CAMKK2 | ENSG00000110931 | NCBI 10645

Details for: CAMKK2

Gene ID: 10645

Symbol: CAMKK2

Ensembl ID: ENSG00000110931

Description: calcium/calmodulin dependent protein kinase kinase 2

Associated with

Activation of ampk downstream of nmdars
(R-HSA-9619483)
Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Activation of rac1 downstream of nmdars
(R-HSA-9619229)
Ca-dependent events
(R-HSA-111996)
Calmodulin induced events
(R-HSA-111933)
Camk iv-mediated phosphorylation of creb
(R-HSA-111932)
Cam pathway
(R-HSA-111997)
Creb1 phosphorylation through the activation of camkii/camkk/camkiv cascasde
(R-HSA-442729)
Dag and ip3 signaling
(R-HSA-1489509)
G-protein mediated events
(R-HSA-112040)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Intracellular signaling by second messengers
(R-HSA-9006925)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Opioid signalling
(R-HSA-111885)
Plc beta mediated events
(R-HSA-112043)
Post nmda receptor activation events
(R-HSA-438064)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Transmission across chemical synapses
(R-HSA-112315)
Atp binding
(GO:0005524)
Calcium-mediated signaling
(GO:0019722)
Calcium ion binding
(GO:0005509)
Calmodulin-dependent protein kinase activity
(GO:0004683)
Calmodulin binding
(GO:0005516)
Camkk-ampk signaling cascade
(GO:0061762)
Cellular response to reactive oxygen species
(GO:0034614)
Cytosol
(GO:0005829)
Mapk cascade
(GO:0000165)
Neuron projection
(GO:0043005)
Nucleoplasm
(GO:0005654)
Positive regulation of autophagy of mitochondrion
(GO:1903599)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein autophosphorylation
(GO:0046777)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of protein kinase activity
(GO:0045859)

Other Information

Proteins

Calcium/calmodulin-dependent protein kinase kinase 2

Genular Protein ID: 667036425

Symbol: KKCC2_HUMAN

Name: Calcium/calmodulin-dependent protein kinase kinase 2

UniProtKB Accession Codes:

Q96RR4 A8K7Q7 O94883 Q8IUG2 Q8IUG3 Q8N3I4 Q8WY03 Q8WY04 Q8WY05 Q8WY06 Q96RP1 Q96RP2 Q96RR3 Q9BWE9 Q9UER3 Q9UES2 Q9Y5N2

Database IDs:

Citations:

PubMed ID: 11395482

Title: Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity.

PubMed ID: 11395482

DOI: 10.1074/jbc.m011720200

PubMed ID: 9822657

Title: Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta.

PubMed ID: 9822657

DOI: 10.1074/jbc.273.48.31880

PubMed ID: 12935886

Title: Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells.

PubMed ID: 12935886

DOI: 10.1016/s0014-5793(03)00817-2

PubMed ID: 9872452

Title: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9872452

DOI: 10.1093/dnares/5.5.277

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9662074

Title: Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase.

PubMed ID: 9662074

DOI: 10.1007/bf02258368

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21957496

Title: Differential effects of PKA-controlled CaMKK2 variants on neuronal differentiation.

PubMed ID: 21957496

DOI: 10.4161/rna.8.6.16691

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 588
Mass: 64746
Checksum: 04E3583561341167
Sequence:

MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME SFIVVTECEP 
GCAVDLGLAR DRPLEADGQE VPLDTSGSQA RPHLSGRKLS LQERSQGGLA AGGSLDMNGR 
CICPSLPYSP VSSPQSSPRL PRRPTVESHH VSITGMQDCV QLNQYTLKDE IGKGSYGVVK 
LAYNENDNTY YAMKVLSKKK LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL 
KKLDHPNVVK LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI 
EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT PAFMAPESLS 
ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS KIKSQALEFP DQPDIAEDLK 
DLITRMLDKN PESRIVVPEI KLHPWVTRHG AEPLPSEDEN CTLVEVTEEE VENSVKHIPS 
LATVILVKTM IRKRSFGNPF EGSRREERSL SAPGNLLTKK PTRECESLSE LKEARQRRQP 
PGHRPAPRGG GGSALVRGSP CVESCWAPAP GSPARMHPLR PEEAMEPE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CAMKK2

Associated with

Other Information

Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity. PubMed ID: 11395482

Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. PubMed ID: 9822657

Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells. PubMed ID: 12935886

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 9872452

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. PubMed ID: 12168954

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase. PubMed ID: 9662074

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Differential effects of PKA-controlled CaMKK2 variants on neuronal differentiation. PubMed ID: 21957496

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846