Details for: GAS2L1

Gene ID: 10634

Symbol: GAS2L1

Ensembl ID: ENSG00000185340

Description: growth arrest specific 2 like 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.28
    Marker Score: 1,855
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.02
    Marker Score: 1,572
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,786
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,010
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.99
    Marker Score: 15,525
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.95
    Marker Score: 873
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,409
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,729
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,035
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.88
    Marker Score: 275
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,271
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.83
    Marker Score: 211
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.78
    Marker Score: 16,673
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.78
    Marker Score: 4,631
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 308
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1,239
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 581
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.76
    Marker Score: 650
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.74
    Marker Score: 934
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.74
    Marker Score: 1,515
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.73
    Marker Score: 1,459
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.73
    Marker Score: 784
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 661
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,996
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.71
    Marker Score: 7,371
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.71
    Marker Score: 6,088
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.71
    Marker Score: 1,794
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.7
    Marker Score: 462
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.69
    Marker Score: 2,717
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.68
    Marker Score: 1,546
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.67
    Marker Score: 392
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.63
    Marker Score: 139
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.63
    Marker Score: 16,240
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.63
    Marker Score: 203
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 393
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.59
    Marker Score: 3,519
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.58
    Marker Score: 35,932
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.58
    Marker Score: 5,506
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.56
    Marker Score: 265
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.55
    Marker Score: 4,730
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.55
    Marker Score: 541
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.54
    Marker Score: 162
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.54
    Marker Score: 19,793
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.54
    Marker Score: 575
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.52
    Marker Score: 762
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.52
    Marker Score: 151
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.52
    Marker Score: 3,174
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.52
    Marker Score: 465
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.51
    Marker Score: 2,431
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.51
    Marker Score: 6,801
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.5
    Marker Score: 456
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.5
    Marker Score: 107
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.5
    Marker Score: 133
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 207
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.49
    Marker Score: 244
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.49
    Marker Score: 519
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.48
    Marker Score: 420
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.48
    Marker Score: 302
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.47
    Marker Score: 115
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.47
    Marker Score: 196
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.47
    Marker Score: 198
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.47
    Marker Score: 1,096
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.46
    Marker Score: 369
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.45
    Marker Score: 306
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.45
    Marker Score: 4,198
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.44
    Marker Score: 9,874
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.44
    Marker Score: 570
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.44
    Marker Score: 277
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.44
    Marker Score: 98
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.44
    Marker Score: 738
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.43
    Marker Score: 467
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.43
    Marker Score: 1,121
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.43
    Marker Score: 263
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.42
    Marker Score: 608
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.41
    Marker Score: 3,208
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.41
    Marker Score: 657
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.41
    Marker Score: 3,543
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.4
    Marker Score: 995
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.4
    Marker Score: 407
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.4
    Marker Score: 97
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.4
    Marker Score: 136
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.4
    Marker Score: 177
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.4
    Marker Score: 613
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.4
    Marker Score: 179
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.39
    Marker Score: 372
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.39
    Marker Score: 661
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.39
    Marker Score: 1,583
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.39
    Marker Score: 400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.38
    Marker Score: 1,578
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.38
    Marker Score: 1,308
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.38
    Marker Score: 187

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GAS2L1 is a protein-coding gene that belongs to the growth arrest specific 2 (GAS2) family. It is characterized by its high expression in specific cell types, such as alveolar capillary type 2 endothelial cells, L5 extratelencephalic projecting glutamatergic cortical neurons, and cardiac muscle myoblasts. GAS2L1 is also notable for its involvement in actin crosslink formation, cytoskeletal anchor activity, and microtubule bundle formation, which are essential for maintaining cellular structure and function. **Pathways and Functions:** GAS2L1 is involved in various cellular pathways, including: 1. **Actin crosslink formation**: GAS2L1 is required for the formation of actin crosslinks, which are essential for maintaining cellular shape and structure. 2. **Cytoskeletal anchor activity**: GAS2L1 acts as a cytoskeletal anchor, binding to microtubules and actin filaments to maintain cellular stability. 3. **Microtubule bundle formation**: GAS2L1 is involved in the formation of microtubule bundles, which are essential for maintaining cellular structure and function. 4. **Cellular response to starvation**: GAS2L1 plays a role in regulating cellular responses to starvation, including the activation of stress pathways and the regulation of protein synthesis. 5. **Protein binding and localization**: GAS2L1 binds to various proteins, including microtubules, actin filaments, and other cytoskeletal proteins, to regulate their localization and function. **Clinical Significance:** GAS2L1 has been implicated in various disease states, including: 1. **Neurological disorders**: GAS2L1 has been linked to neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cardiovascular disease**: GAS2L1 has been implicated in cardiovascular disease, including atherosclerosis and cardiac hypertrophy. 3. **Gastrointestinal disorders**: GAS2L1 has been linked to gastrointestinal disorders, including inflammatory bowel disease and colon cancer. 4. **Cancer**: GAS2L1 has been implicated in cancer, including the regulation of cell proliferation, migration, and invasion. In conclusion, GAS2L1 is a multifunctional gene that plays a critical role in regulating cellular stress responses and microtubule dynamics. Its involvement in various disease states highlights the importance of further research into the mechanisms of GAS2L1 and its potential as a therapeutic target for the treatment of various diseases.

Genular Protein ID: 419887408

Symbol: GA2L1_HUMAN

Name: GAS2-like protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8975699

Title: Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region.

PubMed ID: 8975699

DOI: 10.1006/geno.1996.0625

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12584248

Title: Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules.

PubMed ID: 12584248

DOI: 10.1242/jcs.00272

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24706950

Title: GAS2-like proteins mediate communication between microtubules and actin through interactions with end-binding proteins.

PubMed ID: 24706950

DOI: 10.1242/jcs.140558

Sequence Information:

  • Length: 681
  • Mass: 72717
  • Checksum: A23A10748535D900
  • Sequence:
  • MADPVAGIAG SAAKSVRPFR SSEAYVEAMK EDLAEWLNAL YGLGLPGGGD GFLTGLATGT 
    TLCQHANAVT EAARALAAAR PARGVAFQAH SVVPGSFMAR DNVATFIGWC RVELGVPEVL 
    MFETEDLVLR KNEKSVVLCL LEVARRGARL GLLAPRLVQF EQEIERELRA APPAPNAPAA 
    GEDTTETAPA PGTPARGPRM TPSDLRNLDE LVREILGRCT CPDQFPMIKV SEGKYRVGDS 
    SLLIFVRVLR SHVMVRVGGG WDTLEHYLDK HDPCRCSSTA HRPPQPRVCT FSPQRVSPTT 
    SPRPASPVPG SERRGSRPEM TPVSLRSTKE GPETPPRPRD QLPPHPRSRR YSGDSDSSAS 
    SAQSGPLGTR SDDTGTGPRR ERPSRRLTTG TPASPRRPPA LRSQSRDRLD RGRPRGAPGG 
    RGAQLSVPSP ARRARSQSRE EQAVLLVRRD RDGQHSWVPR GRGSGGSGRS TPQTPRARSP 
    AAPRLSRVSS PSPELGTTPA SIFRTPLQLD PQQEQQLFRR LEEEFLANAR ALEAVASVTP 
    TGPVPDPARA PDPPAPDSAY CSSSSSSSSL SVLGGKCGQP GDSGRTANGL PGPRSQALSS 
    SSDEGSPCPG MGGPLDAPGS PLACTEPSRT WARGRMDTQP DRKPSRIPTP RGPRRPSGPA 
    ELGTWHALHS VTPRAEPDSW M

Genular Protein ID: 142031938

Symbol: A0A5E8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 681
  • Mass: 72689
  • Checksum: 75602C360E35D912
  • Sequence:
  • MADPVAGIAG SAAKSVRPFR SSEAYVEAMK EDLAEWLNAL YGLGLPGGGD GFLTGLATGT 
    TLCQHANAVT EAARALAAAR PARGVAFQAH SVVPGSFMAR DNVATFIGWC RVELGVPEVL 
    MFETEDLVLR KNEKSVVLCL LEVARRGARL GLLAPRLVQF EQEIERELRA APPAPNAPAA 
    GEDTTETAPA PGTPARGPRM TPSDLRNLDE LVREILGRCT CPDQFPMIKV SEGKYRVGDS 
    SLLIFVRVLR SHVMVRVGGG WDTLEHYLDK HDPCRCSSTA HRPPQPRVCT FSPQRVSPTT 
    SPRPASPVPG SERRGSRPEM TPVSLRSTKE GPETPPRPRD QLPPHPRSRR YSGDSDSSAS 
    SAQSGPLGTR SDDTGTGPRR ERPSRRLTTG TPASPRRPPA LRSQSRDRLD RGRPRGAPGG 
    RGAQLSVPSP ARRARSQSRE EQAVLLVRRD RDGQHSWVPR GRGSGGSGRS TPQTPRARSP 
    AAPRLSRVSS PSPELGTTPA SIFRTPLQLD PQQEQQLFRR LEEEFLANAR ALEAVASVTP 
    TGPAPDPARA PDPPAPDSAY CSSSSSSSSL SVLGGKCGQP GDSGRTANGL PGPRSQALSS 
    SSDEGSPCPG MGGPLDAPGS PLACTEPSRT WARGRMDTQP DRKPSRIPTP RGPRRPSGPA 
    ELGTWHALHS VTPRAEPDSW M

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.