Details for: TSBP1

Gene ID: 10665

Symbol: TSBP1

Ensembl ID: ENSG00000204296

Description: testis expressed basic protein 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glial cell (CL0000125)
    Fold Change: 16.31
    Marker Score: 17,930
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 9.52
    Marker Score: 30,484
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 7.56
    Marker Score: 10,478
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 5.66
    Marker Score: 7,057
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 4.95
    Marker Score: 14,668
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 3.87
    Marker Score: 11,298
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.57
    Marker Score: 30,190
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 3.14
    Marker Score: 3,011
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.07
    Marker Score: 8,757
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.04
    Marker Score: 8,731
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 2.44
    Marker Score: 1,669
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.86
    Marker Score: 1,055
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.62
    Marker Score: 1,813
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170,197
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.29
    Marker Score: 2,231
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,684
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.1
    Marker Score: 581
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.1
    Marker Score: 494
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.99
    Marker Score: 1,337
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,351
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.9
    Marker Score: 597
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,276
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.85
    Marker Score: 1,167
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.73
    Marker Score: 426
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.72
    Marker Score: 690
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.7
    Marker Score: 851
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.69
    Marker Score: 2,868
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.65
    Marker Score: 1,003
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 483
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.56
    Marker Score: 194
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.51
    Marker Score: 493
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.51
    Marker Score: 816
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.5
    Marker Score: 4,744
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.47
    Marker Score: 193
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.47
    Marker Score: 2,827
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.44
    Marker Score: 177
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.42
    Marker Score: 872
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.39
    Marker Score: 161
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.38
    Marker Score: 341
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.35
    Marker Score: 196
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.34
    Marker Score: 178
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.33
    Marker Score: 20,425
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.33
    Marker Score: 412
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.32
    Marker Score: 187
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.32
    Marker Score: 70
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.29
    Marker Score: 193
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.29
    Marker Score: 59
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.29
    Marker Score: 551
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.28
    Marker Score: 134
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.27
    Marker Score: 3,652
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.27
    Marker Score: 454
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.27
    Marker Score: 71
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.27
    Marker Score: 77
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.27
    Marker Score: 78
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.26
    Marker Score: 1,075
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.26
    Marker Score: 1,020
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.26
    Marker Score: 75
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 0.26
    Marker Score: 76
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.25
    Marker Score: 75
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.25
    Marker Score: 66
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.25
    Marker Score: 80
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.25
    Marker Score: 76
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.25
    Marker Score: 91
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.25
    Marker Score: 81
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.25
    Marker Score: 77
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.24
    Marker Score: 9,278
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.24
    Marker Score: 302
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.24
    Marker Score: 79
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.24
    Marker Score: 60
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.23
    Marker Score: 75
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.23
    Marker Score: 582
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.22
    Marker Score: 108
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.22
    Marker Score: 60
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.22
    Marker Score: 107
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.21
    Marker Score: 76
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.21
    Marker Score: 120
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.2
    Marker Score: 1,759
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.2
    Marker Score: 77
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.2
    Marker Score: 220
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.19
    Marker Score: 1,482
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.19
    Marker Score: 61
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.19
    Marker Score: 50
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.19
    Marker Score: 461
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.19
    Marker Score: 77
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.19
    Marker Score: 70
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.19
    Marker Score: 103
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.18
    Marker Score: 67
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.18
    Marker Score: 65
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.18
    Marker Score: 62
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.17
    Marker Score: 3,462
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.17
    Marker Score: 78
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.17
    Marker Score: 49
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.17
    Marker Score: 190

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TSBP1, or testis-expressed basic protein 1, is a gene that exhibits tissue-specific expression, predominantly in the retina. Its expression is notable in various retinal cell types, including glial cells, amacrine cells, Mueller cells, retinal ganglion cells, OFF-bipolar cells, ON-bipolar cells, retinal bipolar neurons, retina horizontal cells, retinal rod cells, and retinal cone cells. This widespread expression suggests a pivotal role in retinal development and maintenance. **Pathways and Functions:** TSBP1 is implicated in several cellular pathways, including those involved in membrane and nucleus organization. The gene's involvement in membrane dynamics is particularly intriguing, as it may play a role in maintaining the structural integrity of retinal cells. Furthermore, TSBP1's expression in retinal cells suggests a potential role in regulating cell signaling and communication. The gene's involvement in nucleus organization may also be relevant, given the importance of nuclear architecture in cellular function. **Clinical Significance:** The discovery of TSBP1's expression in the retina has significant implications for our understanding of retinal development and function. Abnormal expression or dysfunction of TSBP1 may contribute to retinal disorders, such as retinitis pigmentosa or age-related macular degeneration. Further research is needed to elucidate the mechanisms by which TSBP1 regulates retinal cell function and to explore its potential as a therapeutic target for retinal diseases. **Implications for Immunology:** While TSBP1 is primarily associated with retinal development and function, its expression in glial cells and other retinal cells raises interesting questions about its potential role in the immune system. Further investigation into the immunological functions of TSBP1 may reveal novel mechanisms of immune regulation and provide insights into the development of immunotherapeutic strategies for retinal diseases. **Conclusion:** In conclusion, TSBP1 is a gene of significant interest that has shed light on the intricacies of retinal development and function. Further research is needed to fully elucidate the mechanisms by which TSBP1 regulates retinal cell function and to explore its potential as a therapeutic target for retinal diseases. As an expert immunologist, I am eager to explore the immunological implications of TSBP1 and to contribute to the development of novel immunotherapeutic strategies for retinal disorders.

Genular Protein ID: 2724616518

Symbol: TSBP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 563
  • Mass: 61626
  • Checksum: D5A75E4624FD2E6E
  • Sequence:
  • MTVLEITLAV ILTLLGLAIL AILLTRWARC KQSEMYISRY SSEQSARLLD YEDGRGSRHA 
    YSTQSDTSYD NRERSKRDYT PSTNSLVSMA SKFSLGQTEL ILLLMCFILA LSRSSIGSIK 
    CLQTTEEPPS RTAGAMMQFT APIPGATGPI KLSQKTIVQT PGPIVQYPGS NAGPPSAPRG 
    PPMAPIIISQ RTARIPQVHT MDSSGKITLT PVVILTGYMD EELAKKSCSK IQILKCGGTA 
    RSQNSREENK EALKNDIIFT NSVESLKSAH IKEPEREGKG TDLEKDKIGM EVKVDSDAGI 
    PKRQETQLKI SEMSIPQGQG AQIKKSVSDV PRGQESQVKK SESGVPKGQE AQVTKSGLVV 
    LKGQEAQVEK SEMGVPRRQE SQVKKSQSGV SKGQEAQVKK RESVVLKGQE AQVEKSELKV 
    PKGQEGQVEK TEADVPKEQE VQEKKSEAGV LKGPESQVKN TEVSVPETLE SQVKKSESGV 
    LKGQEAQEKK ESFEDKGNND KEKERDAEKD PNKKEKGDKN TKGDKGKDKV KGKRESEING 
    EKSKGSKRAK ANTGRKYNKK VEE

Genular Protein ID: 2182559571

Symbol: A0A1U9X7D1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 561
  • Mass: 61251
  • Checksum: 7C0BB8424CF779EF
  • Sequence:
  • MTVLEITLAV ILTLLGLAIL AILLTRWARC KQSEMYISRY SSEQSARLLD YEDGRGSRHA 
    YSTQSDTSYD NRERSKRDYT PSTNSLALSR SSIALPQGSM SSIKCLQTTE EPPSRTAGAM 
    MQFTAPIPGA TGPIKLSQKT IVQTPGPIVQ YPGSNAGPPS APRGPPMAPI IISQRTASQL 
    AAPIIISQRT ARIPQVHTMD SSGKITLTPV VILTGYMDEE LAKKSCSKIQ ILKCGGTARS 
    QNSREENKEA LKNDIIFTNS VESLKSAHIK EPEREGKGTD LEKDKIGMEV KVDSDAGIPK 
    RQETQLKISE MSIPQGQGAQ IKKSVSDVPR GQESQVKKSE SGVPKGQEAQ VTKSGLVVLK 
    GQEAQVEKSE MGVPRRQESQ VKKSQSGVSK GQEAQVKKRE SVVLKGQEAQ VEKSELKVPK 
    GQEGQVEKTE ADVPKEQEVQ EKKSEAGVLK GPESQVKNTE VSVPETLESQ VKKSESGVLK 
    GQEAQEKKES FEDKGNNDKE KERDAEKDPN KKEKGDKNTK GDKGKDKVKG KRESEINGEK 
    SKGSKRAKAN TGRKYNKKVE E

Genular Protein ID: 4052398364

Symbol: B4DXY0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 547
  • Mass: 59669
  • Checksum: 9B497793D7C95707
  • Sequence:
  • MTVLEITLAV ILTLLGLAIL AILLTRWARR KQSEMYISRY SSEQSARLLD YEDGRGSRHA 
    YSTQSERSKR DYTPSTNSLA LSRSSIALPQ GSMSSIKCLQ TTEEPPSRTA GAMMQFTAPI 
    PGATGPIKLS QKTIVQTPGP IVQYPGSNAG PPSAPRGPPM APIIISQRTA SQLAAPIRIP 
    QVHTMDSSGK ITLTPVVILT GYMDEELAKK SCSKIQVLKC GGTARSQNSR EENKEALKND 
    IIFTNSVESL KSAHIKEPER EGKGTDLEKD KIGMEVKVDS DAGIPKRQET QLKISEMSIP 
    QGQGAQIKKS VSDVPRGQES QVKKSESGVP KGQEAQVTKS GLVVLKGQEA QVEKSEMGVP 
    RRQESQVKKS QSGVSKGQEA QVKKRESVVL KGQEAQVEKS ELKVPKGQEG QVEKTEADVP 
    KEQEVQEKKS EAGVLKGPES QVKNTEVSVP ETLESQVKKS ESGVLKGQEA QEKKESFEDK 
    GNNDKEKERD AEKDPNKKEK GDKNTKGDKG KDKVKGKRES EINGEKSKGS KRAKANTGRK 
    YNKKVEE

Genular Protein ID: 3587466327

Symbol: Q13647_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 568
  • Mass: 63319
  • Checksum: 14C666062F0A3E33
  • Sequence:
  • MTVLEITLAV ILTLLGLAIL AILLTRWARR KQSEMYISRY SSEQSARLLD YEDGRGSRHA 
    YQHKVTLHMI TERDPKRDYT PSTNSLALSR SSIALPQGSM SSIKCLQTTE EPPSRTAGAM 
    MQFTALFPEL QDLSSSLKKP LCKLQDLLYN IWIQCQIASH TITGHLQHPR SPMAPIIISQ 
    RTASQLAAPI RIPQVHTMDS SGKITLTPVV ILTGYMDEEL RKKSCSKIQI LKCGGTARSQ 
    IAEKKTRKQL KNDIIFTNSV ESLKSAHIKE PEREGKGTDL EKDKIGMEVK VDSDAGIPKR 
    QETQLKISED EYTTRTGSPN KEKCVRCTKR TGVQVKKSES GVPKGQEAQV TKSGLVVLKG 
    QEAQVEKSEM GVPRRQESQV KKSQSGVSKG QEAQVKKRES VVLKGQEAQV EKSELKVPKG 
    QEGQVEKTEA DVPKEQEVQE KKSEAGVLKG PESQVKNTEV SVPETLESQV KKSESGVLKG 
    QEAQEKKESF EDKGNNDKEK ERDAEKDPNK KEKGDKNTKG DKGKDKVKGK RESEINGEKS 
    KGSKRRRQIQ EGSTTKKWKS KDKFFKGP

Genular Protein ID: 56820979

Symbol: E9PLW3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

Sequence Information:

  • Length: 547
  • Mass: 59630
  • Checksum: F7EEE4655524A3CB
  • Sequence:
  • MTVLEITLAV ILTLLGLAIL AILLTRWARC KQSEMYISRY SSEQSARLLD YEDGRGSRHA 
    YSTQSERSKR DYTPSTNSLA LSRSSIALPQ GSMSSIKCLQ TTEEPPSRTA GAMMQFTAPI 
    PGATGPIKLS QKTIVQTPGP IVQYPGSNAG PPSAPRGPPM APIIISQRTA SQLAAPIRIP 
    QVHTMDSSGK ITLTPVVILT GYMDEELAKK SCSKIQILKC GGTARSQNSR EENKEALKND 
    IIFTNSVESL KSAHIKEPER EGKGTDLEKD KIGMEVKVDS DAGIPKRQET QLKISEMSIP 
    QGQGAQIKKS VSDVPRGQES QVKKSESGVP KGQEAQVTKS GLVVLKGQEA QVEKSEMGVP 
    RRQESQVKKS QSGVSKGQEA QVKKRESVVL KGQEAQVEKS ELKVPKGQEG QVEKTEADVP 
    KEQEVQEKKS EAGVLKGPES QVKNTEVSVP ETLESQVKKS ESGVLKGQEA QEKKESFEDK 
    GNNDKEKERD AEKDPNKKEK GDKNTKGDKG KDKVKGKRES EINGEKSKGS KRAKANTGRK 
    YNKKVEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.