Details for: IGF2BP3

Gene ID: 10643

Symbol: IGF2BP3

Ensembl ID: ENSG00000136231

Description: insulin like growth factor 2 mRNA binding protein 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 5.31
    Marker Score: 6,407
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 4.7
    Marker Score: 7,244
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.67
    Marker Score: 31,013
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 3.24
    Marker Score: 2,663
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.89
    Marker Score: 2,500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.88
    Marker Score: 4,892
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.6
    Marker Score: 46,140
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.25
    Marker Score: 1,261
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.2
    Marker Score: 6,315
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.11
    Marker Score: 11,079
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.05
    Marker Score: 4,239
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.98
    Marker Score: 8,249
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.89
    Marker Score: 1,337
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.85
    Marker Score: 1,318
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.85
    Marker Score: 1,482
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.75
    Marker Score: 783
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.7
    Marker Score: 498
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.6
    Marker Score: 53,990
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.6
    Marker Score: 395
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1,157
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.55
    Marker Score: 6,073
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.48
    Marker Score: 2,084
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.47
    Marker Score: 51,027
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,763
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.45
    Marker Score: 4,750
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.43
    Marker Score: 14,385
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.37
    Marker Score: 1,031
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.36
    Marker Score: 13,763
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.32
    Marker Score: 682
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.3
    Marker Score: 1,380
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.28
    Marker Score: 871
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 488
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.15
    Marker Score: 670
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,786
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.14
    Marker Score: 865
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.1
    Marker Score: 737
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.09
    Marker Score: 421
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.09
    Marker Score: 344
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 499
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.09
    Marker Score: 1,310
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.08
    Marker Score: 9,491
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.06
    Marker Score: 529
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.06
    Marker Score: 2,885
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.04
    Marker Score: 2,173
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.02
    Marker Score: 561
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.02
    Marker Score: 1,770
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.01
    Marker Score: 5,411
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1
    Marker Score: 1,439
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,792
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1
    Marker Score: 1,891
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,016
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.95
    Marker Score: 956
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1,530
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.93
    Marker Score: 218
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.92
    Marker Score: 14,433
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,733
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,178
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.91
    Marker Score: 435
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.9
    Marker Score: 942
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.89
    Marker Score: 6,703
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.87
    Marker Score: 481
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.87
    Marker Score: 594
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.86
    Marker Score: 285
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.85
    Marker Score: 1,183
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.83
    Marker Score: 3,218
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.83
    Marker Score: 2,260
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.83
    Marker Score: 239
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.82
    Marker Score: 398
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.82
    Marker Score: 1,938
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.82
    Marker Score: 1,673
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.82
    Marker Score: 233
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.81
    Marker Score: 863
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.81
    Marker Score: 205
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 606
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.79
    Marker Score: 792
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.78
    Marker Score: 358
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.78
    Marker Score: 732
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.78
    Marker Score: 492
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.77
    Marker Score: 747
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.77
    Marker Score: 1,776
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.77
    Marker Score: 2,575
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.76
    Marker Score: 247
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.76
    Marker Score: 10,049
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.76
    Marker Score: 318
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 689
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.75
    Marker Score: 701
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.74
    Marker Score: 555
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 467
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.72
    Marker Score: 432
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.72
    Marker Score: 384
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.7
    Marker Score: 341
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGF2BP3 is a RNA-binding protein that exhibits a unique ability to bind to specific mRNA sequences, including the 3'- and 5'-UTRs, as well as the 3'-UTR of insulin-like growth factor 2 (IGF2) mRNA. This binding activity is mediated by its RNA recognition motif (RRM) and a C-terminal domain that interacts with the mRNA 3'-UTR. IGF2BP3 has been shown to regulate the translation of target mRNAs, including those involved in cellular development, growth, and differentiation. Its expression is tightly regulated, with a significant increase observed during embryonic development and in response to various cellular stresses. **Pathways and Functions:** IGF2BP3 is involved in several key pathways, including: 1. **Anatomical structure morphogenesis**: IGF2BP3 regulates the expression of genes involved in cell migration, adhesion, and differentiation, thereby influencing tissue morphogenesis. 2. **Crd-mediated mRNA stabilization**: IGF2BP3 interacts with the crd protein, which is involved in the regulation of mRNA stability and translation. 3. **Negative regulation of translation**: IGF2BP3 binds to specific mRNA sequences, thereby inhibiting translation and regulating the levels of protein expression. 4. **Regulation of cytokine production**: IGF2BP3 modulates the expression of cytokines involved in immune responses, highlighting its role in immune system regulation. **Clinical Significance:** IGF2BP3 has been implicated in various diseases, including: 1. **Cancer**: Aberrant expression of IGF2BP3 has been observed in several types of cancer, including breast, lung, and colon cancer, suggesting its potential as a prognostic marker. 2. **Neurological disorders**: IGF2BP3 has been shown to be involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Metabolic disorders**: IGF2BP3 regulates glucose and lipid metabolism, making it a potential target for the treatment of metabolic disorders, such as type 2 diabetes. In conclusion, IGF2BP3 is a critical regulator of gene expression and cellular development, with implications for various physiological and pathological processes. Further research is needed to fully elucidate its functions and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3160412292

Symbol: IF2B3_HUMAN

Name: Insulin-like growth factor 2 mRNA-binding protein 3

UniProtKB Accession Codes:

O00425 A0A4Z5 Q63HM0 Q6MZZ2 Q86VB1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 5 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9178771

Title: Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein.

PubMed ID: 9178771

DOI: 10.1038/sj.onc.1201110

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10525192

Title: Expression of the highly conserved RNA binding protein KOC in embryogenesis.

PubMed ID: 10525192

DOI: 10.1016/s0925-4773(99)00160-4

PubMed ID: 9891060

Title: A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development.

PubMed ID: 9891060

DOI: 10.1128/mcb.19.2.1262

PubMed ID: 11465943

Title: Autoimmune responses to mRNA binding proteins p62 and Koc in diverse malignancies.

PubMed ID: 11465943

DOI: 10.1006/clim.2001.5048

PubMed ID: 12161597

Title: Characterisation of the growth regulating gene IMP3, a candidate for Silver-Russell syndrome.

PubMed ID: 12161597

DOI: 10.1136/jmg.39.8.575

PubMed ID: 12921532

Title: Nuclear transit of human zipcode-binding protein IMP1.

PubMed ID: 12921532

DOI: 10.1042/bj20030943

PubMed ID: 15601260

Title: VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins.

PubMed ID: 15601260

DOI: 10.1042/bc20040151

PubMed ID: 15644775

Title: KOC (K homology domain containing protein overexpressed in cancer): a novel molecular marker that distinguishes between benign and malignant lesions of the pancreas.

PubMed ID: 15644775

DOI: 10.1097/01.pas.0000149688.98333.54

PubMed ID: 16049158

Title: Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer.

PubMed ID: 16049158

DOI: 10.1530/rep.1.00664

PubMed ID: 16541107

Title: RNA-binding IMPs promote cell adhesion and invadopodia formation.

PubMed ID: 16541107

DOI: 10.1038/sj.emboj.7601039

PubMed ID: 16814207

Title: Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study.

PubMed ID: 16814207

DOI: 10.1016/s1470-2045(06)70732-x

PubMed ID: 17192788

Title: IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16(INK4a) expression.

PubMed ID: 17192788

DOI: 10.1038/modpathol.3800735

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20080952

Title: ZBP1 recognition of beta-actin zipcode induces RNA looping.

PubMed ID: 20080952

DOI: 10.1101/gad.1862910

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23640942

Title: Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains.

PubMed ID: 23640942

DOI: 10.1515/hsz-2013-0111

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29476152

Title: Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.

PubMed ID: 29476152

DOI: 10.1038/s41556-018-0045-z

Sequence Information:

  • Length: 579
  • Mass: 63705
  • Checksum: 78884F56A9D98CDE
  • Sequence:
    • MNKLYIGNLS ENAAPSDLES IFKDAKIPVS GPFLVKTGYA FVDCPDESWA LKAIEALSGK 
IELHGKPIEV EHSVPKRQRI RKLQIRNIPP HLQWEVLDSL LVQYGVVESC EQVNTDSETA 
VVNVTYSSKD QARQALDKLN GFQLENFTLK VAYIPDEMAA QQNPLQQPRG RRGLGQRGSS 
RQGSPGSVSK QKPCDLPLRL LVPTQFVGAI IGKEGATIRN ITKQTQSKID VHRKENAGAA 
EKSITILSTP EGTSAACKSI LEIMHKEAQD IKFTEEIPLK ILAHNNFVGR LIGKEGRNLK 
KIEQDTDTKI TISPLQELTL YNPERTITVK GNVETCAKAE EEIMKKIRES YENDIASMNL 
QAHLIPGLNL NALGLFPPTS GMPPPTSGPP SAMTPPYPQF EQSETETVHL FIPALSVGAI 
IGKQGQHIKQ LSRFAGASIK IAPAEAPDAK VRMVIITGPP EAQFKAQGRI YGKIKEENFV 
SPKEEVKLEA HIRVPSFAAG RVIGKGGKTV NELQNLSSAE VVVPRDQTPD ENDQVVVKIT 
GHFYACQVAQ RKIQEILTQV KQHQQQKALQ SGPPQSRRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.