TXNIP | ENSG00000265972 | NCBI 10628

Details for: TXNIP

Gene ID: 10628

Symbol: TXNIP

Ensembl ID: ENSG00000265972

Description: thioredoxin interacting protein

Associated with

Cell recruitment (pro-inflammatory response)
(R-HSA-9664424)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cytoprotection by hmox1
(R-HSA-9707564)
Disease
(R-HSA-1643685)
Foxo-mediated transcription
(R-HSA-9614085)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Inflammasomes
(R-HSA-622312)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-HSA-168643)
Parasitic infection pathways
(R-HSA-9824443)
Purinergic signaling in leishmaniasis infection
(R-HSA-9660826)
Regulation of foxo transcriptional activity by acetylation
(R-HSA-9617629)
Rna polymerase ii transcription
(R-HSA-73857)
The nlrp3 inflammasome
(R-HSA-844456)
Cell cycle
(GO:0007049)
Cellular response to oxidised low-density lipoprotein particle stimulus
(GO:0140052)
Cellular response to tumor cell
(GO:0071228)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Enzyme inhibitor activity
(GO:0004857)
Inflammatory response
(GO:0006954)
Keratinocyte differentiation
(GO:0030216)
Negative regulation of cell division
(GO:0051782)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Platelet-derived growth factor receptor signaling pathway
(GO:0048008)
Positive regulation of apoptotic process
(GO:0043065)
Protein binding
(GO:0005515)
Protein import into nucleus
(GO:0006606)
Protein transport
(GO:0015031)
Regulation of cell population proliferation
(GO:0042127)
Response to calcium ion
(GO:0051592)
Response to estradiol
(GO:0032355)
Response to glucose
(GO:0009749)
Response to hydrogen peroxide
(GO:0042542)
Response to mechanical stimulus
(GO:0009612)
Response to progesterone
(GO:0032570)
Response to xenobiotic stimulus
(GO:0009410)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Thioredoxin-interacting protein

Genular Protein ID: 2329079693

Symbol: TXNIP_HUMAN

Name: Thioredoxin-interacting protein

UniProtKB Accession Codes:

Q9H3M7 B4E3D3 Q16226 Q6PML0 Q9BXG9

Database IDs:

Citations:

PubMed ID: 8086474

Title: Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3.

PubMed ID: 8086474

DOI: 10.1016/0167-4781(94)90242-9

PubMed ID: 17603038

Title: Regulation of the bioavailability of thioredoxin in the lens by a specific thioredoxin-binding protein (TBP-2).

PubMed ID: 17603038

DOI: 10.1016/j.exer.2007.05.001

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12821938

Title: VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression.

PubMed ID: 12821938

DOI: 10.1038/sj.onc.1206610

PubMed ID: 18541147

Title: hnRNP G elicits tumor-suppressive activity in part by upregulating the expression of Txnip.

PubMed ID: 18541147

DOI: 10.1016/j.bbrc.2008.05.175

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068034

Title: The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation.

PubMed ID: 20068034

DOI: 10.1074/jbc.m109.063321

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21460850

Title: TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1.

PubMed ID: 21460850

DOI: 10.1038/onc.2011.102

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23519408

Title: Structure of the N-terminal domain of human thioredoxin-interacting protein.

PubMed ID: 23519408

DOI: 10.1107/s0907444912047099

Sequence Information:

Length: 391
Mass: 43661
Checksum: B0FE2D35D0B0735A
Sequence:

MVMFKKIKSF EVVFNDPEKV YGSGEKVAGR VIVEVCEVTR VKAVRILACG VAKVLWMQGS 
QQCKQTSEYL RYEDTLLLED QPTGENEMVI MRPGNKYEYK FGFELPQGPL GTSFKGKYGC 
VDYWVKAFLD RPSQPTQETK KNFEVVDLVD VNTPDLMAPV SAKKEKKVSC MFIPDGRVSV 
SARIDRKGFC EGDEISIHAD FENTCSRIVV PKAAIVARHT YLANGQTKVL TQKLSSVRGN 
HIISGTCASW RGKSLRVQKI RPSILGCNIL RVEYSLLIYV SVPGSKKVIL DLPLVIGSRS 
GLSSRTSSMA SRTSSEMSWV DLNIPDTPEA PPCYMDVIPE DHRLESPTTP LLDDMDGSQD 
SPIFMYAPEF KFMPPPTYTE VDPCILNNNV Q

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TXNIP

Associated with

Other Information

Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3. PubMed ID: 8086474

Regulation of the bioavailability of thioredoxin in the lens by a specific thioredoxin-binding protein (TBP-2). PubMed ID: 17603038

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression. PubMed ID: 12821938

hnRNP G elicits tumor-suppressive activity in part by upregulating the expression of Txnip. PubMed ID: 18541147

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation. PubMed ID: 20068034

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1. PubMed ID: 21460850

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Structure of the N-terminal domain of human thioredoxin-interacting protein. PubMed ID: 23519408