GNA13 | ENSG00000120063 | NCBI 10672

Details for: GNA13

Gene ID: 10672

Symbol: GNA13

Ensembl ID: ENSG00000120063

Description: G protein subunit alpha 13

Associated with

Cdc42 gtpase cycle
(R-HSA-9013148)
Cell death signalling via nrage, nrif and nade
(R-HSA-204998)
Death receptor signaling
(R-HSA-73887)
G alpha (12/13) signalling events
(R-HSA-416482)
Gpcr downstream signalling
(R-HSA-388396)
Hemostasis
(R-HSA-109582)
Nrage signals death through jnk
(R-HSA-193648)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Rac1 gtpase cycle
(R-HSA-9013149)
Rho gtpase cycle
(R-HSA-9012999)
Signal amplification
(R-HSA-392518)
Signaling by gpcr
(R-HSA-372790)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Thrombin signalling through proteinase activated receptors (pars)
(R-HSA-456926)
Thromboxane signalling through tp receptor
(R-HSA-428930)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Adenylate cyclase-modulating g protein-coupled receptor signaling pathway
(GO:0007188)
Branching involved in blood vessel morphogenesis
(GO:0001569)
Brush border membrane
(GO:0031526)
Cell differentiation
(GO:0030154)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
D5 dopamine receptor binding
(GO:0031752)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
G-protein beta/gamma-subunit complex binding
(GO:0031683)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Heterotrimeric g-protein complex
(GO:0005834)
In utero embryonic development
(GO:0001701)
Melanosome
(GO:0042470)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of vascular associated smooth muscle cell migration
(GO:1904753)
Negative regulation of vascular associated smooth muscle cell proliferation
(GO:1904706)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Platelet activation
(GO:0030168)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Protein binding
(GO:0005515)
Regulation of blood pressure
(GO:0008217)
Regulation of cell shape
(GO:0008360)
Regulation of fibroblast migration
(GO:0010762)
Regulation of small gtpase mediated signal transduction
(GO:0051056)
Rho protein signal transduction
(GO:0007266)
Signal transduction
(GO:0007165)

Other Information

Proteins

Guanine nucleotide-binding protein subunit alpha-13

Genular Protein ID: 2595442186

Symbol: GNA13_HUMAN

Name: Guanine nucleotide-binding protein subunit alpha-13

UniProtKB Accession Codes:

Q14344 B2R977 B7Z7R0 F5H1G8 Q8TD70

Database IDs:

Citations:

PubMed ID: 7791744

Title: Expression of GTP-binding protein alpha subunits in human thymocytes.

PubMed ID: 7791744

DOI: 10.1007/bf00926739

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10026210

Title: A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho.

PubMed ID: 10026210

DOI: 10.1074/jbc.274.9.5868

PubMed ID: 11094164

Title: Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho.

PubMed ID: 11094164

DOI: 10.1016/s0014-5793(00)02224-9

PubMed ID: 10747909

Title: Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding.

PubMed ID: 10747909

DOI: 10.1074/jbc.m000415200

PubMed ID: 11976333

Title: Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin.

PubMed ID: 11976333

DOI: 10.1074/jbc.m201984200

PubMed ID: 12399457

Title: PKA-mediated phosphorylation of Galpha 13 switch I region alters the Galpha beta gamma 13-GPCR complex and inhibits Rho activation.

PubMed ID: 12399457

DOI: 10.1074/jbc.m209219200

PubMed ID: 12515866

Title: Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF.

PubMed ID: 12515866

DOI: 10.1073/pnas.0234057100

PubMed ID: 15339924

Title: Galpha13 stimulates cell migration through cortactin-interacting protein Hax-1.

PubMed ID: 15339924

DOI: 10.1074/jbc.m408836200

PubMed ID: 15240885

Title: A role for Galpha12/Galpha13 in p120ctn regulation.

PubMed ID: 15240885

DOI: 10.1073/pnas.0401366101

PubMed ID: 16202387

Title: Socius, a novel binding partner of Galpha12/13, promotes the Galpha12-induced RhoA activation.

PubMed ID: 16202387

DOI: 10.1016/j.bbrc.2005.09.097

PubMed ID: 16787920

Title: A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion.

PubMed ID: 16787920

DOI: 10.1074/jbc.m604376200

PubMed ID: 16705036

Title: The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis.

PubMed ID: 16705036

DOI: 10.1073/pnas.0510254103

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 18703424

Title: RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits.

PubMed ID: 18703424

DOI: 10.1095/biolreprod.107.067504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23994616

Title: A novel Galphas-binding protein, Gas-2 like 2, facilitates the signaling of the A2A adenosine receptor.

PubMed ID: 23994616

DOI: 10.1016/j.bbamcr.2013.08.009

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27084452

Title: Galpha12/13 signaling promotes cervical cancer invasion through the RhoA/ROCK-JNK signaling axis.

PubMed ID: 27084452

DOI: 10.1016/j.bbrc.2016.04.048

PubMed ID: 36543774

Title: Insights into divalent cation regulation and G13-coupling of orphan receptor GPR35.

PubMed ID: 36543774

DOI: 10.1038/s41421-022-00499-8

Sequence Information:

Length: 377
Mass: 44050
Checksum: 929B7B6473C54F2E
Sequence:

MADFLPSRSV LSVCFPGCLL TSGEAEQQRK SKEIDKCLSR EKTYVKRLVK ILLLGAGESG 
KSTFLKQMRI IHGQDFDQRA REEFRPTIYS NVIKGMRVLV DAREKLHIPW GDNSNQQHGD 
KMMSFDTRAP MAAQGMVETR VFLQYLPAIR ALWADSGIQN AYDRRREFQL GESVKYFLDN 
LDKLGEPDYI PSQQDILLAR RPTKGIHEYD FEIKNVPFKM VDVGGQRSER KRWFECFDSV 
TSILFLVSSS EFDQVLMEDR LTNRLTESLN IFETIVNNRV FSNVSIILFL NKTDLLEEKV 
QIVSIKDYFL EFEGDPHCLR DVQKFLVECF RNKRRDQQQK PLYHHFTTAI NTENIRLVFR 
DVKDTILHDN LKQLMLQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GNA13

Associated with

Other Information

Expression of GTP-binding protein alpha subunits in human thymocytes. PubMed ID: 7791744

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. PubMed ID: 10026210

Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho. PubMed ID: 11094164

Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding. PubMed ID: 10747909

Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin. PubMed ID: 11976333

PKA-mediated phosphorylation of Galpha 13 switch I region alters the Galpha beta gamma 13-GPCR complex and inhibits Rho activation. PubMed ID: 12399457

Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF. PubMed ID: 12515866

Galpha13 stimulates cell migration through cortactin-interacting protein Hax-1. PubMed ID: 15339924

A role for Galpha12/Galpha13 in p120ctn regulation. PubMed ID: 15240885

Socius, a novel binding partner of Galpha12/13, promotes the Galpha12-induced RhoA activation. PubMed ID: 16202387

A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion. PubMed ID: 16787920

The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. PubMed ID: 16705036

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. PubMed ID: 17081065

RGS22, a novel testis-specific regulator of G-protein signaling involved in human and mouse spermiogenesis along with GNA12/13 subunits. PubMed ID: 18703424

Initial characterization of the human central proteome. PubMed ID: 21269460

A novel Galphas-binding protein, Gas-2 like 2, facilitates the signaling of the A2A adenosine receptor. PubMed ID: 23994616

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Galpha12/13 signaling promotes cervical cancer invasion through the RhoA/ROCK-JNK signaling axis. PubMed ID: 27084452

Insights into divalent cation regulation and G13-coupling of orphan receptor GPR35. PubMed ID: 36543774