Details for: CAMKK2

Gene ID: 10645

Symbol: CAMKK2

Ensembl ID: ENSG00000110931

Description: calcium/calmodulin dependent protein kinase kinase 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.71
    Marker Score: 105,075
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.53
    Marker Score: 2,361
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.52
    Marker Score: 14,395
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.39
    Marker Score: 51,265
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.39
    Marker Score: 12,172
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.38
    Marker Score: 12,955
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.35
    Marker Score: 11,611
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.16
    Marker Score: 4,730
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.1
    Marker Score: 4,550
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.05
    Marker Score: 58,846
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.05
    Marker Score: 4,061
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.04
    Marker Score: 15,512
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1
    Marker Score: 917
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,734
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,959
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,396
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.96
    Marker Score: 19,096
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,401
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 484
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.94
    Marker Score: 1,079
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 439
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,713
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.9
    Marker Score: 2,119
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.89
    Marker Score: 9,175
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.88
    Marker Score: 285
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,294
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.86
    Marker Score: 932
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,908
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1,389
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.84
    Marker Score: 2,091
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.84
    Marker Score: 3,878
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.84
    Marker Score: 351
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.83
    Marker Score: 27,999
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.8
    Marker Score: 1,627
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8
    Marker Score: 12,477
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.79
    Marker Score: 5,103
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.79
    Marker Score: 3,413
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.78
    Marker Score: 467
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.78
    Marker Score: 584
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 308
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.76
    Marker Score: 720
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 573
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 495
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.75
    Marker Score: 5,711
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.74
    Marker Score: 765
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,995
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.71
    Marker Score: 2,961
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.69
    Marker Score: 217
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.68
    Marker Score: 1,141
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.68
    Marker Score: 4,065
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 615
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.67
    Marker Score: 235
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.67
    Marker Score: 402
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.67
    Marker Score: 25,403
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.66
    Marker Score: 828
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.66
    Marker Score: 313
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.65
    Marker Score: 177
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.64
    Marker Score: 1,250
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.63
    Marker Score: 368
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.63
    Marker Score: 3,377
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.62
    Marker Score: 414
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.61
    Marker Score: 331
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.61
    Marker Score: 224
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.61
    Marker Score: 299
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.6
    Marker Score: 226
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.6
    Marker Score: 368
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.6
    Marker Score: 2,224
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.6
    Marker Score: 410
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.6
    Marker Score: 372
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.59
    Marker Score: 205
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.59
    Marker Score: 253
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.58
    Marker Score: 144
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.58
    Marker Score: 1,326
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.58
    Marker Score: 702
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.58
    Marker Score: 368
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.56
    Marker Score: 6,326
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.56
    Marker Score: 146
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.56
    Marker Score: 272
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.56
    Marker Score: 11,871
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.55
    Marker Score: 1,067
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.55
    Marker Score: 1,325
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.54
    Marker Score: 222
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.54
    Marker Score: 144
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.54
    Marker Score: 581
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 428
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.53
    Marker Score: 185
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.53
    Marker Score: 596
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.53
    Marker Score: 359
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.53
    Marker Score: 334
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.52
    Marker Score: 181
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.51
    Marker Score: 1,046
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.51
    Marker Score: 251
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.51
    Marker Score: 215
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.51
    Marker Score: 495
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.51
    Marker Score: 5,166
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.51
    Marker Score: 192
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.51
    Marker Score: 285

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Calcium-binding protein kinase**: CAMKK2 is a calcium/calmodulin-dependent protein kinase that exhibits high calcium/calmodulin binding affinity, enabling it to respond to changes in intracellular calcium concentrations. 2. **Dual kinase activity**: CAMKK2 possesses both protein kinase C (PKC) and protein kinase A (PKA) kinase activities, allowing it to phosphorylate and regulate a wide range of downstream targets. 3. **Regulation of AMPK**: CAMKK2 is a key regulator of AMPK activity, which is involved in energy homeostasis, glucose metabolism, and insulin signaling. 4. **Neuronal expression**: CAMKK2 is predominantly expressed in neurons, particularly in L2/3 and L5 intratelencephalic projecting glutamatergic neurons, corticothalamic-projecting glutamatergic cortical neurons, and chandelier Pvalb GABAergic cortical interneurons. **Pathways and Functions:** 1. **Calcium-dependent signaling**: CAMKK2 is activated by an increase in intracellular calcium concentrations, which triggers a cascade of downstream signaling events, including the activation of AMPK, NMDA receptors, and Rac1. 2. **AMPK signaling cascade**: CAMKK2 phosphorylates and activates AMPK, which in turn regulates energy homeostasis, glucose metabolism, and insulin signaling. 3. **NMDA receptor signaling**: CAMKK2 is involved in the regulation of NMDA receptor activity, which is critical for synaptic plasticity, learning, and memory formation. 4. **Rac1 signaling**: CAMKK2 activates Rac1, a small GTPase involved in cytoskeleton reorganization, cell migration, and immune response. 5. **Autophagy regulation**: CAMKK2 positively regulates autophagy of mitochondria, a process essential for maintaining cellular homeostasis and responding to oxidative stress. **Clinical Significance:** 1. **Neurological disorders**: CAMKK2 dysregulation has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 2. **Immune response**: CAMKK2 is involved in the regulation of immune response, particularly in the activation of classical monocytes and the regulation of autophagy. 3. **Metabolic disorders**: CAMKK2 plays a role in regulating energy homeostasis and glucose metabolism, making it a potential therapeutic target for metabolic disorders, such as type 2 diabetes. 4. **Cancer**: CAMKK2 has been implicated in the regulation of autophagy and apoptosis in various types of cancer, including breast, lung, and colon cancer. In conclusion, CAMKK2 is a critical regulator of calcium-dependent signaling pathways, neuronal function, and immune response. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the molecular mechanisms underlying CAMKK2 function and its clinical significance.

Genular Protein ID: 667036425

Symbol: KKCC2_HUMAN

Name: Calcium/calmodulin-dependent protein kinase kinase 2

UniProtKB Accession Codes:

Q96RR4 A8K7Q7 O94883 Q8IUG2 Q8IUG3 Q8N3I4 Q8WY03 Q8WY04 Q8WY05 Q8WY06 Q96RP1 Q96RP2 Q96RR3 Q9BWE9 Q9UER3 Q9UES2 Q9Y5N2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 7 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 3 EMBL 49 EPD 1 Ensembl 11 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 26 PDBsum 23 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 Reactome 4 RefSeq 17 Rhea 6 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11395482

Title: Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity.

PubMed ID: 11395482

DOI: 10.1074/jbc.m011720200

PubMed ID: 9822657

Title: Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta.

PubMed ID: 9822657

DOI: 10.1074/jbc.273.48.31880

PubMed ID: 12935886

Title: Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells.

PubMed ID: 12935886

DOI: 10.1016/s0014-5793(03)00817-2

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9662074

Title: Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase.

PubMed ID: 9662074

DOI: 10.1007/bf02258368

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21957496

Title: Differential effects of PKA-controlled CaMKK2 variants on neuronal differentiation.

PubMed ID: 21957496

DOI: 10.4161/rna.8.6.16691

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 588
  • Mass: 64746
  • Checksum: 04E3583561341167
  • Sequence:
    • MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME SFIVVTECEP 
GCAVDLGLAR DRPLEADGQE VPLDTSGSQA RPHLSGRKLS LQERSQGGLA AGGSLDMNGR 
CICPSLPYSP VSSPQSSPRL PRRPTVESHH VSITGMQDCV QLNQYTLKDE IGKGSYGVVK 
LAYNENDNTY YAMKVLSKKK LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL 
KKLDHPNVVK LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 
EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT PAFMAPESLS 
ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS KIKSQALEFP DQPDIAEDLK 
DLITRMLDKN PESRIVVPEI KLHPWVTRHG AEPLPSEDEN CTLVEVTEEE VENSVKHIPS 
LATVILVKTM IRKRSFGNPF EGSRREERSL SAPGNLLTKK PTRECESLSE LKEARQRRQP 
PGHRPAPRGG GGSALVRGSP CVESCWAPAP GSPARMHPLR PEEAMEPE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.