Details for: EXOC5

Gene ID: 10640

Symbol: EXOC5

Ensembl ID: ENSG00000070367

Description: exocyst complex component 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.04
    Marker Score: 8,501
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.67
    Marker Score: 63,538
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.65
    Marker Score: 101,768
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.63
    Marker Score: 15,447
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.59
    Marker Score: 13,681
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.59
    Marker Score: 6,149
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.58
    Marker Score: 23,694
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.58
    Marker Score: 14,903
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.52
    Marker Score: 30,188
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.51
    Marker Score: 15,629
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.51
    Marker Score: 55,786
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.51
    Marker Score: 11,573
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.5
    Marker Score: 6,210
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.42
    Marker Score: 2,197
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.39
    Marker Score: 1,537
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.38
    Marker Score: 1,990
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.38
    Marker Score: 29,371
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.36
    Marker Score: 5,554
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.31
    Marker Score: 782
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.31
    Marker Score: 1,502
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.28
    Marker Score: 747
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.22
    Marker Score: 5,630
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.21
    Marker Score: 355
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.21
    Marker Score: 4,685
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.2
    Marker Score: 40,651
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.12
    Marker Score: 627
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.11
    Marker Score: 582
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.1
    Marker Score: 316
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.1
    Marker Score: 459
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.06
    Marker Score: 2,337
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.06
    Marker Score: 4,418
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.05
    Marker Score: 2,512
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.01
    Marker Score: 245
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,644
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,869
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.99
    Marker Score: 5,169
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.98
    Marker Score: 667
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,382
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.98
    Marker Score: 24,976
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.97
    Marker Score: 1,221
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.97
    Marker Score: 2,634
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.97
    Marker Score: 1,018
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.95
    Marker Score: 1,029
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,389
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.93
    Marker Score: 465
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.93
    Marker Score: 996
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.93
    Marker Score: 852
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.93
    Marker Score: 540
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.92
    Marker Score: 441
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.91
    Marker Score: 1,099
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.9
    Marker Score: 444
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,687
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.9
    Marker Score: 331
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.89
    Marker Score: 1,004
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.89
    Marker Score: 518
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.89
    Marker Score: 772
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.89
    Marker Score: 242
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.88
    Marker Score: 301
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.88
    Marker Score: 2,966
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.88
    Marker Score: 828
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.88
    Marker Score: 217
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.86
    Marker Score: 7,443
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.86
    Marker Score: 1,114
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.86
    Marker Score: 910
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.86
    Marker Score: 347
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.85
    Marker Score: 532
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.85
    Marker Score: 817
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.85
    Marker Score: 2,077
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.84
    Marker Score: 410
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.84
    Marker Score: 323
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.84
    Marker Score: 1,905
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.83
    Marker Score: 754
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.83
    Marker Score: 568
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.83
    Marker Score: 834
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.82
    Marker Score: 332
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.82
    Marker Score: 4,689
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1,334
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.82
    Marker Score: 12,816
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.82
    Marker Score: 3,030
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.81
    Marker Score: 28,219
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.81
    Marker Score: 876
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 325
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.81
    Marker Score: 200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.81
    Marker Score: 194
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.81
    Marker Score: 998
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.81
    Marker Score: 864
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.8
    Marker Score: 969
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.8
    Marker Score: 764
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.8
    Marker Score: 277
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.8
    Marker Score: 1,129
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.79
    Marker Score: 191
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.79
    Marker Score: 712
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.79
    Marker Score: 4,265
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.79
    Marker Score: 595
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.79
    Marker Score: 1,522
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 603

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location:** The EXOC5 gene is located on chromosome 13q34.3. 2. **Protein Structure:** The EXOC5 protein belongs to the exocyst complex, a heteropentameric complex composed of five subunits (EXOC5, EXOC6, EXOC7, EXOC8, and EXOC9). 3. **Function:** EXOC5 is involved in regulating membrane trafficking, cilia assembly, and cellular polarity. 4. **Subcellular Localization:** EXOC5 is primarily localized to the plasma membrane and the Golgi apparatus. 5. **Expression:** EXOC5 is significantly expressed in various neuronal populations, including GABAergic neurons, and is also found in other cell types, such as epithelial cells and neurons. **Pathways and Functions:** 1. **Cargo Trafficking to the Periciliary Membrane:** EXOC5 regulates the transport of proteins and lipids between the Golgi apparatus and the plasma membrane, facilitating the assembly and maintenance of cilia. 2. **Cilium Assembly:** EXOC5 is essential for the assembly and maintenance of non-motile cilia, which are critical for sensory perception and cellular polarity. 3. **Cytoplasm and Cytosol:** EXOC5 regulates the movement of vesicles and proteins within the cytoplasm and cytosol, influencing cellular polarity and membrane trafficking. 4. **Epithelial Cell Apoptotic Process:** EXOC5 has been implicated in the regulation of epithelial cell apoptosis, which is essential for tissue homeostasis and development. 5. **Establishment of Planar Polarity:** EXOC5 plays a critical role in establishing planar polarity in epithelial cells, which is essential for the proper development and function of tissues. **Clinical Significance:** 1. **Neurological Disorders:** Mutations in the EXOC5 gene have been associated with neurological disorders, such as epilepsy, intellectual disability, and autism spectrum disorder. 2. **Cilia-Related Disorders:** EXOC5 mutations have also been linked to cilia-related disorders, such as primary ciliary dyskinesia and polycystic kidney disease. 3. **Cancer:** Alterations in EXOC5 expression and function have been observed in various types of cancer, including breast, lung, and colon cancer. 4. **Neurodevelopmental Disorders:** EXOC5 has been implicated in the regulation of neurodevelopmental processes, including neuronal migration, differentiation, and synaptic transmission. In conclusion, the EXOC5 gene plays a critical role in regulating membrane trafficking, cilia assembly, and cellular polarity, and its dysregulation has been implicated in various neurological and cilia-related disorders. Further research is needed to fully elucidate the functional significance of EXOC5 and its potential as a therapeutic target for the treatment of these disorders.

Genular Protein ID: 2289451897

Symbol: EXOC5_HUMAN

Name: Exocyst complex component 5

UniProtKB Accession Codes:

O00471 B2R6C5 Q8IW24

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 17 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9119050

Title: Identification and characterization of homologues of the exocyst component Sec10p.

PubMed ID: 9119050

DOI: 10.1016/s0014-5793(97)00109-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18756269

Title: Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs.

PubMed ID: 18756269

DOI: 10.1038/emboj.2008.166

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 708
  • Mass: 81853
  • Checksum: CB03AC6C64DAB50C
  • Sequence:
    • MATTAELFEE PFVADEYIER LVWRTPGGGS RGGPEAFDPK RLLEEFVNHI QELQIMDERI 
QRKVEKLEQQ CQKEAKEFAK KVQELQKSNQ VAFQHFQELD EHISYVATKV CHLGDQLEGV 
NTPRQRAVEA QKLMKYFNEF LDGELKSDVF TNSEKIKEAA DIIQKLHLIA QELPFDRFSE 
VKSKIASKYH DLECQLIQEF TSAQRRGEIS RMREVAAVLL HFKGYSHCVD VYIKQCQEGA 
YLRNDIFEDA GILCQRVNKQ VGDIFSNPET VLAKLIQNVF EIKLQSFVKE QLEECRKSDA 
EQYLKNLYDL YTRTTNLSSK LMEFNLGTDK QTFLSKLIKS IFISYLENYI EVETGYLKSR 
SAMILQRYYD SKNHQKRSIG TGGIQDLKER IRQRTNLPLG PSIDTHGETF LSQEVVVNLL 
QETKQAFERC HRLSDPSDLP RNAFRIFTIL VEFLCIEHID YALETGLAGI PSSDSRNANL 
YFLDVVQQAN TIFHLFDKQF NDHLMPLISS SPKLSECLQK KKEIIEQMEM KLDTGIDRTL 
NCMIGQMKHI LAAEQKKTDF KPEDENNVLI QYTNACVKVC AYVRKQVEKI KNSMDGKNVD 
TVLMELGVRF HRLIYEHLQQ YSYSCMGGML AICDVAEYRK CAKDFKIPMV LHLFDTLHAL 
CNLLVVAPDN LKQVCSGEQL ANLDKNILHS FVQLRADYRS ARLARHFS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.