce kinks in the CENP-B box DNA.

PubMed ID: 11726497

DOI: 10.1093/emboj/20.23.6612

PubMed ID: 14522975

Title: Crystal structure of the human centromere protein B (CENP-B) dimerization domain at 1.65-A resolution.

PubMed ID: 14522975

DOI: 10.1074/jbc.m310388200

Sequence Information:

  • Length: 599
  • Mass: 65171
  • Checksum: 9B4B7DB957A914AA
  • Sequence:
    • MGPKRRQLTF REKSRIIQEV EENPDLRKGE IARRFNIPPS TLSTILKNKR AILASERKYG 
VASTCRKTNK LSPYDKLEGL LIAWFQQIRA AGLPVKGIIL KEKALRIAEE LGMDDFTASN 
GWLDRFRRRH GVVSCSGVAR ARARNAAPRT PAAPASPAAV PSEGSGGSTT GWRAREEQPP 
SVAEGYASQD VFSATETSLW YDFLPDQAAG LCGGDGRPRQ ATQRLSVLLC ANADGSEKLP 
PLVAGKSAKP RAGQAGLPCD YTANSKGGVT TQALAKYLKA LDTRMAAESR RVLLLAGRLA 
AQSLDTSGLR HVQLAFFPPG TVHPLERGVV QQVKGHYRQA MLLKAMAALE GQDPSGLQLG 
LTEALHFVAA AWQAVEPSDI AACFREAGFG GGPNATITTS LKSEGEEEEE EEEEEEEEEG 
EGEEEEEEGE EEEEEGGEGE ELGEEEEVEE EGDVDSDEEE EEDEESSSEG LEAEDWAQGV 
VEAGGSFGAY GAQEEAQCPT LHFLEGGEDS DSDSEEEDDE EEDDEDEDDD DDEEDGDEVP 
VPSFGEAMAY FAMVKRYLTS FPIDDRVQSH ILHLEHDLVH VTRKNHARQA GVRGLGHQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.