Details for: PAIP1

Gene ID: 10605

Symbol: PAIP1

Ensembl ID: ENSG00000172239

Description: poly(A) binding protein interacting protein 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.34
    Marker Score: 9,750
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.99
    Marker Score: 491
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.94
    Marker Score: 7,499
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.84
    Marker Score: 2,648
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.73
    Marker Score: 1,943
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.72
    Marker Score: 1,823
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.71
    Marker Score: 4,643
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.7
    Marker Score: 22,400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.67
    Marker Score: 16,783
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.66
    Marker Score: 7,171
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.62
    Marker Score: 3,814
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.6
    Marker Score: 1,694
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.57
    Marker Score: 3,283
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.56
    Marker Score: 1,044
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.55
    Marker Score: 2,748
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.54
    Marker Score: 10,035
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.48
    Marker Score: 1,582
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.48
    Marker Score: 1,852
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.46
    Marker Score: 436
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166,621
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.45
    Marker Score: 5,359
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.45
    Marker Score: 339
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.44
    Marker Score: 5,662
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.44
    Marker Score: 1,355
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.42
    Marker Score: 48,408
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.4
    Marker Score: 2,386
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.36
    Marker Score: 861
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.36
    Marker Score: 751
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.36
    Marker Score: 856
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.36
    Marker Score: 47,152
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.34
    Marker Score: 5,181
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.3
    Marker Score: 1,225
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.3
    Marker Score: 11,394
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.29
    Marker Score: 1,907
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.29
    Marker Score: 3,140
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.28
    Marker Score: 2,599
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.26
    Marker Score: 425
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.26
    Marker Score: 2,082
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.25
    Marker Score: 592
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.25
    Marker Score: 1,993
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.24
    Marker Score: 2,334
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.24
    Marker Score: 10,661
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.22
    Marker Score: 959
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.21
    Marker Score: 1,306
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.21
    Marker Score: 1,257
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2
    Marker Score: 73,863
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.2
    Marker Score: 30,610
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.19
    Marker Score: 1,945
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.18
    Marker Score: 13,329
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.18
    Marker Score: 4,181
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.18
    Marker Score: 7,145
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.17
    Marker Score: 298
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.17
    Marker Score: 1,879
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.16
    Marker Score: 2,323
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.16
    Marker Score: 381
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.16
    Marker Score: 400
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.15
    Marker Score: 483
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.15
    Marker Score: 2,627
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.15
    Marker Score: 3,275
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.15
    Marker Score: 368
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.15
    Marker Score: 1,768
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.14
    Marker Score: 609
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.14
    Marker Score: 10,835
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.13
    Marker Score: 2,693
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.13
    Marker Score: 429
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.13
    Marker Score: 646
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.13
    Marker Score: 394
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.13
    Marker Score: 9,730
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.13
    Marker Score: 670
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.12
    Marker Score: 1,133
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.12
    Marker Score: 6,668
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.12
    Marker Score: 252
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.12
    Marker Score: 760
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.12
    Marker Score: 1,012
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.1
    Marker Score: 1,699
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.1
    Marker Score: 248
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.09
    Marker Score: 315
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.08
    Marker Score: 2,897
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.08
    Marker Score: 257
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.07
    Marker Score: 1,088
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.07
    Marker Score: 1,294
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.07
    Marker Score: 590
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.06
    Marker Score: 6,922
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.06
    Marker Score: 300
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.06
    Marker Score: 2,661
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.05
    Marker Score: 261
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.05
    Marker Score: 269
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.05
    Marker Score: 9,155
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.05
    Marker Score: 333
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.05
    Marker Score: 390
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.04
    Marker Score: 301
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.04
    Marker Score: 926
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.04
    Marker Score: 925
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.03
    Marker Score: 1,097
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.03
    Marker Score: 2,694
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.02
    Marker Score: 201
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.02
    Marker Score: 5,000
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.01
    Marker Score: 2,296
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.01
    Marker Score: 9,510
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.01
    Marker Score: 1,305

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PAIP1 is a cytoplasmic protein that interacts with PABP, a key regulator of mRNA stability and translation. This interaction modulates mRNA decay, particularly through the Crd-mediated mRNA stabilization pathway, which involves the degradation of maternal mRNAs by maternally stored factors during the maternal-to-zygotic transition (mzt). PAIP1 also regulates translational initiation, translation activator activity, and cytoplasmic translation, highlighting its role in protein synthesis and cellular metabolism. **Pathways and Functions:** PAIP1 is involved in several key pathways, including: 1. **Crd-mediated mRNA stabilization**: PAIP1 interacts with PABP to regulate the stability of maternal mRNAs, which is crucial for the proper development of the embryo. 2. **Deadenylation-dependent mRNA decay**: PAIP1 modulates the decay of mRNAs through the deadenylation pathway, which is essential for regulating gene expression and cellular homeostasis. 3. **Regulation of translational initiation**: PAIP1 regulates the initiation of translation, which is critical for protein synthesis and cellular metabolism. 4. **Translation activator activity**: PAIP1 promotes translation, which is essential for cellular growth, differentiation, and immune responses. 5. **Negative regulation of nuclear-transcribed mRNA catabolic process**: PAIP1 inhibits the degradation of nuclear-transcribed mRNAs, which is essential for regulating gene expression and cellular homeostasis. **Clinical Significance:** PAIP1's role in regulating mRNA stability, translation, and cytoplasmic localization makes it a potential target for therapeutic interventions in various diseases, including: 1. **Neurological disorders**: PAIP1's involvement in neuronal development and function makes it a potential target for treating neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Cancer**: PAIP1's role in regulating mRNA stability and translation may influence cancer progression and metastasis. 3. **Immune disorders**: PAIP1's involvement in immune cell development and function makes it a potential target for treating immune-related disorders, such as autoimmune diseases. In conclusion, PAIP1 is a multifaceted gene that plays a crucial role in regulating mRNA stability, translation, and cytoplasmic localization. Its involvement in various cellular processes and diseases highlights the importance of further research into the functions and clinical significance of PAIP1.

Genular Protein ID: 2004638969

Symbol: PAIP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9H074 A6NKV8 O60455 Q96B61 Q9BS63

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 6 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 5 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9548260

Title: Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation.

PubMed ID: 9548260

DOI: 10.1038/33198

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11051545

Title: A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex.

PubMed ID: 11051545

DOI: 10.1016/s0092-8674(00)00102-1

PubMed ID: 10970864

Title: Multiple portions of poly(A)-binding protein stimulate translation in vivo.

PubMed ID: 10970864

DOI: 10.1093/emboj/19.17.4723

PubMed ID: 11172725

Title: Translational repression by a novel partner of human poly(A) binding protein, Paip2.

PubMed ID: 11172725

DOI: 10.1016/s1097-2765(01)00168-x

PubMed ID: 11997512

Title: Paip1 interacts with poly(A) binding protein through two independent binding motifs.

PubMed ID: 11997512

DOI: 10.1128/mcb.22.11.3769-3782.2002

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 33876849

Title: The SARS-unique domain (SUD) of SARS-CoV and SARS-CoV-2 interacts with human Paip1 to enhance viral RNA translation.

PubMed ID: 33876849

DOI: 10.15252/embj.2019102277

Sequence Information:

  • Length: 479
  • Mass: 53525
  • Checksum: A4820607190A3A43
  • Sequence:
    • MSDGFDRAPG AGRGRSRGLG RGGGGPEGGG FPNGAGPAER ARHQPPQPKA PGFLQPPPLR 
QPRTTPPPGA QCEVPASPQR PSRPGALPEQ TRPLRAPPSS QDKIPQQNSE SAMAKPQVVV 
APVLMSKLSV NAPEFYPSGY SSSYTESYED GCEDYPTLSE YVQDFLNHLT EQPGSFETEI 
EQFAETLNGC VTTDDALQEL VELIYQQATS IPNFSYMGAR LCNYLSHHLT ISPQSGNFRQ 
LLLQRCRTEY EVKDQAAKGD EVTRKRFHAF VLFLGELYLN LEIKGTNGQV TRADILQVGL 
RELLNALFSN PMDDNLICAV KLLKLTGSVL EDAWKEKGKM DMEEIIQRIE NVVLDANCSR 
DVKQMLLKLV ELRSSNWGRV HATSTYREAT PENDPNYFMN EPTFYTSDGV PFTAADPDYQ 
EKYQELLERE DFFPDYEENG TDLSGAGDPY LDDIDDEMDP EIEEAYEKFC LESERKRKQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.