SPINT2 | ENSG00000167642 | NCBI 10653

Details for: SPINT2

Gene ID: 10653

Symbol: SPINT2

Ensembl ID: ENSG00000167642

Description: serine peptidase inhibitor, Kunitz type 2

Associated with

Met receptor activation
(R-HSA-6806942)
Signaling by met
(R-HSA-6806834)
Signaling by mst1
(R-HSA-8852405)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Basement membrane organization
(GO:0071711)
Cellular response to bmp stimulus
(GO:0071773)
Cytoplasm
(GO:0005737)
Endopeptidase inhibitor activity
(GO:0004866)
Epithelial cell morphogenesis involved in placental branching
(GO:0060672)
Establishment or maintenance of cell polarity
(GO:0007163)
Extracellular region
(GO:0005576)
Membrane
(GO:0016020)
Negative regulation of cell-cell adhesion
(GO:0022408)
Negative regulation of cell motility
(GO:2000146)
Negative regulation of neural precursor cell proliferation
(GO:2000178)
Neural tube closure
(GO:0001843)
Plasma membrane
(GO:0005886)
Serine-type endopeptidase inhibitor activity
(GO:0004867)

Other Information

Proteins

Kunitz-type protease inhibitor 2
A0A140VJV6_HUMAN

Genular Protein ID: 3345950000

Symbol: SPIT2_HUMAN

Name: Kunitz-type protease inhibitor 2

UniProtKB Accession Codes:

O43291 A8K667 B4DLU1 O00271 O14895 Q5TZQ3 Q969E0

Database IDs:

Citations:

PubMed ID: 9346890

Title: Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor.

PubMed ID: 9346890

DOI: 10.1074/jbc.272.44.27558

PubMed ID: 9115294

Title: Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains.

PubMed ID: 9115294

DOI: 10.1074/jbc.272.18.12202

PubMed ID: 9434156

Title: Cloning of a new Kunitz-type protease inhibitor with a putative transmembrane domain overexpressed in pancreatic cancer.

PubMed ID: 9434156

DOI: 10.1016/s0167-4781(97)00129-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 20977675

Title: TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor.

PubMed ID: 20977675

DOI: 10.1111/j.1742-4658.2010.07894.x

PubMed ID: 28710277

Title: Phosphorylation of the type II transmembrane serine protease, TMPRSS13, in hepatocyte growth factor activator inhibitor-1 and -2-mediated cell-surface localization.

PubMed ID: 28710277

DOI: 10.1074/jbc.m117.775999

PubMed ID: 34562451

Title: Posttranslational modifications of serine protease TMPRSS13 regulate zymogen activation, proteolytic activity, and cell surface localization.

PubMed ID: 34562451

DOI: 10.1016/j.jbc.2021.101227

PubMed ID: 19185281

Title: Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea.

PubMed ID: 19185281

DOI: 10.1016/j.ajhg.2009.01.004

Sequence Information:

Length: 252
Mass: 28228
Checksum: A7D3360C0EECAB2B
Sequence:

MAQLCGLRRS RAFLALLGSL LLSGVLAADR ERSIHDFCLV SKVVGRCRAS MPRWWYNVTD 
GSCQLFVYGG CDGNSNNYLT KEECLKKCAT VTENATGDLA TSRNAADSSV PSAPRRQDSE 
DHSSDMFNYE EYCTANAVTG PCRASFPRWY FDVERNSCNN FIYGGCRGNK NSYRSEEACM 
LRCFRQQENP PLPLGSKVVV LAGLFVMVLI LFLGASMVYL IRVARRNQER ALRTVWSSGD 
DKEQLVKNTY VL

Genular Protein ID: 562648119

Symbol: A0A140VJV6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VJV6

Database IDs:

Sequence Information:

Length: 195
Mass: 21828
Checksum: 7E046F218A22319B
Sequence:

MAQLCGLRRS RAFLALLGSL LLSGVLAADR ERSIHENATG DLATSRNAAD SSVPSAPRRQ 
DSEDHSSDMF NYEEYCTANA VTGPCRASFP RWYFDVERNS CNNFIYGGCR GNKNSYRSEE 
ACMLRCFRQQ ENPPLPLGSK VVVLAGLFVM VLILFLGASM VYLIRVARRN QERALRTVWS 
SGDDKEQLVK NTYVL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SPINT2

Associated with

Other Information

Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor. PubMed ID: 9346890

Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains. PubMed ID: 9115294

Cloning of a new Kunitz-type protease inhibitor with a putative transmembrane domain overexpressed in pancreatic cancer. PubMed ID: 9434156

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor. PubMed ID: 20977675

Phosphorylation of the type II transmembrane serine protease, TMPRSS13, in hepatocyte growth factor activator inhibitor-1 and -2-mediated cell-surface localization. PubMed ID: 28710277

Posttranslational modifications of serine protease TMPRSS13 regulate zymogen activation, proteolytic activity, and cell surface localization. PubMed ID: 34562451

Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea. PubMed ID: 19185281