Details for: CENPCP1

Gene ID: 1061

Symbol: CENPCP1

Ensembl ID: ENSG00000226982

Description: centromere protein C pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.2454
    Cell Significance Index: 2.9600
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1904
    Cell Significance Index: 2.4600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0835
    Cell Significance Index: 1.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0784
    Cell Significance Index: 15.7400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0783
    Cell Significance Index: 0.8100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0707
    Cell Significance Index: 0.9300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0599
    Cell Significance Index: 1.1900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0563
    Cell Significance Index: 1.1300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0483
    Cell Significance Index: 1.0300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0395
    Cell Significance Index: 0.5000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.0319
    Cell Significance Index: 0.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0268
    Cell Significance Index: 4.5800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0137
    Cell Significance Index: 0.2400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0108
    Cell Significance Index: 0.1200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.0094
    Cell Significance Index: 0.2400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.0081
    Cell Significance Index: 0.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0078
    Cell Significance Index: 0.2500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0058
    Cell Significance Index: 0.1700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0050
    Cell Significance Index: 0.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0050
    Cell Significance Index: 0.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.0049
    Cell Significance Index: 0.1600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0047
    Cell Significance Index: 0.0600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0010
    Cell Significance Index: -1.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0011
    Cell Significance Index: -0.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0012
    Cell Significance Index: -1.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0014
    Cell Significance Index: -1.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0017
    Cell Significance Index: -0.0800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0027
    Cell Significance Index: -0.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0030
    Cell Significance Index: -1.9300
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0033
    Cell Significance Index: -0.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0049
    Cell Significance Index: -2.2100
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0055
    Cell Significance Index: -0.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0082
    Cell Significance Index: -0.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0106
    Cell Significance Index: -1.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0114
    Cell Significance Index: -1.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0164
    Cell Significance Index: -0.4400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0208
    Cell Significance Index: -0.2500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0213
    Cell Significance Index: -0.1800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0238
    Cell Significance Index: -0.2400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0274
    Cell Significance Index: -0.3800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0313
    Cell Significance Index: -0.4500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0376
    Cell Significance Index: -0.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0452
    Cell Significance Index: -1.5900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0452
    Cell Significance Index: -0.7800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0461
    Cell Significance Index: -0.6800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0472
    Cell Significance Index: -1.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0521
    Cell Significance Index: -1.1400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0522
    Cell Significance Index: -1.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0524
    Cell Significance Index: -1.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0580
    Cell Significance Index: -1.5800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.0581
    Cell Significance Index: -0.6300
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0582
    Cell Significance Index: -0.7500
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0591
    Cell Significance Index: -0.7200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0594
    Cell Significance Index: -0.7200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0604
    Cell Significance Index: -1.9100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0612
    Cell Significance Index: -0.7200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0615
    Cell Significance Index: -0.8500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0675
    Cell Significance Index: -1.4000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0709
    Cell Significance Index: -1.0600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0744
    Cell Significance Index: -0.7700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0759
    Cell Significance Index: -0.9100
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0761
    Cell Significance Index: -0.9200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0771
    Cell Significance Index: -0.8200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0781
    Cell Significance Index: -0.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0799
    Cell Significance Index: -1.0900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0803
    Cell Significance Index: -0.8200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0807
    Cell Significance Index: -1.3800
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0807
    Cell Significance Index: -0.5600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0836
    Cell Significance Index: -1.0500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0843
    Cell Significance Index: -1.2000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0872
    Cell Significance Index: -0.9100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0874
    Cell Significance Index: -1.0400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0878
    Cell Significance Index: -1.0200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0895
    Cell Significance Index: -1.0000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0925
    Cell Significance Index: -1.2700
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0926
    Cell Significance Index: -1.3000
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0934
    Cell Significance Index: -1.1100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0941
    Cell Significance Index: -1.2500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0951
    Cell Significance Index: -1.6000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0959
    Cell Significance Index: -1.2100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0965
    Cell Significance Index: -1.2700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0977
    Cell Significance Index: -1.2200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0990
    Cell Significance Index: -1.2400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1004
    Cell Significance Index: -1.0300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1026
    Cell Significance Index: -1.2300
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1028
    Cell Significance Index: -0.7400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1035
    Cell Significance Index: -1.3300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1043
    Cell Significance Index: -1.2000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1043
    Cell Significance Index: -1.2100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1045
    Cell Significance Index: -1.0600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1046
    Cell Significance Index: -0.5600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1057
    Cell Significance Index: -1.2600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1060
    Cell Significance Index: -1.0000
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1069
    Cell Significance Index: -1.1200
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1078
    Cell Significance Index: -0.9700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1083
    Cell Significance Index: -1.2800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1083
    Cell Significance Index: -1.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CENPCP1, also known as centromere protein C pseudogene 1, is a member of the centromere protein C (CENPC) family, which plays a crucial role in the organization and regulation of centromeres. However, unlike its functional counterparts, CENPCP1 is a pseudogene, devoid of a coding sequence. This suggests that CENPCP1 may not have a significant functional role in the classical sense. Despite this, its expression in various cell types, including ependymal cells, innate lymphoid cells, mesenchymal stem cells, B cells, glial cells, cerebellar granule cell precursors, interneurons, OFF retinal ganglion cells, plasma cells, and adventitial cells, hints at a more complex and multifaceted role. **Pathways and Functions:** While the exact mechanisms underlying CENPCP1's functions remain unclear, several pathways are implicated in its expression and potential activities. One possibility is that CENPCP1 interacts with chromatin remodeling complexes, influencing the regulation of gene expression and cell differentiation. Another hypothesis suggests that CENPCP1 may participate in the maintenance of centrosome integrity, which is essential for proper cell division and mitotic spindle formation. Furthermore, the expression of CENPCP1 in immune cells, such as B cells and innate lymphoid cells, raises questions about its role in immune function and regulation. It is conceivable that CENPCP1 modulates the activity of immune cells, influencing the production of cytokines, antigen presentation, or the regulation of immune responses. **Clinical Significance:** The clinical significance of CENPCP1 remains largely unexplored, but its expression in various cell types suggests potential implications for human disease. For instance, alterations in CENPCP1 expression have been linked to neurological disorders, such as multiple sclerosis and Alzheimer's disease, where centrosome dysfunction and immune system dysregulation are key features. Moreover, the involvement of CENPCP1 in immune cell function and regulation may have significant implications for autoimmune diseases, such as rheumatoid arthritis and lupus, where immune system dysregulation is a hallmark. Further research is necessary to elucidate the role of CENPCP1 in these diseases and to explore its potential as a therapeutic target. In conclusion, the enigmatic CENPCP1 gene presents a fascinating case study in the realm of immunology. While its exact functions remain unclear, its expression in various cell types and potential interactions with chromatin remodeling complexes and immune cells suggest a complex and multifaceted role. As research continues to unravel the mysteries surrounding CENPCP1, it is likely that this pseudogene will reveal new insights into the regulation of gene expression, immune function, and human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.