RRAGA | ENSG00000155876 | NCBI 10670

Details for: RRAGA

Gene ID: 10670

Symbol: RRAGA

Ensembl ID: ENSG00000155876

Description: Ras related GTP binding A

Associated with

Amino acids regulate mtorc1
(R-HSA-9639288)
Autophagy
(R-HSA-9612973)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
E3 ubiquitin ligases ubiquitinate target proteins
(R-HSA-8866654)
Energy dependent regulation of mtor by lkb1-ampk
(R-HSA-380972)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Intracellular signaling by second messengers
(R-HSA-9006925)
Macroautophagy
(R-HSA-1632852)
Metabolism of proteins
(R-HSA-392499)
Mtorc1-mediated signalling
(R-HSA-166208)
Mtor signalling
(R-HSA-165159)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Protein ubiquitination
(R-HSA-8852135)
Pten regulation
(R-HSA-6807070)
Regulation of pten gene transcription
(R-HSA-8943724)
Rna polymerase ii transcription
(R-HSA-73857)
Signal transduction
(R-HSA-162582)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
Apoptotic process
(GO:0006915)
Cellular response to amino acid starvation
(GO:0034198)
Cellular response to amino acid stimulus
(GO:0071230)
Cellular response to nutrient levels
(GO:0031669)
Cellular response to starvation
(GO:0009267)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Fnip-folliculin ragc/d gap
(GO:1990877)
Gator1 complex
(GO:1990130)
Glucose homeostasis
(GO:0042593)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Gtr1-gtr2 gtpase complex
(GO:1990131)
Intracellular signal transduction
(GO:0035556)
Lysosomal membrane
(GO:0005765)
Lysosome
(GO:0005764)
Negative regulation of autophagy
(GO:0010507)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphoprotein binding
(GO:0051219)
Positive regulation of torc1 signaling
(GO:1904263)
Positive regulation of tor signaling
(GO:0032008)
Protein-membrane adaptor activity
(GO:0043495)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein localization
(GO:0008104)
Protein localization to lysosome
(GO:0061462)
Protein localization to membrane
(GO:0072657)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

RRAGA_HUMAN

Genular Protein ID: 3804512108

Symbol: RRAGA_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7L523 B2R7L1 O00290 Q15347

Database IDs:

Citations:

PubMed ID: 7499430

Title: Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagBl) with remote similarity to the Ras-related GTPases.

PubMed ID: 7499430

DOI: 10.1074/jbc.270.48.28982

PubMed ID: 8995684

Title: Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers.

PubMed ID: 8995684

DOI: 10.1128/jvi.71.2.1576-1582.1997

PubMed ID: 9394008

Title: RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway.

PubMed ID: 9394008

DOI: 10.1242/jcs.111.1.11

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11073942

Title: Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B.

PubMed ID: 11073942

DOI: 10.1074/jbc.m004389200

PubMed ID: 14660641

Title: A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D.

PubMed ID: 14660641

DOI: 10.1074/jbc.m305935200

PubMed ID: 18497260

Title: The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.

PubMed ID: 18497260

DOI: 10.1126/science.1157535

PubMed ID: 20381137

Title: Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

PubMed ID: 20381137

DOI: 10.1016/j.cell.2010.02.024

PubMed ID: 22980980

Title: Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1.

PubMed ID: 22980980

DOI: 10.1016/j.cell.2012.07.032

PubMed ID: 22575674

Title: SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling.

PubMed ID: 22575674

DOI: 10.1016/j.molcel.2012.04.007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24095279

Title: The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.

PubMed ID: 24095279

DOI: 10.1016/j.molcel.2013.09.016

PubMed ID: 23723238

Title: A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.

PubMed ID: 23723238

DOI: 10.1126/science.1232044

PubMed ID: 25259925

Title: Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.

PubMed ID: 25259925

DOI: 10.1016/j.cell.2014.08.038

PubMed ID: 25561175

Title: SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.

PubMed ID: 25561175

DOI: 10.1038/nature14107

PubMed ID: 25567906

Title: Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.

PubMed ID: 25567906

DOI: 10.1126/science.1257132

PubMed ID: 25936802

Title: The ubiquitination of RagA GTPase by RNF152 negatively regulates mTORC1 activation.

PubMed ID: 25936802

DOI: 10.1016/j.molcel.2015.03.033

PubMed ID: 31036939

Title: The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity.

PubMed ID: 31036939

DOI: 10.1038/s41556-019-0321-6

PubMed ID: 36608670

Title: A central role for regulated protein stability in the control of TFE3 and MITF by nutrients.

PubMed ID: 36608670

DOI: 10.1016/j.molcel.2022.12.013

PubMed ID: 28935770

Title: Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.

PubMed ID: 28935770

DOI: 10.1126/science.aao1583

PubMed ID: 29158492

Title: Structural basis for the assembly of the Ragulator-Rag GTPase complex.

PubMed ID: 29158492

DOI: 10.1038/s41467-017-01762-3

PubMed ID: 29590090

Title: Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.

PubMed ID: 29590090

DOI: 10.1038/nature26158

PubMed ID: 31704029

Title: Cryo-EM structure of the human FLCN-FNIP2-Rag-Ragulator complex.

PubMed ID: 31704029

DOI: 10.1016/j.cell.2019.10.036

PubMed ID: 31601764

Title: Architecture of human Rag GTPase heterodimers and their complex with mTORC1.

PubMed ID: 31601764

DOI: 10.1126/science.aax3939

PubMed ID: 31601708

Title: Structural basis for the docking of mTORC1 on the lysosomal surface.

PubMed ID: 31601708

DOI: 10.1126/science.aay0166

PubMed ID: 31672913

Title: Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.

PubMed ID: 31672913

DOI: 10.1126/science.aax0364

PubMed ID: 32868926

Title: Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.

PubMed ID: 32868926

DOI: 10.1038/s41594-020-0490-9

PubMed ID: 35338845

Title: Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.

PubMed ID: 35338845

DOI: 10.1016/j.molcel.2022.03.002

PubMed ID: 36103527

Title: Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation.

PubMed ID: 36103527

DOI: 10.1126/sciadv.add2926

PubMed ID: 36697823

Title: Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.

PubMed ID: 36697823

DOI: 10.1038/s41586-022-05652-7

Sequence Information:

Length: 313
Mass: 36566
Checksum: B0DA1FC8FA6B766A
Sequence:

MPNTAMKKKV LLMGKSGSGK TSMRSIIFAN YIARDTRRLG ATIDVEHSHV RFLGNLVLNL 
WDCGGQDTFM ENYFTSQRDN IFRNVEVLIY VFDVESRELE KDMHYYQSCL EAILQNSPDA 
KIFCLVHKMD LVQEDQRDLI FKEREEDLRR LSRPLECACF RTSIWDETLY KAWSSIVYQL 
IPNVQQLEMN LRNFAQIIEA DEVLLFERAT FLVISHYQCK EQRDVHRFEK ISNIIKQFKL 
SCSKLAASFQ SMEVRNSNFA AFIDIFTSNT YVMVVMSDPS IPSAATLINI RNARKHFEKL 
ERVDGPKHSL LMR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RRAGA

Associated with

Other Information

Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagBl) with remote similarity to the Ras-related GTPases. PubMed ID: 7499430

Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers. PubMed ID: 8995684

RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway. PubMed ID: 9394008

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. PubMed ID: 11073942

A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D. PubMed ID: 14660641

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. PubMed ID: 18497260

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. PubMed ID: 20381137

Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1. PubMed ID: 22980980

SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling. PubMed ID: 22575674

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. PubMed ID: 24095279

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. PubMed ID: 23723238

Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. PubMed ID: 25259925

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. PubMed ID: 25561175

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. PubMed ID: 25567906

The ubiquitination of RagA GTPase by RNF152 negatively regulates mTORC1 activation. PubMed ID: 25936802

The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity. PubMed ID: 31036939

A central role for regulated protein stability in the control of TFE3 and MITF by nutrients. PubMed ID: 36608670

Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling. PubMed ID: 28935770

Structural basis for the assembly of the Ragulator-Rag GTPase complex. PubMed ID: 29158492

Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes. PubMed ID: 29590090

Cryo-EM structure of the human FLCN-FNIP2-Rag-Ragulator complex. PubMed ID: 31704029

Architecture of human Rag GTPase heterodimers and their complex with mTORC1. PubMed ID: 31601764

Structural basis for the docking of mTORC1 on the lysosomal surface. PubMed ID: 31601708

Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex. PubMed ID: 31672913

Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9. PubMed ID: 32868926

Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. PubMed ID: 35338845

Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation. PubMed ID: 36103527

Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. PubMed ID: 36697823