RGS14 | ENSG00000169220 | NCBI 10636

Details for: RGS14

Gene ID: 10636

Symbol: RGS14

Ensembl ID: ENSG00000169220

Description: regulator of G protein signaling 14

Associated with

G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Chromosome segregation
(GO:0007059)
Cytoplasm
(GO:0005737)
Dendrite
(GO:0030425)
Dendritic spine
(GO:0043197)
G-protein alpha-subunit binding
(GO:0001965)
Gdp-dissociation inhibitor activity
(GO:0005092)
Glutamatergic synapse
(GO:0098978)
G protein-coupled receptor signaling pathway
(GO:0007186)
Gtpase activating protein binding
(GO:0032794)
Gtpase activator activity
(GO:0005096)
Gtpase activity
(GO:0003924)
Learning
(GO:0007612)
Long-term memory
(GO:0007616)
Long-term synaptic potentiation
(GO:0060291)
Microtubule
(GO:0005874)
Microtubule binding
(GO:0008017)
Mitotic cell cycle
(GO:0000278)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of g protein-coupled receptor signaling pathway
(GO:0045744)
Negative regulation of map kinase activity
(GO:0043407)
Negative regulation of synaptic plasticity
(GO:0031914)
Nuclear body
(GO:0016604)
Nucleocytoplasmic transport
(GO:0006913)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Platelet-derived growth factor receptor signaling pathway
(GO:0048008)
Pml body
(GO:0016605)
Positive regulation of neurogenesis
(GO:0050769)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of g protein-coupled receptor signaling pathway
(GO:0008277)
Response to oxidative stress
(GO:0006979)
Signaling receptor complex adaptor activity
(GO:0030159)
Spindle
(GO:0005819)
Spindle organization
(GO:0007051)
Spindle pole
(GO:0000922)
Visual learning
(GO:0008542)
Zygote asymmetric cell division
(GO:0010070)

Other Information

Proteins

Regulator of G-protein signaling 14

Genular Protein ID: 1190180693

Symbol: RGS14_HUMAN

Name: Regulator of G-protein signaling 14

UniProtKB Accession Codes:

O43566 O43565 Q506M1 Q6ZWA4 Q8TD62

Database IDs:

Citations:

PubMed ID: 16819986

Title: Localization of the GoLoco motif carrier regulator of G-protein signalling 12 and 14 proteins in monkey and rat brain.

PubMed ID: 16819986

DOI: 10.1111/j.1460-9568.2006.04838.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15917656

Title: RGS14 is a microtubule-associated protein.

PubMed ID: 15917656

DOI: 10.4161/cc.4.7.1787

PubMed ID: 17635935

Title: Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division.

PubMed ID: 17635935

DOI: 10.1083/jcb.200604114

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 17603074

Title: Structure-based protocol for identifying mutations that enhance protein-protein binding affinities.

PubMed ID: 17603074

DOI: 10.1016/j.jmb.2007.05.096

PubMed ID: 18434541

Title: Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.

PubMed ID: 18434541

DOI: 10.1073/pnas.0801508105

PubMed ID: 21115486

Title: Structural determinants of affinity enhancement between GoLoco motifs and G-protein alpha subunit mutants.

PubMed ID: 21115486

DOI: 10.1074/jbc.m110.190496

Sequence Information:

Length: 566
Mass: 61447
Checksum: 811296228B479C3D
Sequence:

MPGKPKHLGV PNGRMVLAVS DGELSSTTGP QGQGEGRGSS LSIHSLPSGP SSPFPTEEQP 
VASWALSFER LLQDPLGLAY FTEFLKKEFS AENVTFWKAC ERFQQIPASD TQQLAQEARN 
IYQEFLSSQA LSPVNIDRQA WLGEEVLAEP RPDMFRAQQL QIFNLMKFDS YARFVKSPLY 
RECLLAEAEG RPLREPGSSR LGSPDATRKK PKLKPGKSLP LGVEELGQLP PVEGPGGRPL 
RKSFRRELGG TANAALRRES QGSLNSSASL DLGFLAFVSS KSESHRKSLG STEGESESRP 
GKYCCVYLPD GTASLALARP GLTIRDMLAG ICEKRGLSLP DIKVYLVGNE QALVLDQDCT 
VLADQEVRLE NRITFELELT ALERVVRISA KPTKRLQEAL QPILEKHGLS PLEVVLHRPG 
EKQPLDLGKL VSSVAAQRLV LDTLPGVKIS KARDKSPCRS QGCPPRTQDK ATHPPPASPS 
SLVKVPSSAT GKRQTCDIEG LVELLNRVQS SGAHDQRGLL RKEDLVLPEF LQLPAQGPSS 
EETPPQTKSA AQPIGGSLNS TTDSAL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RGS14

Associated with

Other Information

Localization of the GoLoco motif carrier regulator of G-protein signalling 12 and 14 proteins in monkey and rat brain. PubMed ID: 16819986

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

RGS14 is a microtubule-associated protein. PubMed ID: 15917656

Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. PubMed ID: 17635935

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Structure-based protocol for identifying mutations that enhance protein-protein binding affinities. PubMed ID: 17603074

Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. PubMed ID: 18434541

Structural determinants of affinity enhancement between GoLoco motifs and G-protein alpha subunit mutants. PubMed ID: 21115486