Details for: SPINT2

Gene ID: 10653

Symbol: SPINT2

Ensembl ID: ENSG00000167642

Description: serine peptidase inhibitor, Kunitz type 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.06
    Marker Score: 3,176
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.61
    Marker Score: 8,827
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.61
    Marker Score: 6,596
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 3.6
    Marker Score: 2,878
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.51
    Marker Score: 7,988
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.44
    Marker Score: 25,640
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.4
    Marker Score: 10,674
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.36
    Marker Score: 12,959
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.34
    Marker Score: 4,028
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.32
    Marker Score: 2,618
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.3
    Marker Score: 114,253
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.15
    Marker Score: 7,950
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.11
    Marker Score: 4,946
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.08
    Marker Score: 1,062
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.08
    Marker Score: 15,106
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.05
    Marker Score: 5,001
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.05
    Marker Score: 16,011
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.02
    Marker Score: 8,085
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.01
    Marker Score: 14,464
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3
    Marker Score: 19,168
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.99
    Marker Score: 23,363
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.96
    Marker Score: 2,636
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.95
    Marker Score: 6,697
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.95
    Marker Score: 4,889
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.86
    Marker Score: 24,821
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 2.85
    Marker Score: 780
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.84
    Marker Score: 24,503
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.84
    Marker Score: 1,134
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.84
    Marker Score: 2,722
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.8
    Marker Score: 4,508
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.79
    Marker Score: 18,212
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.74
    Marker Score: 1,280
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.69
    Marker Score: 3,806
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.61
    Marker Score: 828
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.6
    Marker Score: 4,606
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.56
    Marker Score: 6,966
  • Cell Name: PP cell (CL0000696)
    Fold Change: 2.54
    Marker Score: 573
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.53
    Marker Score: 25,430
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.49
    Marker Score: 3,663
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.48
    Marker Score: 2,900
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.47
    Marker Score: 3,800
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.46
    Marker Score: 916
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.44
    Marker Score: 2,476
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.43
    Marker Score: 865
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.42
    Marker Score: 3,485
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.42
    Marker Score: 1,614
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.39
    Marker Score: 2,518
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.39
    Marker Score: 5,669
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.38
    Marker Score: 687
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.37
    Marker Score: 1,714
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.36
    Marker Score: 2,502
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.35
    Marker Score: 8,719
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.35
    Marker Score: 1,964
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.32
    Marker Score: 9,118
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.31
    Marker Score: 8,203
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.3
    Marker Score: 1,133
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.29
    Marker Score: 958
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.29
    Marker Score: 1,528
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 2.23
    Marker Score: 900
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 2.2
    Marker Score: 1,214
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.2
    Marker Score: 4,183
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.2
    Marker Score: 744
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.17
    Marker Score: 524
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.16
    Marker Score: 1,473
  • Cell Name: oocyte (CL0000023)
    Fold Change: 2.14
    Marker Score: 530
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.14
    Marker Score: 1,108
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.14
    Marker Score: 8,740
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.1
    Marker Score: 2,177
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.08
    Marker Score: 1,077
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.08
    Marker Score: 4,334
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.04
    Marker Score: 2,157
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.04
    Marker Score: 967
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.03
    Marker Score: 911
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.02
    Marker Score: 2,435
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2
    Marker Score: 5,172
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.99
    Marker Score: 748
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.96
    Marker Score: 1,852
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.93
    Marker Score: 650
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.92
    Marker Score: 11,402
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.92
    Marker Score: 912
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.92
    Marker Score: 935
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.91
    Marker Score: 19,387
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.91
    Marker Score: 668
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.9
    Marker Score: 3,855
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.88
    Marker Score: 604
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.86
    Marker Score: 3,247
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.86
    Marker Score: 436
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.86
    Marker Score: 1,023
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.84
    Marker Score: 7,657
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.83
    Marker Score: 2,162
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.81
    Marker Score: 354
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.8
    Marker Score: 1,103
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.77
    Marker Score: 867
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.77
    Marker Score: 2,217
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.77
    Marker Score: 910
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.74
    Marker Score: 4,734
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.74
    Marker Score: 1,846
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.74
    Marker Score: 557
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.73
    Marker Score: 5,960
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.72
    Marker Score: 746

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SPINT2 is a member of the Kunitz-type protease inhibitor family, which is known for its ability to inhibit serine-type endopeptidases. This gene is characterized by its expression in various cell types, including epithelial cells, progenitor cells, and neural precursor cells. The expression pattern of SPINT2 highlights its potential role in regulating cellular morphogenesis, cell-cell adhesion, and signaling pathways. **Pathways and Functions:** The SPINT2 gene is involved in numerous cellular processes, including: 1. **Basement membrane organization:** SPINT2 is essential for maintaining the integrity of the basement membrane, a critical component of epithelial tissues. 2. **Cellular response to BMP stimulus:** SPINT2 regulates the response of cells to bone morphogenetic protein (BMP) stimuli, which is essential for embryonic development and tissue homeostasis. 3. **Endopeptidase inhibitor activity:** SPINT2 inhibits serine-type endopeptidases, which are involved in protein degradation and signaling pathways. 4. **Epithelial cell morphogenesis involved in placental branching:** SPINT2 is crucial for the morphogenesis of epithelial cells, which is essential for placental development and function. 5. **Signaling by Met, MST1, and receptor tyrosine kinases:** SPINT2 regulates signaling pathways mediated by the Met, MST1, and receptor tyrosine kinases, which are involved in cell growth, differentiation, and survival. **Clinical Significance:** Dysregulation of SPINT2 has been implicated in various diseases, including: 1. **Cancer:** Alterations in SPINT2 expression have been observed in various types of cancer, including prostate, breast, and lung cancer. 2. **Neurological disorders:** SPINT2 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Reproductive disorders:** SPINT2 is essential for placental development and function, and alterations in its expression have been observed in pregnancy-related disorders, such as preeclampsia and gestational diabetes. In conclusion, SPINT2 is a multifunctional gene that plays a critical role in regulating cellular processes, including cell-cell adhesion, signaling pathways, and morphogenesis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying SPINT2 function and its potential therapeutic applications.

Genular Protein ID: 3345950000

Symbol: SPIT2_HUMAN

Name: Kunitz-type protease inhibitor 2

UniProtKB Accession Codes:

O43291 A8K667 B4DLU1 O00271 O14895 Q5TZQ3 Q969E0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 16 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 2 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9346890

Title: Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor.

PubMed ID: 9346890

DOI: 10.1074/jbc.272.44.27558

PubMed ID: 9115294

Title: Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains.

PubMed ID: 9115294

DOI: 10.1074/jbc.272.18.12202

PubMed ID: 9434156

Title: Cloning of a new Kunitz-type protease inhibitor with a putative transmembrane domain overexpressed in pancreatic cancer.

PubMed ID: 9434156

DOI: 10.1016/s0167-4781(97)00129-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 20977675

Title: TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor.

PubMed ID: 20977675

DOI: 10.1111/j.1742-4658.2010.07894.x

PubMed ID: 28710277

Title: Phosphorylation of the type II transmembrane serine protease, TMPRSS13, in hepatocyte growth factor activator inhibitor-1 and -2-mediated cell-surface localization.

PubMed ID: 28710277

DOI: 10.1074/jbc.m117.775999

PubMed ID: 34562451

Title: Posttranslational modifications of serine protease TMPRSS13 regulate zymogen activation, proteolytic activity, and cell surface localization.

PubMed ID: 34562451

DOI: 10.1016/j.jbc.2021.101227

PubMed ID: 19185281

Title: Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea.

PubMed ID: 19185281

DOI: 10.1016/j.ajhg.2009.01.004

Sequence Information:

  • Length: 252
  • Mass: 28228
  • Checksum: A7D3360C0EECAB2B
  • Sequence:
    • MAQLCGLRRS RAFLALLGSL LLSGVLAADR ERSIHDFCLV SKVVGRCRAS MPRWWYNVTD 
GSCQLFVYGG CDGNSNNYLT KEECLKKCAT VTENATGDLA TSRNAADSSV PSAPRRQDSE 
DHSSDMFNYE EYCTANAVTG PCRASFPRWY FDVERNSCNN FIYGGCRGNK NSYRSEEACM 
LRCFRQQENP PLPLGSKVVV LAGLFVMVLI LFLGASMVYL IRVARRNQER ALRTVWSSGD 
DKEQLVKNTY VL

Genular Protein ID: 562648119

Symbol: A0A140VJV6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VJV6

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 1 RefSeq 1 SAM 3 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 195
  • Mass: 21828
  • Checksum: 7E046F218A22319B
  • Sequence:
    • MAQLCGLRRS RAFLALLGSL LLSGVLAADR ERSIHENATG DLATSRNAAD SSVPSAPRRQ 
DSEDHSSDMF NYEEYCTANA VTGPCRASFP RWYFDVERNS CNNFIYGGCR GNKNSYRSEE 
ACMLRCFRQQ ENPPLPLGSK VVVLAGLFVM VLILFLGASM VYLIRVARRN QERALRTVWS 
SGDDKEQLVK NTYVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.