Details for: PRELID3A

Gene ID: 10650

Symbol: PRELID3A

Ensembl ID: ENSG00000141391

Description: PRELI domain containing 3A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.77
    Marker Score: 1,856
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.66
    Marker Score: 2,075
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.14
    Marker Score: 1,764
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.12
    Marker Score: 655
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.12
    Marker Score: 11,551
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.09
    Marker Score: 67,311
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.09
    Marker Score: 4,438
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.04
    Marker Score: 329
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.02
    Marker Score: 8,796
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.02
    Marker Score: 2,071
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.02
    Marker Score: 9,668
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,818
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,043
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.99
    Marker Score: 669
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.99
    Marker Score: 9,277
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,257
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.9
    Marker Score: 372
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.88
    Marker Score: 13,832
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,286
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.84
    Marker Score: 30,997
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.81
    Marker Score: 5,370
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 614
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.79
    Marker Score: 361
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,267
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.77
    Marker Score: 3,242
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.76
    Marker Score: 15,083
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.74
    Marker Score: 308
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.73
    Marker Score: 2,823
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.73
    Marker Score: 5,563
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.72
    Marker Score: 475
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.68
    Marker Score: 629
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.68
    Marker Score: 25,648
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.67
    Marker Score: 9,964
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.65
    Marker Score: 2,699
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.65
    Marker Score: 8,644
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.65
    Marker Score: 177
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.58
    Marker Score: 12,417
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.57
    Marker Score: 1,355
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.53
    Marker Score: 3,208
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 340
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.53
    Marker Score: 921
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.5
    Marker Score: 157
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.49
    Marker Score: 1,001
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.48
    Marker Score: 1,056
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.46
    Marker Score: 166
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.44
    Marker Score: 212
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.44
    Marker Score: 674
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.4
    Marker Score: 242
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.39
    Marker Score: 190
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.39
    Marker Score: 125
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.38
    Marker Score: 891
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.38
    Marker Score: 1,578
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.37
    Marker Score: 165
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 368
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.37
    Marker Score: 455
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.36
    Marker Score: 1,664
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.35
    Marker Score: 639
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.35
    Marker Score: 952
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.34
    Marker Score: 298
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.34
    Marker Score: 143
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.32
    Marker Score: 102
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.32
    Marker Score: 873
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.32
    Marker Score: 309
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.32
    Marker Score: 124
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.32
    Marker Score: 744
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.31
    Marker Score: 81
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.28
    Marker Score: 225
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.28
    Marker Score: 472
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.28
    Marker Score: 279
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.26
    Marker Score: 319
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.26
    Marker Score: 243
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.25
    Marker Score: 143
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.23
    Marker Score: 294
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.23
    Marker Score: 154
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.23
    Marker Score: 334
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.23
    Marker Score: 279
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.23
    Marker Score: 93
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.22
    Marker Score: 150
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.22
    Marker Score: 67
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.22
    Marker Score: 56
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.21
    Marker Score: 140
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.21
    Marker Score: 2,126
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.21
    Marker Score: 62
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.21
    Marker Score: 102
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.21
    Marker Score: 100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.21
    Marker Score: 256

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The PRELID3A gene is characterized by the presence of a PRELI domain, which is a conserved motif involved in phospholipid transfer and intermembrane lipid transfer. This domain is thought to be responsible for the protein's ability to interact with phospholipids and facilitate their transfer between membranes. The gene is also expressed in a variety of cell types, including those involved in immune responses (e.g., thymocytes, immature innate lymphoid cells) and neuronal function (e.g., retinal ganglion cells, neurons). **Pathways and Functions** The PRELID3A gene is involved in several biological pathways, including: 1. **Gene expression (transcription)**: PRELID3A is a transcriptional regulator, and its expression is influenced by the transcription factor TP53. TP53 regulates the transcription of cell death genes and genes involved in cytochrome c release, suggesting a role in regulating cell death and apoptosis. 2. **Intermembrane lipid transfer**: The PRELI domain of PRELID3A is involved in phospholipid transfer and intermembrane lipid transfer, suggesting a role in maintaining membrane structure and function. 3. **Phosphatidic acid transfer activity**: PRELID3A is involved in the transfer of phosphatidic acid, a phospholipid that plays a role in cell signaling and membrane trafficking. 4. **Protein binding**: PRELID3A interacts with other proteins, including those involved in immune responses and neuronal signaling. **Clinical Significance** While the exact clinical significance of PRELID3A remains unclear, its expression in cells involved in immune responses and neuronal function suggests a possible involvement in immune regulation and neuronal signaling. Dysregulation of PRELID3A expression may contribute to various diseases, including: 1. **Autoimmune disorders**: Dysregulation of PRELID3A expression may contribute to autoimmune disorders, such as multiple sclerosis, where there is an imbalance in immune responses. 2. **Neurological disorders**: PRELID3A expression in neurons suggests a possible role in neuronal signaling and function, and dysregulation of its expression may contribute to neurological disorders, such as Alzheimer's disease. 3. **Cancer**: TP53, a transcription factor that regulates PRELID3A expression, is also involved in cancer development and progression. Dysregulation of PRELID3A expression may contribute to cancer development and progression. In conclusion, PRELID3A is a gene that encodes a protein containing a PRELI domain, involved in phospholipid transfer and intermembrane lipid transfer. Its expression in cells involved in immune responses and neuronal function suggests a possible involvement in immune regulation and neuronal signaling. Further research is needed to fully understand the clinical significance of PRELID3A and its role in various diseases.

Genular Protein ID: 2488955575

Symbol: PLD3A_HUMAN

Name: PRELI domain containing protein 3A

UniProtKB Accession Codes:

Q96N28 B0YJ10 B4E0C9 D3DUJ1 Q6AHX2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 9 Ensembl 3 ExpressionAtlas 1 GO 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 26071602

Title: Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes.

PubMed ID: 26071602

DOI: 10.15252/embr.201540229

Sequence Information:

  • Length: 172
  • Mass: 19247
  • Checksum: 111C67F7E43805CD
  • Sequence:
    • MKIWSSEHVF GHPWDTVIQA AMRKYPNPMN PSVLGVDVLQ RRVDGRGRLH SLRLLSTEWG 
LPSLVRAILG TSRTLTYIRE HSVVDPVEKK MELCSTNITL TNLVSVNERL VYTPHPENPE 
MTVLTQEAII TVKGISLGSY LESLMANTIS SNAKKGWAAI EWIIEHSESA VS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.