Details for: SCGB1D1

Gene ID: 10648

Symbol: SCGB1D1

Ensembl ID: ENSG00000168515

Description: secretoglobin family 1D member 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,081
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 9.42
    Marker Score: 5,217
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8,277
  • Cell Name: macrophage (CL0000235)
    Fold Change: 4.19
    Marker Score: 4,664
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3,181
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.02
    Marker Score: 1,718
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.66
    Marker Score: 3,674
  • Cell Name: mast cell (CL0000097)
    Fold Change: 1.99
    Marker Score: 1,154
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.91
    Marker Score: 1,006
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.76
    Marker Score: 735
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,573
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.23
    Marker Score: 284
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.23
    Marker Score: 812
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,650
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,724
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,056
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,404
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.94
    Marker Score: 225
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,341
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 738
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.49
    Marker Score: 935
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.48
    Marker Score: 3,191
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.42
    Marker Score: 6,561
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.41
    Marker Score: 828
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.2
    Marker Score: 96
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2
    Marker Score: 1,191
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.18
    Marker Score: 214
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.18
    Marker Score: 107
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.15
    Marker Score: 273
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.15
    Marker Score: 46
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.14
    Marker Score: 96
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.13
    Marker Score: 78
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.12
    Marker Score: 223
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.12
    Marker Score: 65
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.09
    Marker Score: 123
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.07
    Marker Score: 140
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.06
    Marker Score: 49
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.06
    Marker Score: 97
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.06
    Marker Score: 63
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.05
    Marker Score: 13,018
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.05
    Marker Score: 341
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.05
    Marker Score: 43
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.04
    Marker Score: 42
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.03
    Marker Score: 52
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 70
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.02
    Marker Score: 66
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.02
    Marker Score: 41
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.02
    Marker Score: 21
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.01
    Marker Score: 32
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.01
    Marker Score: 41
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.01
    Marker Score: 22
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.01
    Marker Score: 26
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.01
    Marker Score: 29
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0
    Marker Score: 11
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0
    Marker Score: 14
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 16
  • Cell Name: mural cell (CL0008034)
    Fold Change: 0
    Marker Score: 19

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The SCGB1D1 gene encodes a protein, SG1D1_HUMAN, which belongs to the secretoglobin family of proteins. These proteins are characterized by their structure, which consists of a β-barrel domain and a fibronectin-like domain. The SG1D1_HUMAN protein is a secreted protein, which suggests that it plays a role in extracellular signaling and interactions. The gene is highly expressed in various cell types, including those involved in the immune system, such as macrophages, mast cells, and hematopoietic stem cells. **Pathways and Functions:** The SCGB1D1 gene is involved in several signaling pathways, including the extracellular space and protein binding pathways. The extracellular space pathway suggests that SG1D1_HUMAN interacts with other proteins and molecules in the extracellular environment, influencing cell signaling and communication. The protein binding pathway indicates that SG1D1_HUMAN interacts with other proteins, modulating their activity or function. The gene's expression in various cell types suggests that it plays a role in regulating immune responses, cell differentiation, and tissue homeostasis. Some of the specific functions of the SCGB1D1 gene include: * Modulating immune responses: SG1D1_HUMAN may interact with immune cells, such as macrophages and mast cells, to regulate their activity and function. * Regulating cell differentiation: The gene's expression in oligodendrocyte precursor cells and hematopoietic stem cells suggests that it plays a role in cell differentiation and development. * Maintaining tissue homeostasis: The gene's expression in blood vessel endothelial cells and megakaryocytes suggests that it plays a role in maintaining tissue homeostasis and regulating blood vessel function. **Clinical Significance:** The SCGB1D1 gene has been implicated in several diseases, including: * Immune-related disorders: SG1D1_HUMAN may play a role in regulating immune responses, making it a potential target for the treatment of immune-related disorders, such as autoimmune diseases. * Neurological disorders: The gene's expression in neuronal cells suggests that it may play a role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. * Hematological disorders: The gene's expression in hematopoietic stem cells and megakaryocytes suggests that it may play a role in hematological disorders, such as anemia and leukemia. In conclusion, the SCGB1D1 gene is a multifaceted immunological player that plays a crucial role in regulating immune responses, cell differentiation, and tissue homeostasis. Further research is needed to fully understand the functions of this gene and its clinical significance in various diseases.

Genular Protein ID: 1583961615

Symbol: SG1D1_HUMAN

Name: Secretoglobin family 1D member 1

UniProtKB Accession Codes:

O95968

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10066439

Title: Lipophilins: human peptides homologous to rat prostatein.

PubMed ID: 10066439

DOI: 10.1006/bbrc.1999.0274

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9720917

Title: Lipophilin, a novel heterodimeric protein of human tears.

PubMed ID: 9720917

DOI: 10.1016/s0014-5793(98)00852-7

PubMed ID: 25946035

Title: Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.

PubMed ID: 25946035

DOI: 10.1021/acs.jproteome.5b00179

Sequence Information:

  • Length: 90
  • Mass: 9898
  • Checksum: DF2D4F7565A87D34
  • Sequence:
    • MRLSVCLLLL TLALCCYRAN AVVCQALGSE ITGFLLAGKP VFKFQLAKFK APLEAVAAKM 
EVKKCVDTMA YEKRVLITKT LGKIAEKCDR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.