Details for: IVNS1ABP

Gene ID: 10625

Symbol: IVNS1ABP

Ensembl ID: ENSG00000116679

Description: influenza virus NS1A binding protein

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.83
    Marker Score: 5,149
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.27
    Marker Score: 3,961
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 3.23
    Marker Score: 3,428
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.87
    Marker Score: 7,689
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.52
    Marker Score: 6,358
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.36
    Marker Score: 2,482
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.21
    Marker Score: 1,704
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.11
    Marker Score: 2,991
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.94
    Marker Score: 1,967
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.89
    Marker Score: 817
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.87
    Marker Score: 2,145
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.85
    Marker Score: 5,046
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.79
    Marker Score: 4,082
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.79
    Marker Score: 1,045
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.69
    Marker Score: 4,216
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.67
    Marker Score: 1,263
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.65
    Marker Score: 16,625
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.63
    Marker Score: 2,108
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.62
    Marker Score: 1,746
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.56
    Marker Score: 1,045
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.54
    Marker Score: 720
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.52
    Marker Score: 52,755
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.52
    Marker Score: 13,350
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.52
    Marker Score: 6,313
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.51
    Marker Score: 1,600
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.49
    Marker Score: 4,124
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.49
    Marker Score: 577
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.48
    Marker Score: 502
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.47
    Marker Score: 4,618
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.45
    Marker Score: 37,167
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.43
    Marker Score: 2,099
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.42
    Marker Score: 1,425
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.42
    Marker Score: 718
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.42
    Marker Score: 278
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.41
    Marker Score: 1,504
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.41
    Marker Score: 330
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.39
    Marker Score: 10,349
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.36
    Marker Score: 1,926
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.35
    Marker Score: 822
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.35
    Marker Score: 2,353
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.33
    Marker Score: 45,263
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.32
    Marker Score: 4,698
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.32
    Marker Score: 1,265
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.31
    Marker Score: 1,033
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.3
    Marker Score: 413
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.29
    Marker Score: 1,430
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.28
    Marker Score: 1,333
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.28
    Marker Score: 445
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.27
    Marker Score: 304
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.27
    Marker Score: 1,264
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.26
    Marker Score: 987
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.25
    Marker Score: 498
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.24
    Marker Score: 967
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.23
    Marker Score: 68,912
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.23
    Marker Score: 3,456
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.23
    Marker Score: 358
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.22
    Marker Score: 4,200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.21
    Marker Score: 1,466
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.21
    Marker Score: 5,797
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.2
    Marker Score: 876
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.2
    Marker Score: 452
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.2
    Marker Score: 1,304
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.2
    Marker Score: 1,982
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.19
    Marker Score: 296
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.19
    Marker Score: 2,903
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.18
    Marker Score: 264
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.18
    Marker Score: 1,059
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.18
    Marker Score: 494
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.17
    Marker Score: 1,043
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.17
    Marker Score: 263
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.16
    Marker Score: 255
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.16
    Marker Score: 2,642
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.15
    Marker Score: 6,998
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.14
    Marker Score: 291
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.14
    Marker Score: 276
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.14
    Marker Score: 641
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.14
    Marker Score: 1,230
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.14
    Marker Score: 2,705
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.14
    Marker Score: 299
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.14
    Marker Score: 352
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.13
    Marker Score: 6,711
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.13
    Marker Score: 3,301
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.13
    Marker Score: 458
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.13
    Marker Score: 650
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.13
    Marker Score: 648
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.13
    Marker Score: 326
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.13
    Marker Score: 1,966
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.13
    Marker Score: 1,061
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.13
    Marker Score: 277
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.12
    Marker Score: 970
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.12
    Marker Score: 9,753
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 1.12
    Marker Score: 294
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.12
    Marker Score: 742
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.11
    Marker Score: 2,886
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.11
    Marker Score: 1,183
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.11
    Marker Score: 696
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.11
    Marker Score: 337
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.11
    Marker Score: 2,308
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.1
    Marker Score: 724
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.1
    Marker Score: 747

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IVNS1ABP gene is a non-coding RNA gene that encodes a protein, NS1BP_HUMAN, which is specifically bound by the influenza virus NS1A protein. This interaction is essential for the virus's ability to modulate the host immune response and facilitate its replication. The IVNS1ABP gene is also involved in various cellular processes, including RNA splicing, transcription regulation, and protein ubiquitination. Its expression is restricted to specific cell types, suggesting a cell-type-specific function. **Pathways and Functions:** The IVNS1ABP gene is involved in several key pathways, including: 1. **Intrinsic Apoptotic Signaling Pathway:** IVNS1ABP regulates the intrinsic apoptotic pathway by inhibiting the activity of pro-apoptotic proteins, thereby promoting cell survival and inhibiting programmed cell death. 2. **Negative Regulation of Intrinsic Apoptotic Signaling Pathway:** IVNS1ABP acts as a negative regulator of the intrinsic apoptotic pathway, preventing excessive cell death and promoting viral replication. 3. **Negative Regulation of Protein Ubiquitination:** IVNS1ABP regulates the ubiquitination of proteins, which is a key mechanism for protein degradation and regulation. 4. **Cytoskeleton and Cytosol Regulation:** IVNS1ABP is involved in regulating the cytoskeleton and cytosol, which are essential for cell shape, movement, and intracellular trafficking. **Clinical Significance:** The IVNS1ABP gene has significant clinical implications, particularly in the context of influenza virus infections. Dysregulation of the IVNS1ABP gene could lead to: 1. **Enhanced Viral Replication:** Overexpression of IVNS1ABP could promote viral replication and increase the severity of influenza virus infections. 2. **Immune Evasion:** IVNS1ABP's ability to evade the host immune response could lead to the development of novel therapeutic strategies, such as targeting the IVNS1ABP-NS1A interaction. 3. **Cancer Development:** Alterations in the IVNS1ABP gene could contribute to the development of cancer, particularly in cell types that express this gene, such as lens epithelial cells. In conclusion, the IVNS1ABP gene is a critical component of the influenza virus's immune evasion strategy, and its dysregulation could have significant implications for the development of novel therapeutic strategies. Further research is necessary to fully understand the mechanisms of IVNS1ABP and its role in various cellular processes.

Genular Protein ID: 570242221

Symbol: NS1BP_HUMAN

Name: Influenza virus NS1A-binding protein

UniProtKB Accession Codes:

Q9Y6Y0 A8K8R6 Q1G4T6 Q1G4T7 Q5TF75 Q6NW38 Q7LCG2 Q9NZX0 Q9Y480

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 3 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9696811

Title: NS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells.

PubMed ID: 9696811

DOI: 10.1128/jvi.72.9.7170-7180.1998

PubMed ID: 16582008

Title: The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein.

PubMed ID: 16582008

DOI: 10.1124/mol.106.024380

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23825951

Title: Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing.

PubMed ID: 23825951

DOI: 10.1371/journal.ppat.1003460

PubMed ID: 25619834

Title: KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination.

PubMed ID: 25619834

DOI: 10.1038/onc.2014.435

PubMed ID: 32499645

Title: Whole-genome sequencing of a sporadic primary immunodeficiency cohort.

PubMed ID: 32499645

DOI: 10.1038/s41586-020-2265-1

PubMed ID: 29497022

Title: Crystal structure of the Kelch domain of human NS1-binding protein at 1.98A resolution.

PubMed ID: 29497022

DOI: 10.1107/s2053230x18001577

Sequence Information:

  • Length: 642
  • Mass: 71729
  • Checksum: 456E30DC4E351CCD
  • Sequence:
    • MIPNGYLMFE DENFIESSVA KLNALRKSGQ FCDVRLQVCG HEMLAHRAVL ACCSPYLFEI 
FNSDSDPHGI SHVKFDDLNP EAVEVLLNYA YTAQLKADKE LVKDVYSAAK KLKMDRVKQV 
CGDYLLSRMD VTSCISYRNF ASCMGDSRLL NKVDAYIQEH LLQISEEEEF LKLPRLKLEV 
MLEDNVCLPS NGKLYTKVIN WVQRSIWENG DSLEELMEEV QTLYYSADHK LLDGNLLDGQ 
AEVFGSDDDH IQFVQKKPPR ENGHKQISSS STGCLSSPNA TVQSPKHEWK IVASEKTSNN 
TYLCLAVLDG IFCVIFLHGR NSPQSSPTST PKLSKSLSFE MQQDELIEKP MSPMQYARSG 
LGTAEMNGKL IAAGGYNREE CLRTVECYNP HTDHWSFLAP MRTPRARFQM AVLMGQLYVV 
GGSNGHSDDL SCGEMYDSNI DDWIPVPELR TNRCNAGVCA LNGKLYIVGG SDPYGQKGLK 
NCDVFDPVTK LWTSCAPLNI RRHQSAVCEL GGYLYIIGGA ESWNCLNTVE RYNPENNTWT 
LIAPMNVARR GAGVAVLNGK LFVCGGFDGS HAISCVEMYD PTRNEWKMMG NMTSPRSNAG 
IATVGNTIYA VGGFDGNEFL NTVEVYNLES NEWSPYTKIF QF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.