Details for: SLCO1B1

Gene ID: 10599

Symbol: SLCO1B1

Ensembl ID: ENSG00000134538

Description: solute carrier organic anion transporter family member 1B1

Associated with

Other Information

Genular Protein ID: 4257304221

Symbol: SO1B1_HUMAN

Name: Solute carrier organic anion transporter family member 1B1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10358072

Title: Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1.

PubMed ID: 10358072

DOI: 10.1074/jbc.274.24.17159

PubMed ID: 10601278

Title: A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters.

PubMed ID: 10601278

DOI: 10.1074/jbc.274.52.37161

PubMed ID: 10644574

Title: A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane.

PubMed ID: 10644574

DOI: 10.1152/ajpgi.2000.278.1.g156

PubMed ID: 10779507

Title: Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.

PubMed ID: 10779507

DOI: 10.1074/jbc.m001448200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10873595

Title: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.

PubMed ID: 10873595

DOI: 10.1006/bbrc.2000.2922

PubMed ID: 11159893

Title: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver.

PubMed ID: 11159893

DOI: 10.1053/gast.2001.21176

PubMed ID: 12568656

Title: Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin.

PubMed ID: 12568656

DOI: 10.1042/bj20030034

PubMed ID: 15159445

Title: Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans.

PubMed ID: 15159445

DOI: 10.1124/jpet.104.068056

PubMed ID: 15970799

Title: Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells.

PubMed ID: 15970799

DOI: 10.1097/01.fpc.0000170913.73780.5f

PubMed ID: 16624871

Title: Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans.

PubMed ID: 16624871

DOI: 10.1124/dmd.105.008938

PubMed ID: 16627748

Title: Vectorial transport of enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers.

PubMed ID: 16627748

DOI: 10.1124/jpet.106.103390

PubMed ID: 17412826

Title: Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport.

PubMed ID: 17412826

DOI: 10.1152/ajpgi.00075.2007

PubMed ID: 19129463

Title: Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters.

PubMed ID: 19129463

DOI: 10.1152/ajpcell.00436.2008

PubMed ID: 22232210

Title: Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.

PubMed ID: 22232210

DOI: 10.1172/jci59526

PubMed ID: 23243220

Title: Influence of human OATP1B1, OATP1B3, and OATP1A2 on the pharmacokinetics of methotrexate and paclitaxel in humanized transgenic mice.

PubMed ID: 23243220

DOI: 10.1158/1078-0432.ccr-12-2080

PubMed ID: 23285087

Title: N-Glycosylation dictates proper processing of organic anion transporting polypeptide 1B1.

PubMed ID: 23285087

DOI: 10.1371/journal.pone.0052563

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26979622

Title: A phosphotyrosine switch regulates organic cation transporters.

PubMed ID: 26979622

DOI: 10.1038/ncomms10880

PubMed ID: 26383540

Title: Organic anion transporting polypeptide (OATP)-mediated transport of coproporphyrins I and III.

PubMed ID: 26383540

DOI: 10.3109/00498254.2015.1085111

PubMed ID: 35307651

Title: Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.

PubMed ID: 35307651

DOI: 10.1124/dmd.121.000748

PubMed ID: 11477075

Title: Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans.

PubMed ID: 11477075

DOI: 10.1074/jbc.m103792200

PubMed ID: 12196548

Title: A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter.

PubMed ID: 12196548

DOI: 10.1074/jbc.m207735200

PubMed ID: 12130747

Title: Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis.

PubMed ID: 12130747

DOI: 10.1124/jpet.302.2.804

Sequence Information:

  • Length: 691
  • Mass: 76449
  • Checksum: D13D5130189383A3
  • Sequence:
  • MDQNQHLNKT AEAQPSENKK TRYCNGLKMF LAALSLSFIA KTLGAIIMKS SIIHIERRFE 
    ISSSLVGFID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG CFIMGIGGVL TALPHFFMGY 
    YRYSKETNIN SSENSTSTLS TCLINQILSL NRASPEIVGK GCLKESGSYM WIYVFMGNML 
    RGIGETPIVP LGLSYIDDFA KEGHSSLYLG ILNAIAMIGP IIGFTLGSLF SKMYVDIGYV 
    DLSTIRITPT DSRWVGAWWL NFLVSGLFSI ISSIPFFFLP QTPNKPQKER KASLSLHVLE 
    TNDEKDQTAN LTNQGKNITK NVTGFFQSFK SILTNPLYVM FVLLTLLQVS SYIGAFTYVF 
    KYVEQQYGQP SSKANILLGV ITIPIFASGM FLGGYIIKKF KLNTVGIAKF SCFTAVMSLS 
    FYLLYFFILC ENKSVAGLTM TYDGNNPVTS HRDVPLSYCN SDCNCDESQW EPVCGNNGIT 
    YISPCLAGCK SSSGNKKPIV FYNCSCLEVT GLQNRNYSAH LGECPRDDAC TRKFYFFVAI 
    QVLNLFFSAL GGTSHVMLIV KIVQPELKSL ALGFHSMVIR ALGGILAPIY FGALIDTTCI 
    KWSTNNCGTR GSCRTYNSTS FSRVYLGLSS MLRVSSLVLY IILIYAMKKK YQEKDINASE 
    NGSVMDEANL ESLNKNKHFV PSAGADSETH C

Genular Protein ID: 2429002556

Symbol: Q05CV5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 296
  • Mass: 32903
  • Checksum: 31DD44FCCB6A0912
  • Sequence:
  • MDQNQHLNKT AEAQPSENKK TRYCNGLKMF LAALSLSFIA KTLGAIIMKS SIIHIERRFE 
    ISSSLVGFID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG CFIMGIGGVL TALPHFFMGY 
    YRYSKETNIN SSENSTSTLS TCLINQILSL NRASPEIVGK GCLKESGSYM WIYVFMGNML 
    RGIGETPIVP LGLSYIDDFA KEGHSSLYLG ILNAIAMIGP IIGFTLGSLF SKMYVDIGYV 
    DLSTIRITPT DSRWVGAWWL NFLVSGLFSI ISSIPFFFLP QTPNKPQKKK KKKKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.