Details for: CENPF

Gene ID: 1063

Symbol: CENPF

Ensembl ID: ENSG00000117724

Description: centromere protein F

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 49.2029
    Cell Significance Index: -12.4800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 38.6942
    Cell Significance Index: -15.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 31.8244
    Cell Significance Index: -15.0300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 29.8949
    Cell Significance Index: -12.1500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 22.4434
    Cell Significance Index: -15.0600
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 22.2000
    Cell Significance Index: 10.1100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.8516
    Cell Significance Index: -12.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.9111
    Cell Significance Index: -12.2200
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 6.8526
    Cell Significance Index: 5.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.9204
    Cell Significance Index: -15.8600
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 5.2022
    Cell Significance Index: 29.5700
  • Cell Name: germ cell (CL0000586)
    Fold Change: 4.6532
    Cell Significance Index: 35.1400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.3758
    Cell Significance Index: -13.4400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8494
    Cell Significance Index: -15.1900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.0925
    Cell Significance Index: 33.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.4711
    Cell Significance Index: 66.1000
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.0902
    Cell Significance Index: 5.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.8809
    Cell Significance Index: 357.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6394
    Cell Significance Index: 325.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6086
    Cell Significance Index: 261.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5522
    Cell Significance Index: 87.1000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.5400
    Cell Significance Index: 15.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4576
    Cell Significance Index: 171.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3973
    Cell Significance Index: 138.2300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3216
    Cell Significance Index: 143.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.2941
    Cell Significance Index: 33.0600
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.1895
    Cell Significance Index: 5.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.1816
    Cell Significance Index: 41.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1374
    Cell Significance Index: 132.5500
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 1.0933
    Cell Significance Index: 17.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0834
    Cell Significance Index: 31.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0549
    Cell Significance Index: 22.0800
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.9648
    Cell Significance Index: 11.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9288
    Cell Significance Index: 838.6600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.9182
    Cell Significance Index: 2.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6462
    Cell Significance Index: 352.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6293
    Cell Significance Index: 43.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5809
    Cell Significance Index: 14.5200
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.5728
    Cell Significance Index: 3.8000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.5552
    Cell Significance Index: -1.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4434
    Cell Significance Index: 12.3900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.4405
    Cell Significance Index: 3.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4331
    Cell Significance Index: 13.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4059
    Cell Significance Index: 10.8800
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.3259
    Cell Significance Index: 2.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2556
    Cell Significance Index: 13.2800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.2002
    Cell Significance Index: 1.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1920
    Cell Significance Index: 84.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1582
    Cell Significance Index: 3.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1540
    Cell Significance Index: 4.0500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1503
    Cell Significance Index: 9.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1198
    Cell Significance Index: 5.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1148
    Cell Significance Index: 7.4100
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.1051
    Cell Significance Index: 0.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1043
    Cell Significance Index: 2.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0794
    Cell Significance Index: 2.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0614
    Cell Significance Index: 3.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0561
    Cell Significance Index: 35.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0521
    Cell Significance Index: 1.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0275
    Cell Significance Index: 0.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0263
    Cell Significance Index: 3.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0095
    Cell Significance Index: 1.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0062
    Cell Significance Index: -4.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0064
    Cell Significance Index: -12.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0118
    Cell Significance Index: -21.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0129
    Cell Significance Index: -2.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0140
    Cell Significance Index: -21.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0156
    Cell Significance Index: -8.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0172
    Cell Significance Index: -23.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0180
    Cell Significance Index: -13.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0190
    Cell Significance Index: -13.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0206
    Cell Significance Index: -4.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0208
    Cell Significance Index: -13.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0212
    Cell Significance Index: -7.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0316
    Cell Significance Index: -1.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0345
    Cell Significance Index: -15.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0375
    Cell Significance Index: -6.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0394
    Cell Significance Index: -4.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0475
    Cell Significance Index: -6.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0476
    Cell Significance Index: -13.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0483
    Cell Significance Index: -8.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0794
    Cell Significance Index: -11.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0925
    Cell Significance Index: -5.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0930
    Cell Significance Index: -12.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1011
    Cell Significance Index: -11.5800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1050
    Cell Significance Index: -11.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1403
    Cell Significance Index: -8.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1439
    Cell Significance Index: -14.9800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1456
    Cell Significance Index: -3.6300
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.1568
    Cell Significance Index: -1.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1644
    Cell Significance Index: -11.6300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1658
    Cell Significance Index: -3.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1751
    Cell Significance Index: -13.8700
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1754
    Cell Significance Index: -1.1200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1769
    Cell Significance Index: -1.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1787
    Cell Significance Index: -13.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1798
    Cell Significance Index: -5.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1919
    Cell Significance Index: -9.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2079
    Cell Significance Index: -15.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2082
    Cell Significance Index: -14.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CENPF is a highly conserved protein, with high sequence identity across species, indicating its fundamental importance in maintaining genome stability. It is a member of the centromere protein family, which is characterized by its ability to bind to microtubules and other proteins, facilitating kinetochore assembly and function. CENPF is specifically localized to the outer kinetochore, where it interacts with other kinetochore proteins to regulate chromosome attachment and segregation. **Pathways and Functions:** CENPF is involved in several critical pathways that regulate the cell cycle and genome stability, including: 1. **Amplification of signal from the kinetochores**: CENPF is essential for amplifying signals from the kinetochores, ensuring proper chromosome attachment and segregation. 2. **Amplification of signal from unattached kinetochores via a mad2 inhibitory signal**: CENPF interacts with Mad2 to regulate the inhibitory signal that prevents premature chromosome separation. 3. **Axoneme and microtubule binding**: CENPF binds to microtubules and other proteins, facilitating kinetochore assembly and function. 4. **Cell cycle regulation**: CENPF regulates the G2/M transition, ensuring proper chromosome segregation and mitotic spindle assembly. 5. **Chromosome segregation**: CENPF is essential for proper chromosome segregation, preventing aneuploidy and genomic instability. **Clinical Significance:** Dysregulation of CENPF has been implicated in various human diseases, including: 1. **Cancer**: CENPF mutations have been identified in various cancers, including breast, lung, and colon cancer. 2. **Neurodegenerative diseases**: CENPF dysregulation has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Developmental disorders**: CENPF mutations have been identified in developmental disorders, such as Down syndrome and fragile X syndrome. In conclusion, CENPF plays a critical role in maintaining genome stability and regulating the cell cycle. Its dysregulation has significant clinical implications, highlighting the importance of understanding the molecular mechanisms underlying human diseases. Further research is necessary to elucidate the complex interactions between CENPF and other kinetochore proteins, and to develop targeted therapies for diseases associated with CENPF dysfunction.

Genular Protein ID: 416525403

Symbol: CENPF_HUMAN

Name: Centromere protein F

UniProtKB Accession Codes:

P49454 Q13171 Q13246 Q5VVM7

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 41 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7542657

Title: CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis.

PubMed ID: 7542657

DOI: 10.1083/jcb.130.3.507

PubMed ID: 7651420

Title: Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression.

PubMed ID: 7651420

DOI: 10.1128/mcb.15.9.5017

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7612011

Title: A novel cell-cycle-dependent 350-kDa nuclear protein: C-terminal domain sufficient for nuclear localization.

PubMed ID: 7612011

DOI: 10.1006/bbrc.1995.1959

PubMed ID: 7642639

Title: The C-terminus of mitosin is essential for its nuclear localization, centromere/kinetochore targeting, and dimerization.

PubMed ID: 7642639

DOI: 10.1074/jbc.270.33.19545

PubMed ID: 9763420

Title: Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1.

PubMed ID: 9763420

DOI: 10.1083/jcb.143.1.49

PubMed ID: 10852915

Title: Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules.

PubMed ID: 10852915

DOI: 10.1074/jbc.m003469200

PubMed ID: 12974617

Title: Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport.

PubMed ID: 12974617

DOI: 10.1038/sj.cr.7290172

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17600710

Title: Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes.

PubMed ID: 17600710

DOI: 10.1016/j.cub.2007.05.077

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25564561

Title: The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes.

PubMed ID: 25564561

DOI: 10.1136/jmedgenet-2014-102691

PubMed ID: 26820108

Title: Stroemme Syndrome Is a Ciliary Disorder Caused by Mutations in CENPF.

PubMed ID: 26820108

DOI: 10.1002/humu.22960

Sequence Information:

  • Length: 3114
  • Mass: 357527
  • Checksum: 1FC81972F947B375
  • Sequence:
    • MSWALEEWKE GLPTRALQKI QELEGQLDKL KKEKQQRQFQ LDSLEAALQK QKQKVENEKT 
EGTNLKRENQ RLMEICESLE KTKQKISHEL QVKESQVNFQ EGQLNSGKKQ IEKLEQELKR 
CKSELERSQQ AAQSADVSLN PCNTPQKIFT TPLTPSQYYS GSKYEDLKEK YNKEVEERKR 
LEAEVKALQA KKASQTLPQA TMNHRDIARH QASSSVFSWQ QEKTPSHLSS NSQRTPIRRD 
FSASYFSGEQ EVTPSRSTLQ IGKRDANSSF FDNSSSPHLL DQLKAQNQEL RNKINELELR 
LQGHEKEMKG QVNKFQELQL QLEKAKVELI EKEKVLNKCR DELVRTTAQY DQASTKYTAL 
EQKLKKLTED LSCQRQNAES ARCSLEQKIK EKEKEFQEEL SRQQRSFQTL DQECIQMKAR 
LTQELQQAKN MHNVLQAELD KLTSVKQQLE NNLEEFKQKL CRAEQAFQAS QIKENELRRS 
MEEMKKENNL LKSHSEQKAR EVCHLEAELK NIKQCLNQSQ NFAEEMKAKN TSQETMLRDL 
QEKINQQENS LTLEKLKLAV ADLEKQRDCS QDLLKKREHH IEQLNDKLSK TEKESKALLS 
ALELKKKEYE ELKEEKTLFS CWKSENEKLL TQMESEKENL QSKINHLETC LKTQQIKSHE 
YNERVRTLEM DRENLSVEIR NLHNVLDSKS VEVETQKLAY MELQQKAEFS DQKHQKEIEN 
MCLKTSQLTG QVEDLEHKLQ LLSNEIMDKD RCYQDLHAEY ESLRDLLKSK DASLVTNEDH 
QRSLLAFDQQ PAMHHSFANI IGEQGSMPSE RSECRLEADQ SPKNSAILQN RVDSLEFSLE 
SQKQMNSDLQ KQCEELVQIK GEIEENLMKA EQMHQSFVAE TSQRISKLQE DTSAHQNVVA 
ETLSALENKE KELQLLNDKV ETEQAEIQEL KKSNHLLEDS LKELQLLSET LSLEKKEMSS 
IISLNKREIE ELTQENGTLK EINASLNQEK MNLIQKSESF ANYIDEREKS ISELSDQYKQ 
EKLILLQRCE ETGNAYEDLS QKYKAAQEKN SKLECLLNEC TSLCENRKNE LEQLKEAFAK 
EHQEFLTKLA FAEERNQNLM LELETVQQAL RSEMTDNQNN SKSEAGGLKQ EIMTLKEEQN 
KMQKEVNDLL QENEQLMKVM KTKHECQNLE SEPIRNSVKE RESERNQCNF KPQMDLEVKE 
ISLDSYNAQL VQLEAMLRNK ELKLQESEKE KECLQHELQT IRGDLETSNL QDMQSQEISG 
LKDCEIDAEE KYISGPHELS TSQNDNAHLQ CSLQTTMNKL NELEKICEIL QAEKYELVTE 
LNDSRSECIT ATRKMAEEVG KLLNEVKILN DDSGLLHGEL VEDIPGGEFG EQPNEQHPVS 
LAPLDESNSY EHLTLSDKEV QMHFAELQEK FLSLQSEHKI LHDQHCQMSS KMSELQTYVD 
SLKAENLVLS TNLRNFQGDL VKEMQLGLEE GLVPSLSSSC VPDSSSLSSL GDSSFYRALL 
EQTGDMSLLS NLEGAVSANQ CSVDEVFCSS LQEENLTRKE TPSAPAKGVE ELESLCEVYR 
QSLEKLEEKM ESQGIMKNKE IQELEQLLSS ERQELDCLRK QYLSENEQWQ QKLTSVTLEM 
ESKLAAEKKQ TEQLSLELEV ARLQLQGLDL SSRSLLGIDT EDAIQGRNES CDISKEHTSE 
TTERTPKHDV HQICDKDAQQ DLNLDIEKIT ETGAVKPTGE CSGEQSPDTN YEPPGEDKTQ 
GSSECISELS FSGPNALVPM DFLGNQEDIH NLQLRVKETS NENLRLLHVI EDRDRKVESL 
LNEMKELDSK LHLQEVQLMT KIEACIELEK IVGELKKENS DLSEKLEYFS CDHQELLQRV 
ETSEGLNSDL EMHADKSSRE DIGDNVAKVN DSWKERFLDV ENELSRIRSE KASIEHEALY 
LEADLEVVQT EKLCLEKDNE NKQKVIVCLE EELSVVTSER NQLRGELDTM SKKTTALDQL 
SEKMKEKTQE LESHQSECLH CIQVAEAEVK EKTELLQTLS SDVSELLKDK THLQEKLQSL 
EKDSQALSLT KCELENQIAQ LNKEKELLVK ESESLQARLS ESDYEKLNVS KALEAALVEK 
GEFALRLSST QEEVHQLRRG IEKLRVRIEA DEKKQLHIAE KLKEREREND SLKDKVENLE 
RELQMSEENQ ELVILDAENS KAEVETLKTQ IEEMARSLKV FELDLVTLRS EKENLTKQIQ 
EKQGQLSELD KLLSSFKSLL EEKEQAEIQI KEESKTAVEM LQNQLKELNE AVAALCGDQE 
IMKATEQSLD PPIEEEHQLR NSIEKLRARL EADEKKQLCV LQQLKESEHH ADLLKGRVEN 
LERELEIART NQEHAALEAE NSKGEVETLK AKIEGMTQSL RGLELDVVTI RSEKENLTNE 
LQKEQERISE LEIINSSFEN ILQEKEQEKV QMKEKSSTAM EMLQTQLKEL NERVAALHND 
QEACKAKEQN LSSQVECLEL EKAQLLQGLD EAKNNYIVLQ SSVNGLIQEV EDGKQKLEKK 
DEEISRLKNQ IQDQEQLVSK LSQVEGEHQL WKEQNLELRN LTVELEQKIQ VLQSKNASLQ 
DTLEVLQSSY KNLENELELT KMDKMSFVEK VNKMTAKETE LQREMHEMAQ KTAELQEELS 
GEKNRLAGEL QLLLEEIKSS KDQLKELTLE NSELKKSLDC MHKDQVEKEG KVREEIAEYQ 
LRLHEAEKKH QALLLDTNKQ YEVEIQTYRE KLTSKEECLS SQKLEIDLLK SSKEELNNSL 
KATTQILEEL KKTKMDNLKY VNQLKKENER AQGKMKLLIK SCKQLEEEKE ILQKELSQLQ 
AAQEKQKTGT VMDTKVDELT TEIKELKETL EEKTKEADEY LDKYCSLLIS HEKLEKAKEM 
LETQVAHLCS QQSKQDSRGS PLLGPVVPGP SPIPSVTEKR LSSGQNKASG KRQRSSGIWE 
NGRGPTPATP ESFSKKSKKA VMSGIHPAED TEGTEFEPEG LPEVVKKGFA DIPTGKTSPY 
ILRRTTMATR TSPRLAAQKL ALSPLSLGKE NLAESSKPTA GGSRSQKVKV AQRSPVDSGT 
ILREPTTKSV PVNNLPERSP TDSPREGLRV KRGRLVPSPK AGLESNGSEN CKVQ

Genular Protein ID: 12892532

Symbol: A0A9L9PXU7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A9L9PXU7

Database IDs:

CTD 1 EMBL 2 Ensembl 2 GO 4 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 2 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMR 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 3055
  • Mass: 350542
  • Checksum: 90730AC29D00C55D
  • Sequence:
    • MSWALEEWKE GLPTRALQKI QELEGQLDKL KKEKQQRQFQ LDSLEAALQK QKQKVENEKT 
EGTNLKRENQ RLMEICESLE KTKQKISHEL QVKESQVNFQ EGQLNSGKKQ IEKLEQELKR 
CKSELERSQQ AAQSADVSLN PCNTPQKIFT TPLTPSQYYS GSKYEDLKEK YNKEVEERKR 
LEAEVKALQA KKASQTLPQA TMNHRDIARH QASSSVFSWQ QEKTPSHLSS NSQRTPIRRD 
FSASYFSGEQ EVTPSRSTLQ IGKRDANSSF FDNSSSPHLL DQLKAQNQEL RNKINELELR 
LQGHEKEMKG QVNKFQELQL QLEKAKVELI EKEKVLNKCR DELVRTTAQY DQASTKYTAL 
EQKLKKLTED LSCQRQNAES ARCSLEQKIK EKEKEFQEEL SRQQRSFQTL DQECIQMKAR 
LTQELQQAKN MHNVLQAELD KLTSVKQQLE NNLEEFKQKL CRAEQAFQAS QIKENELRRS 
MEEMKKENNL LKSHSEQKAR EVCHLEAELK NIKQCLNQSQ NFAEEMKAKN TSQETMLRDL 
QEKINQQENS LTLEKLKLAV ADLEKQRDCS QDLLKKREHH IEQLNDKLSK TEKESKALLS 
ALELKKKEYE ELKEEKTLFS CWKSENEKLL TQMESEKENL QSKINHLETC LKTQQIKSHE 
YNERVRTLEM DRENLSVEIR NLHNVLDSKS VEVETQKLAY MELQQKAEFS DQKHQKEIEN 
MCLKTSQLTG QVEDLEHKLQ LLSNEIMDKD RCYQDLHAEY ESLRDLLKSK DASLVTNEDH 
QRSLLAFDQQ PAMHHSFANI IGEQGSMPSE RSECRLEADQ SPKNSAILQN RVDSLEFSLE 
SQKQMNSDLQ KQCEELVQIK GEIEENLMKA EQMHQSFVAE TSQRISKLQE DTSAHQNVVA 
ETLSALENKE KELQLLNDKV ETEQAEIQEL KKSNHLLEDS LKELQLLSET LSLEKKEMSS 
IISLNKREIE ELTQENGTLK EINASLNQEK MNLIQKSESF ANYIDEREKS ISELSDQYKQ 
EKLILLQRCE ETGNAYEDLS QKYKAAQEKN SKLECLLNEC TSLCENRKNE LEQLKEAFAK 
EHQEFLTKLA FAEERNQNLM LELETVQQAL RSEMTDNQNN SKSEAGGLKQ EIMTLKEEQN 
KMQKEVNDLL QENEQLMKVM KTKHECQNLE SEPIRNSVKE RESERNQCNF KPQMDLEVKE 
ISLDSYNAQL VQLEAMLRNK ELKLQESEKE KECLQHELQT IRGDLETSNL QDMQSQEISG 
LKDCEIDAEE KYISGPHELS TSQNDNAHLQ CSLQTTMNKL NELEKICEIL QAEKYELVTE 
LNDSRSECIT ATRKMAEEVG KLLNEVKILN DDSGLLHGEL VEDIPGGEFG EQPNEQHPVS 
LAPLDESNSY EHLTLSDKEV QMHFAELQEK FLSLQSEHKI LHDQHCQMSS KMSELQTYVD 
SLKAENLVLS TNLRNFQGDL VKEMQLGLEE GLVPSLSSSC VPDSSSLSSL GDSSFYRALL 
EQTGDMSLLS NLEGAVSANQ CSVDEVFCSS LQEENLTRKE TPSAPAKGVE ELESLCEVYR 
QSLEKLEEKM ESQGIMKNKE IQELEQLLSS ERQELDCLRK QYLSENEQWQ QKLTSVTLEM 
ESKLAAEKKQ TEQLSLELEV ARLQLQGLDL SSRSLLGIDT EDAIQGRNES CDISKEHTSE 
TTERTPKHDV HQICDKDAQQ DLNLDIEKIT ETGAVKPTGE CSGEQSPDTN YEPPGEDKTQ 
GSSECISELS FSGPNALVPM DFLGNQEDIH NLQLRVKETS NENLRLLHVI EDRDRKVESL 
LNEMKELDSK LHLQEVQLMT KIEACIELEK IVGELKKENS DLSEKLEYFS CDHQELLQRV 
ETSEGLNSDL EMHADKSSRE DIGDNVAKVN DSWKERFLDV ENELSRIRSE KASIEHEALY 
LEADLEVVQT EKLCLEKDNE NKQKVIVCLE EELSVVTSER NQLRGELDTM SKKTTALDQL 
SEKMKEKTQE LESHQSECLH CIQVAEAEVK EKTELLQTLS SDVSELLKDK THLQEKLQSL 
EKDSQALSLT KCELENQIAQ LNKEKELLVK ESESLQARLS ESDYEKLNVS KALEAALVEK 
GEFALRLSST QEEVHQLRRG IEKLRVRIEA DEKKQLHIAE KLKEREREND SLKDKVENLE 
RELQMSEENQ ELVILDAENS KAEVETLKTQ IEEMARSLKV FELDLVTLRS EKENLTKQIQ 
EKQGQLSELD KLLSSFKSLL EEKEQAEIQI KEESKTAVEM LQNQLKELNE AVAALCGDQE 
IMKATEQSLD PPIEEEHQLR NSIEKLRARL EADEKKQLCV LQQLKESEHH ADLLKGRVEN 
LERELEIART NQEHAALEAE NSKGEVETLK AKIEGMTQSL RGLELDVVTI RSEKENLTNE 
LQKEQERISE LEIINSSFEN ILQEKEQEKV QMKEKSSTAM EMLQTQLKEL NERVAALHND 
QEACKAKEQN LSSQVECLEL EKAQLLQGLD EAKNNYIVLQ SSVNGLIQEV EDGKQKLEKK 
DEEISRLKNQ IQDQEQLVSK LSQVEGEHQL WKEQNLELRN LTVELEQKIQ VLQSKNASLQ 
DTLEVLQSSY KNLENELELT KMDKMSFVEK VNKMTAKETE LQREMHEMAQ KTAELQEELS 
GEKNRLAGEL QLLLEEIKSS KYEVEIQTYR EKLTSKEECL SSQKLEIDLL KSSKEELNNS 
LKATTQILEE LKKTKMDNLK YVNQLKKENE RAQGKMKLLI KSCKQLEEEK EILQKELSQL 
QAAQEKQKTG TVMDTKVDEL TTEIKELKET LEEKTKEADE YLDKYCSLLI SHEKLEKAKE 
MLETQVAHLC SQQSKQDSRG SPLLGPVVPG PSPIPSVTEK RLSSGQNKAS GKRQRSSGIW 
ENGRGPTPAT PESFSKKSKK AVMSGIHPAE DTEGTEFEPE GLPEVVKKGF ADIPTGKTSP 
YILRRTTMAT RTSPRLAAQK LALSPLSLGK ENLAESSKPT AGGSRSQKVK VAQRSPVDSG 
TILREPTTKS VPVNNLPERS PTDSPREGLR VKRGRLVPSP KAGLESNGSE NCKVQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.