Details for: CES1
Associated with
Other Information
Genular Protein ID: 2260348460
Symbol: EST1_HUMAN
Name: Acyl-coenzyme A:cholesterol acyltransferase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1918003
Title: A serine esterase released by human alveolar macrophages is closely related to liver microsomal carboxylesterases.
PubMed ID: 1918003
PubMed ID: 8218228
Title: Glycosylation-dependent activity of baculovirus-expressed human liver carboxylesterases: cDNA cloning and characterization of two highly similar enzyme forms.
PubMed ID: 8218228
DOI: 10.1021/bi00094a018
PubMed ID: 8406473
Title: Molecular cloning and characterization of a human carboxylesterase gene.
PubMed ID: 8406473
PubMed ID: 8049197
Title: Purification, cloning, and expression of a human enzyme with acyl coenzyme A: cholesterol acyltransferase activity, which is identical to liver carboxylesterase.
PubMed ID: 8049197
PubMed ID: 10562416
Title: Human egasyn binds beta-glucuronidase but neither the esterase active site of egasyn nor the C-terminus of beta-glucuronidase is involved in their interaction.
PubMed ID: 10562416
PubMed ID: 11015575
Title: Cholesteryl ester hydrolase in human monocyte/macrophage: cloning, sequencing, and expression of full-length cDNA.
PubMed ID: 11015575
PubMed ID: 11812220
Title: Heterologous expression, purification, and characterization of human triacylglycerol hydrolase.
PubMed ID: 11812220
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10518925
Title: cDNA cloning, characterization and stable expression of novel human brain carboxylesterase.
PubMed ID: 10518925
PubMed ID: 7980644
Title: Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine.
PubMed ID: 7980644
PubMed ID: 9490062
Title: Purification and characterization of retinyl ester hydrolase as a member of the non-specific carboxylesterase supergene family.
PubMed ID: 9490062
PubMed ID: 8597091
Title: Molecular aspects of carboxylesterase isoforms in comparison with other esterases.
PubMed ID: 8597091
PubMed ID: 12022871
Title: Structure-function analysis of human triacylglycerol hydrolase by site-directed mutagenesis: identification of the catalytic triad and a glycosylation site.
PubMed ID: 12022871
DOI: 10.1021/bi0255625
PubMed ID: 1997784
Title: Cloning and sequencing of a human liver carboxylesterase isoenzyme.
PubMed ID: 1997784
PubMed ID: 2070086
Title: cDNA cloning and characterization of human monocyte/macrophage serine esterase-1.
PubMed ID: 2070086
PubMed ID: 1748313
Title: Cloning and analysis of a cDNA encoding a human liver carboxylesterase.
PubMed ID: 1748313
PubMed ID: 9169443
Title: Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin.
PubMed ID: 9169443
PubMed ID: 16024911
Title: Redistribution of macrophage cholesteryl ester hydrolase from cytoplasm to lipid droplets upon lipid loading.
PubMed ID: 16024911
PubMed ID: 16971496
Title: Stable overexpression of human macrophage cholesteryl ester hydrolase results in enhanced free cholesterol efflux from human THP1 macrophages.
PubMed ID: 16971496
PubMed ID: 18762277
Title: Inhibition of carboxylesterase 1 is associated with cholesteryl ester retention in human THP-1 monocyte/macrophages.
PubMed ID: 18762277
PubMed ID: 18599737
Title: Hepatic overexpression of cholesteryl ester hydrolase enhances cholesterol elimination and in vivo reverse cholesterol transport.
PubMed ID: 18599737
PubMed ID: 18485328
Title: Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis.
PubMed ID: 18485328
PubMed ID: 21049984
Title: Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2.
PubMed ID: 21049984
DOI: 10.1021/tx1002194
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 12725862
Title: Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine. From binding promiscuity to selective inhibition.
PubMed ID: 12725862
PubMed ID: 12679808
Title: Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme.
PubMed ID: 12679808
DOI: 10.1038/nsb919
Sequence Information:
- Length: 567
- Mass: 62521
- Checksum: D3A00BDCDC7E5DFF
- Sequence:
MWLRAFILAT LSASAAWGHP SSPPVVDTVH GKVLGKFVSL EGFAQPVAIF LGIPFAKPPL GPLRFTPPQP AEPWSFVKNA TSYPPMCTQD PKAGQLLSEL FTNRKENIPL KLSEDCLYLN IYTPADLTKK NRLPVMVWIH GGGLMVGAAS TYDGLALAAH ENVVVVTIQY RLGIWGFFST GDEHSRGNWG HLDQVAALRW VQDNIASFGG NPGSVTIFGE SAGGESVSVL VLSPLAKNLF HRAISESGVA LTSVLVKKGD VKPLAEQIAI TAGCKTTTSA VMVHCLRQKT EEELLETTLK MKFLSLDLQG DPRESQPLLG TVIDGMLLLK TPEELQAERN FHTVPYMVGI NKQEFGWLIP MQLMSYPLSE GQLDQKTAMS LLWKSYPLVC IAKELIPEAT EKYLGGTDDT VKKKDLFLDL IADVMFGVPS VIVARNHRDA GAPTYMYEFQ YRPSFSSDMK PKTVIGDHGD ELFSVFGAPF LKEGASEEEI RLSKMVMKFW ANFARNGNPN GEGLPHWPEY NQKEGYLQIG ANTQAAQKLK DKEVAFWTNL FAKKAVEKPP QTEHIEL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.