TRAPPC2B | ENSG00000256060 | NCBI 10597

Details for: TRAPPC2B

Associated with

Copii vesicle coating
(GO:0048208)
Cytoplasm
(GO:0005737)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum-golgi intermediate compartment
(GO:0005793)
Endoplasmic reticulum to golgi vesicle-mediated transport
(GO:0006888)
Intracellular membrane-bounded organelle
(GO:0043231)
Nuclear outer membrane
(GO:0005640)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of gene expression
(GO:0010628)
Protein binding
(GO:0005515)
Transcription corepressor binding
(GO:0001222)
Transcription regulator inhibitor activity
(GO:0140416)
Trapp complex
(GO:0030008)
Trappiii protein complex
(GO:1990072)
Trappii protein complex
(GO:1990071)
Vesicle coating
(GO:0006901)
Vesicle tethering
(GO:0099022)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

common dendritic progenitor CL0001029

CSI 6.24

rCSI 7.83%

PRS 97.1
placental villous trophoblast CL2000060

CSI 4.23

rCSI 6.54%

PRS 92.91
type B pancreatic cell CL0000169

CSI 4.03

rCSI 8.92%

PRS 94.31
vascular associated smooth muscle cell CL0000359

CSI 3.81

rCSI 12.36%

PRS 93.34
erythrocyte CL0000232

CSI 3.67

rCSI 8.33%

PRS 92.45
plasmablast CL0000980

CSI 3.66

rCSI 2.88%

PRS 95.4
epithelial cell of lung CL0000082

CSI 3.6

rCSI 2.98%

PRS 95.36
rod bipolar cell CL0000751

CSI 3.28

rCSI 5.89%

PRS 90.71
group 3 innate lymphoid cell CL0001071

CSI 3.21

rCSI 2.41%

PRS 96.2
pro-B cell CL0000826

CSI 3.14

rCSI 2.6%

PRS 95.07
pulmonary capillary endothelial cell CL4028001

CSI 3.06

rCSI 5.83%

PRS 97.32
perivascular cell CL4033054

CSI 2.89

rCSI 3.95%

PRS 96.54
CD4-positive helper T cell CL0000492

CSI 2.84

rCSI 2.15%

PRS 98.79
activated CD4-positive, alpha-beta T cell CL0000896

CSI 2.65

rCSI 2.45%

PRS 98.66
double-positive, alpha-beta thymocyte CL0000809

CSI 2.6

rCSI 2.65%

PRS 97.38
keratinocyte CL0000312

CSI 2.59

rCSI 2.17%

PRS 94.06
ciliated epithelial cell CL0000067

CSI 2.41

rCSI 2.12%

PRS 87.73
cerebral cortex GABAergic interneuron CL0010011

CSI 2.4

rCSI 7.09%

PRS 94.05
retina horizontal cell CL0000745

CSI 2.17

rCSI 3.31%

PRS 92.05
enteric smooth muscle cell CL0002504

CSI 2.17

rCSI 3.09%

PRS 94.41
intestinal epithelial cell CL0002563

CSI 2.16

rCSI 2.26%

PRS 92.61
stem cell CL0000034

CSI 2.03

rCSI 1.96%

PRS 91.91
granulocyte CL0000094

CSI 2.02

rCSI 3.09%

PRS 96.92
lung ciliated cell CL1000271

CSI 1.99

rCSI 2.3%

PRS 90.36
peripheral nervous system neuron CL2000032

CSI 1.91

rCSI 2.6%

PRS 89.64
mesenchymal cell CL0008019

CSI 1.87

rCSI 4.76%

PRS 91.2
club cell CL0000158

CSI 1.76

rCSI 2.58%

PRS 91.47
basal cell CL0000646

CSI 1.72

rCSI 2.3%

PRS 92.21
intermediate monocyte CL0002393

CSI 1.67

rCSI 2.53%

PRS 97.13
effector CD4-positive, alpha-beta T cell CL0001044

CSI 1.65

rCSI 4.74%

PRS 99.14
progenitor cell CL0011026

CSI 1.37

rCSI 2.92%

PRS 88.92
forebrain radial glial cell CL0013000

CSI 1

rCSI 3.2%

PRS 93.83
microcirculation associated smooth muscle cell CL0008035

CSI 0.92

rCSI 2.68%

PRS 93.95

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description

## Summary [TRAPPC2B](/details-gene/10597) is a protein-coding gene that encodes a subunit of the trafficking protein particle (TRAPP) complex. This complex is fundamental to intracellular vesicle transport, specifically in the pathway between the endoplasmic reticulum and the Golgi apparatus. Functional annotations indicate [TRAPPC2B](/details-gene/10597) is involved in [COPII vesicle coating](/details-cell/GO:0048208) and may also possess functions related to transcriptional regulation. **Overall**, its expression profile reveals high significance in a diverse array of cell types, including hematopoietic progenitors like the [common dendritic progenitor](/details-cell/CL0001029), highly secretory cells such as the [type B pancreatic cell](/details-cell/CL0000169), and structural cells like the [placental villous trophoblast](/details-cell/CL2000060), highlighting its essential role in cellular maintenance and specialized secretory functions across multiple lineages. ## Cellular Roles and Expression Landscape The expression pattern of [TRAPPC2B](/details-gene/10597) suggests it plays a foundational role in a wide variety of biological systems, rather than being restricted to a single cell lineage. Its significance is particularly pronounced in cells characterized by high rates of protein synthesis, processing, and secretion. - **Function in Secretory Cells:** The gene shows high significance in professional secretory cells, including [type B pancreatic cell](/details-cell/CL0000169) (CSI: 4.03) and [plasmablast](/details-cell/CL0000980) (CSI: 3.66). This is consistent with its established role in the ER-to-Golgi transport pathway, which is essential for the production and secretion of proteins like insulin and antibodies, respectively. Its high CSI in [placental villous trophoblast](/details-cell/CL2000060) (CSI: 4.23) and [epithelial cell of lung](/details-cell/CL0000082) (CSI: 3.60) further supports its importance in tissues with substantial secretory and barrier functions. - **Role in Hematopoiesis and Immunity:** [TRAPPC2B](/details-gene/10597) is the top marker in the [common dendritic progenitor](/details-cell/CL0001029) (CSI: 6.24), indicating a potentially critical role in the development of dendritic cells. Its notable expression in other immune progenitors, such as the [pro-B cell](/details-cell/CL0000826) (CSI: 3.14), and in mature lymphocytes like the [CD4-positive helper T cell](/details-cell/CL0000492) (CSI: 2.84) and [group 3 innate lymphoid cell](/details-cell/CL0001071) (CSI: 3.21), suggests a sustained requirement for efficient protein trafficking throughout immune cell development and effector function, which involves rapid synthesis of receptors and secretion of cytokines. - **Involvement in Vascular and Structural Tissues:** The gene is also significant in [vascular associated smooth muscle cell](/details-cell/CL0000359) (CSI: 3.81) and [pulmonary capillary endothelial cell](/details-cell/CL4028001) (CSI: 3.06). This pattern suggests that the protein trafficking machinery involving [TRAPPC2B](/details-gene/10597) is also vital for the maintenance and function of the circulatory system. ## Pathways and Molecular Function The functions of [TRAPPC2B](/details-gene/10597) are centered on its role as a component of the TRAPP protein complexes, including the [TRAPPII protein complex](/details-cell/GO:1990071) and [TRAPPIII protein complex](/details-cell/GO:1990072). These complexes act as vesicle tethers, ensuring the fidelity of [Endoplasmic reticulum to golgi vesicle-mediated transport](/details-cell/GO:0006888). This biological process is essential for the proper folding, modification, and transport of nascent proteins, a function that directly explains its high expression in secretory cells. Interestingly, functional annotations also point to a potential secondary role in the nucleus. Its localization to the [Nucleus](/details-cell/GO:0005634) and [Nucleoplasm](/details-cell/GO:0005654), combined with molecular function annotations such as [Transcription corepressor binding](/details-cell/GO:0001222) and involvement in the [Positive regulation of gene expression](/details-cell/GO:0010628), suggests that [TRAPPC2B](/details-gene/10597) may have a dual function. It may operate not only in the cytoplasm to regulate protein transport but also within the nucleus to modulate gene expression, although this role is less characterized. ## Research Directions The widespread expression and dual-function potential of [TRAPPC2B](/details-gene/10597) present several avenues for future investigation. Its fundamental role in protein trafficking makes it a critical gene for cellular homeostasis, but its potential nuclear functions remain enigmatic. **Proposed Hypotheses:** 1. The subcellular localization and primary function of [TRAPPC2B](/details-gene/10597) are context-dependent. In terminally differentiated, high-secretion cells like [plasmablast](/details-cell/CL0000980), it predominantly localizes to the cytoplasm to support the secretory pathway. In contrast, in progenitor cells like the [common dendritic progenitor](/details-cell/CL0001029), a significant nuclear pool of [TRAPPC2B](/details-gene/10597) may exist to regulate the gene expression programs governing differentiation. 2. The rate of cytokine and effector molecule secretion by immune cells, such as [CD4-positive helper T cell](/details-cell/CL0000492) and [group 3 innate lymphoid cell](/details-cell/CL0001071), is directly limited by the expression level of [TRAPPC2B](/details-gene/10597). Dysregulation of this gene could therefore impair an effective immune response. **Key Experimental Approach:** To test the hypothesis of dual functionality (Hypothesis 1), a combination of proteomics and genomics could be employed. - An appropriate *in vitro* model, such as a B-cell line induced to differentiate into plasmablasts, could be used. Subcellular fractionation followed by quantitative Western blotting would be performed at different time points to measure the relative abundance of [TRAPPC2B](/details-gene/10597) in the nucleus versus the cytoplasm. Parallel co-immunoprecipitation from nuclear and cytoplasmic lysates, followed by mass spectrometry (Co-IP-MS), would identify compartment-specific binding partners, distinguishing between TRAPP complex components and potential nuclear transcription factors. Finally, chromatin immunoprecipitation sequencing (ChIP-seq) for [TRAPPC2B](/details-gene/10597) in both progenitor and differentiated cells could determine if it directly binds to chromatin to regulate specific gene loci. **Therapeutic Potential:** As a core component of the essential protein trafficking machinery, [TRAPPC2B](/details-gene/10597) is likely a poor candidate for systemic therapeutic targeting due to the high probability of on-target toxicity in healthy tissues. However, in pathologies characterized by cellular hyper-secretion, such as multiple myeloma (a cancer of plasma cells) or certain autoimmune diseases, targeted inhibition of [TRAPPC2B](/details-gene/10597) function might be a viable strategy. Any therapeutic approach would likely involve inhibition to reduce pathological protein secretion, but its development would require delivery systems capable of high specificity for the target cell type to minimize side effects.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.