Details for: TBL3

Gene ID: 10607

Symbol: TBL3

Ensembl ID: ENSG00000183751

Description: transducin beta like 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,747
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,971
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,399
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.95
    Marker Score: 8,211
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,401
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.91
    Marker Score: 620
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,711
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.9
    Marker Score: 1,295
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.87
    Marker Score: 652
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,249
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,904
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.76
    Marker Score: 11,963
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.76
    Marker Score: 1,435
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.75
    Marker Score: 2,934
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 298
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 556
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.71
    Marker Score: 1,624
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2,800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.67
    Marker Score: 1,390
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 607
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.66
    Marker Score: 704
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.65
    Marker Score: 858
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.64
    Marker Score: 674
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.63
    Marker Score: 635
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.62
    Marker Score: 297
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.6
    Marker Score: 298
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.6
    Marker Score: 1,013
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.59
    Marker Score: 1,616
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.59
    Marker Score: 743
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.59
    Marker Score: 394
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.59
    Marker Score: 324
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.59
    Marker Score: 1,599
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.58
    Marker Score: 579
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.58
    Marker Score: 2,506
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.56
    Marker Score: 470
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.56
    Marker Score: 2,300
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.55
    Marker Score: 205
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.55
    Marker Score: 809
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.55
    Marker Score: 348
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.54
    Marker Score: 384
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.54
    Marker Score: 1,280
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.54
    Marker Score: 1,095
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 426
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.52
    Marker Score: 242
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.52
    Marker Score: 128
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.52
    Marker Score: 557
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.51
    Marker Score: 136
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.51
    Marker Score: 161
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.51
    Marker Score: 335
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.5
    Marker Score: 828
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.5
    Marker Score: 1,184
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.5
    Marker Score: 365
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.5
    Marker Score: 518
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.49
    Marker Score: 297
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.49
    Marker Score: 458
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.48
    Marker Score: 5,579
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.47
    Marker Score: 4,805
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.47
    Marker Score: 248
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.47
    Marker Score: 502
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.47
    Marker Score: 989
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.46
    Marker Score: 316
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.46
    Marker Score: 733
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.46
    Marker Score: 108
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.46
    Marker Score: 294
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.46
    Marker Score: 2,200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.46
    Marker Score: 1,360
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.46
    Marker Score: 3,398
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.46
    Marker Score: 2,239
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.45
    Marker Score: 406
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.45
    Marker Score: 171
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.45
    Marker Score: 145
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.45
    Marker Score: 748
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.45
    Marker Score: 276
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.45
    Marker Score: 114
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.45
    Marker Score: 154
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.45
    Marker Score: 110
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.44
    Marker Score: 158
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.44
    Marker Score: 427
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.44
    Marker Score: 2,875
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.44
    Marker Score: 105
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.44
    Marker Score: 495
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.44
    Marker Score: 624
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.43
    Marker Score: 180
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.43
    Marker Score: 507
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.43
    Marker Score: 198
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.43
    Marker Score: 122
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.43
    Marker Score: 4,331
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.43
    Marker Score: 1,004
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.43
    Marker Score: 149
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.42
    Marker Score: 93
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.42
    Marker Score: 209
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.42
    Marker Score: 3,283
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.42
    Marker Score: 107
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.42
    Marker Score: 121

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ribosomal RNA Processing:** TBL3 is a key player in the processing of ssu-rRNA, which is essential for the assembly and function of the small subunit of the ribosome. 2. **Cellular Expression:** TBL3 is highly expressed in various cell types, including cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, epithelial cells of the esophagus, and intestinal crypt stem cells. 3. **Protein Binding:** TBL3 interacts with other proteins involved in RNA processing, such as U3 snRNA and the small-subunit processome. 4. **Cellular Localization:** TBL3 is found in both the nucleolus and cytosol, suggesting its involvement in both nuclear and cytoplasmic processes. **Pathways and Functions:** 1. **90s Preribosome Pathway:** TBL3 is involved in the processing of the 90s preribosome, a complex that assembles the small subunit of the ribosome. 2. **Endonucleolytic Cleavage:** TBL3 participates in the endonucleolytic cleavage of the 5'-end of the ssu-rRNA transcript, which is essential for the maturation of the small subunit. 3. **RNA Binding:** TBL3 interacts with U3 snRNA and the small-subunit processome, suggesting its role in RNA binding and processing. 4. **Ribosomal Biogenesis:** TBL3 is required for the biogenesis of the small subunit of the ribosome, which is essential for protein synthesis. **Clinical Significance:** 1. **Neurological Disorders:** Alterations in TBL3 expression have been linked to neurological disorders, such as epilepsy and schizophrenia, which are characterized by aberrant RNA processing and protein synthesis. 2. **Cancer:** TBL3 has been identified as a potential oncogene in certain types of cancer, including colon cancer, where it is involved in the regulation of cell growth and differentiation. 3. **Genetic Disorders:** Mutations in TBL3 have been associated with genetic disorders, such as proerythroblastosis, which is characterized by abnormal red blood cell production. 4. **Neurodevelopmental Disorders:** TBL3 has been implicated in neurodevelopmental disorders, such as autism spectrum disorder, which is characterized by abnormalities in RNA processing and protein synthesis. In conclusion, TBL3 is a critical component of the ribosomal RNA processing machinery, involved in the editing and maturation of small subunit rRNA. Its dysregulation has been linked to various human diseases, including neurological disorders, cancer, and genetic disorders. Further research is needed to fully elucidate the function and clinical significance of TBL3 in human health and disease.

Genular Protein ID: 1558430830

Symbol: TBL3_HUMAN

Name: Transducin beta-like protein 3

UniProtKB Accession Codes:

Q12788 Q59GD6 Q8IVB7 Q96A78

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 EMBL 8 EMDB 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8307582

Title: A transducin-like gene maps to the autosomal dominant polycystic kidney disease gene region.

PubMed ID: 8307582

DOI: 10.1016/s0888-7543(05)80380-5

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

  • Length: 808
  • Mass: 89035
  • Checksum: 01BDF217F8D17D30
  • Sequence:
    • MAETAAGVGR FKTNYAVERK IEPFYKGGKA QLDQTGQHLF CVCGTRVNIL EVASGAVLRS 
LEQEDQEDIT AFDLSPDNEV LVTASRALLL AQWAWQEGSV TRLWKAIHTA PVATMAFDPT 
STLLATGGCD GAVRVWDIVR HYGTHHFRGS PGVVHLVAFH PDPTRLLLFS SATDAAIRVW 
SLQDRSCLAV LTAHYSAVTS LAFSADGHTM LSSGRDKICI IWDLQSCQAT RTVPVFESVE 
AAVLLPEEPV SQLGVKSPGL YFLTAGDQGT LRVWEAASGQ CVYTQAQPPG PGQELTHCTL 
AHTAGVVLTA TADHNLLLYE ARSLRLQKQF AGYSEEVLDV RFLGPEDSHV VVASNSPCLK 
VFELQTSACQ ILHGHTDIVL ALDVFRKGWL FASCAKDQSV RIWRMNKAGQ VMCVAQGSGH 
THSVGTVCCS RLKESFLVTG SQDCTVKLWP LPKALLSKNT APDNGPILLQ AQTTQRCHDK 
DINSVAIAPN DKLLATGSQD RTAKLWALPQ CQLLGVFSGH RRGLWCVQFS PMDQVLATAS 
ADGTIKLWAL QDFSCLKTFE GHDASVLKVA FVSRGTQLLS SGSDGLVKLW TIKNNECVRT 
LDAHEDKVWG LHCSRLDDHA LTGASDSRVI LWKDVTEAEQ AEEQARQEEQ VVRQQELDNL 
LHEKRYLRAL GLAISLDRPH TVLTVIQAIR RDPEACEKLE ATMLRLRRDQ KEALLRFCVT 
WNTNSRHCHE AQAVLGVLLR REAPEELLAY EGVRAALEAL LPYTERHFQR LSRTLQAAAF 
LDFLWHNMKL PVPAAAPTPW ETHKGALP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.