Details for: PDPN

Gene ID: 10630

Symbol: PDPN

Ensembl ID: ENSG00000162493

Description: podoplanin

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.34
    Marker Score: 79,768
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.07
    Marker Score: 666
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.07
    Marker Score: 861
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.93
    Marker Score: 434
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.93
    Marker Score: 480
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.91
    Marker Score: 480
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.86
    Marker Score: 1,062
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.83
    Marker Score: 2,205
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.64
    Marker Score: 2,258
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.62
    Marker Score: 6,969
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.59
    Marker Score: 1,991
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.47
    Marker Score: 1,724
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.35
    Marker Score: 3,676
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.26
    Marker Score: 1,747
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.21
    Marker Score: 1,991
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.17
    Marker Score: 18,381
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.14
    Marker Score: 968
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.11
    Marker Score: 613
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.06
    Marker Score: 675
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.06
    Marker Score: 2,782
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.06
    Marker Score: 243
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.06
    Marker Score: 475
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,782
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.02
    Marker Score: 2,078
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,801
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,024
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.99
    Marker Score: 627
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.95
    Marker Score: 556
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.94
    Marker Score: 379
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,196
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.9
    Marker Score: 966
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.89
    Marker Score: 3,730
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.89
    Marker Score: 5,267
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.87
    Marker Score: 432
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,278
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.86
    Marker Score: 536
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.85
    Marker Score: 4,199
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.85
    Marker Score: 9,561
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.83
    Marker Score: 204
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 625
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.8
    Marker Score: 359
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.79
    Marker Score: 227
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.78
    Marker Score: 757
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.77
    Marker Score: 316
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,256
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.77
    Marker Score: 1,450
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.76
    Marker Score: 701
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.72
    Marker Score: 257
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.72
    Marker Score: 183
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.71
    Marker Score: 1,292
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.67
    Marker Score: 3,998
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.63
    Marker Score: 418
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.63
    Marker Score: 2,337
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.61
    Marker Score: 152
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.6
    Marker Score: 430
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.58
    Marker Score: 5,867
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.53
    Marker Score: 318
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.52
    Marker Score: 178
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.51
    Marker Score: 1,245
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.5
    Marker Score: 183
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 209
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.5
    Marker Score: 221
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.5
    Marker Score: 214
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.5
    Marker Score: 159
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.49
    Marker Score: 635
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.48
    Marker Score: 108
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.48
    Marker Score: 233
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.48
    Marker Score: 124
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.47
    Marker Score: 529
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.47
    Marker Score: 121
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.46
    Marker Score: 112
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.45
    Marker Score: 5,879
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.44
    Marker Score: 159
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.44
    Marker Score: 1,035
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.44
    Marker Score: 244
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.42
    Marker Score: 518
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.42
    Marker Score: 15,422
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.42
    Marker Score: 867
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.41
    Marker Score: 5,571
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 394
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.4
    Marker Score: 498
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.39
    Marker Score: 2,572
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.38
    Marker Score: 252
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.37
    Marker Score: 537
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.37
    Marker Score: 1,551
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 369
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.36
    Marker Score: 316
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.36
    Marker Score: 616
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.36
    Marker Score: 2,696
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.36
    Marker Score: 106
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.36
    Marker Score: 185
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.35
    Marker Score: 268

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Podoplanin is a member of the nectin family of transmembrane glycoproteins, characterized by its unique structure and expression pattern. It is primarily expressed on the surface of lymphatic endothelial cells, fibroblasts, and certain types of immune cells, such as decidual cells and mesothelial cells. PDPN is a pentaspan transmembrane protein, consisting of five extracellular immunoglobulin-like domains and a single intracellular cytoplasmic tail. Its expression is often associated with the formation of specialized cellular structures, such as filopodia and lamellipodia, which play crucial roles in cell migration and adhesion. **Pathways and Functions:** PDPN's involvement in various cellular processes is mediated through its interactions with other molecules and signaling pathways. Its primary functions include: 1. **Cell adhesion and migration**: PDPN facilitates cell-cell and cell-matrix interactions, enabling the migration of cells during processes such as lymphangiogenesis, wound healing, and tissue repair. 2. **Signaling and activation**: PDPN interacts with various signaling molecules, including chemokines, growth factors, and receptors, to regulate cell proliferation, differentiation, and survival. 3. **Lymphatic endothelial cell fate commitment**: PDPN is essential for the specification of lymphatic endothelial cells and the maintenance of lymphatic vessel integrity. 4. **Immune cell regulation**: PDPN modulates the behavior of immune cells, including T cells, B cells, and dendritic cells, influencing their activation, proliferation, and migration. **Clinical Significance:** PDPN's dysregulation has been implicated in various immune-related diseases, including: 1. **Lymphangiogenesis disorders**: Mutations in the PDPN gene have been associated with lymphedema, a condition characterized by abnormal lymphatic vessel development and function. 2. **Cancer**: PDPN expression has been linked to tumor progression and metastasis in certain types of cancer, including breast cancer and lung cancer. 3. **Autoimmune diseases**: PDPN's role in immune cell regulation and activation has led to its investigation as a potential therapeutic target in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 4. **Inflammatory disorders**: PDPN's involvement in inflammation and immune cell recruitment has made it a potential candidate for the treatment of inflammatory diseases, such as asthma and psoriasis. In conclusion, podoplanin (PDPN) is a multifunctional transmembrane glycoprotein that plays a crucial role in immune regulation and disease pathogenesis. Further research into PDPN's mechanisms of action and its clinical significance is necessary to fully elucidate its potential as a therapeutic target and to develop novel treatments for immune-related disorders.

Genular Protein ID: 1401042436

Symbol: PDPN_HUMAN

Name: Glycoprotein 36

UniProtKB Accession Codes:

Q86YL7 A9Z1Y2 B2R6J8 E9PB68 F6QWX5 O60836 O95128 Q7L375 Q8NBQ8 Q8NBR3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 19 EPD 1 Ensembl 7 ExpressionAtlas 1 GO 44 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 6 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 SAM 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9651190

Title: Evidence against a role of mouse, rat, and two cloned human T1alpha isoforms as a water channel or a regulator of aquaporin-type water channels.

PubMed ID: 9651190

DOI: 10.1165/ajrcmb.19.1.2953

PubMed ID: 10393083

Title: Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium.

PubMed ID: 10393083

DOI: 10.1042/bj3410277

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15515019

Title: Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas.

PubMed ID: 15515019

DOI: 10.1002/ijc.20656

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 17222411

Title: Functional glycosylation of human podoplanin: glycan structure of platelet aggregation-inducing factor.

PubMed ID: 17222411

DOI: 10.1016/j.febslet.2006.12.044

PubMed ID: 24275092

Title: Podoplanin is a substrate of presenilin-1/gamma-secretase.

PubMed ID: 24275092

DOI: 10.1016/j.biocel.2013.11.016

PubMed ID: 14522983

Title: Molecular identification of aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors.

PubMed ID: 14522983

DOI: 10.1074/jbc.m309935200

PubMed ID: 14978162

Title: Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates.

PubMed ID: 14978162

DOI: 10.1097/01.asn.0000113316.52371.2e

PubMed ID: 15231832

Title: Functional sialylated O-glycan to platelet aggregation on Aggrus (T1alpha/Podoplanin) molecules expressed in Chinese hamster ovary cells.

PubMed ID: 15231832

DOI: 10.1074/jbc.m407210200

PubMed ID: 17046996

Title: Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition.

PubMed ID: 17046996

DOI: 10.1242/jcs.03218

PubMed ID: 17616532

Title: Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells.

PubMed ID: 17616532

DOI: 10.1074/jbc.m702327200

PubMed ID: 18215137

Title: Renal cells activate the platelet receptor CLEC-2 through podoplanin.

PubMed ID: 18215137

DOI: 10.1042/bj20071216

PubMed ID: 18541721

Title: Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis.

PubMed ID: 18541721

DOI: 10.1182/blood-2007-11-124693

PubMed ID: 19268462

Title: Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions.

PubMed ID: 19268462

DOI: 10.1016/j.yexcr.2009.02.021

PubMed ID: 20962267

Title: Podoplanin associates with CD44 to promote directional cell migration.

PubMed ID: 20962267

DOI: 10.1091/mbc.e10-06-0489

PubMed ID: 21376833

Title: The transmembrane domain of podoplanin is required for its association with lipid rafts and the induction of epithelial-mesenchymal transition.

PubMed ID: 21376833

DOI: 10.1016/j.biocel.2011.02.010

PubMed ID: 23541579

Title: Extracellular heat shock protein A9 is a novel interaction partner of podoplanin in oral squamous cell carcinoma cells.

PubMed ID: 23541579

DOI: 10.1016/j.bbrc.2013.03.057

PubMed ID: 25486435

Title: Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability.

PubMed ID: 25486435

DOI: 10.1038/onc.2014.388

PubMed ID: 25458834

Title: A platform of C-type lectin-like receptor CLEC-2 for binding O-glycosylated podoplanin and nonglycosylated rhodocytin.

PubMed ID: 25458834

DOI: 10.1016/j.str.2014.09.009

PubMed ID: 26872787

Title: Tailored placement of a turn-forming PA tag into the structured domain of a protein to probe its conformational state.

PubMed ID: 26872787

DOI: 10.1242/jcs.176685

Sequence Information:

  • Length: 162
  • Mass: 16698
  • Checksum: CD96D46FF5BD56A1
  • Sequence:
    • MWKVSALLFV LGSASLWVLA EGASTGQPED DTETTGLEGG VAMPGAEDDV VTPGTSEDRY 
KSGLTTLVAT SVNSVTGIRI EDLPTSESTV HAQEQSPSAT ASNVATSHST EKVDGDTQTT 
VEKDGLSTVT LVGIIVGVLL AIGFIGAIIV VVMRKMSGRY SP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.