Details for: ATP5MG

Gene ID: 10632

Symbol: ATP5MG

Ensembl ID: ENSG00000167283

Description: ATP synthase membrane subunit g

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 8.17
    Marker Score: 5,466
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 7.4
    Marker Score: 7,247
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 7.38
    Marker Score: 8,000
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 5.83
    Marker Score: 3,009
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 5.76
    Marker Score: 4,344
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 5.49
    Marker Score: 73,091
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.45
    Marker Score: 11,508
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 5.04
    Marker Score: 4,282
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 5
    Marker Score: 3,530
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 4.84
    Marker Score: 1,418
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.77
    Marker Score: 2,898
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.74
    Marker Score: 46,988
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 4.73
    Marker Score: 2,524
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.63
    Marker Score: 7,129
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 4.61
    Marker Score: 19,158
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 4.61
    Marker Score: 61,902
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.4
    Marker Score: 3,446
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.31
    Marker Score: 1,588
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 4.24
    Marker Score: 5,089
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.2
    Marker Score: 11,264
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.13
    Marker Score: 230,698
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.12
    Marker Score: 13,009
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.09
    Marker Score: 216,354
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.03
    Marker Score: 53,135
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 4.01
    Marker Score: 2,351
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.99
    Marker Score: 5,203
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.99
    Marker Score: 2,425
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.94
    Marker Score: 11,486
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 3.92
    Marker Score: 6,732
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.9
    Marker Score: 10,786
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 3.9
    Marker Score: 2,512
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.88
    Marker Score: 1,745
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.85
    Marker Score: 3,855
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.72
    Marker Score: 43,285
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.71
    Marker Score: 3,159
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.7
    Marker Score: 3,305
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 3.69
    Marker Score: 2,676
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.68
    Marker Score: 8,996
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.68
    Marker Score: 13,077
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.67
    Marker Score: 15,725
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.66
    Marker Score: 3,266
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.65
    Marker Score: 4,061
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.64
    Marker Score: 6,496
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.6
    Marker Score: 1,850
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.6
    Marker Score: 10,089
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.59
    Marker Score: 122,281
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.52
    Marker Score: 22,961
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.51
    Marker Score: 2,752
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.49
    Marker Score: 3,732
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.49
    Marker Score: 2,935
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.48
    Marker Score: 3,101
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.48
    Marker Score: 4,197
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.46
    Marker Score: 3,413
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.46
    Marker Score: 8,735
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.46
    Marker Score: 2,478
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.46
    Marker Score: 6,494
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.45
    Marker Score: 8,420
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.44
    Marker Score: 1,102
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.44
    Marker Score: 25,573
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.43
    Marker Score: 18,050
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.43
    Marker Score: 3,226
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.43
    Marker Score: 1,129
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.43
    Marker Score: 22,304
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 3.43
    Marker Score: 4,044
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.42
    Marker Score: 3,230
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.41
    Marker Score: 1,176
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.4
    Marker Score: 21,710
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.39
    Marker Score: 5,627
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 3.37
    Marker Score: 1,881
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.36
    Marker Score: 802
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.34
    Marker Score: 1,646
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.33
    Marker Score: 2,769
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.33
    Marker Score: 4,908
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 3.32
    Marker Score: 4,603
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.31
    Marker Score: 3,792
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.31
    Marker Score: 1,825
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.3
    Marker Score: 25,739
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.29
    Marker Score: 2,929
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.29
    Marker Score: 7,501
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.25
    Marker Score: 10,215
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.24
    Marker Score: 4,590
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.24
    Marker Score: 2,847
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 3.23
    Marker Score: 2,333
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 3.21
    Marker Score: 3,336
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.21
    Marker Score: 111,172
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.2
    Marker Score: 2,519
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.19
    Marker Score: 5,234
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.19
    Marker Score: 2,099
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 3.19
    Marker Score: 2,145
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 3.19
    Marker Score: 742
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.18
    Marker Score: 27,660
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.18
    Marker Score: 1,270
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.18
    Marker Score: 12,268
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.18
    Marker Score: 7,218
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.17
    Marker Score: 1,584
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 3.17
    Marker Score: 1,030
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.17
    Marker Score: 9,393
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 3.16
    Marker Score: 7,111
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 3.15
    Marker Score: 2,095
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.15
    Marker Score: 2,241

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization**: The ATP5MG gene is specifically localized to the mitochondrial inner membrane, where it plays a crucial role in the production of ATP through chemiosmotic coupling. 2. **Subunit g of ATP synthase**: The ATP5MG gene encodes for the subunit g of the ATP synthase complex, which is essential for the rotation of the stalk subunit and the subsequent production of ATP. 3. **Significant expression in various cell types**: The ATP5MG gene is widely expressed in various cell types, including hematopoietic stem cells, immune cells, and smooth muscle cells, highlighting its importance in maintaining cellular homeostasis. 4. **Regulation of energy metabolism**: The ATP5MG gene is involved in regulating energy metabolism, particularly in high-energy-demanding tissues, where it plays a crucial role in maintaining ATP homeostasis. **Pathways and Functions:** The ATP5MG gene is involved in several key pathways, including: 1. **Cristae formation**: The ATP5MG gene is involved in the formation of cristae, the folded structure of the mitochondrial inner membrane that increases the surface area for ATP production. 2. **Formation of ATP by chemiosmotic coupling**: The ATP5MG gene plays a crucial role in the production of ATP through chemiosmotic coupling, where the proton gradient generated by the electron transport chain is used to drive ATP synthesis. 3. **Mitochondrial biogenesis and maintenance**: The ATP5MG gene is involved in the regulation of mitochondrial biogenesis and maintenance, particularly in response to energy demands. 4. **Proton-transporting ATP synthase activity**: The ATP5MG gene encodes for the subunit g of the ATP synthase complex, which is essential for the rotation of the stalk subunit and the subsequent production of ATP. **Clinical Significance:** Dysregulation of the ATP5MG gene has been implicated in various diseases, including: 1. **Mitochondrial disorders**: Mutations in the ATP5MG gene have been associated with mitochondrial disorders, such as Kearns-Sayre syndrome and MERRF syndrome. 2. **Metabolic disorders**: Dysregulation of the ATP5MG gene has been implicated in metabolic disorders, such as type 2 diabetes and obesity. 3. **Cancer**: The ATP5MG gene has been shown to be overexpressed in certain types of cancer, including pancreatic cancer and breast cancer. 4. **Neurodegenerative disorders**: Dysregulation of the ATP5MG gene has been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the ATP5MG gene plays a crucial role in maintaining cellular energy homeostasis and regulating energy metabolism. Dysregulation of this gene has been implicated in various diseases, highlighting the importance of further research into the mechanisms of energy metabolism and the development of novel therapeutic strategies.

Genular Protein ID: 1745990535

Symbol: ATP5L_HUMAN

Name: N/A

UniProtKB Accession Codes:

O75964 A8K0K3 Q96BV6 Q9UBZ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 CarbonylDB 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 10 EMDB 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 8 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 103
  • Mass: 11428
  • Checksum: 03D484BCF836E6C2
  • Sequence:
    • MAQFVRNLVE KTPALVNAAV TYSKPRLATF WYYAKVELVP PTPAEIPRAI QSLKKIVNSA 
QTGSFKQLTV KEAVLNGLVA TEVLMWFYVG EIIGKRGIIG YDV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.