Details for: HEXIM1

Gene ID: 10614

Symbol: HEXIM1

Ensembl ID: ENSG00000186834

Description: HEXIM P-TEFb complex subunit 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.82
    Marker Score: 1,818
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.79
    Marker Score: 7,046
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.79
    Marker Score: 1,402
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.67
    Marker Score: 2,467
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.44
    Marker Score: 710
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.37
    Marker Score: 935
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.26
    Marker Score: 2,626
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.22
    Marker Score: 817
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.22
    Marker Score: 1,876
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.21
    Marker Score: 1,270
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2
    Marker Score: 298
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.2
    Marker Score: 1,267
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.2
    Marker Score: 344
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.2
    Marker Score: 5,739
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.15
    Marker Score: 3,607
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.13
    Marker Score: 1,925
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.13
    Marker Score: 2,121
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.1
    Marker Score: 462
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.1
    Marker Score: 2,241
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.1
    Marker Score: 290
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.08
    Marker Score: 723
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.08
    Marker Score: 3,994
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.07
    Marker Score: 1,144
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.07
    Marker Score: 398
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.06
    Marker Score: 243
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.05
    Marker Score: 1,360
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.04
    Marker Score: 258
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.04
    Marker Score: 1,258
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.04
    Marker Score: 11,721
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.04
    Marker Score: 978
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.04
    Marker Score: 16,202
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.03
    Marker Score: 741
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.03
    Marker Score: 2,898
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.03
    Marker Score: 566
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.03
    Marker Score: 6,558
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.02
    Marker Score: 2,411
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.01
    Marker Score: 35,051
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.01
    Marker Score: 320
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1
    Marker Score: 311
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1
    Marker Score: 960
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,618
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1
    Marker Score: 2,259
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,840
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.99
    Marker Score: 319
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,375
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.96
    Marker Score: 2,512
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.96
    Marker Score: 288
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.96
    Marker Score: 32,629
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.96
    Marker Score: 2,256
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.95
    Marker Score: 243
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.95
    Marker Score: 931
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.95
    Marker Score: 186
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.95
    Marker Score: 809
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.95
    Marker Score: 1,236
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.94
    Marker Score: 1,874
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.94
    Marker Score: 224
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.94
    Marker Score: 218
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,378
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.93
    Marker Score: 247
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.93
    Marker Score: 221
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.93
    Marker Score: 894
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.93
    Marker Score: 962
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 474
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.92
    Marker Score: 287
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.91
    Marker Score: 600
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 430
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.91
    Marker Score: 1,539
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,713
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.9
    Marker Score: 593
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.9
    Marker Score: 366
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.9
    Marker Score: 871
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.9
    Marker Score: 210
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5,109
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.89
    Marker Score: 798
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.89
    Marker Score: 4,693
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.89
    Marker Score: 189
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.88
    Marker Score: 307
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.88
    Marker Score: 458
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.88
    Marker Score: 441
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.88
    Marker Score: 11,641
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.88
    Marker Score: 232
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.87
    Marker Score: 5,315
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.87
    Marker Score: 214
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.87
    Marker Score: 872
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.86
    Marker Score: 352
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.86
    Marker Score: 244
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.86
    Marker Score: 649
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.86
    Marker Score: 2,093
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.86
    Marker Score: 1,003
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.86
    Marker Score: 413
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,184
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.85
    Marker Score: 216
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.85
    Marker Score: 7,332
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.85
    Marker Score: 904
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.84
    Marker Score: 202
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.84
    Marker Score: 1,340
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.84
    Marker Score: 914
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.84
    Marker Score: 385
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.84
    Marker Score: 327

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Dual role in transcription regulation**: HEXIM1 is a negative regulator of transcription elongation by RNA polymerase II and a positive regulator of signal transduction by p53 class mediators. 2. **Inhibition of cyclin-dependent protein kinases**: HEXIM1 inhibits the activity of cyclin-dependent protein kinases, which are essential for cell cycle progression. 3. **Binding to snRNPs**: HEXIM1 interacts with snRNPs, which are involved in RNA processing and splicing. 4. **Expression in specific cell types**: HEXIM1 is highly expressed in enterocytes, placental trophoblasts, and thyroid follicular cells, among others. **Pathways and Functions:** 1. **Transcription regulation**: HEXIM1 is involved in the negative regulation of transcription elongation by RNA polymerase II, which is essential for the proper regulation of gene expression. 2. **Immune response**: HEXIM1 has been implicated in the regulation of innate immune response, where it interacts with snRNPs to modulate the activity of immune-related genes. 3. **Cell development**: HEXIM1 is involved in the regulation of heart development and the expression of specific genes in enterocytes and other cell types. 4. **P-TEFb complex**: HEXIM1 is a subunit of the P-TEFb complex, which is a positive transcription elongation factor B that is involved in the regulation of RNA polymerase II activity. **Clinical Significance:** 1. **Cancer**: HEXIM1 has been implicated in the regulation of cancer cell growth and survival, where it may play a role in the development of various cancers. 2. **Infectious diseases**: HEXIM1's role in regulating innate immune response may be crucial in the development of infectious diseases, where it may modulate the activity of immune-related genes. 3. **Developmental disorders**: HEXIM1's involvement in heart development and cell differentiation may be relevant to the development of developmental disorders, such as congenital heart defects. 4. **Therapeutic potential**: HEXIM1's multifunctional nature may provide a target for the development of novel therapeutic strategies for various diseases, including cancer and infectious diseases. In conclusion, HEXIM1 is a multifunctional protein that plays a crucial role in regulating transcription, immune response, and cell development. Its expression in specific cell types and its involvement in various cellular processes make it an attractive target for further research and potential therapeutic applications.

Genular Protein ID: 1896095077

Symbol: HEXI1_HUMAN

Name: Protein HEXIM1

UniProtKB Accession Codes:

O94992 B2R8Y5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12941847

Title: Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors.

PubMed ID: 12941847

PubMed ID: 12581153

Title: Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells.

PubMed ID: 12581153

DOI: 10.1046/j.1365-2443.2003.00618.x

PubMed ID: 14580347

Title: Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA.

PubMed ID: 14580347

DOI: 10.1016/s1097-2765(03)00388-5

PubMed ID: 12832472

Title: MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner.

PubMed ID: 12832472

DOI: 10.1128/mcb.23.14.4859-4869.2003

PubMed ID: 15201869

Title: Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor.

PubMed ID: 15201869

DOI: 10.1038/sj.emboj.7600275

PubMed ID: 15169877

Title: A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb.

PubMed ID: 15169877

DOI: 10.1128/mcb.24.12.5094-5105.2004

PubMed ID: 16362050

Title: Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb.

PubMed ID: 16362050

DOI: 10.1038/sj.emboj.7600883

PubMed ID: 15713661

Title: Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription.

PubMed ID: 15713661

DOI: 10.1074/jbc.m500912200

PubMed ID: 15855166

Title: Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat.

PubMed ID: 15855166

DOI: 10.1074/jbc.m501431200

PubMed ID: 15965233

Title: Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186.

PubMed ID: 15965233

DOI: 10.1074/jbc.m502712200

PubMed ID: 16377779

Title: Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb.

PubMed ID: 16377779

DOI: 10.1093/nar/gki997

PubMed ID: 15940264

Title: The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1.

PubMed ID: 15940264

DOI: 10.1038/sj.onc.1208728

PubMed ID: 15941832

Title: HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b.

PubMed ID: 15941832

DOI: 10.1073/pnas.0409863102

PubMed ID: 17088550

Title: Hexim1 sequesters positive transcription elongation factor b from the class II transactivator on MHC class II promoters.

PubMed ID: 17088550

DOI: 10.1073/pnas.0603079103

PubMed ID: 17643375

Title: Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.

PubMed ID: 17643375

DOI: 10.1016/j.molcel.2007.06.027

PubMed ID: 17452463

Title: Regulation of P-TEFb elongation complex activity by CDK9 acetylation.

PubMed ID: 17452463

DOI: 10.1128/mcb.00857-06

PubMed ID: 17395637

Title: HEXIM1 is a promiscuous double-stranded RNA-binding protein and interacts with RNAs in addition to 7SK in cultured cells.

PubMed ID: 17395637

DOI: 10.1093/nar/gkm150

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19883659

Title: Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA.

PubMed ID: 19883659

DOI: 10.1016/j.jmb.2009.10.055

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28712728

Title: HEXIM1 and NEAT1 Long non-coding RNA form a multi-subunit complex that regulates DNA-mediated innate immune response.

PubMed ID: 28712728

DOI: 10.1016/j.molcel.2017.06.020

PubMed ID: 30134174

Title: Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex.

PubMed ID: 30134174

DOI: 10.1016/j.celrep.2018.07.064

PubMed ID: 17724342

Title: Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb.

PubMed ID: 17724342

DOI: 10.1073/pnas.0701848104

Sequence Information:

  • Length: 359
  • Mass: 40623
  • Checksum: B12845C4E2595FF0
  • Sequence:
    • MAEPFLSEYQ HQPQTSNCTG AAAVQEELNP ERPPGAEERV PEEDSRWQSR AFPQLGGRPG 
PEGEGSLESQ PPPLQTQACP ESSCLREGEK GQNGDDSSAG GDFPPPAEVE PTPEAELLAQ 
PCHDSEASKL GAPAAGGEEE WGQQQRQLGK KKHRRRPSKK KRHWKPYYKL TWEEKKKFDE 
KQSLRASRIR AEMFAKGQPV APYNTTQFLM DDHDQEEPDL KTGLYSKRAA AKSDDTSDDD 
FMEEGGEEDG GSDGMGGDGS EFLQRDFSET YERYHTESLQ NMSKQELIKE YLELEKCLSR 
MEDENNRLRL ESKRLGGDDA RVRELELELD RLRAENLQLL TENELHRQQE RAPLSKFGD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.