Details for: DMRT2

Gene ID: 10655

Symbol: DMRT2

Ensembl ID: ENSG00000173253

Description: doublesex and mab-3 related transcription factor 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 5.39
    Marker Score: 2,985
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 5.35
    Marker Score: 7,676
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.6
    Marker Score: 1,371
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.51
    Marker Score: 4,154
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.05
    Marker Score: 2,067
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.72
    Marker Score: 6,350
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.68
    Marker Score: 886
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.65
    Marker Score: 882
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.61
    Marker Score: 914
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.54
    Marker Score: 620
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 857
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,815
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.11
    Marker Score: 3,132
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.1
    Marker Score: 460
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,052
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,339
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,288
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.86
    Marker Score: 1,405
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.82
    Marker Score: 1,556
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.82
    Marker Score: 475
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 657
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.69
    Marker Score: 1,114
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.68
    Marker Score: 10,566
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.68
    Marker Score: 1,373
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 432
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.65
    Marker Score: 4,853
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.63
    Marker Score: 386
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 463
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.42
    Marker Score: 520
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.42
    Marker Score: 110
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.4
    Marker Score: 519
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.4
    Marker Score: 1,091
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.38
    Marker Score: 405
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.38
    Marker Score: 179
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.35
    Marker Score: 210
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.29
    Marker Score: 454
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.29
    Marker Score: 135
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.28
    Marker Score: 970
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.28
    Marker Score: 85
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.24
    Marker Score: 105
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.24
    Marker Score: 412
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.24
    Marker Score: 171
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.23
    Marker Score: 106
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.23
    Marker Score: 218
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.22
    Marker Score: 58
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.22
    Marker Score: 533
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.22
    Marker Score: 310
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.21
    Marker Score: 121
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.2
    Marker Score: 498
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.19
    Marker Score: 1,651
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.19
    Marker Score: 54
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.18
    Marker Score: 121
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.18
    Marker Score: 111
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.18
    Marker Score: 2,392
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.18
    Marker Score: 254
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: brush cell of trachebronchial tree (CL0002075)
    Fold Change: 0.17
    Marker Score: 53
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.17
    Marker Score: 113
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.17
    Marker Score: 304
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.17
    Marker Score: 104
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.17
    Marker Score: 126
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.16
    Marker Score: 108
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.15
    Marker Score: 74
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.15
    Marker Score: 149
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.15
    Marker Score: 99
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.14
    Marker Score: 4,743
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.13
    Marker Score: 43
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.12
    Marker Score: 37
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.12
    Marker Score: 79
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.11
    Marker Score: 65
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.11
    Marker Score: 123
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.11
    Marker Score: 83
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.11
    Marker Score: 205
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.11
    Marker Score: 254
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.11
    Marker Score: 61
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.11
    Marker Score: 66
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.1
    Marker Score: 239
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.1
    Marker Score: 106
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.1
    Marker Score: 38
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.09
    Marker Score: 22

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DMRT2 is a transcription factor that belongs to the doublesex and mab-3 related transcription factor family. Its expression is widespread, with significant levels detected in various tissues, including hematopoietic stem cells, erythrocytes, and renal intercalated cells. The gene's functional characteristics include: 1. **DNA-binding activity**: DMRT2 exhibits specific DNA-binding capabilities, targeting cis-regulatory regions associated with transcriptional activation. 2. **RNA polymerase II-specific**: DMRT2 interacts with RNA polymerase II, a key enzyme responsible for transcriptional elongation, ensuring precise regulation of gene expression. 3. **Positive regulation**: DMRT2 functions as a positive regulator of transcription, promoting the expression of target genes involved in immune responses, embryonic development, and sex differentiation. **Pathways and Functions:** DMRT2's involvement in various biological pathways highlights its multifaceted role in regulating immune responses, development, and tissue homeostasis: 1. **Embryonic skeletal system development**: DMRT2 is essential for regulating myotome development, a critical process in embryonic skeletal system formation. 2. **Sex differentiation**: DMRT2 plays a crucial role in sex differentiation, influencing the development of male and female reproductive systems. 3. **Immune regulation**: DMRT2 is expressed in hematopoietic stem cells, where it regulates the expression of genes involved in immune cell development and function. 4. **Cellular differentiation**: DMRT2 participates in the regulation of cellular differentiation, influencing the development of various cell types, including erythrocytes and renal intercalated cells. **Clinical Significance:** DMRT2's involvement in various biological processes makes it an attractive candidate for therapeutic targeting in diseases associated with immune dysregulation, embryonic development, and sex differentiation disorders. Potential applications of DMRT2-based therapeutic strategies include: 1. **Immunotherapy**: DMRT2-targeted therapies could modulate immune responses, offering novel treatment options for autoimmune and inflammatory disorders. 2. **Embryonic development disorders**: DMRT2-based therapies might address developmental abnormalities, such as skeletal system malformations and sex differentiation disorders. 3. **Cancer treatment**: DMRT2's role in cellular differentiation and immune regulation makes it a potential target for cancer therapy, particularly in the context of immunotherapies. In conclusion, the study of DMRT2 provides valuable insights into the intricate mechanisms governing immune regulation, embryonic development, and tissue homeostasis. Further research is warranted to fully elucidate the gene's functions and explore its therapeutic potential in various diseases.

Genular Protein ID: 2356453662

Symbol: DMRT2_HUMAN

Name: Doublesex- and mab-3-related transcription factor 2

UniProtKB Accession Codes:

Q9Y5R5 B1ANC0 B9EGJ1 Q9NPG6 Q9NQR6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 10 Ensembl 6 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 10 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10332030

Title: A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators.

PubMed ID: 10332030

DOI: 10.1093/hmg/8.6.989

PubMed ID: 10729224

Title: The human doublesex-related gene, DMRT2, is homologous to a gene involved in somitogenesis and encodes a potential bicistronic transcript.

PubMed ID: 10729224

DOI: 10.1006/geno.2000.6120

PubMed ID: 10857744

Title: A new submicroscopic deletion that refines the 9p region for sex reversal.

PubMed ID: 10857744

DOI: 10.1006/geno.2000.6160

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 561
  • Mass: 61814
  • Checksum: 17D856C78EBB43CB
  • Sequence:
    • MADPQAGSAA GDWEIDVESL ELEEDVCGAP RSTPPGPSPP PADGDCEDDE DDDGVDEDAE 
EEGDGEEAGA SPGMPGQPEQ RGGPQPRPPL APQASPAGTG PRERCTPAGG GAEPRKLSRT 
PKCARCRNHG VVSCLKGHKR FCRWRDCQCA NCLLVVERQR VMAAQVALRR QQATEDKKGL 
SGKQNNFERK AVYQRQVRAP SLLAKSILEG YRPIPAETYV GGTFPLPPPV SDRMRKRRAF 
ADKELENIML EREYKEREML ETSQAAALFL PNRMVPGPDY NSYKSAYSPS PVEPPSKDFC 
NFLPTCLDLT MQYSGSGNME LISSNVSVAT TYRQYPLSSR FLVWPKCGPI SDTLLYQQCL 
LNATTSVQAL KPGASWDLKG ARVQDGLSAE QDMMPSKLEG SLVLPHTPEI QTTRSDLQGH 
QAVPERSAFS PPRRNFSPIV DTDSLAAQGH VLTKISKENT RHPLPLRHNP FHSLFQQTLT 
DKSGPELKTP FVKEAFEETP KKHRECLVKD NQKYTFTIDR CAKDLFVAKQ VGTKLSVNEP 
LSFSVESILK RPSSAITRVS Q

Genular Protein ID: 640893273

Symbol: Q5HYK2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5HYK2

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Genevisible 1 GenomeRNAi 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 PharmGKB 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 405
  • Mass: 45265
  • Checksum: 471C4D5CEF07D750
  • Sequence:
    • MADPQAGSAA GDWEIDATED KKGLSGKQNN FERKAVYQRQ VRAPSLLAKS ILEGYRPIPA 
ETYVGGTFPL PPPVSDRMRK RRAFADKELE NIMLEREYKE REMLETSQAA ALFLPNRMVP 
GPDYNSYKSA YSPSPVEPPS KDFCNFLPTC LDLTMQYSGS GNMELISSNV SVATTYRQYP 
LSSRFLVWPK CGPISDTLLY QQCLLNATTS VQALKPGASW DLKGPRVQDG LSAEQDMMPS 
KLEGSLVLPH TPEIQTTRSD LQGHQAVPER SAFSPPRRNF SPIVDTDSLA AQGHVLTKIS 
KENTRHPLPL RHNPFHTLFQ QTLTDKSGPE LKTPFVKEAF EETPKKHREC LVKDNQKYTF 
TIDRCAKDLF VAKQVGTKLS VNEPLSFSVE SILKRPSSAI TRVSQ

Genular Protein ID: 4032447131

Symbol: Q05C20_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q05C20

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 4 ExpressionAtlas 1 GO 5 Gene3D 1 GenomeRNAi 1 HOGENOM 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 Pfam 1 PharmGKB 1 RefSeq 4 SAM 2 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 226
  • Mass: 24469
  • Checksum: D6DE6CB7EF5EDD43
  • Sequence:
    • MADPQAGSAA GDWEIDVESL ELEEDVCGAP RSTPPGPSPP PADGDCEDDE DDDGVDEDAE 
EEGDGEEAGA SPGMPGQPEQ RGGPQPRPPL APQASPAGTG PRERCTPAGG GAEPRKLSRT 
PKCARCRNHG VVSCLKGHKR FCRWRDCQCA NCLLVVERQR VMAAQVALRR QQATEDKKGL 
SGKQNNFERK AVYQRQVRAP SLLAKSILEV LLGLFYSYYV YIMNHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.