Details for: PDPN

Gene ID: 10630

Symbol: PDPN

Ensembl ID: ENSG00000162493

Description: podoplanin

Associated with

Other Information

Genular Protein ID: 1401042436

Symbol: PDPN_HUMAN

Name: Glycoprotein 36

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9651190

Title: Evidence against a role of mouse, rat, and two cloned human T1alpha isoforms as a water channel or a regulator of aquaporin-type water channels.

PubMed ID: 9651190

DOI: 10.1165/ajrcmb.19.1.2953

PubMed ID: 10393083

Title: Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium.

PubMed ID: 10393083

DOI: 10.1042/bj3410277

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15515019

Title: Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas.

PubMed ID: 15515019

DOI: 10.1002/ijc.20656

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 17222411

Title: Functional glycosylation of human podoplanin: glycan structure of platelet aggregation-inducing factor.

PubMed ID: 17222411

DOI: 10.1016/j.febslet.2006.12.044

PubMed ID: 24275092

Title: Podoplanin is a substrate of presenilin-1/gamma-secretase.

PubMed ID: 24275092

DOI: 10.1016/j.biocel.2013.11.016

PubMed ID: 14522983

Title: Molecular identification of aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors.

PubMed ID: 14522983

DOI: 10.1074/jbc.m309935200

PubMed ID: 14978162

Title: Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates.

PubMed ID: 14978162

DOI: 10.1097/01.asn.0000113316.52371.2e

PubMed ID: 15231832

Title: Functional sialylated O-glycan to platelet aggregation on Aggrus (T1alpha/Podoplanin) molecules expressed in Chinese hamster ovary cells.

PubMed ID: 15231832

DOI: 10.1074/jbc.m407210200

PubMed ID: 17046996

Title: Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition.

PubMed ID: 17046996

DOI: 10.1242/jcs.03218

PubMed ID: 17616532

Title: Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells.

PubMed ID: 17616532

DOI: 10.1074/jbc.m702327200

PubMed ID: 18215137

Title: Renal cells activate the platelet receptor CLEC-2 through podoplanin.

PubMed ID: 18215137

DOI: 10.1042/bj20071216

PubMed ID: 18541721

Title: Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis.

PubMed ID: 18541721

DOI: 10.1182/blood-2007-11-124693

PubMed ID: 19268462

Title: Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions.

PubMed ID: 19268462

DOI: 10.1016/j.yexcr.2009.02.021

PubMed ID: 20962267

Title: Podoplanin associates with CD44 to promote directional cell migration.

PubMed ID: 20962267

DOI: 10.1091/mbc.e10-06-0489

PubMed ID: 21376833

Title: The transmembrane domain of podoplanin is required for its association with lipid rafts and the induction of epithelial-mesenchymal transition.

PubMed ID: 21376833

DOI: 10.1016/j.biocel.2011.02.010

PubMed ID: 23541579

Title: Extracellular heat shock protein A9 is a novel interaction partner of podoplanin in oral squamous cell carcinoma cells.

PubMed ID: 23541579

DOI: 10.1016/j.bbrc.2013.03.057

PubMed ID: 25486435

Title: Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability.

PubMed ID: 25486435

DOI: 10.1038/onc.2014.388

PubMed ID: 25458834

Title: A platform of C-type lectin-like receptor CLEC-2 for binding O-glycosylated podoplanin and nonglycosylated rhodocytin.

PubMed ID: 25458834

DOI: 10.1016/j.str.2014.09.009

PubMed ID: 26872787

Title: Tailored placement of a turn-forming PA tag into the structured domain of a protein to probe its conformational state.

PubMed ID: 26872787

DOI: 10.1242/jcs.176685

Sequence Information:

  • Length: 162
  • Mass: 16698
  • Checksum: CD96D46FF5BD56A1
  • Sequence:
  • MWKVSALLFV LGSASLWVLA EGASTGQPED DTETTGLEGG VAMPGAEDDV VTPGTSEDRY 
    KSGLTTLVAT SVNSVTGIRI EDLPTSESTV HAQEQSPSAT ASNVATSHST EKVDGDTQTT 
    VEKDGLSTVT LVGIIVGVLL AIGFIGAIIV VVMRKMSGRY SP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.