Details for: NPRL2
Associated with
Other Information
Genular Protein ID: 1923623238
Symbol: NPRL2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11085536
Title: The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes.
PubMed ID: 11085536
PubMed ID: 11980673
Title: Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo.
PubMed ID: 11980673
PubMed ID: 18616680
Title: TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling.
PubMed ID: 18616680
PubMed ID: 19521502
Title: A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex.
PubMed ID: 19521502
PubMed ID: 23723238
Title: A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
PubMed ID: 23723238
PubMed ID: 28199306
Title: KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.
PubMed ID: 28199306
DOI: 10.1038/nature21423
PubMed ID: 30651352
Title: Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases.
PubMed ID: 30651352
PubMed ID: 36007018
Title: Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.
PubMed ID: 36007018
PubMed ID: 36528027
Title: Ring domains are essential for GATOR2-dependent mTORC1 activation.
PubMed ID: 36528027
PubMed ID: 29590090
Title: Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.
PubMed ID: 29590090
DOI: 10.1038/nature26158
PubMed ID: 35338845
Title: Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
PubMed ID: 35338845
PubMed ID: 26505888
Title: Mutations in the mammalian target of rapamycin pathway regulators NPRL2 and NPRL3 cause focal epilepsy.
PubMed ID: 26505888
DOI: 10.1002/ana.24547
PubMed ID: 27173016
Title: Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia.
PubMed ID: 27173016
DOI: 10.1111/epi.13391
Sequence Information:
- Length: 380
- Mass: 43658
- Checksum: 5ECA201CE073F964
- Sequence:
MGSGCRIECI FFSEFHPTLG PKITYQVPED FISRELFDTV QVYIITKPEL QNKLITVTAM EKKLIGCPVC IEHKKYSRNA LLFNLGFVCD AQAKTCALEP IVKKLAGYLT TLELESSFVS MEESKQKLVP IMTILLEELN ASGRCTLPID ESNTIHLKVI EQRPDPPVAQ EYDVPVFTKD KEDFFNSQWD LTTQQILPYI DGFRHIQKIS AEADVELNLV RIAIQNLLYY GVVTLVSILQ YSNVYCPTPK VQDLVDDKSL QEACLSYVTK QGHKRASLRD VFQLYCSLSP GTTVRDLIGR HPQQLQHVDE RKLIQFGLMK NLIRRLQKYP VRVTREEQSH PARLYTGCHS YDEICCKTGM SYHELDERLE NDPNIIICWK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.