IGF2BP1 | ENSG00000159217 | NCBI 10642

Details for: IGF2BP1

Gene ID: 10642

Symbol: IGF2BP1

Ensembl ID: ENSG00000159217

Description: insulin like growth factor 2 mRNA binding protein 1

Associated with

Insulin-like growth factor-2 mrna binding proteins (igf2bps/imps/vickzs) bind rna
(R-HSA-428359)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism of rna
(R-HSA-8953854)
Signal transduction
(R-HSA-162582)
Crd-mediated mrna stability complex
(GO:0070937)
Crd-mediated mrna stabilization
(GO:0070934)
Cytoplasm
(GO:0005737)
Cytoplasmic stress granule
(GO:0010494)
Cytosol
(GO:0005829)
Dendrite arborization
(GO:0140059)
Dendritic spine
(GO:0043197)
Filopodium
(GO:0030175)
Growth cone
(GO:0030426)
Lamellipodium
(GO:0030027)
Mrna 3'-utr binding
(GO:0003730)
Mrna 5'-utr binding
(GO:0048027)
Mrna binding
(GO:0003729)
Mrna transport
(GO:0051028)
N6-methyladenosine-containing rna reader activity
(GO:1990247)
Negative regulation of nuclear-transcribed mrna catabolic process, deadenylation-dependent decay
(GO:1900152)
Negative regulation of translation
(GO:0017148)
Nervous system development
(GO:0007399)
Neuronal cell body
(GO:0043025)
Neuronal stem cell population maintenance
(GO:0097150)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
P-body
(GO:0000932)
Pallium cell proliferation in forebrain
(GO:0022013)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of cytoplasmic translation
(GO:2000767)
Protein binding
(GO:0005515)
Regulation of cytokine production
(GO:0001817)
Regulation of gene expression
(GO:0010468)
Regulation of mrna stability involved in response to stress
(GO:0010610)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
Translation regulator activity
(GO:0045182)

Other Information

Proteins

Insulin-like growth factor 2 mRNA-binding protein 1

Genular Protein ID: 2218695526

Symbol: IF2B1_HUMAN

Name: Insulin-like growth factor 2 mRNA-binding protein 1

UniProtKB Accession Codes:

Q9NZI8 C9JT33

Database IDs:

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 9891060

Title: A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development.

PubMed ID: 9891060

DOI: 10.1128/mcb.19.2.1262

PubMed ID: 16356927

Title: The autoregulatory translational control element of poly(A)-binding protein mRNA forms a heteromeric ribonucleoprotein complex.

PubMed ID: 16356927

DOI: 10.1093/nar/gki1014

PubMed ID: 9801297

Title: The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins.

PubMed ID: 9801297

DOI: 10.1093/nar/26.22.5036

PubMed ID: 8132663

Title: Purification and properties of a protein that binds to the C-terminal coding region of human c-myc mRNA.

PubMed ID: 8132663

DOI: 10.1016/s0021-9258(17)37102-8

PubMed ID: 10875929

Title: H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein.

PubMed ID: 10875929

DOI: 10.1074/jbc.m001156200

PubMed ID: 12921532

Title: Nuclear transit of human zipcode-binding protein IMP1.

PubMed ID: 12921532

DOI: 10.1042/bj20030943

PubMed ID: 15282548

Title: Visualization of RNA-protein interactions in living cells: FMRP and IMP1 interact on mRNAs.

PubMed ID: 15282548

DOI: 10.1038/sj.emboj.7600341

PubMed ID: 15314207

Title: Sequential dimerization of human zipcode-binding protein IMP1 on RNA: a cooperative mechanism providing RNP stability.

PubMed ID: 15314207

DOI: 10.1093/nar/gkh754

PubMed ID: 16049158

Title: Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer.

PubMed ID: 16049158

DOI: 10.1530/rep.1.00664

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16541107

Title: RNA-binding IMPs promote cell adhesion and invadopodia formation.

PubMed ID: 16541107

DOI: 10.1038/sj.emboj.7601039

PubMed ID: 17212783

Title: IMP1 interacts with poly(A)-binding protein (PABP) and the autoregulatory translational control element of PABP-mRNA through the KH III-IV domain.

PubMed ID: 17212783

DOI: 10.1111/j.1742-4658.2006.05556.x

PubMed ID: 17101699

Title: ZBP1 regulates mRNA stability during cellular stress.

PubMed ID: 17101699

DOI: 10.1083/jcb.200608071

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16778892

Title: CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signaling.

PubMed ID: 16778892

DOI: 10.1038/nature04839

PubMed ID: 17255263

Title: Increased expression of insulin-like growth factor-II messenger RNA-binding protein 1 is associated with tumor progression in patients with lung cancer.

PubMed ID: 17255263

DOI: 10.1158/1078-0432.ccr-06-1297

PubMed ID: 17932509

Title: Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.

PubMed ID: 17932509

DOI: 10.1038/sj.embor.7401088

PubMed ID: 17893325

Title: ZBP2 facilitates binding of ZBP1 to beta-actin mRNA during transcription.

PubMed ID: 17893325

DOI: 10.1128/mcb.00972-07

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18385235

Title: Insulin-like growth factor II mRNA binding protein 1 associates with Gag protein of human immunodeficiency virus type 1, and its overexpression affects virus assembly.

PubMed ID: 18385235

DOI: 10.1128/jvi.00189-08

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19647520

Title: CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183-mediated degradation.

PubMed ID: 19647520

DOI: 10.1016/j.molcel.2009.06.007

PubMed ID: 19029303

Title: Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs.

PubMed ID: 19029303

DOI: 10.1261/rna.1175909

PubMed ID: 19541769

Title: IGF2BP1 enhances HCV IRES-mediated translation initiation via the 3'UTR.

PubMed ID: 19541769

DOI: 10.1261/rna.1578409

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22279049

Title: IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling.

PubMed ID: 22279049

DOI: 10.1101/gad.177642.111

PubMed ID: 23640942

Title: Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains.

PubMed ID: 23640942

DOI: 10.1515/hsz-2013-0111

PubMed ID: 23069990

Title: Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?

PubMed ID: 23069990

DOI: 10.1007/s00018-012-1186-z

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29476152

Title: Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.

PubMed ID: 29476152

DOI: 10.1038/s41556-018-0045-z

PubMed ID: 32245947

Title: An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis.

PubMed ID: 32245947

DOI: 10.1038/s41467-020-15403-9

PubMed ID: 20080952

Title: ZBP1 recognition of beta-actin zipcode induces RNA looping.

PubMed ID: 20080952

DOI: 10.1101/gad.1862910

Sequence Information:

Length: 577
Mass: 63481
Checksum: 1D036AE5388D05FA
Sequence:

MNKLYIGNLN ESVTPADLEK VFAEHKISYS GQFLVKSGYA FVDCPDEHWA MKAIETFSGK 
VELQGKRLEI EHSVPKKQRS RKIQIRNIPP QLRWEVLDSL LAQYGTVENC EQVNTESETA 
VVNVTYSNRE QTRQAIMKLN GHQLENHALK VSYIPDEQIA QGPENGRRGG FGSRGQPRQG 
SPVAAGAPAK QQQVDIPLRL LVPTQYVGAI IGKEGATIRN ITKQTQSKID VHRKENAGAA 
EKAISVHSTP EGCSSACKMI LEIMHKEAKD TKTADEVPLK ILAHNNFVGR LIGKEGRNLK 
KVEQDTETKI TISSLQDLTL YNPERTITVK GAIENCCRAE QEIMKKVREA YENDVAAMSL 
QSHLIPGLNL AAVGLFPASS SAVPPPPSSV TGAAPYSSFM QAPEQEMVQV FIPAQAVGAI 
IGKKGQHIKQ LSRFASASIK IAPPETPDSK VRMVIITGPP EAQFKAQGRI YGKLKEENFF 
GPKEEVKLET HIRVPASAAG RVIGKGGKTV NELQNLTAAE VVVPRDQTPD ENDQVIVKII 
GHFYASQMAQ RKIRDILAQV KQQHQKGQSN QAQARRK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: IGF2BP1

Associated with

Other Information

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. PubMed ID: 9891060

The autoregulatory translational control element of poly(A)-binding protein mRNA forms a heteromeric ribonucleoprotein complex. PubMed ID: 16356927

The c-myc coding region determinant-binding protein: a member of a family of KH domain RNA-binding proteins. PubMed ID: 9801297

Purification and properties of a protein that binds to the C-terminal coding region of human c-myc mRNA. PubMed ID: 8132663

H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein. PubMed ID: 10875929

Nuclear transit of human zipcode-binding protein IMP1. PubMed ID: 12921532

Visualization of RNA-protein interactions in living cells: FMRP and IMP1 interact on mRNAs. PubMed ID: 15282548

Sequential dimerization of human zipcode-binding protein IMP1 on RNA: a cooperative mechanism providing RNP stability. PubMed ID: 15314207

Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer. PubMed ID: 16049158

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

RNA-binding IMPs promote cell adhesion and invadopodia formation. PubMed ID: 16541107

IMP1 interacts with poly(A)-binding protein (PABP) and the autoregulatory translational control element of PABP-mRNA through the KH III-IV domain. PubMed ID: 17212783

ZBP1 regulates mRNA stability during cellular stress. PubMed ID: 17101699

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signaling. PubMed ID: 16778892

Increased expression of insulin-like growth factor-II messenger RNA-binding protein 1 is associated with tumor progression in patients with lung cancer. PubMed ID: 17255263

Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells. PubMed ID: 17932509

ZBP2 facilitates binding of ZBP1 to beta-actin mRNA during transcription. PubMed ID: 17893325

Molecular composition of IMP1 ribonucleoprotein granules. PubMed ID: 17289661

Insulin-like growth factor II mRNA binding protein 1 associates with Gag protein of human immunodeficiency virus type 1, and its overexpression affects virus assembly. PubMed ID: 18385235

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183-mediated degradation. PubMed ID: 19647520

Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. PubMed ID: 19029303

IGF2BP1 enhances HCV IRES-mediated translation initiation via the 3'UTR. PubMed ID: 19541769

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling. PubMed ID: 22279049

Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains. PubMed ID: 23640942

Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? PubMed ID: 23069990

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. PubMed ID: 29476152

An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis. PubMed ID: 32245947

ZBP1 recognition of beta-actin zipcode induces RNA looping. PubMed ID: 20080952