PMVK | ENSG00000163344 | NCBI 10654

Details for: PMVK

Gene ID: 10654

Symbol: PMVK

Ensembl ID: ENSG00000163344

Description: phosphomevalonate kinase

Associated with

Activation of gene expression by srebf (srebp)
(R-HSA-2426168)
Cholesterol biosynthesis
(R-HSA-191273)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of steroids
(R-HSA-8957322)
Regulation of cholesterol biosynthesis by srebp (srebf)
(R-HSA-1655829)
Atp binding
(GO:0005524)
Cholesterol biosynthetic process
(GO:0006695)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Isopentenyl diphosphate biosynthetic process, mevalonate pathway
(GO:0019287)
Membrane
(GO:0016020)
Peroxisome
(GO:0005777)
Phosphomevalonate kinase activity
(GO:0004631)
Phosphorylation
(GO:0016310)
Protein binding
(GO:0005515)
Response to cholesterol
(GO:0070723)
Sterol biosynthetic process
(GO:0016126)

Other Information

Proteins

Phosphomevalonate kinase

Genular Protein ID: 921268410

Symbol: PMVK_HUMAN

Name: Phosphomevalonate kinase

UniProtKB Accession Codes:

Q15126 Q5TZW9

Database IDs:

Citations:

PubMed ID: 8663599

Title: Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence.

PubMed ID: 8663599

DOI: 10.1074/jbc.271.29.17330

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10191291

Title: Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting.

PubMed ID: 10191291

PubMed ID: 9392419

Title: Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways.

PubMed ID: 9392419

PubMed ID: 14729858

Title: Phosphomevalonate kinase is a cytosolic protein in humans.

PubMed ID: 14729858

DOI: 10.1194/jlr.m300373-jlr200

PubMed ID: 16519518

Title: Phosphomevalonate kinase: functional investigation of the recombinant human enzyme.

PubMed ID: 16519518

DOI: 10.1021/bi052231u

PubMed ID: 17902708

Title: Functional evaluation of conserved basic residues in human phosphomevalonate kinase.

PubMed ID: 17902708

DOI: 10.1021/bi701408t

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 18618710

Title: Crystal structure of human phosphomevalonate kinase at 1.8 A resolution.

PubMed ID: 18618710

DOI: 10.1002/prot.22151

PubMed ID: 26202976

Title: Genomic variations of the mevalonate pathway in porokeratosis.

PubMed ID: 26202976

DOI: 10.7554/elife.06322

PubMed ID: 27052676

Title: Loss-of-function mutation in PMVK causes autosomal dominant disseminated superficial porokeratosis.

PubMed ID: 27052676

DOI: 10.1038/srep24226

Sequence Information:

Length: 192
Mass: 21995
Checksum: D7E720D0DDCCA249
Sequence:

MAPLGGAPRL VLLFSGKRKS GKDFVTEALQ SRLGADVCAV LRLSGPLKEQ YAQEHGLNFQ 
RLLDTSTYKE AFRKDMIRWG EEKRQADPGF FCRKIVEGIS QPIWLVSDTR RVSDIQWFRE 
AYGAVTQTVR VVALEQSRQQ RGWVFTPGVD DAESECGLDN FGDFDWVIEN HGVEQRLEEQ 
LENLIEFIRS RL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PMVK

Associated with

Other Information

Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence. PubMed ID: 8663599

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of phosphomevalonate kinase: chromosomal localization, regulation, and subcellular targeting. PubMed ID: 10191291

Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways. PubMed ID: 9392419

Phosphomevalonate kinase is a cytosolic protein in humans. PubMed ID: 14729858

Phosphomevalonate kinase: functional investigation of the recombinant human enzyme. PubMed ID: 16519518

Functional evaluation of conserved basic residues in human phosphomevalonate kinase. PubMed ID: 17902708

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Crystal structure of human phosphomevalonate kinase at 1.8 A resolution. PubMed ID: 18618710

Genomic variations of the mevalonate pathway in porokeratosis. PubMed ID: 26202976

Loss-of-function mutation in PMVK causes autosomal dominant disseminated superficial porokeratosis. PubMed ID: 27052676