CENPE | ENSG00000138778 | NCBI 1062

Details for: CENPE

Gene ID: 1062

Symbol: CENPE

Ensembl ID: ENSG00000138778

Description: centromere protein E

Associated with

Adaptive immune system
(R-HSA-1280218)
Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Kinesins
(R-HSA-983189)
Membrane trafficking
(R-HSA-199991)
Mhc class ii antigen presentation
(R-HSA-2132295)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Vesicle-mediated transport
(R-HSA-5653656)
Atp binding
(GO:0005524)
Attachment of mitotic spindle microtubules to kinetochore
(GO:0051315)
Cell division
(GO:0051301)
Chromosome
(GO:0005694)
Chromosome, centromeric region
(GO:0000775)
Chromosome segregation
(GO:0007059)
Condensed chromosome, centromeric region
(GO:0000779)
Cytosol
(GO:0005829)
Intercellular bridge
(GO:0045171)
Intracellular membrane-bounded organelle
(GO:0043231)
Kinetochore
(GO:0000776)
Kinetochore assembly
(GO:0051382)
Kinetochore binding
(GO:0043515)
Kinetochore microtubule
(GO:0005828)
Lateral attachment of mitotic spindle microtubules to kinetochore
(GO:0099607)
Membrane
(GO:0016020)
Metaphase chromosome alignment
(GO:0051310)
Microtubule
(GO:0005874)
Microtubule-based movement
(GO:0007018)
Microtubule binding
(GO:0008017)
Microtubule cytoskeleton
(GO:0015630)
Microtubule motor activity
(GO:0003777)
Microtubule plus-end directed mitotic chromosome migration
(GO:0099606)
Midbody
(GO:0030496)
Mitotic cell cycle
(GO:0000278)
Mitotic chromosome movement towards spindle pole
(GO:0007079)
Mitotic metaphase chromosome alignment
(GO:0007080)
Mitotic spindle
(GO:0072686)
Mitotic spindle midzone
(GO:1990023)
Mitotic spindle organization
(GO:0007052)
Nucleus
(GO:0005634)
Positive regulation of protein kinase activity
(GO:0045860)
Protein binding
(GO:0005515)
Regulation of mitotic metaphase/anaphase transition
(GO:0030071)
Spindle midzone
(GO:0051233)

Other Information

Proteins

Centromere-associated protein E

Genular Protein ID: 3139227939

Symbol: CENPE_HUMAN

Name: Centromere-associated protein E

UniProtKB Accession Codes:

Q02224 A6NKY9 A8K2U7 Q4LE75

Database IDs:

Citations:

PubMed ID: 1406971

Title: CENP-E is a putative kinetochore motor that accumulates just before mitosis.

PubMed ID: 1406971

DOI: 10.1038/359536a0

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 7889940

Title: Mitotic HeLa cells contain a CENP-E-associated minus end-directed microtubule motor.

PubMed ID: 7889940

DOI: 10.1002/j.1460-2075.1995.tb07073.x

PubMed ID: 9763420

Title: Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1.

PubMed ID: 9763420

DOI: 10.1083/jcb.143.1.49

PubMed ID: 10852915

Title: Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules.

PubMed ID: 10852915

DOI: 10.1074/jbc.m003469200

PubMed ID: 15297875

Title: Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation.

PubMed ID: 15297875

DOI: 10.1038/sj.emboj.7600347

PubMed ID: 17535814

Title: Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment.

PubMed ID: 17535814

DOI: 10.1074/jbc.m609026200

PubMed ID: 18460473

Title: Septin 7 interacts with centromere-associated protein E and is required for its kinetochore localization.

PubMed ID: 18460473

DOI: 10.1074/jbc.m710591200

PubMed ID: 18374647

Title: SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis.

PubMed ID: 18374647

DOI: 10.1016/j.molcel.2008.01.013

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19625775

Title: Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E.

PubMed ID: 19625775

DOI: 10.4161/cc.8.16.9366

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22110139

Title: CENP-E kinesin interacts with SKAP protein to orchestrate accurate chromosome segregation in mitosis.

PubMed ID: 22110139

DOI: 10.1074/jbc.m111.277194

PubMed ID: 23891108

Title: Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK.

PubMed ID: 23891108

DOI: 10.1016/j.cub.2013.06.040

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23955301

Title: Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips.

PubMed ID: 23955301

DOI: 10.1038/ncb2831

PubMed ID: 24748105

Title: Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism.

PubMed ID: 24748105

DOI: 10.1007/s00439-014-1443-3

PubMed ID: 26321640

Title: CTCF recruits centromeric protein CENP-E to the pericentromeric/centromeric regions of chromosomes through unusual CTCF-binding sites.

PubMed ID: 26321640

DOI: 10.1016/j.celrep.2015.08.005

PubMed ID: 25918224

Title: TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment.

PubMed ID: 25918224

DOI: 10.1083/jcb.201501090

PubMed ID: 25395579

Title: Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways.

PubMed ID: 25395579

DOI: 10.1242/jcs.163659

PubMed ID: 25743205

Title: Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules.

PubMed ID: 25743205

DOI: 10.1038/ncomms7447

PubMed ID: 25908662

Title: Mitosis. Microtubule detyrosination guides chromosomes during mitosis.

PubMed ID: 25908662

DOI: 10.1126/science.aaa5175

PubMed ID: 15236970

Title: Crystal structure of the motor domain of the human kinetochore protein CENP-E.

PubMed ID: 15236970

DOI: 10.1016/j.jmb.2004.05.053

Sequence Information:

Length: 2701
Mass: 316415
Checksum: 4BC59C2EF0B02D88
Sequence:

MAEEGAVAVC VRVRPLNSRE ESLGETAQVY WKTDNNVIYQ VDGSKSFNFD RVFHGNETTK 
NVYEEIAAPI IDSAIQGYNG TIFAYGQTAS GKTYTMMGSE DHLGVIPRAI HDIFQKIKKF 
PDREFLLRVS YMEIYNETIT DLLCGTQKMK PLIIREDVNR NVYVADLTEE VVYTSEMALK 
WITKGEKSRH YGETKMNQRS SRSHTIFRMI LESREKGEPS NCEGSVKVSH LNLVDLAGSE 
RAAQTGAAGV RLKEGCNINR SLFILGQVIK KLSDGQVGGF INYRDSKLTR ILQNSLGGNA 
KTRIICTITP VSFDETLTAL QFASTAKYMK NTPYVNEVST DEALLKRYRK EIMDLKKQLE 
EVSLETRAQA MEKDQLAQLL EEKDLLQKVQ NEKIENLTRM LVTSSSLTLQ QELKAKRKRR 
VTWCLGKINK MKNSNYADQF NIPTNITTKT HKLSINLLRE IDESVCSESD VFSNTLDTLS 
EIEWNPATKL LNQENIESEL NSLRADYDNL VLDYEQLRTE KEEMELKLKE KNDLDEFEAL 
ERKTKKDQEM QLIHEISNLK NLVKHAEVYN QDLENELSSK VELLREKEDQ IKKLQEYIDS 
QKLENIKMDL SYSLESIEDP KQMKQTLFDA ETVALDAKRE SAFLRSENLE LKEKMKELAT 
TYKQMENDIQ LYQSQLEAKK KMQVDLEKEL QSAFNEITKL TSLIDGKVPK DLLCNLELEG 
KITDLQKELN KEVEENEALR EEVILLSELK SLPSEVERLR KEIQDKSEEL HIITSEKDKL 
FSEVVHKESR VQGLLEEIGK TKDDLATTQS NYKSTDQEFQ NFKTLHMDFE QKYKMVLEEN 
ERMNQEIVNL SKEAQKFDSS LGALKTELSY KTQELQEKTR EVQERLNEME QLKEQLENRD 
STLQTVEREK TLITEKLQQT LEEVKTLTQE KDDLKQLQES LQIERDQLKS DIHDTVNMNI 
DTQEQLRNAL ESLKQHQETI NTLKSKISEE VSRNLHMEEN TGETKDEFQQ KMVGIDKKQD 
LEAKNTQTLT ADVKDNEIIE QQRKIFSLIQ EKNELQQMLE SVIAEKEQLK TDLKENIEMT 
IENQEELRLL GDELKKQQEI VAQEKNHAIK KEGELSRTCD RLAEVEEKLK EKSQQLQEKQ 
QQLLNVQEEM SEMQKKINEI ENLKNELKNK ELTLEHMETE RLELAQKLNE NYEEVKSITK 
ERKVLKELQK SFETERDHLR GYIREIEATG LQTKEELKIA HIHLKEHQET IDELRRSVSE 
KTAQIINTQD LEKSHTKLQE EIPVLHEEQE LLPNVKEVSE TQETMNELEL LTEQSTTKDS 
TTLARIEMER LRLNEKFQES QEEIKSLTKE RDNLKTIKEA LEVKHDQLKE HIRETLAKIQ 
ESQSKQEQSL NMKEKDNETT KIVSEMEQFK PKDSALLRIE IEMLGLSKRL QESHDEMKSV 
AKEKDDLQRL QEVLQSESDQ LKENIKEIVA KHLETEEELK VAHCCLKEQE ETINELRVNL 
SEKETEISTI QKQLEAINDK LQNKIQEIYE KEEQFNIKQI SEVQEKVNEL KQFKEHRKAK 
DSALQSIESK MLELTNRLQE SQEEIQIMIK EKEEMKRVQE ALQIERDQLK ENTKEIVAKM 
KESQEKEYQF LKMTAVNETQ EKMCEIEHLK EQFETQKLNL ENIETENIRL TQILHENLEE 
MRSVTKERDD LRSVEETLKV ERDQLKENLR ETITRDLEKQ EELKIVHMHL KEHQETIDKL 
RGIVSEKTNE ISNMQKDLEH SNDALKAQDL KIQEELRIAH MHLKEQQETI DKLRGIVSEK 
TDKLSNMQKD LENSNAKLQE KIQELKANEH QLITLKKDVN ETQKKVSEME QLKKQIKDQS 
LTLSKLEIEN LNLAQKLHEN LEEMKSVMKE RDNLRRVEET LKLERDQLKE SLQETKARDL 
EIQQELKTAR MLSKEHKETV DKLREKISEK TIQISDIQKD LDKSKDELQK KIQELQKKEL 
QLLRVKEDVN MSHKKINEME QLKKQFEAQN LSMQSVRMDN FQLTKKLHES LEEIRIVAKE 
RDELRRIKES LKMERDQFIA TLREMIARDR QNHQVKPEKR LLSDGQQHLT ESLREKCSRI 
KELLKRYSEM DDHYECLNRL SLDLEKEIEF QKELSMRVKA NLSLPYLQTK HIEKLFTANQ 
RCSMEFHRIM KKLKYVLSYV TKIKEEQHES INKFEMDFID EVEKQKELLI KIQHLQQDCD 
VPSRELRDLK LNQNMDLHIE EILKDFSESE FPSIKTEFQQ VLSNRKEMTQ FLEEWLNTRF 
DIEKLKNGIQ KENDRICQVN NFFNNRIIAI MNESTEFEER SATISKEWEQ DLKSLKEKNE 
KLFKNYQTLK TSLASGAQVN PTTQDNKNPH VTSRATQLTT EKIRELENSL HEAKESAMHK 
ESKIIKMQKE LEVTNDIIAK LQAKVHESNK CLEKTKETIQ VLQDKVALGA KPYKEEIEDL 
KMKLVKIDLE KMKNAKEFEK EISATKATVE YQKEVIRLLR ENLRRSQQAQ DTSVISEHTD 
PQPSNKPLTC GGGSGIVQNT KALILKSEHI RLEKEISKLK QQNEQLIKQK NELLSNNQHL 
SNEVKTWKER TLKREAHKQV TCENSPKSPK VTGTASKKKQ ITPSQCKERN LQDPVPKESP 
KSCFFDSRSK SLPSPHPVRY FDNSSLGLCP EVQNAGAESV DSQPGPWHAS SGKDVPECKT 
Q

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CENPE

Associated with

Other Information

CENP-E is a putative kinetochore motor that accumulates just before mitosis. PubMed ID: 1406971

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Mitotic HeLa cells contain a CENP-E-associated minus end-directed microtubule motor. PubMed ID: 7889940

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1. PubMed ID: 9763420

Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules. PubMed ID: 10852915

Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. PubMed ID: 15297875

Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment. PubMed ID: 17535814

Septin 7 interacts with centromere-associated protein E and is required for its kinetochore localization. PubMed ID: 18460473

SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis. PubMed ID: 18374647

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E. PubMed ID: 19625775

Initial characterization of the human central proteome. PubMed ID: 21269460

CENP-E kinesin interacts with SKAP protein to orchestrate accurate chromosome segregation in mitosis. PubMed ID: 22110139

Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK. PubMed ID: 23891108

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips. PubMed ID: 23955301

Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism. PubMed ID: 24748105

CTCF recruits centromeric protein CENP-E to the pericentromeric/centromeric regions of chromosomes through unusual CTCF-binding sites. PubMed ID: 26321640

TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment. PubMed ID: 25918224

Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways. PubMed ID: 25395579

Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules. PubMed ID: 25743205

Mitosis. Microtubule detyrosination guides chromosomes during mitosis. PubMed ID: 25908662

Crystal structure of the motor domain of the human kinetochore protein CENP-E. PubMed ID: 15236970