Details for: CENPE

Gene ID: 1062

Symbol: CENPE

Ensembl ID: ENSG00000138778

Description: centromere protein E

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 37.9273
    Cell Significance Index: -9.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.2119
    Cell Significance Index: -9.4300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 10.8280
    Cell Significance Index: 178.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.4536
    Cell Significance Index: -9.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.0316
    Cell Significance Index: -10.8000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.0692
    Cell Significance Index: -2.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9468
    Cell Significance Index: 180.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9467
    Cell Significance Index: 153.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8259
    Cell Significance Index: 96.2500
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.8072
    Cell Significance Index: 6.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8066
    Cell Significance Index: 95.1200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7929
    Cell Significance Index: 8.6200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.7621
    Cell Significance Index: 16.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7183
    Cell Significance Index: 40.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7171
    Cell Significance Index: 20.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7122
    Cell Significance Index: 77.4700
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.7047
    Cell Significance Index: 8.7500
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.6668
    Cell Significance Index: 3.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6047
    Cell Significance Index: 545.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5875
    Cell Significance Index: 116.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5098
    Cell Significance Index: 352.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4439
    Cell Significance Index: 43.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4207
    Cell Significance Index: 12.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4085
    Cell Significance Index: 8.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3640
    Cell Significance Index: 25.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2345
    Cell Significance Index: 12.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1508
    Cell Significance Index: 3.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1454
    Cell Significance Index: 79.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1302
    Cell Significance Index: 2.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1258
    Cell Significance Index: 4.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0971
    Cell Significance Index: 3.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0873
    Cell Significance Index: 1.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0872
    Cell Significance Index: 17.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0869
    Cell Significance Index: 31.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0747
    Cell Significance Index: 2.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0662
    Cell Significance Index: 1.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0653
    Cell Significance Index: 28.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0489
    Cell Significance Index: 8.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0485
    Cell Significance Index: 2.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0326
    Cell Significance Index: 4.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0224
    Cell Significance Index: 0.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0150
    Cell Significance Index: 0.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0017
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0036
    Cell Significance Index: -0.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0046
    Cell Significance Index: -8.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0068
    Cell Significance Index: -10.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0076
    Cell Significance Index: -10.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0126
    Cell Significance Index: -8.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0138
    Cell Significance Index: -10.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0140
    Cell Significance Index: -10.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0144
    Cell Significance Index: -2.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0156
    Cell Significance Index: -11.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0197
    Cell Significance Index: -8.9200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0203
    Cell Significance Index: -0.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0208
    Cell Significance Index: -11.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0280
    Cell Significance Index: -8.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0310
    Cell Significance Index: -3.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0350
    Cell Significance Index: -1.5500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0407
    Cell Significance Index: -0.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0416
    Cell Significance Index: -4.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0421
    Cell Significance Index: -2.5800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0473
    Cell Significance Index: -0.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0543
    Cell Significance Index: -2.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0574
    Cell Significance Index: -12.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0597
    Cell Significance Index: -0.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0647
    Cell Significance Index: -2.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0652
    Cell Significance Index: -4.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0681
    Cell Significance Index: -8.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0700
    Cell Significance Index: -11.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0717
    Cell Significance Index: -4.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0795
    Cell Significance Index: -5.6200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.0815
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0973
    Cell Significance Index: -11.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0975
    Cell Significance Index: -10.1500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1127
    Cell Significance Index: -2.8100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.1161
    Cell Significance Index: -0.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1205
    Cell Significance Index: -9.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1225
    Cell Significance Index: -8.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1277
    Cell Significance Index: -9.5200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1304
    Cell Significance Index: -1.7400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1355
    Cell Significance Index: -2.8100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1430
    Cell Significance Index: -9.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1495
    Cell Significance Index: -7.0300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1847
    Cell Significance Index: -11.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1875
    Cell Significance Index: -4.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1917
    Cell Significance Index: -10.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1959
    Cell Significance Index: -4.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1980
    Cell Significance Index: -9.2300
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.2260
    Cell Significance Index: -2.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2327
    Cell Significance Index: -6.8400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2376
    Cell Significance Index: -1.4100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2405
    Cell Significance Index: -1.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2569
    Cell Significance Index: -9.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2599
    Cell Significance Index: -8.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2647
    Cell Significance Index: -8.4300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2811
    Cell Significance Index: -10.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2893
    Cell Significance Index: -8.5200
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.2902
    Cell Significance Index: -2.1100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2933
    Cell Significance Index: -3.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CENPE is a highly conserved protein that belongs to the centromere protein family. It is characterized by its unique structure, which includes a coiled-coil domain and a C-terminal binding domain. This domain allows CENPE to interact with microtubules and other kinetochore proteins, facilitating the attachment of the mitotic spindle microtubules to the kinetochore. CENPE is also known for its ability to regulate the activity of microtubule motor proteins, such as kinesin-13, which is essential for the proper segregation of sister chromatids. **Pathways and Functions:** CENPE is involved in several critical pathways that regulate the mitotic cell cycle, including: 1. **Kinetochore assembly and function:** CENPE plays a key role in the assembly and function of the kinetochore, which is essential for the attachment of the mitotic spindle microtubules to the centromere. 2. **Microtubule attachment and regulation:** CENPE regulates the attachment of microtubules to the kinetochore and modulates the activity of microtubule motor proteins, such as kinesin-13. 3. **Cell cycle regulation:** CENPE is involved in the regulation of the mitotic cell cycle, including the metaphase-anaphase transition and the separation of sister chromatids. 4. **Chromosome segregation:** CENPE is essential for the proper segregation of sister chromatids during mitosis, ensuring accurate genome transmission to daughter cells. **Clinical Significance:** Dysregulation of CENPE has been implicated in various diseases, including: 1. **Cancer:** Mutations in CENPE have been associated with several types of cancer, including breast, lung, and colon cancer. 2. **Infertility:** Abnormalities in CENPE expression have been linked to infertility, particularly in cases of premature ovarian failure. 3. **Neurological disorders:** CENPE has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, CENPE is a critical protein that plays a central role in the regulation of the mitotic cell cycle. Its dysregulation has significant implications for human health, and further research is needed to fully understand the complexities of CENPE and its role in disease pathogenesis.

Genular Protein ID: 3139227939

Symbol: CENPE_HUMAN

Name: Centromere-associated protein E

UniProtKB Accession Codes:

Q02224 A6NKY9 A8K2U7 Q4LE75

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 34 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 9 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1406971

Title: CENP-E is a putative kinetochore motor that accumulates just before mitosis.

PubMed ID: 1406971

DOI: 10.1038/359536a0

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 7889940

Title: Mitotic HeLa cells contain a CENP-E-associated minus end-directed microtubule motor.

PubMed ID: 7889940

DOI: 10.1002/j.1460-2075.1995.tb07073.x

PubMed ID: 9763420

Title: Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1.

PubMed ID: 9763420

DOI: 10.1083/jcb.143.1.49

PubMed ID: 10852915

Title: Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules.

PubMed ID: 10852915

DOI: 10.1074/jbc.m003469200

PubMed ID: 15297875

Title: Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation.

PubMed ID: 15297875

DOI: 10.1038/sj.emboj.7600347

PubMed ID: 17535814

Title: Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment.

PubMed ID: 17535814

DOI: 10.1074/jbc.m609026200

PubMed ID: 18460473

Title: Septin 7 interacts with centromere-associated protein E and is required for its kinetochore localization.

PubMed ID: 18460473

DOI: 10.1074/jbc.m710591200

PubMed ID: 18374647

Title: SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis.

PubMed ID: 18374647

DOI: 10.1016/j.molcel.2008.01.013

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19625775

Title: Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E.

PubMed ID: 19625775

DOI: 10.4161/cc.8.16.9366

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22110139

Title: CENP-E kinesin interacts with SKAP protein to orchestrate accurate chromosome segregation in mitosis.

PubMed ID: 22110139

DOI: 10.1074/jbc.m111.277194

PubMed ID: 23891108

Title: Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK.

PubMed ID: 23891108

DOI: 10.1016/j.cub.2013.06.040

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23955301

Title: Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips.

PubMed ID: 23955301

DOI: 10.1038/ncb2831

PubMed ID: 24748105

Title: Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism.

PubMed ID: 24748105

DOI: 10.1007/s00439-014-1443-3

PubMed ID: 26321640

Title: CTCF recruits centromeric protein CENP-E to the pericentromeric/centromeric regions of chromosomes through unusual CTCF-binding sites.

PubMed ID: 26321640

DOI: 10.1016/j.celrep.2015.08.005

PubMed ID: 25918224

Title: TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment.

PubMed ID: 25918224

DOI: 10.1083/jcb.201501090

PubMed ID: 25395579

Title: Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways.

PubMed ID: 25395579

DOI: 10.1242/jcs.163659

PubMed ID: 25743205

Title: Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules.

PubMed ID: 25743205

DOI: 10.1038/ncomms7447

PubMed ID: 25908662

Title: Mitosis. Microtubule detyrosination guides chromosomes during mitosis.

PubMed ID: 25908662

DOI: 10.1126/science.aaa5175

PubMed ID: 15236970

Title: Crystal structure of the motor domain of the human kinetochore protein CENP-E.

PubMed ID: 15236970

DOI: 10.1016/j.jmb.2004.05.053

Sequence Information:

  • Length: 2701
  • Mass: 316415
  • Checksum: 4BC59C2EF0B02D88
  • Sequence:
    • MAEEGAVAVC VRVRPLNSRE ESLGETAQVY WKTDNNVIYQ VDGSKSFNFD RVFHGNETTK 
NVYEEIAAPI IDSAIQGYNG TIFAYGQTAS GKTYTMMGSE DHLGVIPRAI HDIFQKIKKF 
PDREFLLRVS YMEIYNETIT DLLCGTQKMK PLIIREDVNR NVYVADLTEE VVYTSEMALK 
WITKGEKSRH YGETKMNQRS SRSHTIFRMI LESREKGEPS NCEGSVKVSH LNLVDLAGSE 
RAAQTGAAGV RLKEGCNINR SLFILGQVIK KLSDGQVGGF INYRDSKLTR ILQNSLGGNA 
KTRIICTITP VSFDETLTAL QFASTAKYMK NTPYVNEVST DEALLKRYRK EIMDLKKQLE 
EVSLETRAQA MEKDQLAQLL EEKDLLQKVQ NEKIENLTRM LVTSSSLTLQ QELKAKRKRR 
VTWCLGKINK MKNSNYADQF NIPTNITTKT HKLSINLLRE IDESVCSESD VFSNTLDTLS 
EIEWNPATKL LNQENIESEL NSLRADYDNL VLDYEQLRTE KEEMELKLKE KNDLDEFEAL 
ERKTKKDQEM QLIHEISNLK NLVKHAEVYN QDLENELSSK VELLREKEDQ IKKLQEYIDS 
QKLENIKMDL SYSLESIEDP KQMKQTLFDA ETVALDAKRE SAFLRSENLE LKEKMKELAT 
TYKQMENDIQ LYQSQLEAKK KMQVDLEKEL QSAFNEITKL TSLIDGKVPK DLLCNLELEG 
KITDLQKELN KEVEENEALR EEVILLSELK SLPSEVERLR KEIQDKSEEL HIITSEKDKL 
FSEVVHKESR VQGLLEEIGK TKDDLATTQS NYKSTDQEFQ NFKTLHMDFE QKYKMVLEEN 
ERMNQEIVNL SKEAQKFDSS LGALKTELSY KTQELQEKTR EVQERLNEME QLKEQLENRD 
STLQTVEREK TLITEKLQQT LEEVKTLTQE KDDLKQLQES LQIERDQLKS DIHDTVNMNI 
DTQEQLRNAL ESLKQHQETI NTLKSKISEE VSRNLHMEEN TGETKDEFQQ KMVGIDKKQD 
LEAKNTQTLT ADVKDNEIIE QQRKIFSLIQ EKNELQQMLE SVIAEKEQLK TDLKENIEMT 
IENQEELRLL GDELKKQQEI VAQEKNHAIK KEGELSRTCD RLAEVEEKLK EKSQQLQEKQ 
QQLLNVQEEM SEMQKKINEI ENLKNELKNK ELTLEHMETE RLELAQKLNE NYEEVKSITK 
ERKVLKELQK SFETERDHLR GYIREIEATG LQTKEELKIA HIHLKEHQET IDELRRSVSE 
KTAQIINTQD LEKSHTKLQE EIPVLHEEQE LLPNVKEVSE TQETMNELEL LTEQSTTKDS 
TTLARIEMER LRLNEKFQES QEEIKSLTKE RDNLKTIKEA LEVKHDQLKE HIRETLAKIQ 
ESQSKQEQSL NMKEKDNETT KIVSEMEQFK PKDSALLRIE IEMLGLSKRL QESHDEMKSV 
AKEKDDLQRL QEVLQSESDQ LKENIKEIVA KHLETEEELK VAHCCLKEQE ETINELRVNL 
SEKETEISTI QKQLEAINDK LQNKIQEIYE KEEQFNIKQI SEVQEKVNEL KQFKEHRKAK 
DSALQSIESK MLELTNRLQE SQEEIQIMIK EKEEMKRVQE ALQIERDQLK ENTKEIVAKM 
KESQEKEYQF LKMTAVNETQ EKMCEIEHLK EQFETQKLNL ENIETENIRL TQILHENLEE 
MRSVTKERDD LRSVEETLKV ERDQLKENLR ETITRDLEKQ EELKIVHMHL KEHQETIDKL 
RGIVSEKTNE ISNMQKDLEH SNDALKAQDL KIQEELRIAH MHLKEQQETI DKLRGIVSEK 
TDKLSNMQKD LENSNAKLQE KIQELKANEH QLITLKKDVN ETQKKVSEME QLKKQIKDQS 
LTLSKLEIEN LNLAQKLHEN LEEMKSVMKE RDNLRRVEET LKLERDQLKE SLQETKARDL 
EIQQELKTAR MLSKEHKETV DKLREKISEK TIQISDIQKD LDKSKDELQK KIQELQKKEL 
QLLRVKEDVN MSHKKINEME QLKKQFEAQN LSMQSVRMDN FQLTKKLHES LEEIRIVAKE 
RDELRRIKES LKMERDQFIA TLREMIARDR QNHQVKPEKR LLSDGQQHLT ESLREKCSRI 
KELLKRYSEM DDHYECLNRL SLDLEKEIEF QKELSMRVKA NLSLPYLQTK HIEKLFTANQ 
RCSMEFHRIM KKLKYVLSYV TKIKEEQHES INKFEMDFID EVEKQKELLI KIQHLQQDCD 
VPSRELRDLK LNQNMDLHIE EILKDFSESE FPSIKTEFQQ VLSNRKEMTQ FLEEWLNTRF 
DIEKLKNGIQ KENDRICQVN NFFNNRIIAI MNESTEFEER SATISKEWEQ DLKSLKEKNE 
KLFKNYQTLK TSLASGAQVN PTTQDNKNPH VTSRATQLTT EKIRELENSL HEAKESAMHK 
ESKIIKMQKE LEVTNDIIAK LQAKVHESNK CLEKTKETIQ VLQDKVALGA KPYKEEIEDL 
KMKLVKIDLE KMKNAKEFEK EISATKATVE YQKEVIRLLR ENLRRSQQAQ DTSVISEHTD 
PQPSNKPLTC GGGSGIVQNT KALILKSEHI RLEKEISKLK QQNEQLIKQK NELLSNNQHL 
SNEVKTWKER TLKREAHKQV TCENSPKSPK VTGTASKKKQ ITPSQCKERN LQDPVPKESP 
KSCFFDSRSK SLPSPHPVRY FDNSSLGLCP EVQNAGAESV DSQPGPWHAS SGKDVPECKT 
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Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.