USP16 | ENSG00000156256 | NCBI 10600

Details for: USP16

Gene ID: 10600

Symbol: USP16

Ensembl ID: ENSG00000156256

Description: ubiquitin specific peptidase 16

Associated with

Deubiquitination
(R-HSA-5688426)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Ub-specific processing proteases
(R-HSA-5689880)
Cell division
(GO:0051301)
Chromatin remodeling
(GO:0006338)
Cysteine-type deubiquitinase activity
(GO:0004843)
Cysteine-type endopeptidase activity
(GO:0004197)
Cytoplasm
(GO:0005737)
Dna damage response
(GO:0006974)
Histone binding
(GO:0042393)
Histone h2a deubiquitinase activity
(GO:0140950)
Mitotic nuclear division
(GO:0140014)
Monoubiquitinated protein deubiquitination
(GO:0035520)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of ribosome biogenesis
(GO:0090070)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of translational elongation
(GO:0045901)
Protein homotetramerization
(GO:0051289)
Proteolysis
(GO:0006508)
Regulation of cell cycle
(GO:0051726)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Ribosomal small subunit binding
(GO:0043024)
Transcription coactivator activity
(GO:0003713)
Ubiquitin binding
(GO:0043130)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Ubiquitin-processing protease UBP-M

Genular Protein ID: 1416089612

Symbol: UBP16_HUMAN

Name: Ubiquitin-processing protease UBP-M

UniProtKB Accession Codes:

Q9Y5T5 A8MU43 B3KN13 B4DFV8 B4DY37 D3DSD9 Q53GP7 Q53HA0 Q5VKN8 Q8NEL3 Q9H3E6

Database IDs:

Citations:

PubMed ID: 10077596

Title: A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division.

PubMed ID: 10077596

DOI: 10.1073/pnas.96.6.2828

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11753566

Title: Caspase-dependent deubiquitination of monoubiquitinated nucleosomal histone H2A induced by diverse apoptogenic stimuli.

PubMed ID: 11753566

DOI: 10.1038/sj.cdd.4400924

PubMed ID: 17914355

Title: Regulation of cell cycle progression and gene expression by H2A deubiquitination.

PubMed ID: 17914355

DOI: 10.1038/nature06256

PubMed ID: 18925961

Title: Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes.

PubMed ID: 18925961

DOI: 10.1186/1471-2407-8-299

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24025767

Title: Usp16 contributes to somatic stem-cell defects in Down's syndrome.

PubMed ID: 24025767

DOI: 10.1038/nature12530

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 32129764

Title: USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit.

PubMed ID: 32129764

DOI: 10.7554/elife.54435

PubMed ID: 17512543

Title: Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin.

PubMed ID: 17512543

DOI: 10.1016/j.jmb.2007.04.015

Sequence Information:

Length: 823
Mass: 93570
Checksum: C7D4175649BA3E31
Sequence:

MGKKRTKGKT VPIDDSSETL EPVCRHIRKG LEQGNLKKAL VNVEWNICQD CKTDNKVKDK 
AEEETEEKPS VWLCLKCGHQ GCGRNSQEQH ALKHYLTPRS EPHCLVLSLD NWSVWCYVCD 
NEVQYCSSNQ LGQVVDYVRK QASITTPKPA EKDNGNIELE NKKLEKESKN EQEREKKENM 
AKENPPMNSP CQITVKGLSN LGNTCFFNAV MQNLSQTPVL RELLKEVKMS GTIVKIEPPD 
LALTEPLEIN LEPPGPLTLA MSQFLNEMQE TKKGVVTPKE LFSQVCKKAV RFKGYQQQDS 
QELLRYLLDG MRAEEHQRVS KGILKAFGNS TEKLDEELKN KVKDYEKKKS MPSFVDRIFG 
GELTSMIMCD QCRTVSLVHE SFLDLSLPVL DDQSGKKSVN DKNLKKTVED EDQDSEEEKD 
NDSYIKERSD IPSGTSKHLQ KKAKKQAKKQ AKNQRRQQKI QGKVLHLNDI CTIDHPEDSE 
YEAEMSLQGE VNIKSNHISQ EGVMHKEYCV NQKDLNGQAK MIESVTDNQK STEEVDMKNI 
NMDNDLEVLT SSPTRNLNGA YLTEGSNGEV DISNGFKNLN LNAALHPDEI NIEILNDSHT 
PGTKVYEVVN EDPETAFCTL ANREVFNTDE CSIQHCLYQF TRNEKLRDAN KLLCEVCTRR 
QCNGPKANIK GERKHVYTNA KKQMLISLAP PVLTLHLKRF QQAGFNLRKV NKHIKFPEIL 
DLAPFCTLKC KNVAEENTRV LYSLYGVVEH SGTMRSGHYT AYAKARTANS HLSNLVLHGD 
IPQDFEMESK GQWFHISDTH VQAVPTTKVL NSQAYLLFYE RIL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: USP16

Associated with

Other Information

A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division. PubMed ID: 10077596

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 21. PubMed ID: 10830953

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Caspase-dependent deubiquitination of monoubiquitinated nucleosomal histone H2A induced by diverse apoptogenic stimuli. PubMed ID: 11753566

Regulation of cell cycle progression and gene expression by H2A deubiquitination. PubMed ID: 17914355

Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes. PubMed ID: 18925961

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Usp16 contributes to somatic stem-cell defects in Down's syndrome. PubMed ID: 24025767

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit. PubMed ID: 32129764

Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin. PubMed ID: 17512543