Details for: CENPB

Gene ID: 1059

Symbol: CENPB

Ensembl ID: ENSG00000125817

Description: centromere protein B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.66
    Marker Score: 1630
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.18
    Marker Score: 2485.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.02
    Marker Score: 2331
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71736
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47960
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.99
    Marker Score: 1452
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30398
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.96
    Marker Score: 998
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2398
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2705
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.9
    Marker Score: 465
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.89
    Marker Score: 939
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.88
    Marker Score: 382
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5247
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.86
    Marker Score: 194
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4853
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.82
    Marker Score: 5260.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.81
    Marker Score: 1318
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.79
    Marker Score: 557
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.79
    Marker Score: 1597
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.76
    Marker Score: 11916
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 304
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 576
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.75
    Marker Score: 451
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.74
    Marker Score: 1318
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.73
    Marker Score: 183
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.73
    Marker Score: 1944.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.72
    Marker Score: 491
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.72
    Marker Score: 482
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.71
    Marker Score: 614
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.71
    Marker Score: 763
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.71
    Marker Score: 446.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.7
    Marker Score: 1768
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.68
    Marker Score: 3364.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.68
    Marker Score: 4400.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2831
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.67
    Marker Score: 194
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 609
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.66
    Marker Score: 1616
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.65
    Marker Score: 22647
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.65
    Marker Score: 7270
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.64
    Marker Score: 229
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.64
    Marker Score: 313.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.63
    Marker Score: 2351
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.61
    Marker Score: 491
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.61
    Marker Score: 866
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.61
    Marker Score: 284
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.61
    Marker Score: 2914
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.6
    Marker Score: 987
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.59
    Marker Score: 4407
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.59
    Marker Score: 142
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.59
    Marker Score: 624
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.59
    Marker Score: 2443.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.59
    Marker Score: 218
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.58
    Marker Score: 299
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.57
    Marker Score: 375
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.57
    Marker Score: 1283
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.57
    Marker Score: 519
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.56
    Marker Score: 322
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.56
    Marker Score: 1110
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.54
    Marker Score: 484
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.54
    Marker Score: 312
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 427
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.53
    Marker Score: 18149
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.53
    Marker Score: 499
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.53
    Marker Score: 509
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.52
    Marker Score: 365
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.52
    Marker Score: 833
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.51
    Marker Score: 131
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.51
    Marker Score: 283
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.51
    Marker Score: 215
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.51
    Marker Score: 821
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.51
    Marker Score: 293
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.51
    Marker Score: 718
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.51
    Marker Score: 117
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.51
    Marker Score: 28388
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.51
    Marker Score: 504
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.5
    Marker Score: 2633
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.5
    Marker Score: 241
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.5
    Marker Score: 584
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.5
    Marker Score: 532
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.5
    Marker Score: 3027
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.5
    Marker Score: 111
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.5
    Marker Score: 237
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.5
    Marker Score: 843
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.5
    Marker Score: 247
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.49
    Marker Score: 126
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.49
    Marker Score: 635
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.49
    Marker Score: 493
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.49
    Marker Score: 495
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.49
    Marker Score: 4238
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.49
    Marker Score: 312
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.49
    Marker Score: 168
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.48
    Marker Score: 363

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Other Information

**Key characteristics:** * CENPB is a large protein with a molecular weight of approximately 200 kDa. * It is a member of the CENP family of centromeric proteins. * CENPB is responsible for the binding of DNA to centromeric regions, which is essential for proper chromosome segregation. * It is also involved in the regulation of gene expression and cell cycle progression. **Pathways and functions:** * CENPB is involved in the formation of the condensed chromosome, which is a structure that is responsible for packaging and organizing the genetic material of the cell. * It is also involved in the regulation of gene expression by binding to DNA and facilitating the binding of transcription factors. * CENPB is a key regulator of cell cycle progression, as it is involved in the control of cell division. * It is also involved in the regulation of chromosome stability and integrity. **Clinical significance:** * Mutations in the CENPB gene have been linked to a number of human cancers, including breast cancer, ovarian cancer, and leukemia. * Inhibitors of CENPB have been shown to be effective in promoting cell cycle arrest and apoptosis in cancer cells. * Therefore, CENPB is a promising target for cancer therapy. **Additional notes:** * CENPB is a highly conserved protein, with a similar protein being found in yeast. * It is expressed in all eukaryotic cells, but its expression is particularly high in cells that are dividing, such as cells in the nucleus, sperm, and eggs. * CENPB is a multi-functional protein that plays a critical role in the proper functioning of eukaryotic cells.

Genular Protein ID: 3451939280

Symbol: CENPB_HUMAN

Name: Major centromere autoantigen B

UniProtKB Accession Codes:

P07199 Q96EI4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1893793

Title: CENP-B is a highly conserved mammalian centromere protein with homology to the helix-loop-helix family of proteins.

PubMed ID: 1893793

DOI: 10.1007/bf00337514

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2435739

Title: Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen.

PubMed ID: 2435739

DOI: 10.1083/jcb.104.4.817

PubMed ID: 1469042

Title: A human centromere protein, CENP-B, has a DNA binding domain containing four potential alpha helices at the NH2 terminus, which is separable from dimerizing activity.

PubMed ID: 1469042

DOI: 10.1083/jcb.119.6.1413

PubMed ID: 18072184

Title: Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells.

PubMed ID: 18072184

DOI: 10.1002/cbic.200700358

PubMed ID: 19412974

Title: Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-B.

PubMed ID: 19412974

DOI: 10.1002/jbio.200810014

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23978223

Title: Identification of novel alpha-n-methylation of CENP-B that regulates its binding to the centromeric DNA.

PubMed ID: 23978223

DOI: 10.1021/pr400498y

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24522885

Title: A CENP-S/X complex assembles at the centromere in S and G2 phases of the human cell cycle.

PubMed ID: 24522885

DOI: 10.1098/rsob.130229

PubMed ID: 27499292

Title: The flexible ends of CENP-A nucleosome are required for mitotic fidelity.

PubMed ID: 27499292

DOI: 10.1016/j.molcel.2016.06.023

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 9451007

Title: A helix-turn-helix structure unit in human centromere protein B (CENP-B).

PubMed ID: 9451007

DOI: 10.1093/emboj/17.3.827

PubMed ID: 11726497

Title: Crystal structure of the CENP-B protein-DNA complex: the DNA-binding domains of CENP-B induce kinks in the CENP-B box DNA.

PubMed ID: 11726497

DOI: 10.1093/emboj/20.23.6612

PubMed ID: 14522975

Title: Crystal structure of the human centromere protein B (CENP-B) dimerization domain at 1.65-A resolution.

PubMed ID: 14522975

DOI: 10.1074/jbc.m310388200

Sequence Information:

  • Length: 599
  • Mass: 65171
  • Checksum: 9B4B7DB957A914AA
  • Sequence:
    • MGPKRRQLTF REKSRIIQEV EENPDLRKGE IARRFNIPPS TLSTILKNKR AILASERKYG 
VASTCRKTNK LSPYDKLEGL LIAWFQQIRA AGLPVKGIIL KEKALRIAEE LGMDDFTASN 
GWLDRFRRRH GVVSCSGVAR ARARNAAPRT PAAPASPAAV PSEGSGGSTT GWRAREEQPP 
SVAEGYASQD VFSATETSLW YDFLPDQAAG LCGGDGRPRQ ATQRLSVLLC ANADGSEKLP 
PLVAGKSAKP RAGQAGLPCD YTANSKGGVT TQALAKYLKA LDTRMAAESR RVLLLAGRLA 
AQSLDTSGLR HVQLAFFPPG TVHPLERGVV QQVKGHYRQA MLLKAMAALE GQDPSGLQLG 
LTEALHFVAA AWQAVEPSDI AACFREAGFG GGPNATITTS LKSEGEEEEE EEEEEEEEEG 
EGEEEEEEGE EEEEEGGEGE ELGEEEEVEE EGDVDSDEEE EEDEESSSEG LEAEDWAQGV 
VEAGGSFGAY GAQEEAQCPT LHFLEGGEDS DSDSEEEDDE EEDDEDEDDD DDEEDGDEVP 
VPSFGEAMAY FAMVKRYLTS FPIDDRVQSH ILHLEHDLVH VTRKNHARQA GVRGLGHQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.