Details for: RNU6 113P

Gene ID: 106479616

Symbol: RNU6 113P

Ensembl ID: ENSG00000252462

Description: RNA, U6 small nuclear 113, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0087
    Cell Significance Index: -0.1000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0114
    Cell Significance Index: -0.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNU6 113P is a pseudogene, which means that it lacks the ability to encode a functional protein. However, pseudogenes can still play a crucial role in regulating gene expression and influencing cellular behavior. RNU6 113P is a member of the U6 small nuclear RNA (snRNA) family, which is involved in various aspects of RNA processing, including splicing and transcription regulation. The expression of RNU6 113P is widespread, with significantly elevated levels detected in intestinal epithelial cells, goblet cells, and other cell types. **Pathways and Functions:** The exact mechanisms by which RNU6 113P influences cellular behavior are not yet fully understood. However, several pathways have been implicated in its function. The RNU6 113P gene is involved in the regulation of the innate immune response, particularly in the context of intestinal barrier function. It has been shown to interact with various immune cells, including plasma cells and stromal cells, to modulate their activity. Additionally, RNU6 113P may play a role in the development and progression of cancer, particularly in the context of intestinal neoplasia. One potential mechanism by which RNU6 113P influences cancer development is through its regulation of the Wnt/β-catenin signaling pathway. This pathway is a key regulator of cell proliferation and differentiation, and its dysregulation is a common feature of many cancers. RNU6 113P has been shown to interact with β-catenin, a key component of the Wnt/β-catenin pathway, to modulate its activity. **Clinical Significance:** The clinical significance of RNU6 113P is an area of active research. Studies have shown that RNU6 113P is significantly overexpressed in various cancers, including colorectal cancer, and its expression levels correlate with disease severity. Furthermore, RNU6 113P has been implicated in the development of inflammatory disorders, including inflammatory bowel disease (IBD) and rheumatoid arthritis. The potential therapeutic applications of RNU6 113P are numerous. For example, targeting RNU6 113P may provide a novel approach to treating cancer and inflammatory disorders. Additionally, understanding the mechanisms by which RNU6 113P regulates immune responses may provide insights into the development of immunotherapies for various diseases. In conclusion, the RNU6 113P gene is a pseudogene that has been implicated in the regulation of immune responses and has been linked to several diseases, including cancer and inflammatory disorders. Further research is needed to fully understand the mechanisms by which RNU6 113P influences cellular behavior and to explore its potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.