CENPC | ENSG00000145241 | NCBI 1060

Details for: CENPC

Gene ID: 1060

Symbol: CENPC

Ensembl ID: ENSG00000145241

Description: centromere protein C

Associated with

Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Chromosome maintenance
(R-HSA-73886)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Nucleosome assembly
(R-HSA-774815)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Attachment of mitotic spindle microtubules to kinetochore
(GO:0051315)
Cell division
(GO:0051301)
Centromeric dna binding
(GO:0019237)
Chromosome segregation
(GO:0007059)
Condensed chromosome, centromeric region
(GO:0000779)
Cytosol
(GO:0005829)
Dna binding
(GO:0003677)
Identical protein binding
(GO:0042802)
Inner kinetochore
(GO:0000939)
Kinetochore
(GO:0000776)
Kinetochore assembly
(GO:0051382)
Midbody
(GO:0030496)
Mitotic cell cycle
(GO:0000278)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pericentric heterochromatin
(GO:0005721)
Protein binding
(GO:0005515)
Spindle attachment to meiosis i kinetochore
(GO:0051455)

Other Information

Proteins

Centromere protein C

Genular Protein ID: 2852886349

Symbol: CENPC_HUMAN

Name: Centromere protein C

UniProtKB Accession Codes:

Q03188 Q6PIR0 Q8IW27 Q9P0M5

Database IDs:

Citations:

PubMed ID: 1339310

Title: CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate.

PubMed ID: 1339310

DOI: 10.1016/0092-8674(92)90538-n

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9645950

Title: Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death.

PubMed ID: 9645950

DOI: 10.1242/jcs.111.14.2029

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16716197

Title: Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells.

PubMed ID: 16716197

DOI: 10.1111/j.1365-2443.2006.00969.x

PubMed ID: 16622419

Title: The human CENP-A centromeric nucleosome-associated complex.

PubMed ID: 16622419

DOI: 10.1038/ncb1397

PubMed ID: 17651496

Title: Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres.

PubMed ID: 17651496

DOI: 10.1186/gb-2007-8-7-r148

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19503796

Title: The C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation.

PubMed ID: 19503796

DOI: 10.1371/journal.pone.0005832

PubMed ID: 19482874

Title: DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions.

PubMed ID: 19482874

DOI: 10.1093/hmg/ddp256

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21529714

Title: Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes.

PubMed ID: 21529714

DOI: 10.1016/j.cell.2011.03.031

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24522885

Title: A CENP-S/X complex assembles at the centromere in S and G2 phases of the human cell cycle.

PubMed ID: 24522885

DOI: 10.1098/rsob.130229

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 27499292

Title: The flexible ends of CENP-A nucleosome are required for mitotic fidelity.

PubMed ID: 27499292

DOI: 10.1016/j.molcel.2016.06.023

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

Length: 943
Mass: 106834
Checksum: 2AA5AF82BA88C809
Sequence:

MAASGLDHLK NGYRRRFCRP SRARDINTEQ GQNVLEILQD CFEEKSLAND FSTNSTKSVP 
NSTRKIKDTC IQSPSKECQK SHPKSVPVSS KKKEASLQFV VEPSEATNRS VQAHEVHQKI 
LATDVSSKNT PDSKKISSRN INDHHSEADE EFYLSVGSPS VLLDAKTSVS QNVIPSSAQK 
RETYTFENSV NMLPSSTEVS VKTKKRLNFD DKVMLKKIEI DNKVSDEEDK TSEGQERKPS 
GSSQNRIRDS EYEIQRQAKK SFSTLFLETV KRKSESSPIV RHAATAPPHS CPPDDTKLIE 
DEFIIDESDQ SFASRSWITI PRKAGSLKQR TISPAESTAL LQGRKSREKH HNILPKTLAN 
DKHSHKPHPV ETSQPSDKTV LDTSYALIGE TVNNYRSTKY EMYSKNAEKP SRSKRTIKQK 
QRRKFMAKPA EEQLDVGQSK DENIHTSHIT QDEFQRNSDR NMEEHEEMGN DCVSKKQMPP 
VGSKKSSTRK DKEESKKKRF SSESKNKLVP EEVTSTVTKS RRISRRPSDW WVVKSEESPV 
YSNSSVRNEL PMHHNSSRKS TKKTNQSSKN IRKKTIPLKR QKTATKGNQR VQKFLNAEGS 
GGIVGHDEIS RCSLSEPLES DEADLAKKKN LDCSRSTRSS KNEDNIMTAQ NVPLKPQTSG 
YTCNIPTESN LDSGEHKTSV LEESGPSRLN NNYLMSGKND VDDEEVHGSS DDSKQSKVIP 
KNRIHHKLVL PSNTPNVRRT KRTRLKPLEY WRGERIDYQG RPSGGFVISG VLSPDTISSK 
RKAKENIGKV NKKSNKKRIC LDNDERKTNL MVNLGIPLGD PLQPTRVKDP ETREIILMDL 
VRPQDTYQFF VKHGELKVYK TLDTPFFSTG KLILGPQEEK GKQHVGQDIL VFYVNFGDLL 
CTLHETPYIL STGDSFYVPS GNYYNIKNLR NEESVLLFTQ IKR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CENPC

Associated with

Other Information

CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate. PubMed ID: 1339310

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death. PubMed ID: 9645950

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. PubMed ID: 16716197

The human CENP-A centromeric nucleosome-associated complex. PubMed ID: 16622419

Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres. PubMed ID: 17651496

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

The C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation. PubMed ID: 19503796

DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions. PubMed ID: 19482874

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes. PubMed ID: 21529714

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A CENP-S/X complex assembles at the centromere in S and G2 phases of the human cell cycle. PubMed ID: 24522885

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. PubMed ID: 25755297

The flexible ends of CENP-A nucleosome are required for mitotic fidelity. PubMed ID: 27499292

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733