Details for: TXNIP

Gene ID: 10628

Symbol: TXNIP

Ensembl ID: ENSG00000265972

Description: thioredoxin interacting protein

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 9.38
    Marker Score: 26,478
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 9.2
    Marker Score: 122,413
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 5
    Marker Score: 3,290
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.95
    Marker Score: 12,572
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 4.93
    Marker Score: 10,343
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 4.68
    Marker Score: 13,666
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 4.67
    Marker Score: 3,294
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 4.59
    Marker Score: 2,227
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 4.44
    Marker Score: 3,898
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.29
    Marker Score: 42,477
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.29
    Marker Score: 13,532
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 4.22
    Marker Score: 7,004
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.21
    Marker Score: 48,978
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 4.21
    Marker Score: 17,469
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.2
    Marker Score: 4,056
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.15
    Marker Score: 219,365
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.15
    Marker Score: 7,114
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.14
    Marker Score: 36,307
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.11
    Marker Score: 5,351
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.06
    Marker Score: 17,397
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.04
    Marker Score: 2,453
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 4.02
    Marker Score: 3,961
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 4.01
    Marker Score: 1,176
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.97
    Marker Score: 10,020
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.84
    Marker Score: 10,300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.84
    Marker Score: 85,718
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 3.78
    Marker Score: 4,006
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 3.77
    Marker Score: 5,335
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.72
    Marker Score: 207,947
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.71
    Marker Score: 5,376
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.65
    Marker Score: 8,906
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.59
    Marker Score: 10,069
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.54
    Marker Score: 1,888
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.54
    Marker Score: 6,320
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.53
    Marker Score: 5,197
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.5
    Marker Score: 1,808
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.43
    Marker Score: 3,066
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.39
    Marker Score: 3,230
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.39
    Marker Score: 2,851
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 3.39
    Marker Score: 1,101
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.39
    Marker Score: 3,184
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.36
    Marker Score: 3,143
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.31
    Marker Score: 2,847
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.2
    Marker Score: 23,808
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.19
    Marker Score: 2,272
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.18
    Marker Score: 2,830
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 3.16
    Marker Score: 1,104
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.16
    Marker Score: 1,579
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 3.15
    Marker Score: 1,360
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 3.14
    Marker Score: 1,966
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.12
    Marker Score: 2,764
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.11
    Marker Score: 11,073
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 3.11
    Marker Score: 3,351
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 3.09
    Marker Score: 6,049
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.06
    Marker Score: 6,103
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.05
    Marker Score: 105,482
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 3.02
    Marker Score: 1,105
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.99
    Marker Score: 696
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.99
    Marker Score: 3,195
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.99
    Marker Score: 983
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.97
    Marker Score: 1,789
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.95
    Marker Score: 2,160
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.94
    Marker Score: 2,492
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 2.91
    Marker Score: 1,776
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.9
    Marker Score: 2,375
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.9
    Marker Score: 5,570
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.89
    Marker Score: 1,024
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 2.89
    Marker Score: 1,170
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.87
    Marker Score: 73,535
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.87
    Marker Score: 7,150
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.87
    Marker Score: 3,278
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.86
    Marker Score: 8,971
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.85
    Marker Score: 1,672
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.84
    Marker Score: 2,058
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.83
    Marker Score: 2,143
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.83
    Marker Score: 31,827
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.83
    Marker Score: 1,889
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.78
    Marker Score: 861
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.76
    Marker Score: 1,838
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.75
    Marker Score: 697
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.73
    Marker Score: 11,753
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 2.72
    Marker Score: 723
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 2.72
    Marker Score: 944
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 2.72
    Marker Score: 1,518
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.71
    Marker Score: 1,666
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.7
    Marker Score: 1,389
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.7
    Marker Score: 1,541
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.7
    Marker Score: 2,905
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.68
    Marker Score: 2,721
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 2.66
    Marker Score: 1,344
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.65
    Marker Score: 2,008
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.65
    Marker Score: 1,483
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.65
    Marker Score: 2,884
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.64
    Marker Score: 1,493
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.64
    Marker Score: 4,957
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.55
    Marker Score: 944
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.55
    Marker Score: 2,938
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 2.54
    Marker Score: 2,745
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.54
    Marker Score: 1,682
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.53
    Marker Score: 3,059

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TXNIP is a 22-kDa protein that is expressed in various tissues, including the heart, skeletal muscle, and immune cells. It is characterized by its ability to interact with thioredoxin, which is a key player in the regulation of cellular redox status. TXNIP is also a potent inhibitor of the NADPH oxidase system, which is a major source of reactive oxygen species (ROS) in cells. Additionally, TXNIP has been shown to regulate the activity of various transcription factors, including FoxO, which is involved in the regulation of cellular metabolism and stress responses. **Pathways and Functions** TXNIP modulates various signaling pathways involved in cellular stress responses, including: 1. **Oxidative Stress Response**: TXNIP inhibits the NADPH oxidase system, which is a major source of ROS in cells. This inhibition reduces the production of ROS and mitigates oxidative stress. 2. **Endoplasmic Reticulum Stress Response**: TXNIP regulates the activity of the unfolded protein response (UPR), which is a cellular response to ER stress. 3. **Nutrient Deprivation Response**: TXNIP regulates the activity of the mTOR signaling pathway, which is involved in the regulation of cellular metabolism and growth. 4. **Apoptosis**: TXNIP is a pro-apoptotic protein that regulates the activity of various apoptosis-related genes and proteins. **Clinical Significance** Dysregulation of TXNIP has been implicated in various diseases, including: 1. **Metabolic Disorders**: TXNIP has been shown to play a role in the development of metabolic disorders, including insulin resistance and type 2 diabetes. 2. **Cancer**: TXNIP has been shown to regulate the activity of various oncogenes and tumor suppressors, and its dysregulation has been implicated in the development of various types of cancer. 3. **Infectious Diseases**: TXNIP has been shown to regulate the activity of various immune cells and signaling pathways, and its dysregulation has been implicated in the development of infectious diseases, including Leishmania infection. 4. **Cardiovascular Disease**: TXNIP has been shown to regulate the activity of various cardiovascular genes and proteins, and its dysregulation has been implicated in the development of cardiovascular disease. In conclusion, TXNIP is a multifunctional protein that plays a crucial role in regulating cellular stress responses, including oxidative stress, endoplasmic reticulum stress, and nutrient deprivation. Its dysregulation has been implicated in various diseases, including metabolic disorders, cancer, and infectious diseases. Further research is needed to fully understand the role of TXNIP in disease pathogenesis and to develop therapeutic strategies to modulate its activity.

Genular Protein ID: 2329079693

Symbol: TXNIP_HUMAN

Name: Thioredoxin-interacting protein

UniProtKB Accession Codes:

Q9H3M7 B4E3D3 Q16226 Q6PML0 Q9BXG9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 2 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 11 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8086474

Title: Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3.

PubMed ID: 8086474

DOI: 10.1016/0167-4781(94)90242-9

PubMed ID: 17603038

Title: Regulation of the bioavailability of thioredoxin in the lens by a specific thioredoxin-binding protein (TBP-2).

PubMed ID: 17603038

DOI: 10.1016/j.exer.2007.05.001

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12821938

Title: VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression.

PubMed ID: 12821938

DOI: 10.1038/sj.onc.1206610

PubMed ID: 18541147

Title: hnRNP G elicits tumor-suppressive activity in part by upregulating the expression of Txnip.

PubMed ID: 18541147

DOI: 10.1016/j.bbrc.2008.05.175

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068034

Title: The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation.

PubMed ID: 20068034

DOI: 10.1074/jbc.m109.063321

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21460850

Title: TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1.

PubMed ID: 21460850

DOI: 10.1038/onc.2011.102

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23519408

Title: Structure of the N-terminal domain of human thioredoxin-interacting protein.

PubMed ID: 23519408

DOI: 10.1107/s0907444912047099

Sequence Information:

  • Length: 391
  • Mass: 43661
  • Checksum: B0FE2D35D0B0735A
  • Sequence:
    • MVMFKKIKSF EVVFNDPEKV YGSGEKVAGR VIVEVCEVTR VKAVRILACG VAKVLWMQGS 
QQCKQTSEYL RYEDTLLLED QPTGENEMVI MRPGNKYEYK FGFELPQGPL GTSFKGKYGC 
VDYWVKAFLD RPSQPTQETK KNFEVVDLVD VNTPDLMAPV SAKKEKKVSC MFIPDGRVSV 
SARIDRKGFC EGDEISIHAD FENTCSRIVV PKAAIVARHT YLANGQTKVL TQKLSSVRGN 
HIISGTCASW RGKSLRVQKI RPSILGCNIL RVEYSLLIYV SVPGSKKVIL DLPLVIGSRS 
GLSSRTSSMA SRTSSEMSWV DLNIPDTPEA PPCYMDVIPE DHRLESPTTP LLDDMDGSQD 
SPIFMYAPEF KFMPPPTYTE VDPCILNNNV Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.