Details for: CES1

Gene ID: 1066

Symbol: CES1

Ensembl ID: ENSG00000198848

Description: carboxylesterase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 26.4974
    Cell Significance Index: -12.5100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.0512
    Cell Significance Index: -14.3700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 7.9703
    Cell Significance Index: 49.3100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 6.7026
    Cell Significance Index: 98.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 4.4849
    Cell Significance Index: 143.6500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.1864
    Cell Significance Index: 36.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.8109
    Cell Significance Index: 82.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5698
    Cell Significance Index: 311.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9110
    Cell Significance Index: 90.1200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7797
    Cell Significance Index: 14.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7669
    Cell Significance Index: 692.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6404
    Cell Significance Index: 121.8800
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.6176
    Cell Significance Index: 3.2500
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.6156
    Cell Significance Index: 3.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5468
    Cell Significance Index: 59.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4965
    Cell Significance Index: 12.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4957
    Cell Significance Index: 29.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4875
    Cell Significance Index: 79.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3710
    Cell Significance Index: 9.9300
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.3052
    Cell Significance Index: 1.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3015
    Cell Significance Index: 20.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1967
    Cell Significance Index: 9.1700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.1926
    Cell Significance Index: 1.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1834
    Cell Significance Index: 5.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1543
    Cell Significance Index: 19.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0959
    Cell Significance Index: 13.1700
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.0932
    Cell Significance Index: 0.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0834
    Cell Significance Index: 9.5500
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.0715
    Cell Significance Index: 0.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0618
    Cell Significance Index: 38.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0465
    Cell Significance Index: 1.3000
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.0319
    Cell Significance Index: 0.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0272
    Cell Significance Index: 20.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0256
    Cell Significance Index: 0.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0165
    Cell Significance Index: 22.4100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0149
    Cell Significance Index: 0.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0035
    Cell Significance Index: 6.5700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0006
    Cell Significance Index: -0.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0012
    Cell Significance Index: -0.6700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0027
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0039
    Cell Significance Index: -0.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0075
    Cell Significance Index: -13.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0076
    Cell Significance Index: -11.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0153
    Cell Significance Index: -6.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0163
    Cell Significance Index: -11.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0187
    Cell Significance Index: -11.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0199
    Cell Significance Index: -10.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0275
    Cell Significance Index: -12.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0327
    Cell Significance Index: -3.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0370
    Cell Significance Index: -6.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0412
    Cell Significance Index: -11.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0482
    Cell Significance Index: -9.6600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0490
    Cell Significance Index: -1.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0535
    Cell Significance Index: -7.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0578
    Cell Significance Index: -1.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0641
    Cell Significance Index: -11.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0897
    Cell Significance Index: -9.1600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0904
    Cell Significance Index: -0.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0982
    Cell Significance Index: -11.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1006
    Cell Significance Index: -10.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1050
    Cell Significance Index: -12.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1084
    Cell Significance Index: -14.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1120
    Cell Significance Index: -8.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1173
    Cell Significance Index: -1.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1174
    Cell Significance Index: -7.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1181
    Cell Significance Index: -9.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1198
    Cell Significance Index: -8.4800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1430
    Cell Significance Index: -6.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1430
    Cell Significance Index: -16.8600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1476
    Cell Significance Index: -0.9800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1528
    Cell Significance Index: -2.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1691
    Cell Significance Index: -13.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1745
    Cell Significance Index: -2.9200
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1784
    Cell Significance Index: -1.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1835
    Cell Significance Index: -5.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1881
    Cell Significance Index: -6.5900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1951
    Cell Significance Index: -3.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1960
    Cell Significance Index: -9.2100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2088
    Cell Significance Index: -1.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2223
    Cell Significance Index: -14.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2263
    Cell Significance Index: -12.7000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.2364
    Cell Significance Index: -2.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2390
    Cell Significance Index: -12.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2437
    Cell Significance Index: -12.6600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2458
    Cell Significance Index: -3.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2522
    Cell Significance Index: -16.2700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2548
    Cell Significance Index: -3.8100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2597
    Cell Significance Index: -3.7300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2599
    Cell Significance Index: -2.6900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.2646
    Cell Significance Index: -2.9000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2679
    Cell Significance Index: -2.2500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2691
    Cell Significance Index: -2.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2713
    Cell Significance Index: -14.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2828
    Cell Significance Index: -7.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2889
    Cell Significance Index: -9.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2923
    Cell Significance Index: -12.9300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2974
    Cell Significance Index: -4.9000
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.2986
    Cell Significance Index: -3.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** CES1 is a carboxylesterase that hydrolyzes carboxylic esters, including those found in dietary supplements and pharmaceuticals. 2. **Tissue Expression:** CES1 is significantly expressed in various tissues, including the liver, lungs, epithelial cells, and fibroblasts. 3. **Signaling Pathways:** CES1 is involved in several signaling pathways, including those involved in cardiac conduction, cholesterol homeostasis, and the regulation of bile acid biosynthesis. 4. **Regulatory Functions:** CES1 plays a role in the regulation of cholesterol efflux, cholesterol storage, and the response to toxic substances. **Pathways and Functions:** 1. **Cholesterol Metabolism:** CES1 is involved in the regulation of cholesterol efflux, cholesterol storage, and the metabolism of cholesterol esters. 2. **Lipid Catabolism:** CES1 is involved in the hydrolysis of carboxylic esters, including those found in dietary supplements and pharmaceuticals. 3. **Cardiac Conduction:** CES1 is involved in the regulation of cardiac conduction, including the regulation of ion channels and the response to toxic substances. 4. **Bile Acid Biosynthesis:** CES1 is involved in the regulation of bile acid biosynthesis, including the regulation of cholesterol metabolism and the response to toxic substances. 5. **Reverse Cholesterol Transport:** CES1 is involved in the regulation of reverse cholesterol transport, including the regulation of cholesterol efflux and the response to toxic substances. **Clinical Significance:** 1. **Pharmacokinetics:** CES1 plays a role in the pharmacokinetics of various drugs, including those used to treat cardiovascular disease and cholesterol metabolism disorders. 2. **Toxicity:** CES1 is involved in the response to toxic substances, including those used in cancer therapy and environmental pollutants. 3. **Cholesterol Disorders:** CES1 is involved in the regulation of cholesterol metabolism, including the regulation of cholesterol efflux and storage. 4. **Cardiovascular Disease:** CES1 is involved in the regulation of cardiac conduction, including the regulation of ion channels and the response to toxic substances. 5. **Cancer Therapy:** CES1 is involved in the response to toxic substances used in cancer therapy, including those used to treat leukemia and lymphoma. In conclusion, the CES1 gene plays a crucial role in various biological processes, including cholesterol metabolism, lipid catabolism, and the response to toxic substances. Understanding the role of CES1 in these processes is essential for the development of new therapies for cardiovascular disease, cholesterol disorders, and cancer therapy.

Genular Protein ID: 2260348460

Symbol: EST1_HUMAN

Name: Acyl-coenzyme A:cholesterol acyltransferase

UniProtKB Accession Codes:

P23141 A6NIM1 A8K3K8 A8K844 E9PAU8 P82127 Q00015 Q13657 Q14062 Q16737 Q16788 Q549X7 Q549X8 Q86UK2 Q96EE8 Q9UC52 Q9UDG8 Q9UK77 Q9ULY2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 35 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 48 DrugCentral 1 EC 3 EMBL 20 EMDB 1 ESTHER 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 19 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 4 RefSeq 3 Rhea 12 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1918003

Title: A serine esterase released by human alveolar macrophages is closely related to liver microsomal carboxylesterases.

PubMed ID: 1918003

DOI: 10.1016/s0021-9258(18)55139-5

PubMed ID: 8218228

Title: Glycosylation-dependent activity of baculovirus-expressed human liver carboxylesterases: cDNA cloning and characterization of two highly similar enzyme forms.

PubMed ID: 8218228

DOI: 10.1021/bi00094a018

PubMed ID: 8406473

Title: Molecular cloning and characterization of a human carboxylesterase gene.

PubMed ID: 8406473

DOI: 10.1006/geno.1993.1285

PubMed ID: 8049197

Title: Purification, cloning, and expression of a human enzyme with acyl coenzyme A: cholesterol acyltransferase activity, which is identical to liver carboxylesterase.

PubMed ID: 8049197

DOI: 10.1161/01.atv.14.8.1346

PubMed ID: 10562416

Title: Human egasyn binds beta-glucuronidase but neither the esterase active site of egasyn nor the C-terminus of beta-glucuronidase is involved in their interaction.

PubMed ID: 10562416

DOI: 10.1006/abbi.1999.1449

PubMed ID: 11015575

Title: Cholesteryl ester hydrolase in human monocyte/macrophage: cloning, sequencing, and expression of full-length cDNA.

PubMed ID: 11015575

DOI: 10.1152/physiolgenomics.2000.2.1.1

PubMed ID: 11812220

Title: Heterologous expression, purification, and characterization of human triacylglycerol hydrolase.

PubMed ID: 11812220

DOI: 10.1006/prep.2001.1553

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10518925

Title: cDNA cloning, characterization and stable expression of novel human brain carboxylesterase.

PubMed ID: 10518925

DOI: 10.1016/s0014-5793(99)01111-4

PubMed ID: 7980644

Title: Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine.

PubMed ID: 7980644

DOI: 10.1016/0006-2952(94)90461-8

PubMed ID: 9490062

Title: Purification and characterization of retinyl ester hydrolase as a member of the non-specific carboxylesterase supergene family.

PubMed ID: 9490062

DOI: 10.1046/j.1432-1327.1998.2510863.x

PubMed ID: 8597091

Title: Molecular aspects of carboxylesterase isoforms in comparison with other esterases.

PubMed ID: 8597091

DOI: 10.1016/0378-4274(95)03493-5

PubMed ID: 12022871

Title: Structure-function analysis of human triacylglycerol hydrolase by site-directed mutagenesis: identification of the catalytic triad and a glycosylation site.

PubMed ID: 12022871

DOI: 10.1021/bi0255625

PubMed ID: 1997784

Title: Cloning and sequencing of a human liver carboxylesterase isoenzyme.

PubMed ID: 1997784

DOI: 10.1016/0024-3205(91)90515-d

PubMed ID: 2070086

Title: cDNA cloning and characterization of human monocyte/macrophage serine esterase-1.

PubMed ID: 2070086

PubMed ID: 1748313

Title: Cloning and analysis of a cDNA encoding a human liver carboxylesterase.

PubMed ID: 1748313

DOI: 10.1016/0378-1119(91)90448-k

PubMed ID: 9169443

Title: Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin.

PubMed ID: 9169443

DOI: 10.1074/jbc.272.23.14769

PubMed ID: 16024911

Title: Redistribution of macrophage cholesteryl ester hydrolase from cytoplasm to lipid droplets upon lipid loading.

PubMed ID: 16024911

DOI: 10.1194/jlr.m500207-jlr200

PubMed ID: 16971496

Title: Stable overexpression of human macrophage cholesteryl ester hydrolase results in enhanced free cholesterol efflux from human THP1 macrophages.

PubMed ID: 16971496

DOI: 10.1152/ajpcell.00306.2006

PubMed ID: 18762277

Title: Inhibition of carboxylesterase 1 is associated with cholesteryl ester retention in human THP-1 monocyte/macrophages.

PubMed ID: 18762277

DOI: 10.1016/j.bbalip.2008.07.005

PubMed ID: 18599737

Title: Hepatic overexpression of cholesteryl ester hydrolase enhances cholesterol elimination and in vivo reverse cholesterol transport.

PubMed ID: 18599737

DOI: 10.1194/jlr.m800277-jlr200

PubMed ID: 18485328

Title: Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis.

PubMed ID: 18485328

DOI: 10.1016/j.ajhg.2008.04.015

PubMed ID: 21049984

Title: Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2.

PubMed ID: 21049984

DOI: 10.1021/tx1002194

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 12725862

Title: Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine. From binding promiscuity to selective inhibition.

PubMed ID: 12725862

DOI: 10.1016/s1074-5521(03)00071-1

PubMed ID: 12679808

Title: Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme.

PubMed ID: 12679808

DOI: 10.1038/nsb919

Sequence Information:

  • Length: 567
  • Mass: 62521
  • Checksum: D3A00BDCDC7E5DFF
  • Sequence:
    • MWLRAFILAT LSASAAWGHP SSPPVVDTVH GKVLGKFVSL EGFAQPVAIF LGIPFAKPPL 
GPLRFTPPQP AEPWSFVKNA TSYPPMCTQD PKAGQLLSEL FTNRKENIPL KLSEDCLYLN 
IYTPADLTKK NRLPVMVWIH GGGLMVGAAS TYDGLALAAH ENVVVVTIQY RLGIWGFFST 
GDEHSRGNWG HLDQVAALRW VQDNIASFGG NPGSVTIFGE SAGGESVSVL VLSPLAKNLF 
HRAISESGVA LTSVLVKKGD VKPLAEQIAI TAGCKTTTSA VMVHCLRQKT EEELLETTLK 
MKFLSLDLQG DPRESQPLLG TVIDGMLLLK TPEELQAERN FHTVPYMVGI NKQEFGWLIP 
MQLMSYPLSE GQLDQKTAMS LLWKSYPLVC IAKELIPEAT EKYLGGTDDT VKKKDLFLDL 
IADVMFGVPS VIVARNHRDA GAPTYMYEFQ YRPSFSSDMK PKTVIGDHGD ELFSVFGAPF 
LKEGASEEEI RLSKMVMKFW ANFARNGNPN GEGLPHWPEY NQKEGYLQIG ANTQAAQKLK 
DKEVAFWTNL FAKKAVEKPP QTEHIEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.