Details for: TRAPPC2B

Gene ID: 10597

Symbol: TRAPPC2B

Ensembl ID: ENSG00000256060

Description: trafficking protein particle complex subunit 2B

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 7.4
    Marker Score: 10,630
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.87
    Marker Score: 547
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.68
    Marker Score: 1,127
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.58
    Marker Score: 2,758
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.16
    Marker Score: 1,036
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.14
    Marker Score: 4,213
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,687
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,909
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,396
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,390
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.93
    Marker Score: 4,576
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.93
    Marker Score: 3,656
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 473
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.91
    Marker Score: 915
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,696
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.89
    Marker Score: 754
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,030
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,273
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.86
    Marker Score: 1,269
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.86
    Marker Score: 2,104
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.81
    Marker Score: 541
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.81
    Marker Score: 848
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8
    Marker Score: 12,595
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.8
    Marker Score: 6,932
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.8
    Marker Score: 399
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 316
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.79
    Marker Score: 1,280
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.78
    Marker Score: 784
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.78
    Marker Score: 1,387
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.78
    Marker Score: 1,292
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.78
    Marker Score: 518
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.78
    Marker Score: 182
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.77
    Marker Score: 2,975
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.76
    Marker Score: 808
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.75
    Marker Score: 1,420
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.75
    Marker Score: 1,581
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.74
    Marker Score: 409
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.73
    Marker Score: 227
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.73
    Marker Score: 347
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.73
    Marker Score: 782
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 553
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.72
    Marker Score: 256
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.72
    Marker Score: 216
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.72
    Marker Score: 24,802
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.71
    Marker Score: 1,427
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.71
    Marker Score: 522
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.71
    Marker Score: 1,240
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.71
    Marker Score: 1,024
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7
    Marker Score: 450
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.7
    Marker Score: 202
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.7
    Marker Score: 219
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.69
    Marker Score: 341
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.69
    Marker Score: 1,744
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.68
    Marker Score: 711
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.68
    Marker Score: 1,424
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 620
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.68
    Marker Score: 532
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.67
    Marker Score: 458
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.67
    Marker Score: 841
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.66
    Marker Score: 289
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.66
    Marker Score: 956
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.66
    Marker Score: 366
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.66
    Marker Score: 1,087
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.66
    Marker Score: 664
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.66
    Marker Score: 714
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.66
    Marker Score: 162
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.66
    Marker Score: 1,550
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.66
    Marker Score: 295
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.66
    Marker Score: 587
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.65
    Marker Score: 615
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.65
    Marker Score: 536
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.65
    Marker Score: 727
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.65
    Marker Score: 241
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.65
    Marker Score: 2,712
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.65
    Marker Score: 297
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.65
    Marker Score: 1,758
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.64
    Marker Score: 367
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.64
    Marker Score: 129
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.64
    Marker Score: 685
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.63
    Marker Score: 290
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.63
    Marker Score: 151
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.63
    Marker Score: 527
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.63
    Marker Score: 286
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.63
    Marker Score: 357
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.63
    Marker Score: 160
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.63
    Marker Score: 199
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.63
    Marker Score: 253
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.63
    Marker Score: 424
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.63
    Marker Score: 243
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 413
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.62
    Marker Score: 164
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.62
    Marker Score: 610
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.62
    Marker Score: 156
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.62
    Marker Score: 141
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.62
    Marker Score: 331

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAPPC2B is a member of the TRAPP complex, a conserved protein complex involved in various cellular processes, including vesicle formation, transport, and fission. The TRAPP complex is composed of multiple subunits, each with distinct functions, and TRAPPC2B is one of the core subunits. Its expression is widespread, with significantly expressed cells found in the respiratory, nervous, and immune systems. TRAPPC2B is also involved in the regulation of gene expression, acting as a transcription corepressor and inhibitor of transcription regulators. **Pathways and Functions:** TRAPPC2B is involved in several cellular pathways, including: 1. **Vesicle Coating and Transport:** TRAPPC2B is essential for the formation and functioning of vesicles, facilitating the transport of proteins and lipids between the ER, Golgi apparatus, and other cellular compartments. 2. **Endoplasmic Reticulum-Golgi Intermediate Compartment (ER-GIC) Transport:** TRAPPC2B plays a critical role in the transport of proteins and lipids between the ER and Golgi apparatus via the ER-GIC. 3. **Intracellular Membrane-Bounded Organelle Transport:** TRAPPC2B is involved in the transport of proteins and lipids between various intracellular membrane-bounded organelles, including the ER, Golgi apparatus, and lysosomes. 4. **Gene Regulation:** TRAPPC2B acts as a transcription corepressor and inhibitor of transcription regulators, regulating gene expression and cellular differentiation. **Clinical Significance:** Dysregulation of TRAPPC2B has been implicated in various diseases, including: 1. **Respiratory Disorders:** Alterations in TRAPPC2B expression have been linked to respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. 2. **Neurological Disorders:** TRAPPC2B has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 3. **Cancer:** Dysregulation of TRAPPC2B has been observed in various types of cancer, including lung, breast, and colon cancer. 4. **Immunological Disorders:** TRAPPC2B has been implicated in the pathogenesis of immunological disorders, including autoimmune diseases and immunodeficiency disorders. In conclusion, TRAPPC2B is a critical component of the TRAPP complex, playing a pivotal role in various cellular processes, including vesicle coating, transport, and gene regulation. Its significant clinical implications suggest that dysregulation of TRAPPC2B may contribute to the development of various diseases, highlighting the need for further research into the molecular mechanisms underlying its function and its role in disease pathogenesis.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.